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Metabotropic GABA-B receptor subtype 2

 Q9BML6_DROME            Unreviewed;      1220 AA.
Q9BML6;
01-JUN-2001, integrated into UniProtKB/TrEMBL.
01-JUN-2001, sequence version 1.
30-AUG-2017, entry version 87.
SubName: Full=Metabotropic GABA-B receptor subtype 2 {ECO:0000313|EMBL:AAK13421.1};
Name=GABA-B-R2 {ECO:0000313|EMBL:AAK13421.1,
ECO:0000313|FlyBase:FBgn0027575};
ORFNames=CG6706 {ECO:0000313|FlyBase:FBgn0027575};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000313|EMBL:AAK13421.1};
[1] {ECO:0000313|EMBL:AAK13421.1}
NUCLEOTIDE SEQUENCE.
PubMed=11168554; DOI=10.1046/j.1460-9568.2001.01410.x;
Mezler M., Muller T., Raming K.;
"Cloning and functional expression of GABA(B) receptors from
Drosophila.";
Eur. J. Neurosci. 13:477-486(2001).
-!- SUBCELLULAR LOCATION: Cell membrane
{ECO:0000256|SAAS:SAAS00547656}; Multi-pass membrane protein
{ECO:0000256|SAAS:SAAS00547656}.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
{ECO:0000256|SAAS:SAAS00547674}.
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EMBL; AF318273; AAK13421.1; -; mRNA.
ProteinModelPortal; Q9BML6; -.
PaxDb; Q9BML6; -.
PRIDE; Q9BML6; -.
FlyBase; FBgn0027575; GABA-B-R2.
eggNOG; KOG1055; Eukaryota.
eggNOG; ENOG410XNN1; LUCA.
OrthoDB; EOG091G01WG; -.
Reactome; R-DME-1296041; Activation of G protein gated Potassium channels.
Reactome; R-DME-418594; G alpha (i) signalling events.
Reactome; R-DME-420499; Class C/3 (Metabotropic glutamate/pheromone receptors).
Reactome; R-DME-977444; GABA B receptor activation.
Reactome; R-DME-997272; Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
Bgee; FBgn0027575; -.
ExpressionAtlas; Q9BML6; differential.
GO; GO:0038039; C:G-protein coupled receptor heterodimeric complex; IPI:FlyBase.
GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
GO; GO:0005887; C:integral component of plasma membrane; IDA:FlyBase.
GO; GO:0004965; F:G-protein coupled GABA receptor activity; ISS:FlyBase.
GO; GO:0046982; F:protein heterodimerization activity; IPI:FlyBase.
GO; GO:0071260; P:cellular response to mechanical stimulus; IMP:FlyBase.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:FlyBase.
GO; GO:0007214; P:gamma-aminobutyric acid signaling pathway; IDA:FlyBase.
GO; GO:0007194; P:negative regulation of adenylate cyclase activity; IDA:FlyBase.
GO; GO:0046676; P:negative regulation of insulin secretion; IMP:FlyBase.
GO; GO:0031631; P:negative regulation of synaptic vesicle fusion to presynaptic active zone membrane; IDA:FlyBase.
GO; GO:0042048; P:olfactory behavior; IDA:FlyBase.
CDD; cd15294; 7tmC_GABA-B-R2; 1.
Gene3D; 3.80.10.10; -; 1.
InterPro; IPR001828; ANF_lig-bd_rcpt.
InterPro; IPR002455; GPCR3_GABA-B.
InterPro; IPR017978; GPCR_3_C.
InterPro; IPR017979; GPCR_3_CS.
InterPro; IPR002456; GPCR_3_GABA_rcpt_B1.
InterPro; IPR002457; GPCR_3_GABA_rcpt_B2.
InterPro; IPR032675; L_dom-like.
InterPro; IPR028082; Peripla_BP_I.
PANTHER; PTHR10519; PTHR10519; 1.
PANTHER; PTHR10519:SF54; PTHR10519:SF54; 1.
Pfam; PF00003; 7tm_3; 1.
Pfam; PF01094; ANF_receptor; 1.
PRINTS; PR01177; GABAB1RECPTR.
SUPFAM; SSF53822; SSF53822; 1.
PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
2: Evidence at transcript level;
Cell membrane {ECO:0000256|SAAS:SAAS00500778};
G-protein coupled receptor {ECO:0000256|SAAS:SAAS00500783};
Membrane {ECO:0000256|SAAS:SAAS00425515,
ECO:0000256|SAAS:SAAS00500778, ECO:0000256|SAM:Phobius};
Receptor {ECO:0000256|SAAS:SAAS00500783};
Signal {ECO:0000256|SAM:SignalP};
Transducer {ECO:0000256|SAAS:SAAS00500783};
Transmembrane {ECO:0000256|SAAS:SAAS00425515,
ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAAS:SAAS00425515,
ECO:0000256|SAM:Phobius}.
SIGNAL 1 23 {ECO:0000256|SAM:SignalP}.
CHAIN 24 1220 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5004325226.
TRANSMEM 447 468 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 488 518 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 563 584 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 621 642 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 662 679 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 685 707 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 454 729 G_PROTEIN_RECEP_F3_4.
{ECO:0000259|PROSITE:PS50259}.
SEQUENCE 1220 AA; 137977 MW; 2B33DA2C1A1BDA8B CRC64;
MFRPSWFPFA SLLFLLLWST ACGRTAKRSD VYIAGFFPYG DGVENSYTGR GVMPSVKLAL
GHVNEHGKIL ANYRLHMWWN DTQCNAAVGV KSFFDMMHSG PNKVMLFGAA CTHVTDPIAK
ASKHWHLTQL SYADTHPMFT KDAFPNFFRV VPSENAFNAP RLALLKEFNW TRVGTVYQNE
PRYSLPHNHM VADLDAMEVE VVETQSFVND VAESLKKLRE KDVRIILGNF NEHFARKAFC
EAYKLDMYGR AYQWLIMATY STDWWNVTQD SECSVEEIAT ALEGAILVDL LPLSTSGDIT
VAGITADEYL VEYDRLRGTE YSRFHGYTYD GIWAAALAIQ YVAEKREDLL THFDYRVKDW
ESVFLEALRN TSFEGVTGPV RFYNNERKAN ILINQFQLGQ MEKIGEYHSQ KSHLDLSLGK
PVKWVGKTPP KDRTLIYIEH SQVNPTIYIV SASASVIGVI IATVFLAFNI KYRNQRYIKM
SSPHLNNLII VGCMITYLSI IFLGLDTTLS SVAAFPYICT ARAWILMAGF SLSFGAMFSK
TWRVHSIFTD LKLNKKVIKD YQLFMVVGVL LAIDIAIITT WQIADPFYRE TKQLEPLHHE
NIDDVLVIPE NEYCQSEHMT IFVSIIYAYK GLLLVFGAFL AWETRHVSIP ALNDSKHIGF
SVYNVFITCL AGAAISLVLS DRKDLVFVLL SFFIIFCTTA TLCLVFVPKL VELKRNPQGV
VDKRVRATLR PMSKNGRRDS SVCELEQRLR DVKNTNCRFR KALMEKENEL QALIRKLGPE
ARKWIDGVTC TGGSNVGSEL EPILNDDIVR LSAPPVRREM PSTTVTEMTS VDSVTSTHVE
MDNSFVSVQS TVMAPSLPPK KKKQSIVEHH SHAPAPTMMQ PIQQQLQQHL QQHQQMQQQH
LQQQQHQQMQ QQQQQQQHHH RHLEKRNSVS AQTDDNIGSI TSTAGKRSGG DCSSMRERRQ
STASRHYDSG SQTPTARPKY SSSHRNSSTN ISTSQSELSN MCPHSKPSTP AVIKTPTASD
HRRTSMGSAL KSNFVVSQSD LWDTHTLSHA KQRQSPRNYA SPQRCAEHHG GHGMTYDPNT
TSPIQRSVSE KNRNKHRPKP QKGTVCQSET DSERERDPPP NSQPCVQPRK VSRSSNIQHA
AHHHSSPNVA PDKQRSRQRG KQDSSIYGAS SETELLEGET AILPIFRKLL TEKSPNYRGR
SAVGQSCPNI SIKCDIVEYL


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