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Membrane glycoprotein US3

 US03_HCMVT              Reviewed;         186 AA.
B9VXD7;
18-APR-2012, integrated into UniProtKB/Swiss-Prot.
19-OCT-2011, sequence version 1.
10-MAY-2017, entry version 18.
RecName: Full=Membrane glycoprotein US3;
Flags: Precursor;
Name=US3;
Human cytomegalovirus (strain Towne) (HHV-5) (Human herpesvirus 5).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Betaherpesvirinae; Cytomegalovirus.
NCBI_TaxID=10363;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Towne;
PubMed=19553388; DOI=10.1099/vir.0.013250-0;
Bradley A.J., Lurain N.S., Ghazal P., Trivedi U., Cunningham C.,
Baluchova K., Gatherer D., Wilkinson G.W., Dargan D.J., Davison A.J.;
"High-throughput sequence analysis of variants of human
cytomegalovirus strains Towne and AD169.";
J. Gen. Virol. 90:2375-2380(2009).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15105547; DOI=10.1099/vir.0.79888-0;
Dolan A., Cunningham C., Hector R.D., Hassan-Walker A.F., Lee L.,
Addison C., Dargan D.J., McGeoch D.J., Gatherer D., Emery V.C.,
Griffiths P.D., Sinzger C., McSharry B.P., Wilkinson G.W.G.,
Davison A.J.;
"Genetic content of wild-type human cytomegalovirus.";
J. Gen. Virol. 85:1301-1312(2004).
[3]
MUTAGENESIS OF SER-58; GLU-63 AND LYS-64.
PubMed=12525649; DOI=10.1128/JVI.77.3.2147-2156.2003;
Lee S., Park B., Ahn K.;
"Determinant for endoplasmic reticulum retention in the luminal domain
of the human cytomegalovirus US3 glycoprotein.";
J. Virol. 77:2147-2156(2003).
-!- FUNCTION: Retains, but does not degrade MHC class I heterodimers
in the endoplasmic reticulum during the immediate-early period of
virus infection, thereby impairing their transport and maturation.
Forms a complex with beta-2-microglobulin-associated class I heavy
chains, which accumulate in the ER. In consequence, infected cells
are masked for immune recognition by cytotoxic T-lymphocytes.
-!- SUBUNIT: Monomer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane; Single-
pass type I membrane protein.
-!- DEVELOPMENTAL STAGE: Expressed at immediate-early period of virus
infection and at reduced levels at early-late times.
-!- PTM: The signal sequence is not cleaved. {ECO:0000250}.
-!- PTM: N-glycosylated; mostly exists in a high-mannose form.
-!- SIMILARITY: Belongs to the cytomegalovirus US2 family.
{ECO:0000305}.
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EMBL; FJ616285; ACM48091.1; -; Genomic_DNA.
OrthoDB; VOG090000Y5; -.
Proteomes; UP000006907; Genome.
GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005537; F:mannose binding; IEA:UniProtKB-KW.
GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW.
InterPro; IPR009237; Herpes_US2/US3.
InterPro; IPR014756; Ig_E-set.
Pfam; PF05963; Cytomega_US3; 1.
SUPFAM; SSF81296; SSF81296; 1.
1: Evidence at protein level;
Complete proteome; Disulfide bond; Early protein; Glycoprotein;
Host endoplasmic reticulum; Host membrane; Host-virus interaction;
Immunoglobulin domain; Lectin; Mannose-binding; Membrane; Signal;
Transmembrane; Transmembrane helix; Viral immunoevasion.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 186 Membrane glycoprotein US3.
/FTId=PRO_0000416722.
TOPO_DOM 21 160 Lumenal. {ECO:0000255}.
TRANSMEM 161 181 Helical. {ECO:0000255}.
TOPO_DOM 182 186 Cytoplasmic. {ECO:0000255}.
CARBOHYD 60 60 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
DISULFID 44 129 {ECO:0000250}.
MUTAGEN 58 58 S->A: Loss of endoplasmic reticulum
retention. {ECO:0000269|PubMed:12525649}.
MUTAGEN 63 63 E->A: Loss of endoplasmic reticulum
retention. {ECO:0000269|PubMed:12525649}.
MUTAGEN 64 64 K->A: Loss of endoplasmic reticulum
retention. {ECO:0000269|PubMed:12525649}.
SEQUENCE 186 AA; 21515 MW; CB68FE1E6D6B0DE8 CRC64;
MKPVLVLAIL AVLFLRLADS VPRPLDVVVS EIRSAHFRVE ENQCWFHMGM LHYKGRMSGN
FTEKHFVSVG IVSQSYMDRL QVSGEQYHHD ERGAYFEWNI GGHPVPHTVD MVDITLSTRW
GDPKKYAACV PQVRMDYSSQ TINWYLQRSI RDDNWGLLFR TLLVYLFSLV VLVLLTVGVS
ARLRFI


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