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Membrane lipoprotein TmpC (Membrane protein C) (35 kDa antigen) (Lipoprotein TpN35) (Purine nucleoside receptor A) (PnrA)

 TMPC_TREPA              Reviewed;         353 AA.
P29724; O83339;
01-APR-1993, integrated into UniProtKB/Swiss-Prot.
15-DEC-1998, sequence version 2.
25-OCT-2017, entry version 110.
RecName: Full=Membrane lipoprotein TmpC;
Short=Membrane protein C;
AltName: Full=35 kDa antigen;
AltName: Full=Lipoprotein TpN35;
AltName: Full=Purine nucleoside receptor A;
Short=PnrA;
Flags: Precursor;
Name=tmpC; OrderedLocusNames=TP_0319;
Treponema pallidum (strain Nichols).
Bacteria; Spirochaetes; Spirochaetales; Spirochaetaceae; Treponema.
NCBI_TaxID=243276;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], MUTAGENESIS OF CYS-21,
DIACYLGLYCEROL AT CYS-21, AND PALMITOYLATION AT CYS-21.
STRAIN=Nichols;
PubMed=1894360;
Schouls L.M., van der Heide H.G.J., van Embden J.D.A.;
"Characterization of the 35-kilodalton Treponema pallidum subsp.
pallidum recombinant lipoprotein TmpC and antibody response to
lipidated and nonlipidated T. pallidum antigens.";
Infect. Immun. 59:3536-3546(1991).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Nichols;
PubMed=9665876; DOI=10.1126/science.281.5375.375;
Fraser C.M., Norris S.J., Weinstock G.M., White O., Sutton G.G.,
Dodson R.J., Gwinn M.L., Hickey E.K., Clayton R.A., Ketchum K.A.,
Sodergren E., Hardham J.M., McLeod M.P., Salzberg S.L., Peterson J.D.,
Khalak H.G., Richardson D.L., Howell J.K., Chidambaram M.,
Utterback T.R., McDonald L.A., Artiach P., Bowman C., Cotton M.D.,
Fujii C., Garland S.A., Hatch B., Horst K., Roberts K.M., Sandusky M.,
Weidman J.F., Smith H.O., Venter J.C.;
"Complete genome sequence of Treponema pallidum, the syphilis
spirochete.";
Science 281:375-388(1998).
[3]
X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 36-353 IN COMPLEXES WITH
NUCLEOSIDES, PARTIAL PROTEIN SEQUENCE, FUNCTION, INDUCTION, AND
SUBUNIT.
PubMed=16418175; DOI=10.1074/jbc.M511405200;
Deka R.K., Brautigam C.A., Yang X.F., Blevins J.S., Machius M.,
Tomchick D.R., Norgard M.V.;
"The PnrA (Tp0319; TmpC) lipoprotein represents a new family of
bacterial purine nucleoside receptor encoded within an ATP-binding
cassette (ABC)-like operon in Treponema pallidum.";
J. Biol. Chem. 281:8072-8081(2006).
-!- FUNCTION: Binds purine nucleosides and may play a role in purine
nucleoside uptake. May be part of an ABC-type nucleoside uptake
system. Has highest affinity for guanosine, followed by inosine
and adenosine. Has very low affinity for cytidine and does not
bind thymidine. {ECO:0000269|PubMed:16418175}.
-!- SUBUNIT: Monomer. {ECO:0000269|PubMed:16418175}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor
{ECO:0000305}.
-!- INDUCTION: Encoded in an operon with TP_0320, TP_0321, TP_0322 and
TP_0323 that may code for an ABC-type nucleoside uptake system,
with TP_0322 and/or TP_0323 encoding putative permeases, and
TP_0319 encoding a ligand-binding protein.
{ECO:0000269|PubMed:16418175}.
-!- SIMILARITY: Belongs to the BMP lipoprotein family. {ECO:0000305}.
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EMBL; X57836; CAA40968.1; -; Genomic_DNA.
EMBL; AE000520; AAC65302.1; -; Genomic_DNA.
PIR; H71340; H71340.
RefSeq; WP_010881767.1; NC_021490.2.
PDB; 2FQW; X-ray; 1.71 A; A=36-353.
PDB; 2FQX; X-ray; 1.70 A; A=36-353.
PDB; 2FQY; X-ray; 1.90 A; A=36-353.
PDBsum; 2FQW; -.
PDBsum; 2FQX; -.
PDBsum; 2FQY; -.
ProteinModelPortal; P29724; -.
SMR; P29724; -.
STRING; 243276.TP0319; -.
TCDB; 3.A.1.2.10; the atp-binding cassette (abc) superfamily.
EnsemblBacteria; AAC65302; AAC65302; TP_0319.
KEGG; tpa:TP_0319; -.
eggNOG; ENOG4107TFB; Bacteria.
eggNOG; COG1744; LUCA.
KO; K07335; -.
OMA; PTVTIFM; -.
EvolutionaryTrace; P29724; -.
Proteomes; UP000000811; Chromosome.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0006810; P:transport; IEA:UniProtKB-KW.
InterPro; IPR028082; Peripla_BP_I.
InterPro; IPR003760; PnrA-like.
Pfam; PF02608; Bmp; 1.
SUPFAM; SSF53822; SSF53822; 1.
PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
1: Evidence at protein level;
3D-structure; Cell membrane; Complete proteome;
Direct protein sequencing; Lipoprotein; Membrane; Palmitate;
Reference proteome; Signal; Transport.
SIGNAL 1 20
CHAIN 21 353 Membrane lipoprotein TmpC.
/FTId=PRO_0000018007.
BINDING 47 47 Guanosine.
BINDING 57 57 Guanosine.
BINDING 128 128 Guanosine.
BINDING 206 206 Guanosine.
BINDING 232 232 Guanosine; via amide nitrogen.
BINDING 258 258 Guanosine.
BINDING 280 280 Guanosine.
LIPID 21 21 N-palmitoyl cysteine.
{ECO:0000255|PROSITE-ProRule:PRU00303,
ECO:0000269|PubMed:1894360}.
LIPID 21 21 S-diacylglycerol cysteine.
{ECO:0000305|PubMed:1894360}.
MUTAGEN 21 21 C->S: Loss of lipid incorporation and
cleavage at alternative processing site.
{ECO:0000269|PubMed:1894360}.
CONFLICT 11 11 G -> A (in Ref. 1; CAA40968).
{ECO:0000305}.
CONFLICT 159 159 A -> R (in Ref. 1; CAA40968).
{ECO:0000305}.
STRAND 41 49 {ECO:0000244|PDB:2FQX}.
STRAND 53 55 {ECO:0000244|PDB:2FQX}.
HELIX 56 70 {ECO:0000244|PDB:2FQX}.
STRAND 74 79 {ECO:0000244|PDB:2FQX}.
HELIX 83 85 {ECO:0000244|PDB:2FQX}.
HELIX 86 95 {ECO:0000244|PDB:2FQX}.
STRAND 99 105 {ECO:0000244|PDB:2FQX}.
TURN 106 108 {ECO:0000244|PDB:2FQX}.
HELIX 109 118 {ECO:0000244|PDB:2FQX}.
STRAND 124 129 {ECO:0000244|PDB:2FQX}.
STRAND 137 142 {ECO:0000244|PDB:2FQX}.
HELIX 144 161 {ECO:0000244|PDB:2FQX}.
STRAND 166 172 {ECO:0000244|PDB:2FQX}.
TURN 176 178 {ECO:0000244|PDB:2FQX}.
HELIX 179 192 {ECO:0000244|PDB:2FQX}.
STRAND 197 202 {ECO:0000244|PDB:2FQX}.
HELIX 209 221 {ECO:0000244|PDB:2FQX}.
STRAND 226 230 {ECO:0000244|PDB:2FQX}.
HELIX 232 234 {ECO:0000244|PDB:2FQX}.
HELIX 235 247 {ECO:0000244|PDB:2FQX}.
STRAND 253 259 {ECO:0000244|PDB:2FQX}.
HELIX 262 265 {ECO:0000244|PDB:2FQX}.
STRAND 268 270 {ECO:0000244|PDB:2FQX}.
STRAND 272 280 {ECO:0000244|PDB:2FQX}.
HELIX 282 294 {ECO:0000244|PDB:2FQX}.
STRAND 303 306 {ECO:0000244|PDB:2FQX}.
TURN 308 311 {ECO:0000244|PDB:2FQX}.
STRAND 312 314 {ECO:0000244|PDB:2FQX}.
HELIX 324 338 {ECO:0000244|PDB:2FQX}.
HELIX 349 351 {ECO:0000244|PDB:2FQX}.
SEQUENCE 353 AA; 37769 MW; CB373138C8C4337D CRC64;
MREKWVRAFA GVFCAMLLIG CSKSDRPQMG NAGGAEGGDF VVGMVTDSGD IDDKSFNQQV
WEGISRFAQE NNAKCKYVTA STDAEYVPSL SAFADENMGL VVACGSFLVE AVIETSARFP
KQKFLVIDAV VQDRDNVVSA VFGQNEGSFL VGVAAALKAK EAGKSAVGFI VGMELGMMPL
FEAGFEAGVK AVDPDIQVVV EVANTFSDPQ KGQALAAKLY DSGVNVIFQV AGGTGNGVIK
EARDRRLNGQ DVWVIGVDRD QYMDGVYDGS KSVVLTSMVK RADVAAERIS KMAYDGSFPG
GQSIMFGLED KAVGIPEENP NLSSAVMEKI RSFEEKIVSK EIVVPVRSAR MMN


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