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Metal transporter nramp1 homolog (Natural resistance-associated membrane protein 1)

 NRAM1_DICDI             Reviewed;         533 AA.
Q869V1; Q550F8;
08-APR-2008, integrated into UniProtKB/Swiss-Prot.
01-JUN-2003, sequence version 1.
28-MAR-2018, entry version 86.
RecName: Full=Metal transporter nramp1 homolog;
AltName: Full=Natural resistance-associated membrane protein 1;
Name=nramp1; Synonyms=nramp, slc11a1; ORFNames=DDB_G0276973;
Dictyostelium discoideum (Slime mold).
Eukaryota; Amoebozoa; Mycetozoa; Dictyostelids; Dictyosteliales;
Dictyosteliaceae; Dictyostelium.
NCBI_TaxID=44689;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
PubMed=12097910; DOI=10.1038/nature00847;
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A.,
Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G.,
Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A.,
Platzer M., Rosenthal A., Noegel A.A.;
"Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
Nature 418:79-85(2002).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=AX4;
PubMed=15875012; DOI=10.1038/nature03481;
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A.,
Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q.,
Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F.,
Bankier A.T., Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P.,
Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P.,
Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N.,
Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M.,
Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I.,
Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R.,
Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
Knights A., Loulseged H., Mungall K.L., Oliver K., Price C.,
Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D.,
Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S.,
Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T.,
Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A.,
Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M.,
Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G.,
Kuspa A.;
"The genome of the social amoeba Dictyostelium discoideum.";
Nature 435:43-57(2005).
[3]
FUNCTION, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, AND SUBCELLULAR
LOCATION.
PubMed=16445684; DOI=10.1111/j.1600-0854.2005.00356.x;
Peracino B., Wagner C., Balest A., Balbo A., Pergolizzi B.,
Noegel A.A., Steinert M., Bozzaro S.;
"Function and mechanism of action of Dictyostelium Nramp1 (Slc11a1) in
bacterial infection.";
Traffic 7:22-38(2006).
-!- FUNCTION: Depletes iron from the phagolysosome in an ATP-dependent
process. May rather act as a symporter of protons and metal
cations in an ATP-dependent process. Nramp1 overexpression
protected cells from L.pneumophila infection.
{ECO:0000269|PubMed:16445684}.
-!- SUBCELLULAR LOCATION: Membrane {ECO:0000250}; Multi-pass membrane
protein {ECO:0000250}. Note=Located at vesicles of variable size,
which are distributed all over the cytoplasm, in part clustered at
a perinuclear site. Several tiny vesicles travel rapidly outward
from and towards the perinuclear cluster. These vesicles are part
of the endo- and phagolysosomal pathway.
{ECO:0000269|PubMed:16445684}.
-!- DEVELOPMENTAL STAGE: Expressed during the growth-phase and down-
regulated to barely detectable levels upon starvation.
{ECO:0000269|PubMed:16445684}.
-!- DISRUPTION PHENOTYPE: More permissive hosts than wild-type cells
for intracellular growth of L.pneumophila and M.avium.
{ECO:0000269|PubMed:16445684}.
-!- SIMILARITY: Belongs to the NRAMP family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AAFI02000019; EAL68988.1; -; Genomic_DNA.
RefSeq; XP_642974.1; XM_637882.1.
SMR; Q869V1; -.
STRING; 44689.DDB0232113; -.
TCDB; 2.A.55.2.9; the metal ion (mn(2+)-iron) transporter (nramp) family.
PaxDb; Q869V1; -.
EnsemblProtists; EAL68988; EAL68988; DDB_G0276973.
GeneID; 8620846; -.
KEGG; ddi:DDB_G0276973; -.
dictyBase; DDB_G0276973; nramp1.
eggNOG; KOG1291; Eukaryota.
eggNOG; COG1914; LUCA.
InParanoid; Q869V1; -.
KO; K21398; -.
OMA; SLRPVMN; -.
PhylomeDB; Q869V1; -.
Reactome; R-DDI-1222556; ROS, RNS production in phagocytes.
Reactome; R-DDI-425410; Metal ion SLC transporters.
Reactome; R-DDI-6798695; Neutrophil degranulation.
Reactome; R-DDI-6803544; Ion influx/efflux at host-pathogen interface.
Reactome; R-DDI-917937; Iron uptake and transport.
PRO; PR:Q869V1; -.
Proteomes; UP000002195; Chromosome 2.
Proteomes; UP000002195; Unassembled WGS sequence.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0044354; C:macropinosome; IDA:dictyBase.
GO; GO:0016020; C:membrane; IDA:dictyBase.
GO; GO:0032010; C:phagolysosome; IDA:dictyBase.
GO; GO:0005802; C:trans-Golgi network; IDA:dictyBase.
GO; GO:0012506; C:vesicle membrane; IDA:dictyBase.
GO; GO:0015093; F:ferrous iron transmembrane transporter activity; IDA:dictyBase.
GO; GO:0005381; F:iron ion transmembrane transporter activity; IDA:dictyBase.
GO; GO:0006879; P:cellular iron ion homeostasis; IDA:dictyBase.
GO; GO:0042742; P:defense response to bacterium; IMP:dictyBase.
GO; GO:1903988; P:ferrous iron export across plasma membrane; IMP:dictyBase.
GO; GO:0034755; P:iron ion transmembrane transport; IDA:dictyBase.
GO; GO:0006828; P:manganese ion transport; IDA:dictyBase.
GO; GO:0006909; P:phagocytosis; IEP:dictyBase.
GO; GO:0009617; P:response to bacterium; IMP:dictyBase.
HAMAP; MF_00221; NRAMP; 1.
InterPro; IPR001046; NRAMP_fam.
PANTHER; PTHR11706; PTHR11706; 1.
Pfam; PF01566; Nramp; 1.
PRINTS; PR00447; NATRESASSCMP.
TIGRFAMs; TIGR01197; nramp; 1.
2: Evidence at transcript level;
Complete proteome; Glycoprotein; Ion transport; Iron; Iron transport;
Membrane; Reference proteome; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 533 Metal transporter nramp1 homolog.
/FTId=PRO_0000328222.
TOPO_DOM 1 68 Cytoplasmic. {ECO:0000255}.
TRANSMEM 69 89 Helical. {ECO:0000255}.
TOPO_DOM 90 101 Extracellular. {ECO:0000255}.
TRANSMEM 102 122 Helical. {ECO:0000255}.
TOPO_DOM 123 158 Cytoplasmic. {ECO:0000255}.
TRANSMEM 159 179 Helical. {ECO:0000255}.
TOPO_DOM 180 182 Extracellular. {ECO:0000255}.
TRANSMEM 183 203 Helical. {ECO:0000255}.
TOPO_DOM 204 212 Cytoplasmic. {ECO:0000255}.
TRANSMEM 213 233 Helical. {ECO:0000255}.
TOPO_DOM 234 256 Extracellular. {ECO:0000255}.
TRANSMEM 257 277 Helical. {ECO:0000255}.
TOPO_DOM 278 302 Cytoplasmic. {ECO:0000255}.
TRANSMEM 303 323 Helical. {ECO:0000255}.
TOPO_DOM 324 348 Extracellular. {ECO:0000255}.
TRANSMEM 349 368 Helical. {ECO:0000255}.
TOPO_DOM 369 387 Cytoplasmic. {ECO:0000255}.
TRANSMEM 388 408 Helical. {ECO:0000255}.
TOPO_DOM 409 415 Extracellular. {ECO:0000255}.
TRANSMEM 416 436 Helical. {ECO:0000255}.
TOPO_DOM 437 457 Cytoplasmic. {ECO:0000255}.
TRANSMEM 458 478 Helical. {ECO:0000255}.
TOPO_DOM 479 481 Extracellular. {ECO:0000255}.
TRANSMEM 482 502 Helical. {ECO:0000255}.
TOPO_DOM 503 533 Cytoplasmic. {ECO:0000255}.
COMPBIAS 15 29 Poly-Asn.
CARBOHYD 253 253 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
SEQUENCE 533 AA; 60034 MW; 0EA56D60A9B4E264 CRC64;
MTPRIESEES APLVNKNNNN NNDNNNNNNV DEENPLIIES GIPIEDLEQK NKPYLIKVPN
IDKPDSKWIN FKTLWAFTGP GFLMSIAYLD PGNLESDIQA GAMAGYQLLW VLFWSTVIGF
WLQMLASRLG VVTGKHLAEH CREQYPKTPR LLLWLMTELA IIGSDIQEVI GTAIALQILS
NGHIPLWAGV LFTAADTFTF LFLEKYGIRK LEAFFCSLIA IMAISFGVEY IISKPDQIEV
VKGVFIPLCS QNNISQAVGI LGAVVMPHNI YLHSALVQSR EIDRKSETQV KIANKYNRLE
SAFALIISFI INLLLVSVFA KGFYGETTEI GLSSAADFLM DKYGKVAKYI WAIGLFSAGQ
CSTMTGTYSG QFVMEGFLKL KIAPWKRLLI TRCTAIVPAM VVAILSTSHL DSLDQWLNIL
QSIQLPFAVV PVLLFTSSEK IMGSKFKNHW LNNQFVRFLS LLIIAINIYL IITFSMQISE
SAWMISIVSI SFFFYFIFIV YLSMGQENFN SMTKKIKNLF NNNSNQTYNN INY


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