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Membrane progestin receptor beta (mPR beta) (Lysosomal membrane protein in brain 1) (Membrane progesterone P4 receptor beta) (Membrane progesterone receptor beta) (Progesterone and adipoQ receptor family member 8) (Progestin and adipoQ receptor family member 8) (Progestin and adipoQ receptor family member VIII)

 PAQR8_MOUSE             Reviewed;         354 AA.
Q80ZE5; Q3UHI5; Q8C891; Q8CCW9; Q9DA71;
16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
16-AUG-2004, sequence version 2.
25-OCT-2017, entry version 102.
RecName: Full=Membrane progestin receptor beta {ECO:0000250|UniProtKB:Q8TEZ7};
Short=mPR beta {ECO:0000250|UniProtKB:Q8TEZ7};
AltName: Full=Lysosomal membrane protein in brain 1 {ECO:0000303|PubMed:11676489};
AltName: Full=Membrane progesterone P4 receptor beta {ECO:0000250|UniProtKB:Q8TEZ7};
AltName: Full=Membrane progesterone receptor beta {ECO:0000250|UniProtKB:Q8TEZ7};
AltName: Full=Progesterone and adipoQ receptor family member 8;
AltName: Full=Progestin and adipoQ receptor family member 8 {ECO:0000250|UniProtKB:Q8TEZ7};
AltName: Full=Progestin and adipoQ receptor family member VIII;
Name=Paqr8 {ECO:0000312|MGI:MGI:1921479}; Synonyms=Mprb;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
STRAIN=CD-1; TISSUE=Testis;
PubMed=12601167; DOI=10.1073/pnas.0436133100;
Zhu Y., Bond J., Thomas P.;
"Identification, classification, and partial characterization of genes
in humans and other vertebrates homologous to a fish membrane
progestin receptor.";
Proc. Natl. Acad. Sci. U.S.A. 100:2237-2242(2003).
[2]
NUCLEOTIDE SEQUENCE [MRNA].
STRAIN=C57BL/6J;
PubMed=16044242; DOI=10.1007/s00239-004-0375-2;
Tang Y.T., Hu T., Arterburn M., Boyle B., Bright J.M., Emtage P.C.,
Funk W.D.;
"PAQR proteins: a novel membrane receptor family defined by an ancient
7-transmembrane pass motif.";
J. Mol. Evol. 61:372-380(2005).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Head, Medulla oblongata, and Testis;
PubMed=16141072; DOI=10.1126/science.1112014;
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M.,
Davis M.J., Wilming L.G., Aidinis V., Allen J.E.,
Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L.,
Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M.,
Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R.,
Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G.,
di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G.,
Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M.,
Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N.,
Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T.,
Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H.,
Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K.,
Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J.,
Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L.,
Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K.,
Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P.,
Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O.,
Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G.,
Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M.,
Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B.,
Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K.,
Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A.,
Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K.,
Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C.,
Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J.,
Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y.,
Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T.,
Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N.,
Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N.,
Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S.,
Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J.,
Hayashizaki Y.;
"The transcriptional landscape of the mammalian genome.";
Science 309:1559-1563(2005).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=C57BL/6J; TISSUE=Brain;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
TISSUE SPECIFICITY.
PubMed=11676489; DOI=10.1006/bbrc.2001.5825;
Suzuki T., Ganesh S., Agarwala K.L., Morita R., Sugimoto Y.,
Inazawa J., Delgado-Escueta A.V., Yamakawa K.;
"A novel gene in the chromosomal region for juvenile myoclonic
epilepsy on 6p12 encodes a brain-specific lysosomal membrane
protein.";
Biochem. Biophys. Res. Commun. 288:626-636(2001).
-!- FUNCTION: Plasma membrane progesterone (P4) receptor coupled to G
proteins. Seems to act through a G(i) mediated pathway (By
similarity). May be involved in oocyte maturation
(PubMed:12601167). Also binds dehydroepiandrosterone (DHEA),
pregnanolone, pregnenolone and allopregnanolone (By similarity).
{ECO:0000250|UniProtKB:Q8TEZ7, ECO:0000269|PubMed:12601167}.
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000250|UniProtKB:Q8TEZ7}; Multi-pass membrane protein
{ECO:0000255}. Note=Colocalizes with a lysosomal protein
CTSD/cathepsin D. {ECO:0000250|UniProtKB:Q8TEZ7}.
-!- TISSUE SPECIFICITY: Expressed in brain and testis.
{ECO:0000269|PubMed:11676489}.
-!- MISCELLANEOUS: Non-classical progesterone receptors involved in
extranuclear signaling are classified in 2 groups: the class II
progestin and adipoQ receptor (PAQR) family (also called mPRs)
(PAQR5, PAQR6, PAQR7, PAQR8 and PAQR9) and the b5-like
heme/steroid-binding protein family (also called MAPRs) (PGRMC1,
PGRMC2, NENF and CYB5D2). {ECO:0000250|UniProtKB:Q8TEZ7}.
-!- SIMILARITY: Belongs to the ADIPOR family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=BAC27629.1; Type=Frameshift; Positions=324; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AF313617; AAO47230.1; -; mRNA.
EMBL; AY424297; AAR08385.1; -; mRNA.
EMBL; AK006107; BAB24412.1; -; mRNA.
EMBL; AK029772; BAC26609.1; -; mRNA.
EMBL; AK031969; BAC27629.1; ALT_FRAME; mRNA.
EMBL; AK048045; BAC33221.1; -; mRNA.
EMBL; AK147376; BAE27872.1; -; mRNA.
EMBL; BC059813; AAH59813.1; -; mRNA.
CCDS; CCDS14844.1; -.
RefSeq; NP_083105.3; NM_028829.3.
RefSeq; XP_006495640.1; XM_006495577.2.
RefSeq; XP_006495641.1; XM_006495578.3.
UniGene; Mm.40780; -.
ProteinModelPortal; Q80ZE5; -.
STRING; 10090.ENSMUSP00000069127; -.
iPTMnet; Q80ZE5; -.
PhosphoSitePlus; Q80ZE5; -.
MaxQB; Q80ZE5; -.
PaxDb; Q80ZE5; -.
PRIDE; Q80ZE5; -.
Ensembl; ENSMUST00000068880; ENSMUSP00000069127; ENSMUSG00000025931.
Ensembl; ENSMUST00000167119; ENSMUSP00000128781; ENSMUSG00000025931.
Ensembl; ENSMUST00000187651; ENSMUSP00000140913; ENSMUSG00000025931.
Ensembl; ENSMUST00000189400; ENSMUSP00000141054; ENSMUSG00000025931.
GeneID; 74229; -.
KEGG; mmu:74229; -.
UCSC; uc007ald.1; mouse.
CTD; 85315; -.
MGI; MGI:1921479; Paqr8.
eggNOG; KOG0748; Eukaryota.
eggNOG; COG1272; LUCA.
GeneTree; ENSGT00530000062965; -.
HOGENOM; HOG000230872; -.
HOVERGEN; HBG052504; -.
InParanoid; Q80ZE5; -.
OMA; REPYIHA; -.
OrthoDB; EOG091G0QDA; -.
PhylomeDB; Q80ZE5; -.
TreeFam; TF319738; -.
PRO; PR:Q80ZE5; -.
Proteomes; UP000000589; Chromosome 1.
Bgee; ENSMUSG00000025931; -.
CleanEx; MM_PAQR8; -.
Genevisible; Q80ZE5; MM.
GO; GO:0005794; C:Golgi apparatus; ISO:MGI.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; ISO:MGI.
GO; GO:0005496; F:steroid binding; IBA:GO_Central.
GO; GO:0003707; F:steroid hormone receptor activity; IBA:GO_Central.
GO; GO:0007275; P:multicellular organism development; IEA:UniProtKB-KW.
GO; GO:0048477; P:oogenesis; IEA:UniProtKB-KW.
GO; GO:0048545; P:response to steroid hormone; IBA:GO_Central.
InterPro; IPR004254; AdipoR/HlyIII-related.
PANTHER; PTHR20855; PTHR20855; 1.
Pfam; PF03006; HlyIII; 1.
2: Evidence at transcript level;
Cell membrane; Complete proteome; Developmental protein;
Differentiation; Lipid-binding; Membrane; Oogenesis; Receptor;
Reference proteome; Steroid-binding; Transmembrane;
Transmembrane helix.
CHAIN 1 354 Membrane progestin receptor beta.
/FTId=PRO_0000218841.
TOPO_DOM 1 76 Cytoplasmic. {ECO:0000255}.
TRANSMEM 77 97 Helical; Name=1. {ECO:0000255}.
TOPO_DOM 98 111 Extracellular. {ECO:0000255}.
TRANSMEM 112 132 Helical; Name=2. {ECO:0000255}.
TOPO_DOM 133 173 Cytoplasmic. {ECO:0000255}.
TRANSMEM 174 194 Helical; Name=3. {ECO:0000255}.
TOPO_DOM 195 213 Extracellular. {ECO:0000255}.
TRANSMEM 214 234 Helical; Name=4. {ECO:0000255}.
TOPO_DOM 235 243 Cytoplasmic. {ECO:0000255}.
TRANSMEM 244 264 Helical; Name=5. {ECO:0000255}.
TOPO_DOM 265 283 Extracellular. {ECO:0000255}.
TRANSMEM 284 304 Helical; Name=6. {ECO:0000255}.
TOPO_DOM 305 315 Cytoplasmic. {ECO:0000255}.
TRANSMEM 316 336 Helical; Name=7. {ECO:0000255}.
TOPO_DOM 337 354 Extracellular. {ECO:0000255}.
CONFLICT 41 41 D -> G (in Ref. 3; AAR08385/BAC33221).
{ECO:0000305}.
CONFLICT 116 116 I -> V (in Ref. 1; AAO47230).
{ECO:0000305}.
CONFLICT 177 177 I -> L (in Ref. 1; AAO47230).
{ECO:0000305}.
CONFLICT 339 339 T -> S (in Ref. 1; AAO47230).
{ECO:0000305}.
SEQUENCE 354 AA; 40430 MW; 14544CBB3338B538 CRC64;
MTTAILERLS TLSMSGQQLR RLPKILEEGL PKMPCTVPET DVPQLFREPY IHAGYRPTGH
EWRYYFFSLF QKHNEVVNVW THLLAALAVL LRFWAFVEAG ALQWASPHTL PLLLFILSSI
TYLTCSLLAH LLQSKSELSH YTFYFVDYVG VSVYQYGSAL AHFFYSSDQA WYELFWIFFL
PAAAFCGWLS CAGCCYAKYR YRRPYPVMRK ICQVVPAGLA FVLDISPVAH RVALCHLAGC
QEQAAWYHTL QILFFLVSAY FFSCPVPEKY FPGSCDIVGH GHQIFHAFLS VCTLSQLEAI
LLDYQGRHEI FLQRHGPLSV YSACLSFFVL AACSAATATL LRHKVKDRLI KKDS


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