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Metalloendopeptidase (EC 3 4 24 -)

 H2QVU7_PANTR            Unreviewed;       986 AA.
H2QVU7; A0A2J8N969;
21-MAR-2012, integrated into UniProtKB/TrEMBL.
21-MAR-2012, sequence version 1.
07-NOV-2018, entry version 65.
RecName: Full=Metalloendopeptidase {ECO:0000256|RuleBase:RU361183};
EC=3.4.24.- {ECO:0000256|RuleBase:RU361183};
Name=BMP1 {ECO:0000313|EMBL:JAA21771.1,
ECO:0000313|Ensembl:ENSPTRP00000034342, ECO:0000313|VGNC:VGNC:1173};
ORFNames=CK820_G0013417 {ECO:0000313|EMBL:PNI68321.1};
Pan troglodytes (Chimpanzee).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Pan.
NCBI_TaxID=9598 {ECO:0000313|Ensembl:ENSPTRP00000034342, ECO:0000313|Proteomes:UP000002277};
[1] {ECO:0000313|Ensembl:ENSPTRP00000034342, ECO:0000313|Proteomes:UP000002277}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16136131; DOI=10.1038/nature04072;
Chimpanzee sequencing and analysis consortium;
"Initial sequence of the chimpanzee genome and comparison with the
human genome.";
Nature 437:69-87(2005).
[2] {ECO:0000313|Ensembl:ENSPTRP00000034342}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2012) to UniProtKB.
[3] {ECO:0000313|EMBL:JAA21771.1}
NUCLEOTIDE SEQUENCE.
TISSUE=Skeletal muscle {ECO:0000313|EMBL:JAA37730.1}, and
Smooth vascular {ECO:0000313|EMBL:JAA21771.1};
Maudhoo M.D., Meehan D.T., Norgren R.B.Jr.;
"De novo assembly of the reference chimpanzee transcriptome from
NextGen mRNA sequences.";
Submitted (OCT-2012) to the EMBL/GenBank/DDBJ databases.
[4] {ECO:0000313|EMBL:PNI68321.1}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Yerkes chimp pedigree #C0471 {ECO:0000313|EMBL:PNI68321.1};
TISSUE=Blood {ECO:0000313|EMBL:PNI68321.1};
Pollen A., Hastie A., Hormozdiari F., Dougherty M., Liu R.,
Chaisson M., Hoppe E., Hill C., Pang A., Hillier L., Baker C.,
Armstrong J., Shendure J., Paten B., Wilson R., Chao H., Schneider V.,
Ventura M., Kronenberg Z., Murali S., Gordon D., Cantsilieris S.,
Munson K., Nelson B., Raja A., Underwood J., Diekhans M., Fiddes I.,
Haussler D., Eichler E.;
"High-resolution comparative analysis of great ape genomes.";
Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000256|PIRSR:PIRSR001199-2,
ECO:0000256|RuleBase:RU361183};
Note=Binds 1 zinc ion per subunit. {ECO:0000256|PIRSR:PIRSR001199-
2, ECO:0000256|RuleBase:RU361183};
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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EMBL; AACZ04065688; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; GABF01000374; JAA21771.1; -; mRNA.
EMBL; GABE01007009; JAA37730.1; -; mRNA.
EMBL; NBAG03000233; PNI68321.1; -; Genomic_DNA.
RefSeq; XP_016814692.1; XM_016959203.1.
STRING; 9598.ENSPTRP00000034342; -.
Ensembl; ENSPTRT00000037161; ENSPTRP00000034342; ENSPTRG00000020054.
GeneID; 464042; -.
KEGG; ptr:464042; -.
CTD; 649; -.
VGNC; VGNC:1173; BMP1.
eggNOG; KOG3714; Eukaryota.
eggNOG; ENOG410ZPX7; LUCA.
GeneTree; ENSGT00760000119018; -.
KO; K05502; -.
OMA; KGFEASH; -.
OrthoDB; EOG091G009U; -.
TreeFam; TF314351; -.
Proteomes; UP000002277; Chromosome 8.
Bgee; ENSPTRG00000020054; Expressed in 6 organ(s), highest expression level in liver.
GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0004222; F:metalloendopeptidase activity; IEA:UniProtKB-UniRule.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0061036; P:positive regulation of cartilage development; IEA:Ensembl.
CDD; cd00041; CUB; 5.
CDD; cd04281; ZnMc_BMP1_TLD; 1.
Gene3D; 2.60.120.290; -; 5.
Gene3D; 3.40.390.10; -; 1.
InterPro; IPR015446; BMP_1/tolloid-like.
InterPro; IPR000859; CUB_dom.
InterPro; IPR001881; EGF-like_Ca-bd_dom.
InterPro; IPR013032; EGF-like_CS.
InterPro; IPR000742; EGF-like_dom.
InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
InterPro; IPR018097; EGF_Ca-bd_CS.
InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
InterPro; IPR024079; MetalloPept_cat_dom_sf.
InterPro; IPR001506; Peptidase_M12A.
InterPro; IPR006026; Peptidase_Metallo.
InterPro; IPR035914; Sperma_CUB_dom_sf.
InterPro; IPR034036; ZnMP_TLD/BMP1.
Pfam; PF01400; Astacin; 1.
Pfam; PF00431; CUB; 5.
Pfam; PF07645; EGF_CA; 1.
PIRSF; PIRSF001199; BMP_1/tolloid-like; 1.
PRINTS; PR00480; ASTACIN.
SMART; SM00042; CUB; 5.
SMART; SM00181; EGF; 2.
SMART; SM00179; EGF_CA; 2.
SMART; SM00235; ZnMc; 1.
SUPFAM; SSF49854; SSF49854; 5.
SUPFAM; SSF57184; SSF57184; 1.
PROSITE; PS00010; ASX_HYDROXYL; 2.
PROSITE; PS01180; CUB; 5.
PROSITE; PS01186; EGF_2; 2.
PROSITE; PS50026; EGF_3; 2.
PROSITE; PS01187; EGF_CA; 2.
2: Evidence at transcript level;
Calcium {ECO:0000256|SAAS:SAAS00909960};
Complete proteome {ECO:0000313|Proteomes:UP000002277};
Disulfide bond {ECO:0000256|SAAS:SAAS00601599};
EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076,
ECO:0000256|SAAS:SAAS00032677};
Hydrolase {ECO:0000256|RuleBase:RU361183,
ECO:0000256|SAAS:SAAS01068076};
Metal-binding {ECO:0000256|PIRSR:PIRSR001199-2,
ECO:0000256|RuleBase:RU361183, ECO:0000256|SAAS:SAAS00973795};
Metalloprotease {ECO:0000256|RuleBase:RU361183,
ECO:0000256|SAAS:SAAS01068076};
Protease {ECO:0000256|RuleBase:RU361183,
ECO:0000256|SAAS:SAAS01068076};
Reference proteome {ECO:0000313|Proteomes:UP000002277};
Repeat {ECO:0000256|SAAS:SAAS00594563};
Signal {ECO:0000256|RuleBase:RU361183};
Zinc {ECO:0000256|PIRSR:PIRSR001199-2, ECO:0000256|RuleBase:RU361183,
ECO:0000256|SAAS:SAAS00973802}.
SIGNAL 1 22 {ECO:0000256|RuleBase:RU361183}.
CHAIN 23 986 Metalloendopeptidase.
{ECO:0000256|RuleBase:RU361183}.
/FTId=PRO_5015019815.
DOMAIN 322 434 CUB. {ECO:0000259|PROSITE:PS01180}.
DOMAIN 435 547 CUB. {ECO:0000259|PROSITE:PS01180}.
DOMAIN 547 588 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 591 703 CUB. {ECO:0000259|PROSITE:PS01180}.
DOMAIN 703 743 EGF-like. {ECO:0000259|PROSITE:PS50026}.
DOMAIN 747 859 CUB. {ECO:0000259|PROSITE:PS01180}.
DOMAIN 860 976 CUB. {ECO:0000259|PROSITE:PS01180}.
ACT_SITE 214 214 {ECO:0000256|PIRSR:PIRSR001199-1}.
METAL 213 213 Zinc; catalytic.
{ECO:0000256|PIRSR:PIRSR001199-2}.
METAL 217 217 Zinc; catalytic.
{ECO:0000256|PIRSR:PIRSR001199-2}.
METAL 223 223 Zinc; catalytic.
{ECO:0000256|PIRSR:PIRSR001199-2}.
SEQUENCE 986 AA; 111167 MW; 627331D61A0B4FAF CRC64;
MPGVARLPLL LGLLLLPRPG RPLDLADYTY DLAEEDDSEP LNYKDPCKAA AFLGDIALDE
EDLRAFQVQQ AADLRQHTAR KSSIKAAVAG NTSTPSCQST NGQPQRGACG RWRGRSRSRR
AATSRPERVW PDGVIPFVIG GNFTGSQRAV FRQAMRHWEK HTCVTFLERT DEDSYIVFTY
RPCGCCSYVG RRGGGPQAIS IGKNCDKFGI VVHELGHVVG FWHEHTRPDR DRHVSIVREN
IQPGQEYNFL KMEPQEVESL GETYDFDSIM HYARNTFSRG IFLDTIVPKY EVNGVKPPIG
QRTRLSKGDI AQARKLYKCP ACGETLQDST GNFSSPEYPN GYSAHMHCVW RISVTPGEKI
ILNFTSLDLY RSRLCWYDYV EVRDGFWRKA PLRGRFCGSK LPEPIVSTDS RLWVEFRSSS
NWVGKGFFAV YEAICGGDVK KDYGHIQSPN YPDDYRPSKV CIWRIQVSEG FHVGLTFQSF
EIERHDSCAY DYLEVRDGHS ESSTLIGRYC GYEKPDDIKS TSSRLWLKFV SDGSINKAGF
AVNFFKEVDE CSRPNRGGCE QRCLNTLGSY KCSCDPGYEL APDKRRCEAA CGGFLTKLNG
SITSPGWPKE YPPNKNCIWQ LVAPTQYRIS LQFDFFETEG NDVCKYDFVE VRSGLTADSK
LHGKFCGSEK PEVITSQYNN MRVEFKSDNT VSKKGFKAHF FSDKDECSKD NGGCQQDCVN
TFGSYECQCR SGFVLHDNKH DCKEAGCDHK VTSTSGTITS PNWPDKYPSK KECTWAISST
PGHRVKLTFM EMDIESQPEC AYDHLEVFDG RDAKAPVLGR FCGSKKPEPV LATGSRMFLR
FYSDNSVQRK GFQASHATEC GGQVRADVKT KDLYSHAQFG DNNYPGGVDC EWVIVAEEGY
GVELVFQTFE VEEETDCGYD YMELFDGYDS TAPRLGRYCG SGPPEEVYSA GDSVLVKFHS
DDTITKKGFH LRYTSTKFQD TLHSRK


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