Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Metallothionein-3 (MT-3) (Growth inhibitory factor) (GIF) (Metallothionein-III) (MT-III)

 MT3_HORSE               Reviewed;          68 AA.
P37360;
01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
01-OCT-1994, sequence version 1.
23-MAY-2018, entry version 92.
RecName: Full=Metallothionein-3;
Short=MT-3;
AltName: Full=Growth inhibitory factor;
Short=GIF;
AltName: Full=Metallothionein-III;
Short=MT-III;
Name=MT3;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796;
[1]
PROTEIN SEQUENCE, AND ACETYLATION AT MET-1.
TISSUE=Brain;
PubMed=8200454; DOI=10.1016/0014-5793(94)00452-8;
Pountney D.L., Fundel S.M., Faller P., Birchler N.E., Hunziker P.,
Vasak M.;
"Isolation, primary structures and metal binding properties of
neuronal growth inhibitory factor (GIF) from bovine and equine
brain.";
FEBS Lett. 345:193-197(1994).
-!- FUNCTION: Binds heavy metals. Contains three zinc and three copper
atoms per polypeptide chain and only a negligible amount of
cadmium.
-!- TISSUE SPECIFICITY: Brain.
-!- SIMILARITY: Belongs to the metallothionein superfamily. Type 1
family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
PIR; S44392; S44392.
ProteinModelPortal; P37360; -.
SMR; P37360; -.
STRING; 9796.ENSECAP00000012822; -.
iPTMnet; P37360; -.
PaxDb; P37360; -.
eggNOG; ENOG410JHA0; Eukaryota.
eggNOG; ENOG4111CXS; LUCA.
HOGENOM; HOG000236262; -.
InParanoid; P37360; -.
Proteomes; UP000002281; Unplaced.
GO; GO:0016234; C:inclusion body; ISS:UniProtKB.
GO; GO:0005622; C:intracellular; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO; GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
GO; GO:0046870; F:cadmium ion binding; ISS:UniProtKB.
GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0008144; F:drug binding; ISS:UniProtKB.
GO; GO:0030295; F:protein kinase activator activity; ISS:UniProtKB.
GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO; GO:0032148; P:activation of protein kinase B activity; ISS:UniProtKB.
GO; GO:0014002; P:astrocyte development; ISS:UniProtKB.
GO; GO:0055073; P:cadmium ion homeostasis; ISS:UniProtKB.
GO; GO:0044242; P:cellular lipid catabolic process; ISS:UniProtKB.
GO; GO:0071276; P:cellular response to cadmium ion; ISS:UniProtKB.
GO; GO:0035690; P:cellular response to drug; ISS:UniProtKB.
GO; GO:0071732; P:cellular response to nitric oxide; ISS:UniProtKB.
GO; GO:0034599; P:cellular response to oxidative stress; ISS:UniProtKB.
GO; GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.
GO; GO:0006707; P:cholesterol catabolic process; ISS:UniProtKB.
GO; GO:0006112; P:energy reserve metabolic process; ISS:UniProtKB.
GO; GO:0070371; P:ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:0016570; P:histone modification; ISS:UniProtKB.
GO; GO:0033210; P:leptin-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0010507; P:negative regulation of autophagy; ISS:UniProtKB.
GO; GO:0030517; P:negative regulation of axon extension; ISS:UniProtKB.
GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
GO; GO:2000117; P:negative regulation of cysteine-type endopeptidase activity; ISS:UniProtKB.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0060547; P:negative regulation of necrotic cell death; ISS:UniProtKB.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
GO; GO:0051354; P:negative regulation of oxidoreductase activity; ISS:UniProtKB.
GO; GO:2000378; P:negative regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0043085; P:positive regulation of catalytic activity; ISS:UniProtKB.
GO; GO:0010942; P:positive regulation of cell death; ISS:UniProtKB.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
GO; GO:0097214; P:positive regulation of lysosomal membrane permeability; ISS:UniProtKB.
GO; GO:0010940; P:positive regulation of necrotic cell death; ISS:UniProtKB.
GO; GO:2000376; P:positive regulation of oxygen metabolic process; ISS:UniProtKB.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
GO; GO:0036091; P:positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.
GO; GO:0000060; P:protein import into nucleus, translocation; ISS:UniProtKB.
GO; GO:0043491; P:protein kinase B signaling; ISS:UniProtKB.
GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
GO; GO:0060049; P:regulation of protein glycosylation; ISS:UniProtKB.
GO; GO:0032095; P:regulation of response to food; ISS:UniProtKB.
GO; GO:0019430; P:removal of superoxide radicals; ISS:UniProtKB.
GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
GO; GO:0055069; P:zinc ion homeostasis; ISS:UniProtKB.
GO; GO:0006829; P:zinc ion transport; ISS:UniProtKB.
Gene3D; 4.10.10.10; -; 1.
InterPro; IPR003019; Metalthion.
InterPro; IPR017854; Metalthion_dom_sf.
InterPro; IPR023587; Metalthion_dom_sf_vert.
InterPro; IPR000006; Metalthion_vert.
InterPro; IPR018064; Metalthion_vert_metal_BS.
PANTHER; PTHR23299; PTHR23299; 1.
Pfam; PF00131; Metallothio; 1.
PRINTS; PR00860; MTVERTEBRATE.
SUPFAM; SSF57868; SSF57868; 1.
PROSITE; PS00203; METALLOTHIONEIN_VRT; 1.
1: Evidence at protein level;
Acetylation; Complete proteome; Copper; Direct protein sequencing;
Metal-binding; Metal-thiolate cluster; Phosphoprotein;
Reference proteome; Zinc.
CHAIN 1 68 Metallothionein-3.
/FTId=PRO_0000197249.
REGION 1 30 Beta.
REGION 31 68 Alpha.
METAL 6 6 Divalent metal cation; cluster B.
{ECO:0000250}.
METAL 8 8 Divalent metal cation; cluster B.
{ECO:0000250}.
METAL 14 14 Divalent metal cation; cluster B.
{ECO:0000250}.
METAL 16 16 Divalent metal cation; cluster B.
{ECO:0000250}.
METAL 20 20 Divalent metal cation; cluster B.
{ECO:0000250}.
METAL 22 22 Divalent metal cation; cluster B.
{ECO:0000250}.
METAL 25 25 Divalent metal cation; cluster B.
{ECO:0000250}.
METAL 27 27 Divalent metal cation; cluster B.
{ECO:0000250}.
METAL 30 30 Divalent metal cation; cluster B.
{ECO:0000250}.
METAL 34 34 Divalent metal cation; cluster A.
{ECO:0000250}.
METAL 35 35 Divalent metal cation; cluster A.
{ECO:0000250}.
METAL 37 37 Divalent metal cation; cluster A.
{ECO:0000250}.
METAL 38 38 Divalent metal cation; cluster A.
{ECO:0000250}.
METAL 42 42 Divalent metal cation; cluster A.
{ECO:0000250}.
METAL 45 45 Divalent metal cation; cluster A.
{ECO:0000250}.
METAL 49 49 Divalent metal cation; cluster A.
{ECO:0000250}.
METAL 51 51 Divalent metal cation; cluster A.
{ECO:0000250}.
METAL 64 64 Divalent metal cation; cluster A.
{ECO:0000250}.
METAL 66 66 Divalent metal cation; cluster A.
{ECO:0000250}.
METAL 67 67 Divalent metal cation; cluster A.
{ECO:0000250}.
MOD_RES 1 1 N-acetylmethionine.
{ECO:0000269|PubMed:8200454}.
MOD_RES 33 33 Phosphoserine.
{ECO:0000250|UniProtKB:P28184}.
SEQUENCE 68 AA; 6927 MW; 5998E0F17FC52CE6 CRC64;
MDPETCPCPT GGSCTCSGEC KCEGCKCTSC KKSCCSCCPA ECEKCAKDCV CKGGEGAEAE
AEKCSCCQ


Related products :

Catalog number Product name Quantity
EIAAB25598 GIF,Growth inhibitory factor,Metallothionein-3,Metallothionein-III,MT3,MT-3,MT-III,Oryctolagus cuniculus,Rabbit
EIAAB25599 GIF,Growth inhibitory factor,Metallothionein-3,Metallothionein-III,Mt3,MT-3,MT-III,Rat,Rattus norvegicus
EIAAB25600 GIF,Growth inhibitory factor,Metallothionein-3,Metallothionein-III,Mouse,Mt3,MT-3,MT-III,Mus musculus
EIAAB25597 Bos taurus,Bovine,GIF,Growth inhibitory factor,Metallothionein-3,Metallothionein-III,MT3,MT-3,MT-III
EIAAB25602 GIF,GIFB,Growth inhibitory factor,Homo sapiens,Human,Metallothionein-3,Metallothionein-III,MT3,MT-3,MT-III
EIAAB25601 GIF,Growth inhibitory factor,Metallothionein-3,Metallothionein-III,MT3,MT-3,MT-III,Pig,Sus scrofa
E1868h ELISA kit CES1,Homo sapiens,Human,Metallothionein-2,Metallothionein-2A,Metallothionein-II,MT2,MT-2,MT2A,MT-II 96T
E1868h ELISA CES1,Homo sapiens,Human,Metallothionein-2,Metallothionein-2A,Metallothionein-II,MT2,MT-2,MT2A,MT-II 96T
U1868h CLIA CES1,Homo sapiens,Human,Metallothionein-2,Metallothionein-2A,Metallothionein-II,MT2,MT-2,MT2A,MT-II 96T
EIAAB25581 Homo sapiens,Human,Metallothionein-1G,Metallothionein-1K,Metallothionein-IG,MT1G,MT-1G,MT1K,MT-1K,MT1M,MT-IG
U1868h CLIA kit CES1,Homo sapiens,Human,Metallothionein-2,Metallothionein-2A,Metallothionein-II,MT2,MT-2,MT2A,MT-II 96T
EIAAB25582 Homo sapiens,Human,Metallothionein-0,Metallothionein-1H,Metallothionein-IH,MT-0,MT1H,MT-1H,MT-IH
U1119h CLIA Homo sapiens,Human,Metallothionein-1A,Metallothionein-IA,MT1A,MT-1A,MT1S,MT-IA 96T
E1119h ELISA Homo sapiens,Human,Metallothionein-1A,Metallothionein-IA,MT1A,MT-1A,MT1S,MT-IA 96T
E1119h ELISA kit Homo sapiens,Human,Metallothionein-1A,Metallothionein-IA,MT1A,MT-1A,MT1S,MT-IA 96T
EIAAB25580 Homo sapiens,Human,Metallothionein-1F,Metallothionein-IF,MT1F,MT-1F,MT-IF,PRO0376
EIAAB25584 Homo sapiens,Human,Metallothionein-1M,Metallothionein-IM,MT1K,MT1M,MT-1M,MT-IM
EIAAB25573 Homo sapiens,Human,Metallothionein-1B,Metallothionein-IB,MT1B,MT-1B,MT1Q,MT-IB
M04406201-100 Antibodies Metallothionein polyclonal rabbit anti-cod metallothionein Purified CS-2 KH-1 100 μl
M04406201-500 Antibodies Metallothionein polyclonal rabbit anti-cod metallothionein Purified CS-3 KH-1 500 μl
E1868b ELISA kit Bos taurus,Bovine,Metallothionein-2,Metallothionein-II,MT2,MT-2,MT2A,MT-II 96T
EIAAB25583 Homo sapiens,Human,Metallothionein-1L,Metallothionein-IL,MT1L,MT-1L,MT-IL
E1119b ELISA kit Bos taurus,Bovine,Metallothionein-1A,Metallothionein-IA,MT1A,MT-1A,MTC,MT-IA,MT-IA 96T
U1868b CLIA Bos taurus,Bovine,Metallothionein-2,Metallothionein-II,MT2,MT-2,MT2A,MT-II 96T
EIAAB25577 Homo sapiens,Human,Metallothionein-1E,Metallothionein-IE,MT1E,MT-1E,MT-IE


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur