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Mitochondrial dynamics protein MID51 (Mitochondrial dynamics protein of 51 kDa homolog) (Mitochondrial elongation factor 1) (Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like)

 MID51_RAT               Reviewed;         463 AA.
Q5XIS8;
13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
23-NOV-2004, sequence version 1.
12-SEP-2018, entry version 87.
RecName: Full=Mitochondrial dynamics protein MID51;
AltName: Full=Mitochondrial dynamics protein of 51 kDa homolog;
AltName: Full=Mitochondrial elongation factor 1;
AltName: Full=Smith-Magenis syndrome chromosomal region candidate gene 7 protein-like;
Name=Mief1; Synonyms=Mid51, Smcr7l;
Rattus norvegicus (Rat).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Rattus.
NCBI_TaxID=10116;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Testis;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[2]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-55, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=22673903; DOI=10.1038/ncomms1871;
Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A.,
Lundby C., Olsen J.V.;
"Quantitative maps of protein phosphorylation sites across 14
different rat organs and tissues.";
Nat. Commun. 3:876-876(2012).
-!- FUNCTION: Mitochondrial outer membrane protein which regulates
mitochondrial fission. Promotes the recruitment and association of
the fission mediator dynamin-related protein 1 (DNM1L) to the
mitochondrial surface independently of the mitochondrial fission
FIS1 and MFF proteins. Regulates DNM1L GTPase activity and DNM1L
oligomerization. Binds ADP and can also bind GDP, although with
lower affinity. Does not bind CDP, UDP, ATP, AMP or GTP. Inhibits
DNM1L GTPase activity in the absence of bound ADP. Requires ADP to
stimulate DNM1L GTPase activity and the assembly of DNM1L into
long, oligomeric tubules with a spiral pattern, as opposed to the
ring-like DNM1L oligomers observed in the absence of bound ADP.
Does not require ADP for its function in recruiting DNM1L (By
similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer. Interacts with DNM1L (By similarity).
{ECO:0000250}.
-!- SUBCELLULAR LOCATION: Mitochondrion outer membrane {ECO:0000250};
Single-pass membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the MID49/MID51 family. {ECO:0000305}.
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EMBL; BC083593; AAH83593.1; -; mRNA.
RefSeq; NP_001007710.1; NM_001007709.1.
RefSeq; XP_006242143.1; XM_006242081.2.
RefSeq; XP_006242145.1; XM_006242083.3.
RefSeq; XP_008763940.1; XM_008765718.2.
UniGene; Rn.62655; -.
SMR; Q5XIS8; -.
STRING; 10116.ENSRNOP00000023843; -.
iPTMnet; Q5XIS8; -.
PhosphoSitePlus; Q5XIS8; -.
PaxDb; Q5XIS8; -.
PRIDE; Q5XIS8; -.
Ensembl; ENSRNOT00000023843; ENSRNOP00000023843; ENSRNOG00000017553.
Ensembl; ENSRNOT00000092569; ENSRNOP00000075752; ENSRNOG00000017553.
GeneID; 315141; -.
KEGG; rno:315141; -.
UCSC; RGD:1359173; rat.
CTD; 54471; -.
RGD; 1359173; Mief1.
eggNOG; ENOG410IK9T; Eukaryota.
eggNOG; ENOG41109RH; LUCA.
GeneTree; ENSGT00390000013127; -.
HOGENOM; HOG000038002; -.
HOVERGEN; HBG054078; -.
InParanoid; Q5XIS8; -.
OMA; EDTIMNI; -.
OrthoDB; EOG091G079I; -.
PhylomeDB; Q5XIS8; -.
TreeFam; TF331032; -.
PRO; PR:Q5XIS8; -.
Proteomes; UP000002494; Chromosome 7.
Bgee; ENSRNOG00000017553; Expressed in 10 organ(s), highest expression level in testis.
ExpressionAtlas; Q5XIS8; baseline and differential.
Genevisible; Q5XIS8; RN.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005741; C:mitochondrial outer membrane; ISS:UniProtKB.
GO; GO:0005739; C:mitochondrion; ISS:UniProtKB.
GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
GO; GO:0000166; F:nucleotide binding; IEA:UniProtKB-KW.
GO; GO:0071456; P:cellular response to hypoxia; IEP:RGD.
GO; GO:0000266; P:mitochondrial fission; ISS:UniProtKB.
GO; GO:0090141; P:positive regulation of mitochondrial fission; ISS:UniProtKB.
GO; GO:0090314; P:positive regulation of protein targeting to membrane; ISS:UniProtKB.
InterPro; IPR024810; Mab-21_dom.
Pfam; PF03281; Mab-21; 1.
SMART; SM01265; Mab-21; 1.
1: Evidence at protein level;
Complete proteome; Membrane; Mitochondrion;
Mitochondrion outer membrane; Nucleotide-binding; Phosphoprotein;
Reference proteome; Transmembrane; Transmembrane helix.
CHAIN 1 463 Mitochondrial dynamics protein MID51.
/FTId=PRO_0000310451.
TOPO_DOM 1 23 Mitochondrial intermembrane.
{ECO:0000255}.
TRANSMEM 24 46 Helical. {ECO:0000255}.
TOPO_DOM 47 463 Cytoplasmic. {ECO:0000255}.
REGION 49 195 Dimerization. {ECO:0000250}.
REGION 160 169 Important for interaction with DNM1L.
{ECO:0000250}.
REGION 234 243 Important for interaction with DNM1L.
{ECO:0000250}.
BINDING 187 187 ADP. {ECO:0000250}.
BINDING 189 189 ADP. {ECO:0000250}.
BINDING 201 201 ADP. {ECO:0000250}.
BINDING 340 340 ADP. {ECO:0000250}.
BINDING 342 342 ADP. {ECO:0000250}.
BINDING 368 368 ADP. {ECO:0000250}.
MOD_RES 55 55 Phosphoserine.
{ECO:0000244|PubMed:22673903}.
MOD_RES 59 59 Phosphoserine.
{ECO:0000250|UniProtKB:Q9NQG6}.
MOD_RES 79 79 Phosphoserine.
{ECO:0000250|UniProtKB:Q8BGV8}.
MOD_RES 94 94 Phosphoserine.
{ECO:0000250|UniProtKB:Q9NQG6}.
SEQUENCE 463 AA; 51309 MW; 1A079546AE474513 CRC64;
MAGAGERKGK KDDNGIGTAI DFVLSNARLV LGVGGAAMLG IATLAVKRMY DRAISAPTSP
TRLSHSGKRS WEEPNWMGSP RLLNRDMKTG LSRSLQTLPT DSSAFDTDTF CPPRPKPLAR
RGQVDLKKSR LRMSLQEKLL SYYRNRAAIP AGEQARAKQA AVDICAELRS FLRAKLPDMP
LRDMYLSGSL YDDLQVVTAD HIQLIVPLVL EQNLWSCIPG EDTIMNIPGF FLVRRENPEY
FPRGSSYWDR CVVGGYLSPK TVADTFEKVV AGSINWPAIG SLLDYVIRPA PPPEALTLEV
QYERDKHLVI DFLPSVTLGD TVLVARPHRL AQYDNLWRLS LRPAETARLR ALDQADSGCR
SLCLKILKAI CKSTPALGHL TASQLTNVIL HLSQEEADWS PDMLADRFLQ ALRGLISYLE
AGVLPSALNP KVNLFAELTP HEIDELGYTL YCSLSEPEVL LQT


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