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Metabotropic GABA-B receptor subtype 3, isoform F

 X2J488_DROME            Unreviewed;       357 AA.
X2J488;
11-JUN-2014, integrated into UniProtKB/TrEMBL.
11-JUN-2014, sequence version 1.
30-AUG-2017, entry version 34.
SubName: Full=Metabotropic GABA-B receptor subtype 3, isoform F {ECO:0000313|EMBL:AHN54068.1};
Name=GABA-B-R3 {ECO:0000313|EMBL:AHN54068.1,
ECO:0000313|FlyBase:FBgn0031275};
Synonyms=anon-WO0170980.13 {ECO:0000313|EMBL:AHN54068.1},
anon-WO0170980.14 {ECO:0000313|EMBL:AHN54068.1},
D-Gaba3 {ECO:0000313|EMBL:AHN54068.1},
D-GABA[[B]]R3 {ECO:0000313|EMBL:AHN54068.1},
Dmel\CG3022 {ECO:0000313|EMBL:AHN54068.1},
GABA B R3 {ECO:0000313|EMBL:AHN54068.1},
GABA-BR3 {ECO:0000313|EMBL:AHN54068.1},
GABA[[B]]-R3 {ECO:0000313|EMBL:AHN54068.1},
GABA[[B]]R3 {ECO:0000313|EMBL:AHN54068.1},
GB3 {ECO:0000313|EMBL:AHN54068.1};
ORFNames=CG3022 {ECO:0000313|EMBL:AHN54068.1,
ECO:0000313|FlyBase:FBgn0031275},
Dmel_CG3022 {ECO:0000313|EMBL:AHN54068.1};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000313|EMBL:AHN54068.1, ECO:0000313|Proteomes:UP000000803};
[1] {ECO:0000313|EMBL:AHN54068.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=10731132; DOI=10.1126/science.287.5461.2185;
Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
"The genome sequence of Drosophila melanogaster.";
Science 287:2185-2195(2000).
[2] {ECO:0000313|EMBL:AHN54068.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537568;
Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
"Finishing a whole-genome shotgun: release 3 of the Drosophila
melanogaster euchromatic genome sequence.";
Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
[3] {ECO:0000313|EMBL:AHN54068.1, ECO:0000313|Proteomes:UP000000803}
GENOME REANNOTATION.
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
Lewis S.E.;
"Annotation of the Drosophila melanogaster euchromatic genome: a
systematic review.";
Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
[4] {ECO:0000313|EMBL:AHN54068.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537573;
Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
Ashburner M., Celniker S.E.;
"The transposable elements of the Drosophila melanogaster euchromatin:
a genomics perspective.";
Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002).
[5] {ECO:0000313|EMBL:AHN54068.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=12537574;
Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
Karpen G.H.;
"Heterochromatic sequences in a Drosophila whole-genome shotgun
assembly.";
Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
[6] {ECO:0000313|EMBL:AHN54068.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
Ashburner M., Anxolabehere D.;
"Combined evidence annotation of transposable elements in genome
sequences.";
PLoS Comput. Biol. 1:166-175(2005).
[7] {ECO:0000313|EMBL:AHN54068.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=17569856; DOI=10.1126/science.1139815;
Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
"The Release 5.1 annotation of Drosophila melanogaster
heterochromatin.";
Science 316:1586-1591(2007).
[8] {ECO:0000313|EMBL:AHN54068.1, ECO:0000313|Proteomes:UP000000803}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
PubMed=17569867; DOI=10.1126/science.1139816;
Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
Dimitri P., Karpen G.H., Celniker S.E.;
"Sequence finishing and mapping of Drosophila melanogaster
heterochromatin.";
Science 316:1625-1628(2007).
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AE014134; AHN54068.1; -; Genomic_DNA.
RefSeq; NP_001285553.1; NM_001298624.1.
UniGene; Dm.2814; -.
ProteinModelPortal; X2J488; -.
SMR; X2J488; -.
PaxDb; X2J488; -.
PRIDE; X2J488; -.
EnsemblMetazoa; FBtr0343786; FBpp0310351; FBgn0031275.
GeneID; 33248; -.
CTD; 33248; -.
FlyBase; FBgn0031275; GABA-B-R3.
eggNOG; KOG1055; Eukaryota.
eggNOG; ENOG410XNN1; LUCA.
GeneTree; ENSGT00530000063129; -.
OrthoDB; EOG091G01WG; -.
GenomeRNAi; 33248; -.
Proteomes; UP000000803; Chromosome 2L.
Bgee; FBgn0031275; -.
ExpressionAtlas; X2J488; differential.
GO; GO:0016021; C:integral component of membrane; ISS:FlyBase.
GO; GO:0004965; F:G-protein coupled GABA receptor activity; ISS:FlyBase.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; ISS:FlyBase.
GO; GO:0010906; P:regulation of glucose metabolic process; IMP:FlyBase.
GO; GO:0030431; P:sleep; IMP:FlyBase.
InterPro; IPR001828; ANF_lig-bd_rcpt.
InterPro; IPR002455; GPCR3_GABA-B.
InterPro; IPR028082; Peripla_BP_I.
PANTHER; PTHR10519; PTHR10519; 1.
Pfam; PF01094; ANF_receptor; 1.
SUPFAM; SSF53822; SSF53822; 1.
4: Predicted;
Complete proteome {ECO:0000313|Proteomes:UP000000803};
Membrane {ECO:0000256|SAAS:SAAS00425515};
Receptor {ECO:0000313|EMBL:AHN54068.1};
Reference proteome {ECO:0000313|Proteomes:UP000000803};
Signal {ECO:0000256|SAM:SignalP};
Transmembrane {ECO:0000256|SAAS:SAAS00425515};
Transmembrane helix {ECO:0000256|SAAS:SAAS00425515}.
SIGNAL 1 34 {ECO:0000256|SAM:SignalP}.
CHAIN 35 357 {ECO:0000256|SAM:SignalP}.
/FTId=PRO_5004949751.
DOMAIN 175 332 ANF_receptor. {ECO:0000259|Pfam:PF01094}.
SEQUENCE 357 AA; 39081 MW; 2CE668227D69841E CRC64;
MRIIQPVQGT RYGPWPAVGL RLVLALAWAT SAAAAMESSA ELQALGYEAI RPGAASISTS
SPSSSPPGES ASTVTAGGTP IPPRSDWKYK RTKVKRRQQR LNSHSNLPGS TNASHAHHLL
NLPPRQRYLK VNQVFESERR MSPAEMQRNH GKIVLLGLFE LSTSRGPRPD GLSELGAATM
AVEHINRKRL LPGYTLELVT NDTQCDPGVG VDRFFHAIYT QPSTRMVMLL GSACSEVTES
LAKVVPYWNI VQVSFGSTSP ALSDRREFPY FYRTVAPDSS HNPARIAFIR KFGWGTVTTF
SQNEEVHSLA VNNLVTELEA ANISCAATIT FAATDFKEQL LLLRSAWINV SLADHIA


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