Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Metal-binding regulatory protein cuf1

 CUF1_SCHPO              Reviewed;         411 AA.
Q09728;
01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
01-NOV-1995, sequence version 1.
18-JUL-2018, entry version 133.
RecName: Full=Metal-binding regulatory protein cuf1;
Name=cuf1; ORFNames=SPAC31A2.11c;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
STRAIN=FY254;
PubMed=10593913; DOI=10.1074/jbc.274.51.36252;
Labbe S., Pena M.M.O., Fernandes A.R., Thiele D.J.;
"A copper-sensing transcription factor regulates iron uptake genes in
Schizosaccharomyces pombe.";
J. Biol. Chem. 274:36252-36260(1999).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[3]
FUNCTION, SUBCELLULAR LOCATION, AND MUTAGENESIS OF LYS-13; ARG-16;
ARG-19; LYS-24; ARG-28; LYS-45; ARG-47; ARG-50; ARG-53; CYS-328;
CYS-330; CYS-334; CYS-336 AND CYS-339.
PubMed=16467469; DOI=10.1128/EC.5.2.277-292.2006;
Beaudoin J., Labbe S.;
"Copper induces cytoplasmic retention of fission yeast transcription
factor cuf1.";
Eukaryot. Cell 5:277-292(2006).
-!- FUNCTION: Copper-sensing transcription factor that regulates iron
uptake genes. Under copper starvation conditions activates the
transcription of the copper transport genes, ctr4, ctr5 and ctr6.
{ECO:0000269|PubMed:10593913, ECO:0000269|PubMed:16467469}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16467469}.
Nucleus {ECO:0000269|PubMed:16467469}. Note=Cytoplasmic in
presence of excess copper ions. The Cys-His motif (328-342)
interacts with the N-terminal nuclear localization signal region
leading to sequestration in the cytoplasm. Nuclear under copper
starvation conditions.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; AF175404; AAD51063.1; -; Genomic_DNA.
EMBL; AJ243832; CAB52304.1; -; Genomic_DNA.
EMBL; CU329670; CAA90469.1; -; Genomic_DNA.
PIR; T38609; S58105.
RefSeq; NP_592923.1; NM_001018324.2.
ProteinModelPortal; Q09728; -.
SMR; Q09728; -.
BioGrid; 279627; 8.
STRING; 4896.SPAC31A2.11c.1; -.
MaxQB; Q09728; -.
PaxDb; Q09728; -.
PRIDE; Q09728; -.
EnsemblFungi; SPAC31A2.11c.1; SPAC31A2.11c.1:pep; SPAC31A2.11c.
GeneID; 2543198; -.
KEGG; spo:SPAC31A2.11c; -.
EuPathDB; FungiDB:SPAC31A2.11c; -.
PomBase; SPAC31A2.11c; cuf1.
InParanoid; Q09728; -.
OMA; KCRIARI; -.
OrthoDB; EOG092C4HSL; -.
PRO; PR:Q09728; -.
Proteomes; UP000002485; Chromosome I.
GO; GO:0005737; C:cytoplasm; IDA:PomBase.
GO; GO:0005634; C:nucleus; IDA:PomBase.
GO; GO:0005507; F:copper ion binding; IMP:PomBase.
GO; GO:0000978; F:RNA polymerase II proximal promoter sequence-specific DNA binding; IDA:PomBase.
GO; GO:0001202; F:RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding; IDA:PomBase.
GO; GO:0006878; P:cellular copper ion homeostasis; IMP:PomBase.
GO; GO:0006879; P:cellular iron ion homeostasis; IMP:PomBase.
GO; GO:0071468; P:cellular response to acidic pH; IBA:GO_Central.
GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:PomBase.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:PomBase.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 3.90.430.10; -; 1.
InterPro; IPR001083; Cu_fist_DNA-bd_dom.
InterPro; IPR036395; Cu_fist_DNA-bd_dom_sf.
Pfam; PF00649; Copper-fist; 1.
PRINTS; PR00617; COPPERFIST.
SMART; SM01090; Copper-fist; 1.
SMART; SM00412; Cu_FIST; 1.
SUPFAM; SSF57879; SSF57879; 1.
PROSITE; PS01119; COPPER_FIST_1; 1.
PROSITE; PS50073; COPPER_FIST_2; 1.
1: Evidence at protein level;
Complete proteome; Copper; Cytoplasm; DNA-binding; Metal-binding;
Nucleus; Reference proteome; Transcription; Transcription regulation;
Zinc.
CHAIN 1 411 Metal-binding regulatory protein cuf1.
/FTId=PRO_0000194930.
DNA_BIND 1 40 Copper-fist. {ECO:0000255|PROSITE-
ProRule:PRU00055}.
METAL 11 11 Zinc. {ECO:0000255|PROSITE-
ProRule:PRU00055}.
METAL 14 14 Zinc. {ECO:0000255|PROSITE-
ProRule:PRU00055}.
METAL 23 23 Zinc. {ECO:0000255|PROSITE-
ProRule:PRU00055}.
METAL 25 25 Zinc. {ECO:0000255|PROSITE-
ProRule:PRU00055}.
MUTAGEN 13 13 K->A: No nuclear localization.
{ECO:0000269|PubMed:16467469}.
MUTAGEN 16 16 R->A: No nuclear localization.
{ECO:0000269|PubMed:16467469}.
MUTAGEN 19 19 R->A: No nuclear localization.
{ECO:0000269|PubMed:16467469}.
MUTAGEN 24 24 K->A: No nuclear localization.
{ECO:0000269|PubMed:16467469}.
MUTAGEN 28 28 R->A: No nuclear localization.
{ECO:0000269|PubMed:16467469}.
MUTAGEN 45 45 K->A: No nuclear localization.
{ECO:0000269|PubMed:16467469}.
MUTAGEN 47 47 R->A: No nuclear localization.
{ECO:0000269|PubMed:16467469}.
MUTAGEN 50 50 R->A: No nuclear localization.
{ECO:0000269|PubMed:16467469}.
MUTAGEN 53 53 R->A: No nuclear localization.
{ECO:0000269|PubMed:16467469}.
MUTAGEN 328 328 C->A: Constitutive nuclear localization.
{ECO:0000269|PubMed:16467469}.
MUTAGEN 330 330 C->A: Constitutive nuclear localization.
{ECO:0000269|PubMed:16467469}.
MUTAGEN 334 334 C->A: Constitutive nuclear localization.
{ECO:0000269|PubMed:16467469}.
MUTAGEN 336 336 C->A: Constitutive nuclear localization.
{ECO:0000269|PubMed:16467469}.
MUTAGEN 339 339 C->A: Constitutive nuclear localization.
{ECO:0000269|PubMed:16467469}.
SEQUENCE 411 AA; 45473 MW; DB18E877B65D5699 CRC64;
MVVINNVKMA CMKCIRGHRS STCKHNDREL FPIRPKGRPI SQCEKCRIAR ITRHLHVKCT
CNSRKKGSKC STSSTTDLDS SSASNSSCSI PSSISEKLLP RDNVKTHCPK RSASCCGKKP
DVMPLKINLE SQTDFMGMPL QSQRPHSESY RMLPEPEKFK SEYGYPSQFL PIEKLTSNVA
YPPNYNNYLK SPYQQPTNFP PEIQYNYSHS PQHSIQEAEE AAVYGPPVYR SGYQILYNNN
TDSIAAAAAT HDLYPQPDVP LTFAMLADGN YVPLPSSTNT YGPSNSYGYE ININESTNHV
DSSYLPHPIQ LSNYFTLPSS CAQADAACQC GDNCECLGCL THPNNATTLA ALNHISALEK
ETISHTDLHH TFKHEVNSSN NYELTNDELA ASSPLYTSSS VPPSHITTGS T


Related products :

Catalog number Product name Quantity
EIAAB25653 Homo sapiens,hPCl2,Human,Metal regulatory transcription factor 2,Metal-response element DNA-binding protein M96,Metal-response element-binding transcription factor 2,MTF2,PCL2,Polycomb-like protein 2
EIAAB25652 Metal regulatory transcription factor 2,Metal-response element DNA-binding protein M96,Metal-response element-binding transcription factor 2,Mouse,mPCl2,Mtf2,Mus musculus,Pcl2,Polycomb-like protein 2,
18-003-42503 Metal-response element-binding transcription factor 2 - Metal-response element DNA-binding protein M96; Metal-regulatory transcription factor 2; PCL2 Polyclonal 0.05 mg Aff Pur
EIAAB47434 HD gene regulatory region-binding protein 2,HDBP2,HDBP-2,HD-regulating factor 2,HDRF-2,Homo sapiens,Human,Huntington disease gene regulatory region-binding protein 2,Papillomavirus regulatory factor 1
15-288-21968B Zinc finger protein 395 - Papillomavirus-binding factor; Papillomavirus regulatory factor 1; PRF-1; Huntington disease gene regulatory region-binding protein 2; HDBP-2; HD gene regulatory region-bindi 0.05 mg
10-288-21968F Zinc finger protein 395 - Papillomavirus-binding factor; Papillomavirus regulatory factor 1; PRF-1; Huntington disease gene regulatory region-binding protein 2; HDBP-2; HD gene regulatory region-bindi 0.1 mg
10-288-21968F Zinc finger protein 395 - Papillomavirus-binding factor; Papillomavirus regulatory factor 1; PRF-1; Huntington disease gene regulatory region-binding protein 2; HDBP-2; HD gene regulatory region-bindi 0.05 mg
15-288-21968B Zinc finger protein 395 - Papillomavirus-binding factor; Papillomavirus regulatory factor 1; PRF-1; Huntington disease gene regulatory region-binding protein 2; HDBP-2; HD gene regulatory region-bindi 0.1 mg
15-288-21968A Zinc finger protein 395 - Papillomavirus-binding factor; Papillomavirus regulatory factor 1; PRF-1; Huntington disease gene regulatory region-binding protein 2; HDBP-2; HD gene regulatory region-bindi 0.1 mg
15-288-21968A Zinc finger protein 395 - Papillomavirus-binding factor; Papillomavirus regulatory factor 1; PRF-1; Huntington disease gene regulatory region-binding protein 2; HDBP-2; HD gene regulatory region-bindi 0.05 mg
18-003-43101 Zinc finger protein 395 - Papillomavirus-binding factor; Papillomavirus regulatory factor 1; PRF-1; Huntington disease gene regulatory region-binding protein 2; HDBP-2; HD gene regulatory region-bindi 0.05 mg Aff Pur
18-003-44056 PR domain zinc finger protein 1 - PR domain-containing protein 1; Beta-interferon gene positive regulatory domain I-binding factor; BLIMP-1; Positive regulatory domain I-binding factor 1; PRDI-binding 0.1 mg Protein A
EIAAB39839 ADD1,Adipocyte determination- and differentiation-dependent factor 1,Rat,Rattus norvegicus,Srebf1,Srebp1,SREBP-1,Sterol regulatory element-binding protein 1,Sterol regulatory element-binding transcrip
EIAAB39837 Mouse,Mus musculus,Srebf1,Srebp1,SREBP-1,Sterol regulatory element-binding protein 1,Sterol regulatory element-binding transcription factor 1
EIAAB39841 Mouse,Mus musculus,Srebf2,Srebp2,SREBP-2,Sterol regulatory element-binding protein 2,Sterol regulatory element-binding transcription factor 2
20-372-60058 KH-type splicing regulatory protein (FUSE binding protein 2) - Mouse monoclonal anti-human KHSRP antibody; FUSE-binding protein 2; KH type-splicing regulatory protein; KSRP; p75 Monoclonal 0.1 mg
EIAAB39840 Rat,Rattus norvegicus,Srebf2,SREBP-2,Sterol regulatory element-binding protein 2,Sterol regulatory element-binding transcription factor 2
EIAAB39842 bHLHd2,BHLHD2,Class D basic helix-loop-helix protein 2,Homo sapiens,Human,SREBF2,SREBP2,SREBP-2,Sterol regulatory element-binding protein 2,Sterol regulatory element-binding transcription factor 2
EIAAB39838 bHLHd1,BHLHD1,Class D basic helix-loop-helix protein 1,Homo sapiens,Human,SREBF1,SREBP1,SREBP-1,Sterol regulatory element-binding protein 1,Sterol regulatory element-binding transcription factor 1
18-003-43157 Sterol regulatory element-binding protein 1 - SREBP-1; Sterol regulatory element-binding transcription factor 1 Polyclonal 0.05 mg Aff Pur
18-003-42931 Sterol regulatory element-binding protein 2 - SREBP-2; Sterol regulatory element-binding transcription factor 2 Polyclonal 0.05 mg Aff Pur
EIAAB39218 BASS1,Bax antagonist selected in saccharomyces 1,C21orf50,DBP5,Homo sapiens,HSPC310,HSPC312,Human,KIAA1019,Negative regulatory element-binding protein,NRE-binding protein,NREBP,Protein DBP-5,Protein S
EIAAB39836 ADD1,Adipocyte determination and differentiation-dependent factor 1,Pig,SREBF1,SREBP1,SREBP-1,Sterol regulatory element-binding protein 1,Sterol regulatory element-binding transcription factor 1,Sus s
EIAAB13331 Epithelial splicing regulatory protein 1,ESRP1,Homo sapiens,Human,RBM35A,RNA-binding motif protein 35A,RNA-binding protein 35A
EIAAB13335 Epithelial splicing regulatory protein 2,ESRP2,Homo sapiens,Human,PP7059,RBM35B,RNA-binding motif protein 35B,RNA-binding protein 35B


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur