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 MEL_VESMC               Reviewed;          70 AA.
01-FEB-2003, integrated into UniProtKB/Swiss-Prot.
01-FEB-2003, sequence version 1.
22-NOV-2017, entry version 60.
RecName: Full=Melittin;
Flags: Precursor;
Vespula maculifrons (Eastern yellow jacket) (Wasp).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Hymenoptera; Apocrita; Aculeata;
Vespoidea; Vespidae; Vespinae; Vespula.
TISSUE=Venom gland;
Shi W.J., Zhang S.F., Zhang C.-X., Cheng J.A.;
"Cloning and comparative analysis of the venom prepromelittin genes
from four wasp species.";
Yi Chuan Xue Bao 30:555-559(2003).
-!- FUNCTION: Has strong hemolytic activity. Integrates into cell
membranes and has multiple effects, probably, as a result of its
interaction with negatively charged phospholipids. It inhibits
well known transport pumps such as the Na(+)-K(+)-ATPase and the
H(+)-K(+)-ATPase. Increases the permeability of cell membranes to
ions, particularly Na(+) and indirectly Ca(2+), because of the
Na(+)-Ca(2+)-exchange (By similarity). {ECO:0000250}.
-!- SUBUNIT: Monomer and homotetramer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Target cell membrane
{ECO:0000250}. Note=Forms a transmembrane alpha-helix in the
target cell membrane. Forms a membrane channel in the prey (By
similarity). {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- SIMILARITY: Belongs to the melittin family. {ECO:0000305}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
EMBL; AF487911; AAO12205.1; -; mRNA.
ProteinModelPortal; P59262; -.
SMR; P59262; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0044218; C:other organism cell membrane; IEA:UniProtKB-SubCell.
GO; GO:0004860; F:protein kinase inhibitor activity; IEA:InterPro.
GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
GO; GO:0044179; P:hemolysis in other organism; IEA:UniProtKB-KW.
GO; GO:0006811; P:ion transport; IEA:UniProtKB-KW.
InterPro; IPR002116; Melittin/Api_allergen.
Pfam; PF01372; Melittin; 1.
ProDom; PD014636; Melittin/Api_allergen; 1.
2: Evidence at transcript level;
Amidation; Cytolysis; Hemolysis; Ion transport; Membrane; Secreted;
Signal; Target cell membrane; Target membrane; Toxin; Transmembrane;
SIGNAL 1 21 {ECO:0000250}.
PROPEP 22 43 Removed by a dipeptidylpeptidase.
PEPTIDE 44 69 Melittin.
MOD_RES 69 69 Glutamine amide. {ECO:0000250}.
SEQUENCE 70 AA; 7585 MW; 607F52C091C23BB6 CRC64;

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