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Membrane-associated protein TcaA

 TCAA_STAA8              Reviewed;         460 AA.
Q2G2I1;
20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
21-MAR-2006, sequence version 1.
25-OCT-2017, entry version 67.
RecName: Full=Membrane-associated protein TcaA;
Name=tcaA; OrderedLocusNames=SAOUHSC_02635;
Staphylococcus aureus (strain NCTC 8325).
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
Staphylococcus.
NCBI_TaxID=93061;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=NCTC 8325;
Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W.,
Iandolo J.J.;
"The Staphylococcus aureus NCTC 8325 genome.";
(In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
Gram positive pathogens, 2nd edition, pp.381-412, ASM Press,
Washington D.C. (2006).
[2]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=11042376; DOI=10.1016/S0304-4165(00)00133-1;
Brandenberger M., Tschierske M., Giachino P., Wada A.,
Berger-Baechi B.;
"Inactivation of a novel three-cistronic operon tcaR-tcaA-tcaB
increases teicoplanin resistance in Staphylococcus aureus.";
Biochim. Biophys. Acta 1523:135-139(2000).
[3]
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=15155184; DOI=10.1128/AAC.48.6.1953-1959.2004;
Maki H., McCallum N., Bischoff M., Wada A., Berger-Baechi B.;
"TcaA inactivation increases glycopeptide resistance in Staphylococcus
aureus.";
Antimicrob. Agents Chemother. 48:1953-1959(2004).
[4]
INDUCTION.
PubMed=16891058; DOI=10.1016/j.bbagen.2006.06.008;
McCallum N., Spehar G., Bischoff M., Berger-Bachi B.;
"Strain dependence of the cell wall-damage induced stimulon in
Staphylococcus aureus.";
Biochim. Biophys. Acta 1760:1475-1481(2006).
-!- FUNCTION: Plays a major role in decreasing resistance to
glycopeptide antibiotics. {ECO:0000269|PubMed:11042376,
ECO:0000269|PubMed:15155184}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass
membrane protein {ECO:0000250}.
-!- INDUCTION: Strongly induced by teicoplanin, vancomycin and
oxacillin in strain RN4220, a restriction defective laboratory
strain derived from NCTC 8325. {ECO:0000269|PubMed:16891058}.
-!- DISRUPTION PHENOTYPE: Increased in resistance against glycopeptide
antibiotics, especially teicoplanin. The resistance phenotype is
lowered by several folds in strains carrying mutations in the rsbU
gene which codes for a positive regulator of sigma-B.
{ECO:0000269|PubMed:11042376, ECO:0000269|PubMed:15155184}.
-!- SIMILARITY: Belongs to the TcaA family. {ECO:0000305}.
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EMBL; CP000253; ABD31644.1; -; Genomic_DNA.
RefSeq; WP_000833797.1; NC_007795.1.
RefSeq; YP_501096.1; NC_007795.1.
ProteinModelPortal; Q2G2I1; -.
SMR; Q2G2I1; -.
STRING; 93061.SAOUHSC_02635; -.
EnsemblBacteria; ABD31644; ABD31644; SAOUHSC_02635.
GeneID; 3921412; -.
KEGG; sao:SAOUHSC_02635; -.
PATRIC; fig|93061.5.peg.2383; -.
eggNOG; ENOG4105T65; Bacteria.
eggNOG; COG4640; LUCA.
HOGENOM; HOG000090101; -.
KO; K21463; -.
OMA; RTYNWTY; -.
PRO; PR:Q2G2I1; -.
Proteomes; UP000008816; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
Gene3D; 2.20.28.20; -; 1.
InterPro; IPR023599; Mem_prot_TcaA.
InterPro; IPR029038; MetRS_Zn.
PIRSF; PIRSF032522; TcaA; 1.
2: Evidence at transcript level;
Antibiotic resistance; Cell membrane; Complete proteome; Membrane;
Metal-binding; Reference proteome; Transmembrane; Transmembrane helix;
Zinc; Zinc-finger.
CHAIN 1 460 Membrane-associated protein TcaA.
/FTId=PRO_0000333169.
TOPO_DOM 1 49 Cytoplasmic. {ECO:0000255}.
TRANSMEM 50 70 Helical. {ECO:0000255}.
TOPO_DOM 71 460 Extracellular. {ECO:0000255}.
ZN_FING 4 21 C4-type. {ECO:0000255}.
SEQUENCE 460 AA; 52114 MW; 99B31F11D2987FC6 CRC64;
MKSCPKCGQQ AQDDVQICTQ CGHKFDSRQA LYRKSTDEDI QTNNIKMRKM VPWAIGFFIL
ILIIILFFLL RNFNSPEAQT KILVNAIENN DKQKVATLLS TKDNKVDSEE AKVYINYIKD
EVGLKQFVSD LKNTVHKLNK SKTSVASYIQ TRSGQNILRV SKNGTRYIFF DNMSFTAPTK
QPIVKPKEKT KYEFKSGGKK KMVIAEANKV TPIGNFIPGT YRIPAMKSTE NGDFAGHLKF
DFRQSNSETV DVTEDFEEAN ISVTLKGDTK LNDSSKKVTI NDHEMAFSSS KTYGPYPQNK
DITISASGKA KDKTFTTQTK TIKASDLKYN TEITLNFDSE DIEDYVEKKE KEENSLKNKL
IEFFAGYSLA NNAAFNQSDF DFVSSYIKKG SSFYDDVKKR VSKGSLMMIS SPQIIDAEKH
GDKITATVRL INENGKQVDK EYELEQGSQD RLQLIKTSEK


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