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Membrane-anchored lipid-binding protein LAM1 (Lipid transfer protein anchored at membrane contact sites 1) (Yeast suicide protein 1)
LAM1_YEAST Reviewed; 1228 AA.
P38851; D3DLA4;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
01-FEB-1995, sequence version 1.
28-MAR-2018, entry version 119.
RecName: Full=Membrane-anchored lipid-binding protein LAM1 {ECO:0000303|PubMed:26001273};
AltName: Full=Lipid transfer protein anchored at membrane contact sites 1 {ECO:0000303|PubMed:26001273};
AltName: Full=Yeast suicide protein 1 {ECO:0000303|PubMed:15657396};
Name=LAM1 {ECO:0000303|PubMed:26001273};
Synonyms=YSP1 {ECO:0000303|PubMed:15657396};
OrderedLocusNames=YHR155W {ECO:0000312|SGD:S000001198};
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina;
Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.
NCBI_TaxID=559292;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 204508 / S288c;
PubMed=8091229; DOI=10.1126/science.8091229;
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J.,
Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J.,
Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y.,
Latreille P., Louis E.J., Macri C., Mardis E., Menezes S., Mouser L.,
Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K.,
Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R.,
Vaudin M.;
"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome
VIII.";
Science 265:2077-2082(1994).
[2]
GENOME REANNOTATION.
STRAIN=ATCC 204508 / S288c;
PubMed=24374639; DOI=10.1534/g3.113.008995;
Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M.,
Cherry J.M.;
"The reference genome sequence of Saccharomyces cerevisiae: Then and
now.";
G3 (Bethesda) 4:389-398(2014).
[3]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=14562095; DOI=10.1038/nature02026;
Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
Weissman J.S., O'Shea E.K.;
"Global analysis of protein localization in budding yeast.";
Nature 425:686-691(2003).
[4]
LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
PubMed=14562106; DOI=10.1038/nature02046;
Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A.,
Dephoure N., O'Shea E.K., Weissman J.S.;
"Global analysis of protein expression in yeast.";
Nature 425:737-741(2003).
[5]
DOMAIN.
PubMed=15023338; DOI=10.1016/S1097-2765(04)00083-8;
Yu J.W., Mendrola J.M., Audhya A., Singh S., Keleti D., DeWald D.B.,
Murray D., Emr S.D., Lemmon M.A.;
"Genome-wide analysis of membrane targeting by S.cerevisiae pleckstrin
homology domains.";
Mol. Cell 13:677-688(2004).
[6]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=15657396; DOI=10.1083/jcb.200408145;
Pozniakovsky A.I., Knorre D.A., Markova O.V., Hyman A.A.,
Skulachev V.P., Severin F.F.;
"Role of mitochondria in the pheromone- and amiodarone-induced
programmed death of yeast.";
J. Cell Biol. 168:257-269(2005).
[7]
FUNCTION.
PubMed=18800175;
Lushchak V., Abrat O., Miedzobrodzki J., Semchyshyn H.;
"Pdr12p-dependent and -independent fluorescein extrusion from baker's
yeast cells.";
Acta Biochim. Pol. 55:595-601(2008).
[8]
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=26001273; DOI=10.7554/eLife.07253;
Gatta A.T., Wong L.H., Sere Y.Y., Calderon-Norena D.M., Cockcroft S.,
Menon A.K., Levine T.P.;
"A new family of StART domain proteins at membrane contact sites has a
role in ER-PM sterol transport.";
Elife 4:E07253-E07253(2015).
-!- FUNCTION: Involved in mitochondrial fragmentation during
programmed cell death in response to high levels of alpha-factor
mating pheromone or the drug amiodarone (PubMed:15657396,
PubMed:18800175). May be involved in sterol transfer between
intracellular membranes (PubMed:26001273).
{ECO:0000269|PubMed:15657396, ECO:0000269|PubMed:18800175,
ECO:0000269|PubMed:26001273}.
-!- INTERACTION:
P36008:TEF4; NbExp=3; IntAct=EBI-3774829, EBI-6329;
-!- SUBCELLULAR LOCATION: Mitochondrion membrane
{ECO:0000269|PubMed:14562095, ECO:0000269|PubMed:15657396};
Single-pass membrane protein {ECO:0000255}. Endoplasmic reticulum
membrane {ECO:0000269|PubMed:26001273}; Single-pass membrane
protein {ECO:0000255}. Note=Localizes to puncta in the cell
periphery representing cortical endoplasmic reticulum (cER)-plasma
membrane (PM) membrane contact sites.
{ECO:0000269|PubMed:26001273}.
-!- DOMAIN: The VASt domain bind sterols.
{ECO:0000250|UniProtKB:P38800}.
-!- MISCELLANEOUS: Present with 1170 molecules/cell in log phase SD
medium. {ECO:0000269|PubMed:14562106}.
-!- SIMILARITY: Belongs to the SIP3 family. {ECO:0000305}.
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EMBL; U10397; AAB68977.1; -; Genomic_DNA.
EMBL; BK006934; DAA06848.1; -; Genomic_DNA.
PIR; S46754; S46754.
RefSeq; NP_012025.1; NM_001179286.1.
ProteinModelPortal; P38851; -.
SMR; P38851; -.
BioGrid; 36589; 65.
IntAct; P38851; 13.
MINT; P38851; -.
STRING; 4932.YHR155W; -.
TCDB; 9.B.198.1.1; the membrane-anchored lipid-binding protein (lam) family.
MaxQB; P38851; -.
PaxDb; P38851; -.
PRIDE; P38851; -.
TopDownProteomics; P38851; -.
EnsemblFungi; YHR155W; YHR155W; YHR155W.
GeneID; 856560; -.
KEGG; sce:YHR155W; -.
EuPathDB; FungiDB:YHR155W; -.
SGD; S000001198; LAM1.
GeneTree; ENSGT00390000016474; -.
HOGENOM; HOG000057112; -.
InParanoid; P38851; -.
OrthoDB; EOG092C0B9T; -.
BioCyc; YEAST:G3O-31190-MONOMER; -.
PRO; PR:P38851; -.
Proteomes; UP000002311; Chromosome VIII.
GO; GO:0032541; C:cortical endoplasmic reticulum; IDA:SGD.
GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
GO; GO:0005739; C:mitochondrion; IDA:SGD.
GO; GO:0015248; F:sterol transporter activity; IC:SGD.
GO; GO:0032366; P:intracellular sterol transport; IMP:SGD.
Gene3D; 1.20.1270.60; -; 1.
Gene3D; 2.30.29.30; -; 1.
InterPro; IPR027267; AH/BAR_dom_sf.
InterPro; IPR011993; PH-like_dom_sf.
InterPro; IPR001849; PH_domain.
InterPro; IPR031968; VASt.
Pfam; PF16016; DUF4782; 1.
Pfam; PF00169; PH; 1.
SMART; SM00233; PH; 1.
SUPFAM; SSF103657; SSF103657; 2.
PROSITE; PS50003; PH_DOMAIN; 1.
PROSITE; PS51778; VAST; 1.
1: Evidence at protein level;
Complete proteome; Endoplasmic reticulum; Glycoprotein; Membrane;
Mitochondrion; Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 1228 Membrane-anchored lipid-binding protein
LAM1.
/FTId=PRO_0000202927.
TOPO_DOM 1 1062 Cytoplasmic.
{ECO:0000305|PubMed:26001273}.
TRANSMEM 1063 1083 Helical. {ECO:0000255}.
TOPO_DOM 1084 1228 Lumenal. {ECO:0000250|UniProtKB:P38717}.
DOMAIN 308 421 PH. {ECO:0000255|PROSITE-
ProRule:PRU00145}.
DOMAIN 773 978 VASt. {ECO:0000255|PROSITE-
ProRule:PRU01114}.
CARBOHYD 1205 1205 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
SEQUENCE 1228 AA; 143584 MW; C8872EAE8270A4B6 CRC64;
MHEHKAELRL ITVALNEAST DSPSFRASVN YFHTRMESLS SWMHSTVDYV ENTYKPSFQD
FQRIKETLFS QLLPSPILLS NGFVSNQPYT PLLVRDFTRD VSDLSNTVMK IILGDENSQY
TAALSALSSD AINPYFNKRK TFEYYQRKYD SFLTDFLAAT NDGNTLIPQN LQNETFKLVD
IKHKYIEASL DLTEAISLMK VNLDKFLIET IDIVRKNNVI TTKDTKDVID ITPELTETLK
DWTDWIESNL QTLQALSSKL SEAKYAILKL SLARMKPSRL IQDYDLKSIQ NLKFNLPKSI
SNGNNSEEKG LSGWLYMKTT VGHDPKRVVW VRRWCFLQNN VFGVFSLSPS KTYVEETDKF
GILWITVEYL PKEPRNFCFK LRIQNPNCKT EEENTYIDII LQAESIDELK SWINTLTSHK
RIALSIKEEN DPRYQLARKK IEPQFFEFAS SSSTSTDKLL TSFSSKTLTL VEELKKNYMS
EDDIYSIIDN KAYHLRVIST PIATQLTHLA LFSTFLSVSN YYPCATQANT WGTANWNDLS
YLVNPLKGSS VHKPATVSNS SRFSVSYPDY YPYSLKVDDI QFRSIFFSVN HDFLQVPKEL
VLLRYSSVWC PNNKQKFASM AFVTLNHIYV YLNISGFSYL RRIDLLDIDS IEYDKSPKHV
SSRMLHMQRG DGLRFNMSVF FTDRRAVASK LQFLIENKAM HIPKGEKEVL EIFQELDEEI
ENEKKIIKDN LSESEHYSKD YDYLLKSTYD HHFENTNETP MELMSRKLRL EREAWCYFQD
NFKVGSKTLF HVLFGDKSQV FPSSLFLCKK GSNLNNNSYW ERIRRAKEDA SCQFELCRKL
QFQLNRTSNF IKDLLWLKDD NDNFKLVLQQ RVTKIKQGYY FEVEEGPIIV KFPLCHPLLL
RVRFIIAECI TSQGESLKKC DLAILYDFNY VESIDKLNTK VEKLWLFERI HLNWALRYCK
LEHSEINRKT REYLKKFNDR EKMSDVIKLC GFLGVLPKER IENDEKAGDF MQPVYINYDF
LSLSKIFTKL TVFYLSSVII KTMKVLLAMV MVIFKCFSKV NKTLYYCLLI SAVTNLFFVG
KSIHSYFSVK SAETLFQNYA NGDQRGLQIM HRSLTVPDLN LLTRKMMDND QENPVFKRFD
EDKNAYQYKG TRQEIAIKRN QVLTELKILQ NTEKELVQGS YRKFIITERD KCITTQNEIF
DLWINDTKLQ DYCMACFAEY NRLSAIPV
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Pathways :
WP1502: Mitochondrial biogenesis
WP1624: Bacterial secretion system
WP1665: Limonene and pinene degradation
WP1689: Porphyrin and chlorophyll metabolism
WP1692: Protein export
WP1713: Two-component system
WP1714: Tyrosine metabolism
WP2199: Seed Development
WP1531: Vitamin D synthesis
WP1616: ABC transporters
WP2292: Chemokine signaling pathway
WP731: Sterol regulatory element binding protein related
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
Related Genes :
[CAPRIN1 GPIAP1 GPIP137 M11S1 RNG105] Caprin-1 (Cell cycle-associated protein 1) (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105)
[YSP2 LAM2 LTC4 YDR326C] Membrane-anchored lipid-binding protein YSP2 (Lipid transfer at contact site protein 4) (Lipid transfer protein anchored at membrane contact sites 3) (Yeast suicide protein 2)
[Caprin1 Gpiap Gpiap1 Gpip137 M11s1 Rng105 G5E5] Caprin-1 (Cytoplasmic activation- and proliferation-associated protein 1) (GPI-anchored membrane protein 1) (GPI-anchored protein p137) (GPI-p137) (p137GPI) (Membrane component chromosome 11 surface marker 1) (RNA granule protein 105)
[LAM6 LTC1 YLR072W] Membrane-anchored lipid-binding protein LAM6 (Lipid transfer at contact site protein 1) (Lipid transfer protein anchored at membrane contact sites 1)
[SIP3 LAM3 YNL257C N0844] Membrane-anchored lipid-binding protein SIP3 (Lipid transfer protein anchored at membrane contact sites 3) (SNF1-interacting protein 3)
[RET CDHF12 CDHR16 PTC RET51] Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
[Ret] Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
[Ret] Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]
[LTPG1 At1g27950 F13K9.6] Non-specific lipid transfer protein GPI-anchored 1 (AtLTPG-1) (Protein LTP-GPI-ANCHORED 1)
[Gpihbp1 Hbp1] Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) (GPI-anchored HDL-binding protein 1) (High density lipoprotein-binding protein 1)
[GPIHBP1 HBP1] Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPI-HBP1) (GPI-anchored HDL-binding protein 1) (High density lipoprotein-binding protein 1)
[CX3CL1 FKN NTT SCYD1 A-152E5.2] Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine]
[Cx3cl1 Cx3c Fkn Scyd1] Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine]
[LAM1 YSP1 YHR155W] Membrane-anchored lipid-binding protein LAM1 (Lipid transfer protein anchored at membrane contact sites 1) (Yeast suicide protein 1)
[LAM4 LTC3 YHR080C] Membrane-anchored lipid-binding protein LAM4 (Lipid transfer at contact site protein 3) (Lipid transfer protein anchored at membrane contact sites 1)
[Cx3cl1 Acc1 Fkn Scyd1] Fractalkine (C-X3-C motif chemokine 1) (CX3C membrane-anchored chemokine) (Neurotactin) (Small-inducible cytokine D1) [Cleaved into: Processed fractalkine]
[LTPG2 XYP5 At3g43720 T28A8.10] Non-specific lipid transfer protein GPI-anchored 2 (AtLTPG-2) (Protein LTP-GPI-ANCHORED 2) (Xylogen-like protein 5) (AtXYP5)
[GET3 ARR4 YDL100C D2371] ATPase GET3 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Golgi to ER traffic protein 3) (Guided entry of tail-anchored proteins 3)
[Majin] Membrane-anchored junction protein
[LRE At4g26466 M3E9] GPI-anchored protein LORELEI
[GET2 HUR2 RMD7 YER083C] Golgi to ER traffic protein 2 (Guided entry of tail-anchored proteins 2) (Hydroxyurea resistance protein 2) (Required for meiotic nuclear division protein 7)
[GAS1 GGP1 YMR307W YM9952.09] 1,3-beta-glucanosyltransferase GAS1 (EC 2.4.1.-) (Glycolipid-anchored surface protein 1) (Glycoprotein GP115)
[MUB2 At5g15460 T20K14.70] Membrane-anchored ubiquitin-fold protein 2 (AtMUB2) (Membrane-anchored ub-fold protein 2) (NTGP5)
[LAM5 LTC2 YFL042C] Membrane-anchored lipid-binding protein LAM5 (Lipid transfer at contact site protein 2) (Lipid transfer protein anchored at membrane contact sites 1)
[VNN2] Vascular non-inflammatory molecule 2 (Vanin-2) (EC 3.5.1.92) (Glycosylphosphatidyl inositol-anchored protein GPI-80) (Protein FOAP-4)
[MUB3 At4g24990 F13M23.130] Membrane-anchored ubiquitin-fold protein 3 (AtMUB3) (Membrane-anchored ub-fold protein 3) (ATGP4)
[LYM1 At1g21880 T26F17.10 T26F17_5] LysM domain-containing GPI-anchored protein 1
[GET1 MDM39 YGL020C] Golgi to ER traffic protein 1 (Guided entry of tail-anchored proteins 1) (Mitochondrial distribution and morphology protein 39)
[PGA10 CRW2 RBT51 RBT8 CAALFM_C400450CA CaO19.13119 CaO19.5674] GPI-anchored protein 10 (Repressed by TUP1 protein 51) (Repressed by TUP1 protein 8)
[PGA7 CRW3 RBT6 CAALFM_C400120WA CaO19.13080 CaO19.5635] Predicted GPI-anchored protein 7 (Repressed by TUP1 protein 6)
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