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Microtubule-associated tumor suppressor candidate 2 (Cardiac zipper protein) (Microtubule plus-end tracking protein TIP150) (Tracking protein of 150 kDa)

 MTUS2_HUMAN             Reviewed;        1369 AA.
Q5JR59; A7E292; B4DF81; O94872; Q08E97; Q5JQR3; Q8N5E2;
06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
22-SEP-2009, sequence version 3.
25-OCT-2017, entry version 113.
RecName: Full=Microtubule-associated tumor suppressor candidate 2;
AltName: Full=Cardiac zipper protein;
AltName: Full=Microtubule plus-end tracking protein TIP150;
Short=Tracking protein of 150 kDa;
Name=MTUS2; Synonyms=CAZIP, KIAA0774, TIP150;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=9872452; DOI=10.1093/dnares/5.5.277;
Nagase T., Ishikawa K., Suyama M., Kikuno R., Miyajima N., Tanaka A.,
Kotani H., Nomura N., Ohara O.;
"Prediction of the coding sequences of unidentified human genes. XI.
The complete sequences of 100 new cDNA clones from brain which code
for large proteins in vitro.";
DNA Res. 5:277-286(1998).
[2]
SEQUENCE REVISION.
Ohara O., Suyama M., Nagase T., Ishikawa K., Kikuno R.;
Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
TISSUE=Cerebellum;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057823; DOI=10.1038/nature02379;
Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E.,
Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E.,
Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.,
Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R.,
Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S.,
Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M.,
Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J.,
Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E.,
Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L.,
Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J.,
Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S.,
Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J.,
Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M.,
King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A.,
Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S.,
Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I.,
Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S.,
Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A.,
Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B.,
Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L.,
Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M.,
Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.;
"The DNA sequence and analysis of human chromosome 13.";
Nature 428:522-528(2004).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
TISSUE=Pancreas;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[6]
TISSUE SPECIFICITY.
PubMed=19806667; DOI=10.1002/dvdy.22107;
Du Puy L., Beqqali A., Monshouwer-Kloots J., Haagsman H.P.,
Roelen B.A., Passier R.;
"CAZIP, a novel protein expressed in the developing heart and nervous
system.";
Dev. Dyn. 238:2903-2911(2009).
[7]
FUNCTION, INTERACTION WITH KIF2C AND MAPRE1, HOMODIMERIZATION, AND
SUBCELLULAR LOCATION.
PubMed=19543227; DOI=10.1038/embor.2009.94;
Jiang K., Wang J., Liu J., Ward T., Wordeman L., Davidson A., Wang F.,
Yao X.;
"TIP150 interacts with and targets MCAK at the microtubule plus
ends.";
EMBO Rep. 10:857-865(2009).
-!- FUNCTION: Binds microtubules. Together with MAPRE1 may target the
microtubule depolymerase KIF2C to the plus-end of microtubules.
May regulate the dynamics of microtubules at their growing distal
tip. {ECO:0000269|PubMed:19543227}.
-!- SUBUNIT: Homodimer. Interacts with KIF2C and MAPRE1; the
interaction is direct and probably targets MTUS2 and KIF2C to
microtubules. {ECO:0000269|PubMed:19543227}.
-!- INTERACTION:
A8K8Y5:-; NbExp=3; IntAct=EBI-742948, EBI-10174635;
Q6ZVW3:-; NbExp=3; IntAct=EBI-742948, EBI-10255586;
Q9H6F0:-; NbExp=3; IntAct=EBI-742948, EBI-10307481;
Q08AH1:ACSM1; NbExp=4; IntAct=EBI-11522433, EBI-2818055;
Q8WTP8:AEN; NbExp=3; IntAct=EBI-742948, EBI-8637627;
Q08117:AES; NbExp=3; IntAct=EBI-742948, EBI-717810;
Q08117-2:AES; NbExp=5; IntAct=EBI-11522433, EBI-11741437;
Q9UHB7:AFF4; NbExp=3; IntAct=EBI-742948, EBI-395282;
Q9UHB7-2:AFF4; NbExp=3; IntAct=EBI-742948, EBI-10261324;
P29972:AQP1; NbExp=3; IntAct=EBI-742948, EBI-745213;
Q99728:BARD1; NbExp=4; IntAct=EBI-11522433, EBI-473181;
A8K571:BMP7; NbExp=3; IntAct=EBI-742948, EBI-10174327;
Q13895:BYSL; NbExp=5; IntAct=EBI-742948, EBI-358049;
Q9NVL8:C14orf105; NbExp=3; IntAct=EBI-742948, EBI-10238351;
Q9NX04:C1orf109; NbExp=3; IntAct=EBI-742948, EBI-8643161;
Q8TAB5:C1orf216; NbExp=4; IntAct=EBI-742948, EBI-747505;
Q0VAL7:C21orf58; NbExp=3; IntAct=EBI-742948, EBI-10226774;
Q53TS8:C2CD6; NbExp=3; IntAct=EBI-742948, EBI-739879;
Q7Z7H3:CATIP; NbExp=3; IntAct=EBI-742948, EBI-10258233;
Q8NEC5:CATSPER1; NbExp=3; IntAct=EBI-742948, EBI-744545;
Q9HC52:CBX8; NbExp=3; IntAct=EBI-742948, EBI-712912;
Q8IYX3:CCDC116; NbExp=4; IntAct=EBI-742948, EBI-744311;
Q8IYE0-2:CCDC146; NbExp=3; IntAct=EBI-742948, EBI-10247802;
Q96LX7:CCDC17; NbExp=3; IntAct=EBI-742948, EBI-719840;
Q8IWA6:CCDC60; NbExp=3; IntAct=EBI-742948, EBI-10262147;
Q8TD31-3:CCHCR1; NbExp=3; IntAct=EBI-742948, EBI-10175300;
Q86Y33:CDC20B; NbExp=3; IntAct=EBI-742948, EBI-10260504;
Q6P1J9:CDC73; NbExp=5; IntAct=EBI-742948, EBI-930143;
Q07002:CDK18; NbExp=3; IntAct=EBI-742948, EBI-746238;
Q15078:CDK5R1; NbExp=3; IntAct=EBI-742948, EBI-746189;
Q8N619:CDK5R1; NbExp=3; IntAct=EBI-742948, EBI-10266998;
Q8TAM4:CDK5R1; NbExp=3; IntAct=EBI-742948, EBI-10271838;
Q8IVW4:CDKL3; NbExp=4; IntAct=EBI-11522433, EBI-3919850;
Q8IYX8:CEP57L1; NbExp=3; IntAct=EBI-742948, EBI-1104570;
Q8IYX8-2:CEP57L1; NbExp=3; IntAct=EBI-742948, EBI-10181988;
Q96GE4:CEP95; NbExp=3; IntAct=EBI-742948, EBI-372775;
Q8TCT0:CERK; NbExp=3; IntAct=EBI-742948, EBI-10274247;
Q14746-2:COG2; NbExp=3; IntAct=EBI-742948, EBI-10233912;
Q02930-3:CREB5; NbExp=3; IntAct=EBI-742948, EBI-10192698;
Q49AN0:CRY2; NbExp=3; IntAct=EBI-742948, EBI-2212355;
Q9UBR2:CTSZ; NbExp=3; IntAct=EBI-742948, EBI-8636823;
Q2TBE0:CWF19L2; NbExp=3; IntAct=EBI-742948, EBI-5453285;
O14625:CXCL11; NbExp=3; IntAct=EBI-742948, EBI-2871971;
A2VCK2:DCDC2B; NbExp=3; IntAct=EBI-742948, EBI-10173222;
Q9UJW0:DCTN4; NbExp=4; IntAct=EBI-742948, EBI-2134033;
Q15398:DLGAP5; NbExp=3; IntAct=EBI-742948, EBI-748280;
Q9NQL9:DMRT3; NbExp=3; IntAct=EBI-742948, EBI-9679045;
Q92608:DOCK2; NbExp=3; IntAct=EBI-742948, EBI-448771;
O60941:DTNB; NbExp=3; IntAct=EBI-742948, EBI-740402;
O95990-4:FAM107A; NbExp=4; IntAct=EBI-11522433, EBI-11977223;
Q8NE31:FAM13C; NbExp=3; IntAct=EBI-742948, EBI-751248;
Q3B820:FAM161A; NbExp=4; IntAct=EBI-11522433, EBI-719941;
Q5TZK3:FAM74A6; NbExp=3; IntAct=EBI-742948, EBI-10247271;
Q86YD7:FAM90A1; NbExp=3; IntAct=EBI-742948, EBI-6658203;
Q96D16:FBXL18; NbExp=3; IntAct=EBI-742948, EBI-744419;
Q9NWN3:FBXO34; NbExp=3; IntAct=EBI-742948, EBI-719816;
O94868:FCHSD2; NbExp=4; IntAct=EBI-742948, EBI-1215612;
Q9BVV2:FNDC11; NbExp=3; IntAct=EBI-742948, EBI-744935;
Q8TAE8:GADD45GIP1; NbExp=4; IntAct=EBI-11522433, EBI-372506;
Q9H3Q3:GAL3ST2; NbExp=3; IntAct=EBI-742948, EBI-10306373;
A4D1E9:GTPBP10; NbExp=3; IntAct=EBI-742948, EBI-5453796;
Q96CS2:HAUS1; NbExp=3; IntAct=EBI-742948, EBI-2514791;
P08631:HCK; NbExp=3; IntAct=EBI-742948, EBI-346340;
P56524:HDAC4; NbExp=3; IntAct=EBI-742948, EBI-308629;
Q03933-2:HSF2; NbExp=3; IntAct=EBI-742948, EBI-10223348;
L7RT22:ITGB5; NbExp=3; IntAct=EBI-742948, EBI-10178729;
Q92993:KAT5; NbExp=3; IntAct=EBI-742948, EBI-399080;
Q99661:KIF2C; NbExp=4; IntAct=EBI-742948, EBI-1642317;
Q96BZ8:LENG1; NbExp=3; IntAct=EBI-742948, EBI-726510;
Q7Z4I7-5:LIMS2; NbExp=3; IntAct=EBI-742948, EBI-10257651;
P25791:LMO2; NbExp=3; IntAct=EBI-742948, EBI-739696;
Q8TBB1:LNX1; NbExp=3; IntAct=EBI-742948, EBI-739832;
Q96L50:LRR1; NbExp=3; IntAct=EBI-742948, EBI-2510106;
Q96S90:LYSMD1; NbExp=3; IntAct=EBI-742948, EBI-10293291;
P43361:MAGEA8; NbExp=3; IntAct=EBI-742948, EBI-10182930;
Q15691:MAPRE1; NbExp=7; IntAct=EBI-742948, EBI-1004115;
Q6IPE9:MARK4; NbExp=3; IntAct=EBI-742948, EBI-10250211;
P55081:MFAP1; NbExp=3; IntAct=EBI-742948, EBI-1048159;
P00540:MOS; NbExp=4; IntAct=EBI-11522433, EBI-1757866;
Q9Y3B7:MRPL11; NbExp=4; IntAct=EBI-11522433, EBI-5453723;
Q9Y217:MTMR6; NbExp=3; IntAct=EBI-742948, EBI-766064;
Q9GZM8:NDEL1; NbExp=3; IntAct=EBI-742948, EBI-928842;
Q9UHB4:NDOR1; NbExp=3; IntAct=EBI-742948, EBI-10249760;
P18615:NELFE; NbExp=3; IntAct=EBI-742948, EBI-348444;
Q5HYW2:NHSL2; NbExp=4; IntAct=EBI-11522433, EBI-2859639;
Q8NFP7:NUDT10; NbExp=3; IntAct=EBI-742948, EBI-726826;
Q14990:ODF1; NbExp=3; IntAct=EBI-742948, EBI-10234557;
Q5VU43:PDE4DIP; NbExp=3; IntAct=EBI-742948, EBI-1105124;
Q13526:PIN1; NbExp=3; IntAct=EBI-742948, EBI-714158;
Q99959:PKP2; NbExp=4; IntAct=EBI-742948, EBI-702235;
Q99959-2:PKP2; NbExp=5; IntAct=EBI-11522433, EBI-10987518;
Q9NRQ2:PLSCR4; NbExp=4; IntAct=EBI-742948, EBI-769257;
Q9Y2S7:POLDIP2; NbExp=3; IntAct=EBI-742948, EBI-713000;
Q8WUT1:POLDIP3; NbExp=3; IntAct=EBI-742948, EBI-10276663;
Q8NEY8:PPHLN1; NbExp=3; IntAct=EBI-742948, EBI-474076;
Q6NYC8:PPP1R18; NbExp=3; IntAct=EBI-742948, EBI-2557469;
Q13131:PRKAA1; NbExp=3; IntAct=EBI-742948, EBI-1181405;
Q8WWY3:PRPF31; NbExp=5; IntAct=EBI-11522433, EBI-1567797;
P25786:PSMA1; NbExp=6; IntAct=EBI-742948, EBI-359352;
Q8WUK0:PTPMT1; NbExp=3; IntAct=EBI-742948, EBI-7199479;
Q8TBN0:RAB3IL1; NbExp=4; IntAct=EBI-11522433, EBI-743796;
P41220:RGS2; NbExp=3; IntAct=EBI-742948, EBI-712388;
Q8TCX5:RHPN1; NbExp=3; IntAct=EBI-742948, EBI-746325;
Q96HH0:ROBO3; NbExp=3; IntAct=EBI-742948, EBI-10288358;
P27694:RPA1; NbExp=3; IntAct=EBI-742948, EBI-621389;
P32969:RPL9P9; NbExp=3; IntAct=EBI-742948, EBI-358122;
Q14D33:RTP5; NbExp=3; IntAct=EBI-742948, EBI-10217913;
Q9NUL5:RYDEN; NbExp=3; IntAct=EBI-742948, EBI-10313866;
O95171:SCEL; NbExp=3; IntAct=EBI-742948, EBI-7543896;
Q9BWG6:SCNM1; NbExp=4; IntAct=EBI-11522433, EBI-748391;
O00560:SDCBP; NbExp=3; IntAct=EBI-742948, EBI-727004;
Q8WWX9:SELENOM; NbExp=3; IntAct=EBI-742948, EBI-10277687;
Q9C0A6-2:SETD5; NbExp=3; IntAct=EBI-742948, EBI-10303449;
Q9H788:SH2D4A; NbExp=3; IntAct=EBI-742948, EBI-747035;
Q9H788-2:SH2D4A; NbExp=3; IntAct=EBI-742948, EBI-10308083;
Q08AM8:SH3RF2; NbExp=3; IntAct=EBI-742948, EBI-10225873;
Q9UHI7:SLC23A1; NbExp=3; IntAct=EBI-742948, EBI-1759386;
P12236:SLC25A6; NbExp=4; IntAct=EBI-742948, EBI-356254;
Q9GZT3:SLIRP; NbExp=3; IntAct=EBI-742948, EBI-1050793;
Q969G3:SMARCE1; NbExp=3; IntAct=EBI-742948, EBI-455078;
O95863:SNAI1; NbExp=3; IntAct=EBI-742948, EBI-1045459;
P09012:SNRPA; NbExp=3; IntAct=EBI-742948, EBI-607085;
P08579:SNRPB2; NbExp=3; IntAct=EBI-742948, EBI-1053651;
Q13573:SNW1; NbExp=3; IntAct=EBI-742948, EBI-632715;
Q6RVD6:SPATA8; NbExp=3; IntAct=EBI-742948, EBI-8635958;
Q9H0A9-2:SPATC1L; NbExp=4; IntAct=EBI-11522433, EBI-11995806;
Q9UQ90:SPG7; NbExp=4; IntAct=EBI-742948, EBI-717201;
O75716:STK16; NbExp=3; IntAct=EBI-742948, EBI-749295;
Q5T7P8-2:SYT6; NbExp=3; IntAct=EBI-742948, EBI-10246152;
Q9BSH4:TACO1; NbExp=4; IntAct=EBI-11522433, EBI-747797;
Q15543:TAF13; NbExp=4; IntAct=EBI-11522433, EBI-1026992;
Q15560:TCEA2; NbExp=4; IntAct=EBI-11522433, EBI-710310;
Q9BT49:THAP7; NbExp=3; IntAct=EBI-742948, EBI-741350;
Q96S44:TP53RK; NbExp=3; IntAct=EBI-742948, EBI-739588;
Q8IWZ5:TRIM42; NbExp=3; IntAct=EBI-742948, EBI-5235829;
Q3SY00:TSGA10IP; NbExp=3; IntAct=EBI-742948, EBI-10241197;
Q63HK5:TSHZ3; NbExp=3; IntAct=EBI-742948, EBI-9053916;
Q99757:TXN2; NbExp=3; IntAct=EBI-742948, EBI-2932492;
O75604:USP2; NbExp=3; IntAct=EBI-742948, EBI-743272;
Q9BTA9:WAC; NbExp=3; IntAct=EBI-742948, EBI-749118;
Q9BTA9-2:WAC; NbExp=3; IntAct=EBI-742948, EBI-10298216;
Q96HA8:WDYHV1; NbExp=4; IntAct=EBI-11522433, EBI-741158;
Q53FD0:ZC2HC1C; NbExp=4; IntAct=EBI-742948, EBI-740767;
G3V1X1:ZFC3H1; NbExp=3; IntAct=EBI-742948, EBI-6448783;
Q6ZN57:ZFP2; NbExp=3; IntAct=EBI-742948, EBI-7236323;
Q9BQ24:ZFYVE21; NbExp=3; IntAct=EBI-742948, EBI-2849569;
Q96NC0:ZMAT2; NbExp=3; IntAct=EBI-742948, EBI-2682299;
P52737:ZNF136; NbExp=4; IntAct=EBI-742948, EBI-749129;
P17024:ZNF20; NbExp=3; IntAct=EBI-742948, EBI-717634;
Q9UNY5:ZNF232; NbExp=3; IntAct=EBI-742948, EBI-749023;
P15622-3:ZNF250; NbExp=3; IntAct=EBI-742948, EBI-10177272;
P17036:ZNF3; NbExp=3; IntAct=EBI-742948, EBI-1640965;
Q86U76:ZNF3; NbExp=3; IntAct=EBI-742948, EBI-10258769;
Q86UD4:ZNF329; NbExp=3; IntAct=EBI-742948, EBI-7233259;
Q9Y3M9:ZNF337; NbExp=3; IntAct=EBI-742948, EBI-714987;
Q86VK4:ZNF410; NbExp=3; IntAct=EBI-742948, EBI-720304;
Q09FC8:ZNF415; NbExp=3; IntAct=EBI-742948, EBI-10226171;
Q8TAU3:ZNF417; NbExp=4; IntAct=EBI-11522433, EBI-740727;
Q9BUY5:ZNF426; NbExp=3; IntAct=EBI-742948, EBI-743265;
Q8NDP4:ZNF439; NbExp=4; IntAct=EBI-742948, EBI-747580;
Q8IYI8:ZNF440; NbExp=3; IntAct=EBI-742948, EBI-726439;
Q9ULM2:ZNF490; NbExp=4; IntAct=EBI-742948, EBI-1105370;
Q7Z3I7:ZNF572; NbExp=6; IntAct=EBI-742948, EBI-10172590;
Q9P0T4:ZNF581; NbExp=3; IntAct=EBI-742948, EBI-745520;
Q96SQ5:ZNF587; NbExp=3; IntAct=EBI-742948, EBI-6427977;
Q96NL3:ZNF599; NbExp=3; IntAct=EBI-742948, EBI-8653994;
Q96SK3:ZNF607; NbExp=3; IntAct=EBI-742948, EBI-747175;
Q9P2J8:ZNF624; NbExp=5; IntAct=EBI-11522433, EBI-9116427;
Q9BS34:ZNF670; NbExp=3; IntAct=EBI-742948, EBI-745276;
A8K8V0:ZNF785; NbExp=3; IntAct=EBI-742948, EBI-3925400;
Q08AG5:ZNF844; NbExp=3; IntAct=EBI-742948, EBI-10225757;
O43309:ZSCAN12; NbExp=3; IntAct=EBI-742948, EBI-1210440;
Q16670:ZSCAN26; NbExp=4; IntAct=EBI-11522433, EBI-3920053;
-!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
{ECO:0000269|PubMed:19543227}. Note=Associated with the
microtubule network at the growing distal tip (the plus-end) of
microtubules.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=3;
Name=1;
IsoId=Q5JR59-2; Sequence=Displayed;
Name=2;
IsoId=Q5JR59-3; Sequence=VSP_023541, VSP_023543;
Note=No experimental confirmation available.;
Name=3;
IsoId=Q5JR59-4; Sequence=VSP_023540;
-!- TISSUE SPECIFICITY: Detected in embryonic stem cells
differentiating to cardiomyocytes. {ECO:0000269|PubMed:19806667}.
-!- SIMILARITY: In the C-terminal section; belongs to the MTUS1
family. {ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAI50246.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=BAA34494.2; Type=Erroneous initiation; Evidence={ECO:0000305};
Sequence=CAI39910.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=CAI39912.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=CAI40386.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=CAI40565.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=CAI40566.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Sequence=CAI41204.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AB018317; BAA34494.2; ALT_INIT; mRNA.
EMBL; AK293970; BAG57342.1; -; mRNA.
EMBL; AL596114; CAI39910.1; ALT_SEQ; Genomic_DNA.
EMBL; AL160255; CAI39910.1; JOINED; Genomic_DNA.
EMBL; AL596092; CAI39910.1; JOINED; Genomic_DNA.
EMBL; AL607144; CAI39910.1; JOINED; Genomic_DNA.
EMBL; AL596114; CAI39912.1; ALT_SEQ; Genomic_DNA.
EMBL; AL607144; CAI39912.1; JOINED; Genomic_DNA.
EMBL; AL596092; CAI40386.1; ALT_SEQ; Genomic_DNA.
EMBL; AL160255; CAI40386.1; JOINED; Genomic_DNA.
EMBL; AL596114; CAI40386.1; JOINED; Genomic_DNA.
EMBL; AL607144; CAI40386.1; JOINED; Genomic_DNA.
EMBL; AL607144; CAI40565.1; ALT_SEQ; Genomic_DNA.
EMBL; AL160255; CAI40565.1; JOINED; Genomic_DNA.
EMBL; AL596092; CAI40565.1; JOINED; Genomic_DNA.
EMBL; AL596114; CAI40565.1; JOINED; Genomic_DNA.
EMBL; AL607144; CAI40566.1; ALT_SEQ; Genomic_DNA.
EMBL; AL596114; CAI40566.1; JOINED; Genomic_DNA.
EMBL; AL160255; CAI41204.1; ALT_SEQ; Genomic_DNA.
EMBL; AL596092; CAI41204.1; JOINED; Genomic_DNA.
EMBL; AL596114; CAI41204.1; JOINED; Genomic_DNA.
EMBL; AL607144; CAI41204.1; JOINED; Genomic_DNA.
EMBL; BC032481; AAH32481.1; -; mRNA.
EMBL; BC119654; AAI19655.1; -; mRNA.
EMBL; BC119655; AAI19656.1; -; mRNA.
EMBL; BC129985; AAI29986.1; -; mRNA.
EMBL; BC150245; AAI50246.1; ALT_INIT; mRNA.
CCDS; CCDS41874.1; -. [Q5JR59-3]
RefSeq; NP_001028774.2; NM_001033602.2.
RefSeq; NP_056048.1; NM_015233.5. [Q5JR59-3]
UniGene; Hs.22287; -.
ProteinModelPortal; Q5JR59; -.
SMR; Q5JR59; -.
BioGrid; 116880; 203.
IntAct; Q5JR59; 321.
MINT; MINT-1457050; -.
STRING; 9606.ENSP00000392057; -.
iPTMnet; Q5JR59; -.
PhosphoSitePlus; Q5JR59; -.
BioMuta; MTUS2; -.
DMDM; 259016371; -.
EPD; Q5JR59; -.
PaxDb; Q5JR59; -.
PeptideAtlas; Q5JR59; -.
PRIDE; Q5JR59; -.
DNASU; 23281; -.
Ensembl; ENST00000380808; ENSP00000370186; ENSG00000132938. [Q5JR59-3]
Ensembl; ENST00000542829; ENSP00000445403; ENSG00000132938. [Q5JR59-4]
GeneID; 23281; -.
KEGG; hsa:23281; -.
UCSC; uc001usm.5; human. [Q5JR59-2]
CTD; 23281; -.
DisGeNET; 23281; -.
EuPathDB; HostDB:ENSG00000132938.18; -.
GeneCards; MTUS2; -.
H-InvDB; HIX0020942; -.
HGNC; HGNC:20595; MTUS2.
HPA; HPA031473; -.
HPA; HPA031474; -.
HPA; HPA031475; -.
neXtProt; NX_Q5JR59; -.
OpenTargets; ENSG00000132938; -.
PharmGKB; PA165505194; -.
eggNOG; ENOG410IJWE; Eukaryota.
eggNOG; ENOG411103Z; LUCA.
GeneTree; ENSGT00390000006245; -.
InParanoid; Q5JR59; -.
PhylomeDB; Q5JR59; -.
ChiTaRS; MTUS2; human.
GenomeRNAi; 23281; -.
PRO; PR:Q5JR59; -.
Proteomes; UP000005640; Chromosome 13.
Bgee; ENSG00000132938; -.
CleanEx; HS_KIAA0774; -.
ExpressionAtlas; Q5JR59; baseline and differential.
Genevisible; Q5JR59; HS.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
GO; GO:0005634; C:nucleus; IDA:CACAO.
GO; GO:0008017; F:microtubule binding; IDA:UniProtKB.
GO; GO:0042803; F:protein homodimerization activity; IPI:UniProtKB.
InterPro; IPR033339; MTUS2.
PANTHER; PTHR24200:SF8; PTHR24200:SF8; 1.
1: Evidence at protein level;
Alternative splicing; Coiled coil; Complete proteome; Cytoplasm;
Cytoskeleton; Microtubule; Polymorphism; Reference proteome.
CHAIN 1 1369 Microtubule-associated tumor suppressor
candidate 2.
/FTId=PRO_0000280111.
REGION 641 980 Mediates interaction with MAPRE1.
{ECO:0000269|PubMed:19543227}.
REGION 801 1150 Localization to the growing distal tip of
microtubules.
REGION 801 890 Sufficient for interaction with KIF2C.
{ECO:0000269|PubMed:19543227}.
COILED 991 1335 {ECO:0000255}.
VAR_SEQ 1 1111 Missing (in isoform 3).
{ECO:0000303|PubMed:14702039,
ECO:0000303|PubMed:15489334}.
/FTId=VSP_023540.
VAR_SEQ 1 1021 Missing (in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_023541.
VAR_SEQ 1022 1039 AICGFDALAVATQHFFRK -> MGHCCCKPYNCLQCLDKT
(in isoform 2).
{ECO:0000303|PubMed:15489334}.
/FTId=VSP_023543.
VARIANT 955 955 P -> H (in dbSNP:rs12874207).
/FTId=VAR_055941.
VARIANT 1071 1071 L -> Q (in dbSNP:rs17073511).
/FTId=VAR_058831.
CONFLICT 942 942 Q -> P (in Ref. 1; BAA34494 and 5;
AAI50246). {ECO:0000305}.
SEQUENCE 1369 AA; 150195 MW; 4BF7A754AB1ED7CF CRC64;
MSVPVAPKKS CYTQLRDNRN AARNNNESIL SLGDTNANQI MLEVSSSHDE SKTCDLGDEI
GNTNSSEPEN RTHFHKEFHQ LQGFGKGSQA GSASLKDFRL SSTIQRELNE EHTVERGTDS
LQTTRSIQGP SLSSWRNVMS EASLDVLAKR DAEIPRHVPK DKLAKTLDNE ELRRHSLERA
SSSVAAVGSL TPQHPQPLSL DSREARGQIP GGGEGPQKTL PDHAVPAAFP ATDSTSEGKS
VRHPKPSTSE SKQSTPSETQ TVGAHVLQVC SEHTSHSAHP EPALNLTLAS KEIPSKLEAQ
LGQGKGEAKL DLKYVPPRRV EQEGKAAQEG YLGCHKEENL SALEGRDPCG EAHPEATDAL
GHLLNSDLHH LGVGRGNCEE KRGVNPGEQD SLHTTPKQGS ASLGGADNQP TGKISPCAGE
KLGERTSSSF SPGDSHVAFI PNNLTDSKPL DVIEEERRLG SGNKDSVMVL VFNPSVGENK
TEVPEPLDPQ SGRSEARESK EVTTSVAENR NLLENADKIE STSARADSVL NIPAPLHPET
TVNMTYQPTT PSSSFQDVSV FGMDAGSPLV VPPPTDSARL LNTSPKVPDK NTCPSGIPKP
VFTHSKDTPS SQEGMENYQV EKTEERTETK PIIMPKPKHV RPKIITYIRR NPQALGQVDA
SLVPVGLPYA PPTCTMPLPH EEKAAGGDLK PSANLYEKFK PDLQKPRVFS SGLMVSGIKP
PGHPFSQMSE KFLQEVTDHP GKEEFCSPPY AHYEVPPTFY RSAMLLKPQL GLGAMSRLPS
AKSRILIASQ RSSASAIHPP GPITTATSLY SSDPSADLKK ASSSNAAKSN LPKSGLRPPG
YSRLPAAKLA AFGFVRSSSV SSVSSTQSGD SAQPEQGRPA TRSTFGNEEQ PVLKASLPSK
DTPKGAGRVA PPASSSVTAP RRSLLPAPKS TSTPAGTKKD AQKDQDTNKP AVSSPKRVAA
STTKLHSPGY PKQRTAAARN GFPPKPDPQA REAERQLVLR LKERCEQQTR QLGVAQGELK
RAICGFDALA VATQHFFRKN ESALVKEKEL SIELANIRDE VAFHTAKCEK LQKEKEELER
RFEDEVKRLG WQQQAELQEL EERLQLQFEA EMARLQEEHG DQLLSIRCQH QEQVEDLTAS
HDAALLEMEN NHTVAITILQ DDHDHKVQEL MSTHELEKKE LEENFEKLRL SLQDQVDTLT
FQSQSLRDRA RRFEEALRKN TEEQLEIALA PYQHLEEDMK SLKQVLEMKN QQIHEQEKKI
LELEKLAEKN IILEEKIQVL QQQNEDLKAR IDQNTVVTRQ LSEENANLQE YVEKETQEKK
RLSRTNEELL WKLQTGDPTS PIKLSPTSPV YRGSSSGPSS PARVSTTPR


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