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Minor capsid protein L2

 A0A1X9RQT2_HPV82        Unreviewed;       473 AA.
A0A1X9RQT2;
30-AUG-2017, integrated into UniProtKB/TrEMBL.
30-AUG-2017, sequence version 1.
20-JUN-2018, entry version 5.
RecName: Full=Minor capsid protein L2 {ECO:0000256|HAMAP-Rule:MF_04003, ECO:0000256|SAAS:SAAS00613768};
Name=L2 {ECO:0000256|HAMAP-Rule:MF_04003};
Human papillomavirus type 82.
Viruses; dsDNA viruses, no RNA stage; Papillomaviridae;
Firstpapillomavirinae; Alphapapillomavirus.
NCBI_TaxID=129724 {ECO:0000313|EMBL:ARQ82645.1};
NCBI_TaxID=9606; Homo sapiens (Human).
[1] {ECO:0000313|EMBL:ARQ82645.1}
NUCLEOTIDE SEQUENCE.
STRAIN=92B {ECO:0000313|EMBL:ARQ82645.1};
de Oliveira G.R., Siqueira J.D., Finger-Jardim F., Vieira V.C.,
Silva R.L., Goncalves C.V., Soares E., de Martinez A.M.B.,
Soares M.A.;
"Characterization of high and low-risk human papillomavirus complete
genomes isolated from cervical specimens in southern Brazil.";
Mem. Inst. Oswaldo Cruz 0:0-0(2017).
-!- FUNCTION: Minor protein of the capsid that localizes along the
inner surface of the virion, within the central cavities beneath
the L1 pentamers. Plays a role in capsid stabilization through
interaction with the major capsid protein L1. Once the virion
enters the host cell, L2 escorts the genomic DNA into the nucleus
by promoting escape from the endosomal compartments and traffic
through the host Golgi network. Plays a role through its
interaction with host dynein in the intracellular microtubule-
dependent transport of viral capsid toward the nucleus. Mediates
the viral genome import into the nucleus through binding to host
importins. Once within the nucleus, L2 localizes viral genomes to
host PML bodies in order to activate early gene expression for
establishment of infection. Later on, promotes late gene
expression by interacting with the viral E2 protein and by
inhibiting its transcriptional activation functions. During virion
assembly, encapsidates the genome by direct interaction with the
viral DNA. {ECO:0000256|HAMAP-Rule:MF_04003,
ECO:0000256|SAAS:SAAS00613761}.
-!- SUBUNIT: Interacts with major capsid protein L1. Interacts with
E2; this interaction inhibits E2 transcriptional activity but not
the DNA replication function E2. Interacts with host HSPA8; this
interaction is required for L2 nuclear translocation. Interacts
with host importins KPNB2 and KPNB3. Forms a complex with importin
alpha2-beta1 heterodimers via interaction with the importin alpha2
adapter. Interacts with host DYNLT1; this interaction is essential
for virus intracellular transport during entry.
{ECO:0000256|HAMAP-Rule:MF_04003}.
-!- SUBCELLULAR LOCATION: Host nucleus {ECO:0000256|HAMAP-
Rule:MF_04003, ECO:0000256|SAAS:SAAS00613765}. Virion
{ECO:0000256|HAMAP-Rule:MF_04003}.
-!- PTM: Highly phosphorylated. {ECO:0000256|HAMAP-Rule:MF_04003}.
-!- SIMILARITY: Belongs to the papillomaviridae L2 protein family.
{ECO:0000256|HAMAP-Rule:MF_04003, ECO:0000256|SAAS:SAAS00613766}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_04003}.
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EMBL; KX514421; ARQ82645.1; -; Genomic_DNA.
GO; GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
GO; GO:0019028; C:viral capsid; IEA:UniProtKB-UniRule.
GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
GO; GO:0005198; F:structural molecule activity; IEA:UniProtKB-UniRule.
GO; GO:0075521; P:microtubule-dependent intracellular transport of viral material towards nucleus; IEA:UniProtKB-UniRule.
GO; GO:0046718; P:viral entry into host cell; IEA:UniProtKB-KW.
GO; GO:0075732; P:viral penetration into host nucleus; IEA:UniProtKB-KW.
HAMAP; MF_04003; PPV_L2; 1.
InterPro; IPR000784; Late_L2.
Pfam; PF00513; Late_protein_L2; 1.
3: Inferred from homology;
Capsid protein {ECO:0000256|HAMAP-Rule:MF_04003,
ECO:0000256|SAAS:SAAS00613767};
Cytoplasmic inwards viral transport {ECO:0000256|HAMAP-Rule:MF_04003,
ECO:0000256|SAAS:SAAS00613762};
Disulfide bond {ECO:0000256|HAMAP-Rule:MF_04003,
ECO:0000256|SAAS:SAAS00613769};
DNA-binding {ECO:0000256|HAMAP-Rule:MF_04003,
ECO:0000256|SAAS:SAAS00613774};
Host nucleus {ECO:0000256|HAMAP-Rule:MF_04003,
ECO:0000256|SAAS:SAAS00613770};
Host-virus interaction {ECO:0000256|HAMAP-Rule:MF_04003,
ECO:0000256|SAAS:SAAS00613762};
Late protein {ECO:0000256|HAMAP-Rule:MF_04003};
Microtubular inwards viral transport {ECO:0000256|HAMAP-Rule:MF_04003,
ECO:0000256|SAAS:SAAS00613762};
Phosphoprotein {ECO:0000256|HAMAP-Rule:MF_04003};
Viral penetration into host nucleus {ECO:0000256|HAMAP-Rule:MF_04003,
ECO:0000256|SAAS:SAAS00613771};
Virion {ECO:0000256|HAMAP-Rule:MF_04003,
ECO:0000256|SAAS:SAAS00613767};
Virus entry into host cell {ECO:0000256|HAMAP-Rule:MF_04003,
ECO:0000256|SAAS:SAAS00613762, ECO:0000256|SAAS:SAAS00613771}.
MOTIF 454 462 Nuclear localization signal.
{ECO:0000256|HAMAP-Rule:MF_04003}.
DISULFID 21 27 {ECO:0000256|HAMAP-Rule:MF_04003}.
SEQUENCE 473 AA; 51028 MW; E3A6B839DF4FDA5D CRC64;
MVAARARRRK RASVTQLYST CKAAGTCPPD VIPKVEGTTL ADKILQWSGL GIFLGGLGIG
TGSGTGGRTG YIPLGGGGRP GVVDIAPARP PIIIEPVAPT EPSIVNLVED SSIINSGSTI
PTFTGTHGFE ITSSSTTTPA VLDITPSAGT VHVTSTNIEN PLYIEPPFIE APQSGEVSGH
IFTSTPTSGT HGYEEIPMEV FASNVTTGKE PISSTPTPGV RRIAAPRLYS RAFSQVKVTN
PDFISKPSTF VTFDNPAFEP ADTSLSFEEP TDVAPDPDFL DIIKLHRPAL TSRRGTVRFS
RLGQKATIRT RSGKQIGARV HYYHDISSIA PAEELEMQPL LSPSTNNYSY DIYADLDEAE
TGFMQPTQTT PMLRSPFSPL STQLPSLSSS VSSSYANVTI PFSTTYNVPI HTGPDVVLPT
SPTVWPFIPH TSIDTQHAIV IQGGDYYLWP YTYLLRKRRK RIPYFFADGF VAY


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