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Methionine-R-sulfoxide reductase B1-A (MsrB) (MsrB1-A) (EC 1.8.4.-) (Selenoprotein X-A) (SePR) (SelX-A)

 MSB1A_DANRE             Reviewed;         110 AA.
Q802G6; Q6NWX6;
26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
23-MAR-2010, sequence version 3.
12-APR-2017, entry version 75.
RecName: Full=Methionine-R-sulfoxide reductase B1-A;
Short=MsrB;
Short=MsrB1-A;
EC=1.8.4.-;
AltName: Full=Selenoprotein X-A;
Short=SePR;
Short=SelX-A;
Name=msrb1; Synonyms=sepx1, sepx1a;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Embryo;
PubMed=12915322; DOI=10.1016/S1567-133X(03)00054-1;
Thisse C., Degrave A., Kryukov G.V., Gladyshev V.N.,
Obrecht-Pflumio S., Krol A., Thisse B., Lescure A.;
"Spatial and temporal expression patterns of selenoprotein genes
during embryogenesis in zebrafish.";
Gene Expr. Patterns 3:525-532(2003).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Kidney;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Methionine-sulfoxide reductase that specifically reduces
methionine (R)-sulfoxide back to methionine. While in many cases,
methionine oxidation is the result of random oxidation following
oxidative stress, methionine oxidation is also a post-
translational modification that takes place on specific residue.
Acts as a regulator of actin assembly by reducing methionine (R)-
sulfoxide mediated by MICALs (mical1, mical2 or mical3) on actin,
thereby promoting filament repolymerization. Plays a role in
innate immunity by reducing oxidized actin, leading to actin
repolymerization in macrophages (By similarity). {ECO:0000250}.
-!- CATALYTIC ACTIVITY: L-methionine + oxidized thioredoxin = L-
methionine R-oxide + reduced thioredoxin.
{ECO:0000250|UniProtKB:Q9JLC3}.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000250|UniProtKB:Q9JLC3};
Note=Binds 1 zinc ion per subunit. {ECO:0000250|UniProtKB:Q9JLC3};
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q9JLC3}.
Nucleus {ECO:0000250|UniProtKB:Q9JLC3}. Cytoplasm, cytoskeleton
{ECO:0000250|UniProtKB:Q9JLC3}.
-!- TISSUE SPECIFICITY: In the embryo, expressed in the polster,
paraxial mesoderm, tectum, otic vesicle and liver.
{ECO:0000269|PubMed:12915322}.
-!- SIMILARITY: Belongs to the MsrB Met sulfoxide reductase family.
{ECO:0000305}.
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EMBL; AY216585; AAO86699.1; -; mRNA.
EMBL; BC067380; AAH67380.1; -; mRNA.
RefSeq; NP_840073.2; NM_178288.5.
UniGene; Dr.24956; -.
STRING; 7955.ENSDARP00000115071; -.
PaxDb; Q802G6; -.
Ensembl; ENSDART00000131758; ENSDARP00000122736; ENSDARG00000025436.
GeneID; 352916; -.
KEGG; dre:352916; -.
CTD; 352916; -.
ZFIN; ZDB-GENE-030411-3; msrb1a.
eggNOG; KOG0856; Eukaryota.
eggNOG; COG0229; LUCA.
GeneTree; ENSGT00510000047678; -.
HOVERGEN; HBG002192; -.
InParanoid; Q802G6; -.
KO; K07305; -.
PhylomeDB; Q802G6; -.
Reactome; R-DRE-5676934; Protein repair.
PRO; PR:Q802G6; -.
Proteomes; UP000000437; Chromosome 3.
Bgee; ENSDARG00000025436; -.
ExpressionAtlas; Q802G6; baseline and differential.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0003779; F:actin binding; ISS:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0033743; F:peptide-methionine (R)-S-oxide reductase activity; ISS:UniProtKB.
GO; GO:0030041; P:actin filament polymerization; ISS:UniProtKB.
GO; GO:0045087; P:innate immune response; ISS:UniProtKB.
GO; GO:0030091; P:protein repair; IEA:InterPro.
GO; GO:0006979; P:response to oxidative stress; IEA:InterPro.
InterPro; IPR028427; Met_Sox_Rdtase.
InterPro; IPR002579; Met_Sox_Rdtase_MsrB.
InterPro; IPR011057; Mss4-like.
PANTHER; PTHR10173; PTHR10173; 1.
Pfam; PF01641; SelR; 1.
SUPFAM; SSF51316; SSF51316; 1.
PROSITE; PS51790; MSRB; 1.
2: Evidence at transcript level;
Complete proteome; Cytoplasm; Cytoskeleton; Immunity; Innate immunity;
Metal-binding; Nucleus; Oxidoreductase; Reference proteome;
Selenocysteine; Zinc.
CHAIN 1 110 Methionine-R-sulfoxide reductase B1-A.
/FTId=PRO_0000318636.
DOMAIN 1 104 MsrB. {ECO:0000255|PROSITE-
ProRule:PRU01126}.
ACT_SITE 93 93 Nucleophile. {ECO:0000255|PROSITE-
ProRule:PRU01126}.
METAL 23 23 Zinc. {ECO:0000255|PROSITE-
ProRule:PRU01126}.
METAL 26 26 Zinc. {ECO:0000255|PROSITE-
ProRule:PRU01126}.
METAL 69 69 Zinc. {ECO:0000255|PROSITE-
ProRule:PRU01126}.
METAL 72 72 Zinc. {ECO:0000255|PROSITE-
ProRule:PRU01126}.
NON_STD 93 93 Selenocysteine. {ECO:0000250}.
CONFLICT 52 52 E -> K (in Ref. 1; AAO86699).
{ECO:0000305}.
SEQUENCE 110 AA; 12553 MW; 0639C892C7861174 CRC64;
MSFCSFSGGE IYKDHFESGM YVCAQCGYEL FSSRSKYEHS SPWPAFTETI HEDSVSKQEE
RWGAYKVRCG KCGNGLGHEF VNDGPKHGLS RFUIFSSSLK FIPKVKNEQQ


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