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Midkine-B (MK-B) (Pleiotrophic factor-alpha-2) (PTF-alpha-2) (X-PTF-alpha2)

 MKB_XENLA               Reviewed;         142 AA.
P48531; Q6GQG8;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
28-MAR-2018, entry version 78.
RecName: Full=Midkine-B;
Short=MK-B;
AltName: Full=Pleiotrophic factor-alpha-2;
Short=PTF-alpha-2;
Short=X-PTF-alpha2;
Flags: Precursor;
Name=mdk-b;
Xenopus laevis (African clawed frog).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus;
Xenopus.
NCBI_TaxID=8355;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
TISSUE=Brain;
PubMed=7677748; DOI=10.1006/bbrc.1995.2305;
Tsujimura A., Yasojima K., Kuboki Y., Suzuki A., Ueno N., Shiokawa K.,
Hashimoto-Gotoh T.;
"Developmental and differential regulations in gene expression of
Xenopus pleiotrophic factors-alpha and -beta.";
Biochem. Biophys. Res. Commun. 214:432-439(1995).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Ovary;
NIH - Xenopus Gene Collection (XGC) project;
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Inhibits mesoderm formation and promotes neural
formation during development. Plays a role in development of the
neuromuscular junction (NMJ). Has antibacterial activity against
both Gram-positive and Gram-negative bacteria (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
-!- TISSUE SPECIFICITY: In adults, expression is highest in the brain,
eye and bone, with lower expression in the heart and lung. Not
expressed in the ovary. In the tailbud stage embryo, expressed in
the head and tail regions as well as in the central nervous system
(CNS). {ECO:0000269|PubMed:7677748}.
-!- SIMILARITY: Belongs to the pleiotrophin family. {ECO:0000305}.
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EMBL; D42057; BAA07657.1; -; mRNA.
EMBL; BC072776; AAH72776.1; -; mRNA.
PIR; JC4273; JC4273.
RefSeq; NP_001084019.1; NM_001090550.1.
RefSeq; XP_018112064.1; XM_018256575.1.
RefSeq; XP_018112065.1; XM_018256576.1.
UniGene; Xl.899; -.
ProteinModelPortal; P48531; -.
SMR; P48531; -.
GeneID; 399256; -.
KEGG; xla:399256; -.
CTD; 399256; -.
Xenbase; XB-GENE-6254190; mdk.
HOVERGEN; HBG008317; -.
KO; K06828; -.
GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
GO; GO:0043395; F:heparan sulfate proteoglycan binding; ISS:UniProtKB.
GO; GO:0008201; F:heparin binding; ISS:UniProtKB.
GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
GO; GO:0007528; P:neuromuscular junction development; ISS:UniProtKB.
GO; GO:0051781; P:positive regulation of cell division; IEA:UniProtKB-KW.
GO; GO:0009617; P:response to bacterium; ISS:UniProtKB.
Gene3D; 2.20.60.10; -; 1.
Gene3D; 2.30.90.10; -; 1.
InterPro; IPR000762; Midkine_heparin-bd_GF.
InterPro; IPR020090; PTN/MK_C_dom.
InterPro; IPR038130; PTN/MK_C_dom_sf.
InterPro; IPR020091; PTN/MK_diS_sf.
InterPro; IPR020089; PTN/MK_N_dom.
InterPro; IPR037122; PTN/MK_N_dom_sf.
InterPro; IPR020092; PTN_MK_heparin-bd_GF_CS.
PANTHER; PTHR13850; PTHR13850; 1.
Pfam; PF01091; PTN_MK_C; 1.
Pfam; PF05196; PTN_MK_N; 1.
PRINTS; PR00269; PTNMIDKINE.
ProDom; PD005592; PTN_MK_hepar_bd; 1.
SMART; SM00193; PTN; 1.
SUPFAM; SSF57288; SSF57288; 2.
PROSITE; PS00619; PTN_MK_1; 1.
PROSITE; PS00620; PTN_MK_2; 1.
2: Evidence at transcript level;
Antibiotic; Antimicrobial; Developmental protein; Disulfide bond;
Growth factor; Heparin-binding; Mitogen; Secreted; Signal.
SIGNAL 1 20 {ECO:0000255}.
CHAIN 21 142 Midkine-B.
/FTId=PRO_0000024667.
DISULFID 36 60 {ECO:0000250}.
DISULFID 44 69 {ECO:0000250}.
DISULFID 51 73 {ECO:0000250}.
DISULFID 83 115 {ECO:0000250}.
DISULFID 93 125 {ECO:0000250}.
SEQUENCE 142 AA; 15595 MW; BB47060745F88B28 CRC64;
MELRAFCVIL LITILAVSSQ AAKNKKEKGK KGASDCTEWT WGSCIPNSKD CGAGTREGTC
KEETRKLKCK IPCNWKKDFG ADCKYKFENW GECNATTGQK VRSGTLKKAL YNADCQQTVE
AAKPCSLKTK SKSKGKKGKG KE


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