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Metalloendopeptidase (EC 3 4 24 -)

 F7HAA9_MACMU            Unreviewed;       984 AA.
F7HAA9;
27-JUL-2011, integrated into UniProtKB/TrEMBL.
30-NOV-2016, sequence version 2.
07-NOV-2018, entry version 73.
RecName: Full=Metalloendopeptidase {ECO:0000256|RuleBase:RU361183};
EC=3.4.24.- {ECO:0000256|RuleBase:RU361183};
Name=BMP1 {ECO:0000313|Ensembl:ENSMMUP00000017110};
Macaca mulatta (Rhesus macaque).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9544 {ECO:0000313|Ensembl:ENSMMUP00000017110, ECO:0000313|Proteomes:UP000006718};
[1] {ECO:0000313|Ensembl:ENSMMUP00000017110, ECO:0000313|Proteomes:UP000006718}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000017110,
ECO:0000313|Proteomes:UP000006718};
PubMed=17431167; DOI=10.1126/science.1139247;
Gibbs R.A., Rogers J., Katze M.G., Bumgarner R., Weinstock G.M.,
Mardis E.R., Remington K.A., Strausberg R.L., Venter J.C.,
Wilson R.K., Batzer M.A., Bustamante C.D., Eichler E.E., Hahn M.W.,
Hardison R.C., Makova K.D., Miller W., Milosavljevic A., Palermo R.E.,
Siepel A., Sikela J.M., Attaway T., Bell S., Bernard K.E., Buhay C.J.,
Chandrabose M.N., Dao M., Davis C., Delehaunty K.D., Ding Y.,
Dinh H.H., Dugan-Rocha S., Fulton L.A., Gabisi R.A., Garner T.T.,
Godfrey J., Hawes A.C., Hernandez J., Hines S., Holder M., Hume J.,
Jhangiani S.N., Joshi V., Khan Z.M., Kirkness E.F., Cree A.,
Fowler R.G., Lee S., Lewis L.R., Li Z., Liu Y.-S., Moore S.M.,
Muzny D., Nazareth L.V., Ngo D.N., Okwuonu G.O., Pai G., Parker D.,
Paul H.A., Pfannkoch C., Pohl C.S., Rogers Y.-H.C., Ruiz S.J.,
Sabo A., Santibanez J., Schneider B.W., Smith S.M., Sodergren E.,
Svatek A.F., Utterback T.R., Vattathil S., Warren W., White C.S.,
Chinwalla A.T., Feng Y., Halpern A.L., Hillier L.W., Huang X.,
Minx P., Nelson J.O., Pepin K.H., Qin X., Sutton G.G., Venter E.,
Walenz B.P., Wallis J.W., Worley K.C., Yang S.-P., Jones S.M.,
Marra M.A., Rocchi M., Schein J.E., Baertsch R., Clarke L., Csuros M.,
Glasscock J., Harris R.A., Havlak P., Jackson A.R., Jiang H., Liu Y.,
Messina D.N., Shen Y., Song H.X.-Z., Wylie T., Zhang L., Birney E.,
Han K., Konkel M.K., Lee J., Smit A.F.A., Ullmer B., Wang H., Xing J.,
Burhans R., Cheng Z., Karro J.E., Ma J., Raney B., She X., Cox M.J.,
Demuth J.P., Dumas L.J., Han S.-G., Hopkins J., Karimpour-Fard A.,
Kim Y.H., Pollack J.R., Vinar T., Addo-Quaye C., Degenhardt J.,
Denby A., Hubisz M.J., Indap A., Kosiol C., Lahn B.T., Lawson H.A.,
Marklein A., Nielsen R., Vallender E.J., Clark A.G., Ferguson B.,
Hernandez R.D., Hirani K., Kehrer-Sawatzki H., Kolb J., Patil S.,
Pu L.-L., Ren Y., Smith D.G., Wheeler D.A., Schenck I., Ball E.V.,
Chen R., Cooper D.N., Giardine B., Hsu F., Kent W.J., Lesk A.,
Nelson D.L., O'brien W.E., Pruefer K., Stenson P.D., Wallace J.C.,
Ke H., Liu X.-M., Wang P., Xiang A.P., Yang F., Barber G.P.,
Haussler D., Karolchik D., Kern A.D., Kuhn R.M., Smith K.E.,
Zwieg A.S.;
"Evolutionary and biomedical insights from the rhesus macaque
genome.";
Science 316:222-234(2007).
[2] {ECO:0000313|Ensembl:ENSMMUP00000017110}
IDENTIFICATION.
STRAIN=17573 {ECO:0000313|Ensembl:ENSMMUP00000017110};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000256|PIRSR:PIRSR001199-2,
ECO:0000256|RuleBase:RU361183};
Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR001199-
2, ECO:0000256|RuleBase:RU361183};
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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EMBL; JSUE03040997; -; NOT_ANNOTATED_CDS; Genomic_DNA.
STRING; 9544.ENSMMUP00000017110; -.
MEROPS; M12.005; -.
Ensembl; ENSMMUT00000018279; ENSMMUP00000017110; ENSMMUG00000013031.
eggNOG; KOG3714; Eukaryota.
eggNOG; ENOG410ZPX7; LUCA.
GeneTree; ENSGT00760000119018; -.
OrthoDB; EOG091G009U; -.
TreeFam; TF314351; -.
Proteomes; UP000006718; Chromosome 8.
Bgee; ENSMMUG00000013031; Expressed in 14 organ(s), highest expression level in lung.
ExpressionAtlas; F7HAA9; baseline.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0061036; P:positive regulation of cartilage development; IEA:Ensembl.
CDD; cd00041; CUB; 5.
CDD; cd04281; ZnMc_BMP1_TLD; 1.
Gene3D; 2.60.120.290; -; 5.
Gene3D; 3.40.390.10; -; 1.
InterPro; IPR015446; BMP_1/tolloid-like.
InterPro; IPR000859; CUB_dom.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
InterPro; IPR018097; EGF_Ca-bd_CS.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR024079; MetalloPept_cat_dom_sf.
InterPro; IPR001506; Peptidase_M12A.
InterPro; IPR006026; Peptidase_Metallo.
InterPro; IPR035914; Sperma_CUB_dom_sf.
InterPro; IPR034036; ZnMP_TLD/BMP1.
Pfam; PF01400; Astacin; 1.
Pfam; PF00431; CUB; 5.
Pfam; PF07645; EGF_CA; 1.
PIRSF; PIRSF001199; BMP_1/tolloid-like; 1.
PRINTS; PR00480; ASTACIN.
SMART; SM00042; CUB; 5.
SMART; SM00181; EGF; 2.
SMART; SM00179; EGF_CA; 2.
SMART; SM00235; ZnMc; 1.
SUPFAM; SSF49854; SSF49854; 5.
SUPFAM; SSF57184; SSF57184; 1.
PROSITE; PS00010; ASX_HYDROXYL; 2.
PROSITE; PS01180; CUB; 5.
PROSITE; PS01186; EGF_2; 2.
PROSITE; PS50026; EGF_3; 2.
PROSITE; PS01187; EGF_CA; 2.
4: Predicted;
Calcium {ECO:0000256|SAAS:SAAS00909960};
Complete proteome {ECO:0000313|Proteomes:UP000006718};
Disulfide bond {ECO:0000256|SAAS:SAAS00601599};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
ECO:0000256|SAAS:SAAS00032677};
Hydrolase {ECO:0000256|RuleBase:RU361183,
ECO:0000256|SAAS:SAAS01068076};
Metal-binding {ECO:0000256|PIRSR:PIRSR001199-2,
ECO:0000256|RuleBase:RU361183, ECO:0000256|SAAS:SAAS00973795};
Metalloprotease {ECO:0000256|RuleBase:RU361183,
ECO:0000256|SAAS:SAAS01068076};
Protease {ECO:0000256|RuleBase:RU361183,
ECO:0000256|SAAS:SAAS01068076};
Reference proteome {ECO:0000313|Proteomes:UP000006718};
Repeat {ECO:0000256|SAAS:SAAS00594563};
Signal {ECO:0000256|RuleBase:RU361183};
Zinc {ECO:0000256|PIRSR:PIRSR001199-2, ECO:0000256|RuleBase:RU361183,
ECO:0000256|SAAS:SAAS00973802}.
SIGNAL 1 22 {ECO:0000256|RuleBase:RU361183}.
CHAIN 23 984 Metalloendopeptidase.
{ECO:0000256|RuleBase:RU361183}.
/FTId=PRO_5008813884.
DOMAIN 320 432 CUB. {ECO:0000259|PROSITE:PS01180}.
DOMAIN 433 545 CUB. {ECO:0000259|PROSITE:PS01180}.
DOMAIN 545 586 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 589 701 CUB. {ECO:0000259|PROSITE:PS01180}.
DOMAIN 701 741 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 745 857 CUB. {ECO:0000259|PROSITE:PS01180}.
DOMAIN 858 974 CUB. {ECO:0000259|PROSITE:PS01180}.
ACT_SITE 212 212 {ECO:0000256|PIRSR:PIRSR001199-1}.
METAL 211 211 Zinc; catalytic.
{ECO:0000256|PIRSR:PIRSR001199-2}.
METAL 215 215 Zinc; catalytic.
{ECO:0000256|PIRSR:PIRSR001199-2}.
METAL 221 221 Zinc; catalytic.
{ECO:0000256|PIRSR:PIRSR001199-2}.
SEQUENCE 984 AA; 110939 MW; 3B633216DA8F4BCF CRC64;
MPGVARLPLL LGLLLLPRPG RPLDLADYTY DLAEEDDSEP LNYKDPCKAA AFLGDIALDE
EDLRAFQVQQ AADLRQHTTR KSSIKGAGKS GAKGCQSTNG QPQRGACGRW RGRSRSRRAA
TSRPERVWPD GVIPFVIGGN FTGSQRAVFR QAMRHWEKHT CVTFLERTDE DSYIVFTYRP
CGCCSYVGRR GGGPQAISIG KNCDKFGIVV HELGHVVGFW HEHTRPDRDR HVSIVRENIQ
PGQEYNFLKM EPQEVESLGE TYDFDSIMHY ARNTFSRGIF LDTIVPKYEV NGVKPPIGQR
TRLSKGDIAQ ARKLYKCPAC GETLQDSTGN FSSPEYPNGY SAHMHCVWRI SVTPGEKIIL
NFTSLDLYRS RLCWYDYVEV RDGFWRKAPL RGRFCGSKLP EPIVSTDSRL WVEFRSSSNW
VGKGFFAVYE AICGGDVKKD YGHIQSPNYP DDYRPSKVCI WRIQVSEGFH VGLTFQSFEI
ERHDSCAYDY LEVRDGHSES STLIGRYCGY EKPDDIKSTS SRLWLKFVSD GSINKAGFAV
NFFKEVDECS RPNRGGCEQR CLNTLGSYKC SCDPGYELAP DKRRCEAACG GFLTKLNGSI
TSPGWPKEYP PNKNCIWQLV APTQYRISLQ FDFFETEGND VCKYDFVEVR SGLTADSKLH
GKFCGSEKPE VITSQYNNMR VEFKSDNTVS KKGFKAHFFS DKDECSKDNG GCQQDCVNTF
GSYECQCRSG FVLHDNKHDC KEAGCDHKVT STSGTITSPN WPDKYPSKKE CTWAISSTPG
HRVKLTFMEM DIESQPECAY DHLEVFDGRD AKAPVLGRFC GSKKPEPVLA TGSRMFLRFY
SDNSVQRKGF QASHGTECGG QVRADVKTKD LYSHAQFGDN NYPGGVDCEW VIVAEEGYGV
ELVFQTFEVE EETDCGYDYM ELFDGYDSTA PRLGRYCGSG PPEEVYSAGD SVLVKFHSDD
TITKKGFHLR YTSTKFQDTL HSRK


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