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Mitochondrial uncoupling protein 4 (AtPUMP4) (Mitochondrial dicarboxylate carrier 2)

 PUMP4_ARATH             Reviewed;         313 AA.
Q9SB52;
28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
01-MAY-2000, sequence version 1.
22-NOV-2017, entry version 123.
RecName: Full=Mitochondrial uncoupling protein 4;
Short=AtPUMP4;
AltName: Full=Mitochondrial dicarboxylate carrier 2;
Name=PUMP4; Synonyms=DIC2, UCP4; OrderedLocusNames=At4g24570;
ORFNames=F22K18.230;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND TISSUE SPECIFICITY.
STRAIN=cv. Columbia; TISSUE=Root;
PubMed=18039180; DOI=10.1042/BJ20070867;
Palmieri L., Picault N., Arrigoni R., Besin E., Palmieri F.,
Hodges M.;
"Molecular identification of three Arabidopsis thaliana mitochondrial
dicarboxylate carrier isoforms: organ distribution, bacterial
expression, reconstitution into liposomes and functional
characterization.";
Biochem. J. 410:621-629(2008).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=10617198; DOI=10.1038/47134;
Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G.,
Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N.,
Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M.,
Weichselgartner M., de Simone V., Obermaier B., Mache R., Mueller M.,
Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T.,
Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I.,
Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P.,
Langham S.-A., McCullagh B., Bilham L., Robben J.,
van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F.,
Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E.,
Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W.,
Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P.,
Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H.,
De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R.,
van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S.,
Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R.,
Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S.,
Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H.,
Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A.,
Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R.,
Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S.,
Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E.,
Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A.,
Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T.,
Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C.,
Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S.,
Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K.,
Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L.,
Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J.,
Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J.,
Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D.,
Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D.,
Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C.,
Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C.,
Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R.,
Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S.,
Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A.,
Chen E., Marra M.A., Martienssen R., McCombie W.R.;
"Sequence and analysis of chromosome 4 of the plant Arabidopsis
thaliana.";
Nature 402:769-777(1999).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
The Arabidopsis Information Portal (Araport);
Submitted (MAY-2016) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
PubMed=14593172; DOI=10.1126/science.1088305;
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J.,
Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F.,
Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.,
Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J.,
Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y.,
Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P.,
Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F.,
Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M.,
Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J.,
Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T.,
Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y.,
Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.;
"Empirical analysis of transcriptional activity in the Arabidopsis
genome.";
Science 302:842-846(2003).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
Feldmann K.A.;
"Full-length cDNA from Arabidopsis thaliana.";
Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
[6]
TISSUE SPECIFICITY, INDUCTION BY COLD, GENE FAMILY, AND NOMENCLATURE.
PubMed=16473895; DOI=10.1093/jxb/erj070;
Borecky J., Nogueira F.T., de Oliveira K.A., Maia I.G., Vercesi A.E.,
Arruda P.;
"The plant energy-dissipating mitochondrial systems: depicting the
genomic structure and the expression profiles of the gene families of
uncoupling protein and alternative oxidase in monocots and dicots.";
J. Exp. Bot. 57:849-864(2006).
-!- FUNCTION: PUMPS are mitochondrial transporter proteins that create
proton leaks across the inner mitochondrial membrane, thus
uncoupling oxidative phosphorylation. This leads to a decrease in
the efficiency of oxidative phosphorylation and an increase in
heat production. May be involved in protecting plant cells against
oxidative stress damage (By similarity). Recombinant PUMP4,
reconstituted into liposomes, transports a wide range of
dicarboxylic acids including malate, oxaloacetate and succinate as
well as phosphate, sulfate and thiosulfate. However, it is unknown
if these transports are of any biological significance in vivo.
{ECO:0000250, ECO:0000269|PubMed:18039180}.
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}.
-!- TISSUE SPECIFICITY: Expressed in roots, leaves, stems and flowers.
{ECO:0000269|PubMed:16473895, ECO:0000269|PubMed:18039180}.
-!- INDUCTION: By cold stress. {ECO:0000269|PubMed:16473895}.
-!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29)
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AM236863; CAJ86455.1; -; mRNA.
EMBL; AL035356; CAA23006.1; -; Genomic_DNA.
EMBL; AL161561; CAB79367.1; -; Genomic_DNA.
EMBL; CP002687; AEE84927.1; -; Genomic_DNA.
EMBL; AY042859; AAK68799.1; -; mRNA.
EMBL; BT008712; AAP42725.1; -; mRNA.
EMBL; AY084853; AAM61418.1; -; mRNA.
PIR; T05577; T05577.
RefSeq; NP_194188.1; NM_118590.2.
UniGene; At.20057; -.
UniGene; At.67088; -.
ProteinModelPortal; Q9SB52; -.
SMR; Q9SB52; -.
STRING; 3702.AT4G24570.1; -.
iPTMnet; Q9SB52; -.
PaxDb; Q9SB52; -.
EnsemblPlants; AT4G24570.1; AT4G24570.1; AT4G24570.
GeneID; 828559; -.
Gramene; AT4G24570.1; AT4G24570.1; AT4G24570.
KEGG; ath:AT4G24570; -.
Araport; AT4G24570; -.
TAIR; locus:2121974; AT4G24570.
eggNOG; KOG0759; Eukaryota.
eggNOG; ENOG410XQHU; LUCA.
HOGENOM; HOG000165139; -.
InParanoid; Q9SB52; -.
KO; K13577; -.
OMA; SWFRQLT; -.
OrthoDB; EOG09360KFV; -.
PhylomeDB; Q9SB52; -.
Reactome; R-ATH-1614517; Sulfide oxidation to sulfate.
Reactome; R-ATH-428643; Organic anion transporters.
Reactome; R-ATH-70263; Gluconeogenesis.
PRO; PR:Q9SB52; -.
Proteomes; UP000006548; Chromosome 4.
ExpressionAtlas; Q9SB52; baseline and differential.
Genevisible; Q9SB52; AT.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
GO; GO:0005310; F:dicarboxylic acid transmembrane transporter activity; IDA:TAIR.
GO; GO:0015140; F:malate transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015131; F:oxaloacetate transmembrane transporter activity; IBA:GO_Central.
GO; GO:1901677; F:phosphate transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015117; F:thiosulfate transmembrane transporter activity; IBA:GO_Central.
GO; GO:0071423; P:malate transmembrane transport; IBA:GO_Central.
GO; GO:0006839; P:mitochondrial transport; IDA:TAIR.
GO; GO:0015729; P:oxaloacetate transport; IBA:GO_Central.
GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
GO; GO:0071422; P:succinate transmembrane transport; IBA:GO_Central.
GO; GO:0008272; P:sulfate transport; IBA:GO_Central.
GO; GO:0015709; P:thiosulfate transport; IBA:GO_Central.
Gene3D; 1.50.40.10; -; 1.
InterPro; IPR002067; Mit_carrier.
InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
InterPro; IPR023395; Mt_carrier_dom_sf.
Pfam; PF00153; Mito_carr; 3.
PRINTS; PR00926; MITOCARRIER.
SUPFAM; SSF103506; SSF103506; 1.
PROSITE; PS50920; SOLCAR; 3.
2: Evidence at transcript level;
Complete proteome; Membrane; Mitochondrion;
Mitochondrion inner membrane; Reference proteome; Repeat;
Stress response; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 313 Mitochondrial uncoupling protein 4.
/FTId=PRO_0000420258.
TRANSMEM 6 26 Helical; Name=1. {ECO:0000255}.
TRANSMEM 84 104 Helical; Name=2. {ECO:0000255}.
TRANSMEM 130 150 Helical; Name=3. {ECO:0000255}.
TRANSMEM 189 209 Helical; Name=4. {ECO:0000255}.
TRANSMEM 230 250 Helical; Name=5. {ECO:0000255}.
TRANSMEM 282 302 Helical; Name=6. {ECO:0000255}.
REPEAT 4 115 Solcar 1.
REPEAT 124 215 Solcar 2.
REPEAT 224 309 Solcar 3.
SEQUENCE 313 AA; 32873 MW; B6B418A3C8393C92 CRC64;
MGVKSFVEGG IASVIAGCST HPLDLIKVRL QLHGEAPSTT TVTLLRPALA FPNSSPAAFL
ETTSSVPKVG PISLGINIVK SEGAAALFSG VSATLLRQTL YSTTRMGLYE VLKNKWTDPE
SGKLNLSRKI GAGLVAGGIG AAVGNPADVA MVRMQADGRL PLAQRRNYAG VGDAIRSMVK
GEGVTSLWRG SALTINRAMI VTAAQLASYD QFKEGILENG VMNDGLGTHV VASFAAGFVA
SVASNPVDVI KTRVMNMKVG AYDGAWDCAV KTVKAEGAMA LYKGFVPTVC RQGPFTVVLF
VTLEQVRKLL RDF


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