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Metallothionein

 A5HC27_CAPHI            Unreviewed;        68 AA.
A5HC27;
12-JUN-2007, integrated into UniProtKB/TrEMBL.
12-JUN-2007, sequence version 1.
20-JUN-2018, entry version 52.
RecName: Full=Metallothionein {ECO:0000256|RuleBase:RU000621};
Capra hircus (Goat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Capra.
NCBI_TaxID=9925 {ECO:0000313|EMBL:ABQ08696.1};
[1] {ECO:0000313|EMBL:ABQ08696.1}
NUCLEOTIDE SEQUENCE.
Wang L., Wu J.P., Yang L., Zhang L.P.;
"Cloning and analysis of goat MT-III gene.";
Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Metallothioneins have a high content of cysteine
residues that bind various heavy metals.
{ECO:0000256|RuleBase:RU000621}.
-!- SIMILARITY: Belongs to the metallothionein superfamily. Type 1
family. {ECO:0000256|RuleBase:RU000621,
ECO:0000256|SAAS:SAAS00671996}.
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EMBL; EF471976; ABQ08696.1; -; mRNA.
RefSeq; XP_013826441.1; XM_013970987.2.
UniGene; Chi.36587; -.
ProteinModelPortal; A5HC27; -.
Ensembl; ENSCHIT00000028834; ENSCHIP00000020993; ENSCHIG00000019450.
GeneID; 100860760; -.
KEGG; chx:100860760; -.
CTD; 4504; -.
HOVERGEN; HBG009063; -.
KO; K14740; -.
GO; GO:0016234; C:inclusion body; IEA:Ensembl.
GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
GO; GO:0008021; C:synaptic vesicle; IEA:Ensembl.
GO; GO:0046870; F:cadmium ion binding; IEA:Ensembl.
GO; GO:0005507; F:copper ion binding; IEA:Ensembl.
GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Ensembl.
GO; GO:0008144; F:drug binding; IEA:Ensembl.
GO; GO:0030295; F:protein kinase activator activity; IEA:Ensembl.
GO; GO:0008270; F:zinc ion binding; IEA:Ensembl.
GO; GO:0032148; P:activation of protein kinase B activity; IEA:Ensembl.
GO; GO:0014002; P:astrocyte development; IEA:Ensembl.
GO; GO:0055073; P:cadmium ion homeostasis; IEA:Ensembl.
GO; GO:0044242; P:cellular lipid catabolic process; IEA:Ensembl.
GO; GO:0071276; P:cellular response to cadmium ion; IEA:Ensembl.
GO; GO:0071456; P:cellular response to hypoxia; IEA:Ensembl.
GO; GO:0071732; P:cellular response to nitric oxide; IEA:Ensembl.
GO; GO:0006882; P:cellular zinc ion homeostasis; IEA:Ensembl.
GO; GO:0006707; P:cholesterol catabolic process; IEA:Ensembl.
GO; GO:0006112; P:energy reserve metabolic process; IEA:Ensembl.
GO; GO:0070371; P:ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0016570; P:histone modification; IEA:Ensembl.
GO; GO:0033210; P:leptin-mediated signaling pathway; IEA:Ensembl.
GO; GO:0010507; P:negative regulation of autophagy; IEA:Ensembl.
GO; GO:0030517; P:negative regulation of axon extension; IEA:Ensembl.
GO; GO:0060547; P:negative regulation of necrotic cell death; IEA:Ensembl.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; IEA:Ensembl.
GO; GO:0051354; P:negative regulation of oxidoreductase activity; IEA:Ensembl.
GO; GO:2000378; P:negative regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:Ensembl.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0097214; P:positive regulation of lysosomal membrane permeability; IEA:Ensembl.
GO; GO:0010940; P:positive regulation of necrotic cell death; IEA:Ensembl.
GO; GO:2000376; P:positive regulation of oxygen metabolic process; IEA:Ensembl.
GO; GO:0036091; P:positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; IEA:Ensembl.
GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
GO; GO:0000060; P:protein import into nucleus, translocation; IEA:Ensembl.
GO; GO:0043491; P:protein kinase B signaling; IEA:Ensembl.
GO; GO:0050821; P:protein stabilization; IEA:Ensembl.
GO; GO:0060049; P:regulation of protein glycosylation; IEA:Ensembl.
GO; GO:0032095; P:regulation of response to food; IEA:Ensembl.
GO; GO:0019430; P:removal of superoxide radicals; IEA:Ensembl.
GO; GO:0006829; P:zinc ion transport; IEA:Ensembl.
Gene3D; 4.10.10.10; -; 1.
InterPro; IPR003019; Metalthion.
InterPro; IPR017854; Metalthion_dom_sf.
InterPro; IPR023587; Metalthion_dom_sf_vert.
InterPro; IPR000006; Metalthion_vert.
PANTHER; PTHR23299; PTHR23299; 1.
Pfam; PF00131; Metallothio; 1.
PRINTS; PR00860; MTVERTEBRATE.
SUPFAM; SSF57868; SSF57868; 1.
2: Evidence at transcript level;
Metal-binding {ECO:0000256|RuleBase:RU000621,
ECO:0000256|SAAS:SAAS00286479};
Metal-thiolate cluster {ECO:0000256|RuleBase:RU000621,
ECO:0000256|SAAS:SAAS00286479}.
SEQUENCE 68 AA; 6927 MW; 1DD000EE1EC2AE71 CRC64;
MDPETCPCPT GGSCTCSDSC KCEGCTCASS KKSCCSCCPA ECEKCAKDCV CKGGEGAEAE
EKKCSCCQ


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