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Methyl-accepting chemotaxis protein PctC

 PCTC_PSEAE              Reviewed;         632 AA.
Q9HW93; O32440;
22-JAN-2014, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
05-JUL-2017, entry version 92.
RecName: Full=Methyl-accepting chemotaxis protein PctC;
Name=pctC; OrderedLocusNames=PA4307;
Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 /
JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1).
Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
Pseudomonadaceae; Pseudomonas.
NCBI_TaxID=208964;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DISRUPTION PHENOTYPE.
STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
1C / PRS 101 / PAO1;
PubMed=9353923; DOI=10.1099/00221287-143-10-3223;
Taguchi K., Fukutomi H., Kuroda A., Kato J., Ohtake H.;
"Genetic identification of chemotactic transducers for amino acids in
Pseudomonas aeruginosa.";
Microbiology 143:3223-3229(1997).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
1C / PRS 101 / PAO1;
PubMed=10984043; DOI=10.1038/35023079;
Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T.,
Reizer J., Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
"Complete genome sequence of Pseudomonas aeruginosa PAO1, an
opportunistic pathogen.";
Nature 406:959-964(2000).
[3]
FUNCTION IN REPELLENT RESPONSES, AND DISRUPTION PHENOTYPE.
STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
1C / PRS 101 / PAO1;
PubMed=16233808; DOI=10.1263/jbb.99.396;
Shitashiro M., Tanaka H., Hong C.S., Kuroda A., Takiguchi N.,
Ohtake H., Kato J.;
"Identification of chemosensory proteins for trichloroethylene in
Pseudomonas aeruginosa.";
J. Biosci. Bioeng. 99:396-402(2005).
[4]
FUNCTION, AND DOMAIN.
STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 /
1C / PRS 101 / PAO1;
PubMed=23650915; DOI=10.1111/mmi.12255;
Rico-Jimenez M., Munoz-Martinez F., Garcia-Fontana C., Fernandez M.,
Morel B., Ortega A., Ramos J.L., Krell T.;
"Paralogous chemoreceptors mediate chemotaxis towards protein amino
acids and the non-protein amino acid gamma-aminobutyrate (GABA).";
Mol. Microbiol. 88:1230-1243(2013).
-!- FUNCTION: Chemotactic-signal transducers respond to changes in the
concentration of attractants and repellents in the environment,
transduce a signal from the outside to the inside of the cell, and
facilitate sensory adaptation through the variation of the level
of methylation. Responds to L-His, L-Pro and GABA. Also involved
in repellent responses to trichloroethylene (TCE), chloroform and
methylthiocyanate. {ECO:0000269|PubMed:16233808,
ECO:0000269|PubMed:23650915, ECO:0000269|PubMed:9353923}.
-!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-
pass membrane protein {ECO:0000305}.
-!- DOMAIN: The ligand binding region binds directly to 2 L-amino
acids. {ECO:0000269|PubMed:23650915}.
-!- DISRUPTION PHENOTYPE: Mutant shows no defect in chemotaxis toward
L-amino acids. Mutant shows also decreased chemotactic responses
to TCE, chloroform and methylthiocyanate.
{ECO:0000269|PubMed:16233808, ECO:0000269|PubMed:9353923}.
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EMBL; D86947; BAA23410.1; -; Genomic_DNA.
EMBL; AE004091; AAG07695.1; -; Genomic_DNA.
PIR; H83106; H83106.
RefSeq; NP_252997.1; NC_002516.2.
RefSeq; WP_003148124.1; NC_002516.2.
ProteinModelPortal; Q9HW93; -.
SMR; Q9HW93; -.
STRING; 208964.PA4307; -.
PaxDb; Q9HW93; -.
PRIDE; Q9HW93; -.
EnsemblBacteria; AAG07695; AAG07695; PA4307.
GeneID; 881576; -.
KEGG; pae:PA4307; -.
PATRIC; fig|208964.12.peg.4510; -.
PseudoCAP; PA4307; -.
eggNOG; ENOG4105C8Q; Bacteria.
eggNOG; COG0840; LUCA.
HOGENOM; HOG000148078; -.
InParanoid; Q9HW93; -.
KO; K03406; -.
OMA; YIAHPTI; -.
PhylomeDB; Q9HW93; -.
Proteomes; UP000002438; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0016597; F:amino acid binding; IDA:PseudoCAP.
GO; GO:0004871; F:signal transducer activity; IEA:UniProtKB-KW.
GO; GO:0006935; P:chemotaxis; IMP:PseudoCAP.
GO; GO:0043200; P:response to amino acid; IMP:PseudoCAP.
CDD; cd06225; HAMP; 1.
InterPro; IPR033479; dCache_1.
InterPro; IPR003660; HAMP_dom.
InterPro; IPR004089; MCPsignal_dom.
InterPro; IPR029151; Sensor-like.
InterPro; IPR000727; T_SNARE_dom.
Pfam; PF02743; dCache_1; 1.
Pfam; PF00672; HAMP; 1.
Pfam; PF00015; MCPsignal; 1.
SMART; SM00304; HAMP; 2.
SMART; SM00283; MA; 1.
SUPFAM; SSF103190; SSF103190; 1.
PROSITE; PS50111; CHEMOTAXIS_TRANSDUC_2; 1.
PROSITE; PS50885; HAMP; 1.
1: Evidence at protein level;
Cell inner membrane; Cell membrane; Chemotaxis; Complete proteome;
Membrane; Methylation; Reference proteome; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 632 Methyl-accepting chemotaxis protein PctC.
/FTId=PRO_0000424851.
TOPO_DOM 1 10 Cytoplasmic. {ECO:0000255}.
TRANSMEM 11 31 Helical. {ECO:0000255}.
TOPO_DOM 32 279 Periplasmic. {ECO:0000255}.
TRANSMEM 280 300 Helical. {ECO:0000255}.
TOPO_DOM 301 632 Cytoplasmic. {ECO:0000255}.
DOMAIN 143 219 Cache.
DOMAIN 301 355 HAMP. {ECO:0000255|PROSITE-
ProRule:PRU00102}.
DOMAIN 360 596 Methyl-accepting transducer.
{ECO:0000255|PROSITE-ProRule:PRU00284}.
CONFLICT 176 177 DM -> EW (in Ref. 1; BAA23410).
{ECO:0000305}.
CONFLICT 490 490 A -> D (in Ref. 1; BAA23410).
{ECO:0000305}.
CONFLICT 573 573 S -> C (in Ref. 1; BAA23410).
{ECO:0000305}.
SEQUENCE 632 AA; 68308 MW; F5A7D3DA33440882 CRC64;
MLRSLSFAKK ILLAAALVVV FAFSCFILYN DYRQREAVRT DTENYLGEIG TLTASNIQSW
LEGRMHLVEG LASQLALLDQ PDEANIARQL EQPVFSRNFA SVYLGEAASG TFTMRPYDAM
PEGYDPRTRA WYKDALAADR LIVTEPFVDA GTGEQILAMS LPVRHAGQLL GVAAGDMKLE
TLTAILNSLK FDGAGYAFLV SDAGKILLHP DSGLVLKTLA EAYPKGAPNI VPGVHEVELD
GSSQFVSFTP VKGLPGVTWY VALVLDRDTA YSMLSEFRTS AIVATLIAVV GIMLLLGMLI
RVLMQPLTDM GRAMQDIAQG EGDLTKRLKV TSNDEFGTLA NAFNRFVERI HESIREVAGT
ARQLHDVAQL VVNASNSSMA NSDEQSNRTN SVAAAINELG AAAQEIARNA ADASHHASDA
NHQAEDGKQV VEQTIRAMNE LSEKISASCA NIEALNSRTV NIGQILEVIK GISEQTNLLA
LNAAIEAARA GEAGRGFAVV ADEVRNLAHR AQESAQQIQK MIEELQVGAR EAVATMTESQ
RYSLESVEIA NRAGERLGSV TSRIGEIDSM NQSVATATEE QTAVVDSLNM DITEINTLNQ
EGVENLQATL RACGELETQA GRLRHLVDSF KI


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