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Membrane glycoprotein US3 (Glycoprotein E) (Protein HQLF1) (gpUS3 IE)

 US03_HCMVA              Reviewed;         186 AA.
P09712; Q7M6H1;
01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
01-JUL-1989, sequence version 1.
23-MAY-2018, entry version 83.
RecName: Full=Membrane glycoprotein US3;
AltName: Full=Glycoprotein E;
AltName: Full=Protein HQLF1;
AltName: Full=gpUS3 IE;
Name=US3;
Human cytomegalovirus (strain AD169) (HHV-5) (Human herpesvirus 5).
Viruses; dsDNA viruses, no RNA stage; Herpesvirales; Herpesviridae;
Betaherpesvirinae; Cytomegalovirus.
NCBI_TaxID=10360;
NCBI_TaxID=9606; Homo sapiens (Human).
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3031311; DOI=10.1016/0022-2836(86)90359-1;
Weston K.M., Barrell B.G.;
"Sequence of the short unique region, short repeats, and part of the
long repeats of human cytomegalovirus.";
J. Mol. Biol. 192:177-208(1986).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=2829427; DOI=10.1016/0042-6822(88)90481-3;
Weston K.M.;
"An enhancer element in the short unique region of human
cytomegalovirus regulates the production of a group of abundant
immediate early transcripts.";
Virology 162:406-416(1988).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=2161319;
Chee M.S., Bankier A.T., Beck S., Bohni R., Brown C.M., Cerny R.,
Horsnell T., Hutchison C.A. III, Kouzarides T., Martignetti J.A.,
Preddie E., Satchwell S.C., Tomlinson P., Weston K.M., Barrell B.G.;
"Analysis of the protein-coding content of the sequence of human
cytomegalovirus strain AD169.";
Curr. Top. Microbiol. Immunol. 154:125-169(1990).
[4]
GENOME REANNOTATION.
PubMed=12533697; DOI=10.1099/vir.0.18606-0;
Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J.,
Alcendor D.J., McGeoch D.J., Hayward G.S.;
"The human cytomegalovirus genome revisited: comparison with the
chimpanzee cytomegalovirus genome.";
J. Gen. Virol. 84:17-28(2003).
[5]
ERRATUM.
Davison A.J., Dolan A., Akter P., Addison C., Dargan D.J.,
Alcendor D.J., McGeoch D.J., Hayward G.S.;
J. Gen. Virol. 84:1053-1053(2003).
[6]
FUNCTION.
PubMed=8876135; DOI=10.1073/pnas.93.21.11327;
Jones T.R., Wiertz E.J.H.J., Sun L., Fish K.N., Nelson J.A.,
Ploegh H.L.;
"Human cytomegalovirus US3 impairs transport and maturation of major
histocompatibility complex class I heavy chains.";
Proc. Natl. Acad. Sci. U.S.A. 93:11327-11333(1996).
[7]
FUNCTION, SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
PubMed=8855296; DOI=10.1073/pnas.93.20.10990;
Ahn K., Angulo A., Ghazal P., Peterson P.A., Yang Y., Frueh K.;
"Human cytomegalovirus inhibits antigen presentation by a sequential
multistep process.";
Proc. Natl. Acad. Sci. U.S.A. 93:10990-10995(1996).
-!- FUNCTION: Retains, but does not degrade MHC class I heterodimers
in the endoplasmic reticulum during the immediate-early period of
virus infection, thereby impairing their transport and maturation.
Forms a complex with beta-2-microglobulin-associated class I heavy
chains, which accumulate in the ER. In consequence, infected cells
are masked for immune recognition by cytotoxic T-lymphocytes.
{ECO:0000269|PubMed:8855296, ECO:0000269|PubMed:8876135}.
-!- SUBUNIT: Monomer. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Host endoplasmic reticulum membrane
{ECO:0000269|PubMed:8855296}; Single-pass type I membrane protein
{ECO:0000269|PubMed:8855296}.
-!- DEVELOPMENTAL STAGE: Expressed at immediate-early period of virus
infection and at reduced levels at early-late times.
{ECO:0000269|PubMed:8855296}.
-!- PTM: The signal sequence is not cleaved. {ECO:0000250}.
-!- PTM: N-glycosylated; mostly exists in a high-mannose form.
-!- SIMILARITY: Belongs to the cytomegalovirus US2 family.
{ECO:0000305}.
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EMBL; X17403; CAA35314.1; -; Genomic_DNA.
EMBL; X04650; CAB37097.1; -; Genomic_DNA.
EMBL; M18921; AAA45958.1; -; Genomic_DNA.
EMBL; BK000394; DAA00217.1; -; Genomic_DNA.
PIR; F26078; QQBEC6.
PRIDE; P09712; -.
OrthoDB; VOG090000Y5; -.
Proteomes; UP000008991; Genome.
Proteomes; UP000008992; Genome.
GO; GO:0044167; C:host cell endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005537; F:mannose binding; IEA:UniProtKB-KW.
GO; GO:0030683; P:evasion or tolerance by virus of host immune response; IEA:UniProtKB-KW.
InterPro; IPR009237; Herpes_US2/US3.
InterPro; IPR014756; Ig_E-set.
Pfam; PF05963; Cytomega_US3; 1.
SUPFAM; SSF81296; SSF81296; 1.
2: Evidence at transcript level;
Complete proteome; Disulfide bond; Early protein; Glycoprotein;
Host endoplasmic reticulum; Host membrane; Host-virus interaction;
Immunoglobulin domain; Lectin; Mannose-binding; Membrane;
Reference proteome; Signal; Transmembrane; Transmembrane helix;
Viral immunoevasion.
CHAIN 1 186 Membrane glycoprotein US3.
/FTId=PRO_0000223277.
SIGNAL 1 ? Not cleaved. {ECO:0000250}.
TOPO_DOM 1 160 Lumenal. {ECO:0000255}.
TRANSMEM 161 181 Helical. {ECO:0000255}.
TOPO_DOM 182 186 Cytoplasmic. {ECO:0000255}.
DOMAIN 35 133 Ig-like H-type.
CARBOHYD 60 60 N-linked (GlcNAc...) asparagine; by host.
{ECO:0000255}.
DISULFID 44 129 {ECO:0000250}.
SEQUENCE 186 AA; 21574 MW; 671753C1AA75920D CRC64;
MKPVLVLAIL AVLFLRLADS VPRPLDVVVS EIRSAHFRVE ENQCWFHMGM LYFKGRMSGN
FTEKHFVNVG IVSQSYMDRL QVSGEQYHHD ERGAYFEWNI GGHPVTHTVD MVDITLSTRW
GDPKKYAACV PQVRMDYSSQ TINWYLQRSM RDDNWGLLFR TLLVYLFSLV VLVLLTVGVS
ARLRFI


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