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Metallothionein-3 (MT-3) (Growth inhibitory factor) (GIF) (Metallothionein-III) (MT-III)

 MT3_HORSE               Reviewed;          68 AA.
01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
01-OCT-1994, sequence version 1.
07-NOV-2018, entry version 93.
RecName: Full=Metallothionein-3;
AltName: Full=Growth inhibitory factor;
AltName: Full=Metallothionein-III;
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
PubMed=8200454; DOI=10.1016/0014-5793(94)00452-8;
Pountney D.L., Fundel S.M., Faller P., Birchler N.E., Hunziker P.,
Vasak M.;
"Isolation, primary structures and metal binding properties of
neuronal growth inhibitory factor (GIF) from bovine and equine
FEBS Lett. 345:193-197(1994).
-!- FUNCTION: Binds heavy metals. Contains three zinc and three copper
atoms per polypeptide chain and only a negligible amount of
-!- SIMILARITY: Belongs to the metallothionein superfamily. Type 1
family. {ECO:0000305}.
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
PIR; S44392; S44392.
ProteinModelPortal; P37360; -.
SMR; P37360; -.
STRING; 9796.ENSECAP00000012822; -.
iPTMnet; P37360; -.
PaxDb; P37360; -.
eggNOG; ENOG410JHA0; Eukaryota.
HOGENOM; HOG000236262; -.
InParanoid; P37360; -.
Proteomes; UP000002281; Unplaced.
GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
GO; GO:0016234; C:inclusion body; ISS:UniProtKB.
GO; GO:0005622; C:intracellular; ISS:UniProtKB.
GO; GO:0005634; C:nucleus; ISS:UniProtKB.
GO; GO:0048471; C:perinuclear region of cytoplasm; ISS:UniProtKB.
GO; GO:0008021; C:synaptic vesicle; ISS:UniProtKB.
GO; GO:0046870; F:cadmium ion binding; ISS:UniProtKB.
GO; GO:0005507; F:copper ion binding; ISS:UniProtKB.
GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0008144; F:drug binding; ISS:UniProtKB.
GO; GO:0046872; F:metal ion binding; IBA:GO_Central.
GO; GO:0030295; F:protein kinase activator activity; ISS:UniProtKB.
GO; GO:0008270; F:zinc ion binding; ISS:UniProtKB.
GO; GO:0032148; P:activation of protein kinase B activity; ISS:UniProtKB.
GO; GO:0014002; P:astrocyte development; ISS:UniProtKB.
GO; GO:0055073; P:cadmium ion homeostasis; ISS:UniProtKB.
GO; GO:0044242; P:cellular lipid catabolic process; ISS:UniProtKB.
GO; GO:0071276; P:cellular response to cadmium ion; ISS:UniProtKB.
GO; GO:0071280; P:cellular response to copper ion; IBA:GO_Central.
GO; GO:0035690; P:cellular response to drug; ISS:UniProtKB.
GO; GO:0071732; P:cellular response to nitric oxide; ISS:UniProtKB.
GO; GO:0034599; P:cellular response to oxidative stress; ISS:UniProtKB.
GO; GO:0071294; P:cellular response to zinc ion; IBA:GO_Central.
GO; GO:0006882; P:cellular zinc ion homeostasis; ISS:UniProtKB.
GO; GO:0006707; P:cholesterol catabolic process; ISS:UniProtKB.
GO; GO:0010273; P:detoxification of copper ion; IBA:GO_Central.
GO; GO:0006112; P:energy reserve metabolic process; ISS:UniProtKB.
GO; GO:0070371; P:ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:0016570; P:histone modification; ISS:UniProtKB.
GO; GO:0033210; P:leptin-mediated signaling pathway; ISS:UniProtKB.
GO; GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
GO; GO:0010507; P:negative regulation of autophagy; ISS:UniProtKB.
GO; GO:0030517; P:negative regulation of axon extension; ISS:UniProtKB.
GO; GO:0030308; P:negative regulation of cell growth; ISS:UniProtKB.
GO; GO:2000117; P:negative regulation of cysteine-type endopeptidase activity; ISS:UniProtKB.
GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; ISS:UniProtKB.
GO; GO:0060547; P:negative regulation of necrotic cell death; ISS:UniProtKB.
GO; GO:0043524; P:negative regulation of neuron apoptotic process; ISS:UniProtKB.
GO; GO:0051354; P:negative regulation of oxidoreductase activity; ISS:UniProtKB.
GO; GO:2000378; P:negative regulation of reactive oxygen species metabolic process; ISS:UniProtKB.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0043085; P:positive regulation of catalytic activity; ISS:UniProtKB.
GO; GO:0010942; P:positive regulation of cell death; ISS:UniProtKB.
GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; ISS:UniProtKB.
GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
GO; GO:0097214; P:positive regulation of lysosomal membrane permeability; ISS:UniProtKB.
GO; GO:0010940; P:positive regulation of necrotic cell death; ISS:UniProtKB.
GO; GO:2000376; P:positive regulation of oxygen metabolic process; ISS:UniProtKB.
GO; GO:0001934; P:positive regulation of protein phosphorylation; ISS:UniProtKB.
GO; GO:0036091; P:positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress; ISS:UniProtKB.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
GO; GO:0030949; P:positive regulation of vascular endothelial growth factor receptor signaling pathway; ISS:UniProtKB.
GO; GO:0000060; P:protein import into nucleus, translocation; ISS:UniProtKB.
GO; GO:0043491; P:protein kinase B signaling; ISS:UniProtKB.
GO; GO:0050821; P:protein stabilization; ISS:UniProtKB.
GO; GO:0060049; P:regulation of protein glycosylation; ISS:UniProtKB.
GO; GO:0032095; P:regulation of response to food; ISS:UniProtKB.
GO; GO:0019430; P:removal of superoxide radicals; ISS:UniProtKB.
GO; GO:0001666; P:response to hypoxia; ISS:UniProtKB.
GO; GO:0055069; P:zinc ion homeostasis; ISS:UniProtKB.
GO; GO:0006829; P:zinc ion transport; ISS:UniProtKB.
Gene3D;; -; 1.
InterPro; IPR003019; Metalthion.
InterPro; IPR017854; Metalthion_dom_sf.
InterPro; IPR023587; Metalthion_dom_sf_vert.
InterPro; IPR000006; Metalthion_vert.
InterPro; IPR018064; Metalthion_vert_metal_BS.
PANTHER; PTHR23299; PTHR23299; 1.
Pfam; PF00131; Metallothio; 1.
SUPFAM; SSF57868; SSF57868; 1.
1: Evidence at protein level;
Acetylation; Complete proteome; Copper; Direct protein sequencing;
Metal-binding; Metal-thiolate cluster; Phosphoprotein;
Reference proteome; Zinc.
CHAIN 1 68 Metallothionein-3.
REGION 1 30 Beta.
REGION 31 68 Alpha.
METAL 6 6 Divalent metal cation; cluster B.
METAL 8 8 Divalent metal cation; cluster B.
METAL 14 14 Divalent metal cation; cluster B.
METAL 16 16 Divalent metal cation; cluster B.
METAL 20 20 Divalent metal cation; cluster B.
METAL 22 22 Divalent metal cation; cluster B.
METAL 25 25 Divalent metal cation; cluster B.
METAL 27 27 Divalent metal cation; cluster B.
METAL 30 30 Divalent metal cation; cluster B.
METAL 34 34 Divalent metal cation; cluster A.
METAL 35 35 Divalent metal cation; cluster A.
METAL 37 37 Divalent metal cation; cluster A.
METAL 38 38 Divalent metal cation; cluster A.
METAL 42 42 Divalent metal cation; cluster A.
METAL 45 45 Divalent metal cation; cluster A.
METAL 49 49 Divalent metal cation; cluster A.
METAL 51 51 Divalent metal cation; cluster A.
METAL 64 64 Divalent metal cation; cluster A.
METAL 66 66 Divalent metal cation; cluster A.
METAL 67 67 Divalent metal cation; cluster A.
MOD_RES 1 1 N-acetylmethionine.
MOD_RES 33 33 Phosphoserine.
SEQUENCE 68 AA; 6927 MW; 5998E0F17FC52CE6 CRC64;

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