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Mitochondrial uncoupling protein 6 (AtPUMP6) (Mitochondrial dicarboxylate carrier 3)

 PUMP6_ARATH             Reviewed;         337 AA.
Q9FY68;
28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
01-MAR-2001, sequence version 1.
25-APR-2018, entry version 114.
RecName: Full=Mitochondrial uncoupling protein 6;
Short=AtPUMP6;
AltName: Full=Mitochondrial dicarboxylate carrier 3;
Name=PUMP6; Synonyms=DIC3, UCP6; OrderedLocusNames=At5g09470;
ORFNames=T5E8.270;
Arabidopsis thaliana (Mouse-ear cress).
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae;
Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae;
Arabidopsis.
NCBI_TaxID=3702;
[1]
NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
STRAIN=cv. Columbia; TISSUE=Flower bud;
PubMed=18039180; DOI=10.1042/BJ20070867;
Palmieri L., Picault N., Arrigoni R., Besin E., Palmieri F.,
Hodges M.;
"Molecular identification of three Arabidopsis thaliana mitochondrial
dicarboxylate carrier isoforms: organ distribution, bacterial
expression, reconstitution into liposomes and functional
characterization.";
Biochem. J. 410:621-629(2008).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=cv. Columbia;
PubMed=11130714; DOI=10.1038/35048507;
Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K.,
Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S.,
Nakazaki N., Naruo K., Okumura S., Shinpo S., Takeuchi C., Wada T.,
Watanabe A., Yamada M., Yasuda M., Sato S., de la Bastide M.,
Huang E., Spiegel L., Gnoj L., O'Shaughnessy A., Preston R.,
Habermann K., Murray J., Johnson D., Rohlfing T., Nelson J.,
Stoneking T., Pepin K., Spieth J., Sekhon M., Armstrong J., Becker M.,
Belter E., Cordum H., Cordes M., Courtney L., Courtney W., Dante M.,
Du H., Edwards J., Fryman J., Haakensen B., Lamar E., Latreille P.,
Leonard S., Meyer R., Mulvaney E., Ozersky P., Riley A., Strowmatt C.,
Wagner-McPherson C., Wollam A., Yoakum M., Bell M., Dedhia N.,
Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D., Baker J.,
Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S.,
Langham S.-A., McCullagh B., Robben J., Grymonprez B., Zimmermann W.,
Ramsperger U., Wedler H., Balke K., Wedler E., Peters S.,
van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R.,
Weitzenegger T., Bothe G., Rose M., Hauf J., Berneiser S., Hempel S.,
Feldpausch M., Lamberth S., Villarroel R., Gielen J., Ardiles W.,
Bents O., Lemcke K., Kolesov G., Mayer K.F.X., Rudd S., Schoof H.,
Schueller C., Zaccaria P., Mewes H.-W., Bevan M., Fransz P.F.;
"Sequence and analysis of chromosome 5 of the plant Arabidopsis
thaliana.";
Nature 408:823-826(2000).
[3]
GENOME REANNOTATION.
STRAIN=cv. Columbia;
PubMed=27862469; DOI=10.1111/tpj.13415;
Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
Town C.D.;
"Araport11: a complete reannotation of the Arabidopsis thaliana
reference genome.";
Plant J. 89:789-804(2017).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
STRAIN=cv. Columbia;
De Los Reyes C., Quan R., Chen H., Bautista V.R., Kim C.J.,
Ecker J.R.;
"Arabidopsis ORF clones.";
Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
[5]
GENE FAMILY, AND NOMENCLATURE.
PubMed=16473895; DOI=10.1093/jxb/erj070;
Borecky J., Nogueira F.T., de Oliveira K.A., Maia I.G., Vercesi A.E.,
Arruda P.;
"The plant energy-dissipating mitochondrial systems: depicting the
genomic structure and the expression profiles of the gene families of
uncoupling protein and alternative oxidase in monocots and dicots.";
J. Exp. Bot. 57:849-864(2006).
-!- FUNCTION: PUMPS are mitochondrial transporter proteins that create
proton leaks across the inner mitochondrial membrane, thus
uncoupling oxidative phosphorylation. This leads to a decrease in
the efficiency of oxidative phosphorylation and an increase in
heat production. May be involved in protecting plant cells against
oxidative stress damage (By similarity). Recombinant PUMP6,
reconstituted into liposomes, transports a wide range of
dicarboxylic acids including malate, oxaloacetate and succinate as
well as phosphate, sulfate and thiosulfate. However, it is unknown
if these transports are of any biological significance in vivo.
{ECO:0000250, ECO:0000269|PubMed:18039180}.
-!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
Multi-pass membrane protein {ECO:0000250}.
-!- SIMILARITY: Belongs to the mitochondrial carrier (TC 2.A.29)
family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AM236861; CAJ86453.1; -; mRNA.
EMBL; AL391712; CAC05473.1; -; Genomic_DNA.
EMBL; CP002688; AED91400.1; -; Genomic_DNA.
EMBL; BT033087; ACF04810.1; -; mRNA.
RefSeq; NP_196509.1; NM_120984.2.
UniGene; At.65498; -.
ProteinModelPortal; Q9FY68; -.
SMR; Q9FY68; -.
BioGrid; 16084; 2.
STRING; 3702.AT5G09470.1; -.
PaxDb; Q9FY68; -.
EnsemblPlants; AT5G09470.1; AT5G09470.1; AT5G09470.
GeneID; 830806; -.
Gramene; AT5G09470.1; AT5G09470.1; AT5G09470.
KEGG; ath:AT5G09470; -.
Araport; AT5G09470; -.
TAIR; locus:2184832; AT5G09470.
eggNOG; KOG0759; Eukaryota.
eggNOG; ENOG410XQHU; LUCA.
HOGENOM; HOG000165139; -.
InParanoid; Q9FY68; -.
OMA; GMLGTCI; -.
OrthoDB; EOG09360KFV; -.
PhylomeDB; Q9FY68; -.
Reactome; R-ATH-1614517; Sulfide oxidation to sulfate.
Reactome; R-ATH-428643; Organic anion transporters.
Reactome; R-ATH-70263; Gluconeogenesis.
PRO; PR:Q9FY68; -.
Proteomes; UP000006548; Chromosome 5.
ExpressionAtlas; Q9FY68; baseline and differential.
Genevisible; Q9FY68; AT.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005743; C:mitochondrial inner membrane; IBA:GO_Central.
GO; GO:0015297; F:antiporter activity; IBA:GO_Central.
GO; GO:0005310; F:dicarboxylic acid transmembrane transporter activity; IDA:TAIR.
GO; GO:0015140; F:malate transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015131; F:oxaloacetate transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015141; F:succinate transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015116; F:sulfate transmembrane transporter activity; IBA:GO_Central.
GO; GO:0015117; F:thiosulfate transmembrane transporter activity; IBA:GO_Central.
GO; GO:0071423; P:malate transmembrane transport; IBA:GO_Central.
GO; GO:0006839; P:mitochondrial transport; IDA:TAIR.
GO; GO:0015729; P:oxaloacetate transport; IBA:GO_Central.
GO; GO:0035435; P:phosphate ion transmembrane transport; IBA:GO_Central.
GO; GO:0071422; P:succinate transmembrane transport; IBA:GO_Central.
GO; GO:0008272; P:sulfate transport; IBA:GO_Central.
GO; GO:0015709; P:thiosulfate transport; IBA:GO_Central.
Gene3D; 1.50.40.10; -; 2.
InterPro; IPR002067; Mit_carrier.
InterPro; IPR018108; Mitochondrial_sb/sol_carrier.
InterPro; IPR023395; Mt_carrier_dom_sf.
Pfam; PF00153; Mito_carr; 3.
PRINTS; PR00926; MITOCARRIER.
SUPFAM; SSF103506; SSF103506; 2.
PROSITE; PS50920; SOLCAR; 3.
2: Evidence at transcript level;
Complete proteome; Membrane; Mitochondrion;
Mitochondrion inner membrane; Reference proteome; Repeat;
Stress response; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 337 Mitochondrial uncoupling protein 6.
/FTId=PRO_0000420260.
TRANSMEM 6 26 Helical; Name=1. {ECO:0000255}.
TRANSMEM 105 125 Helical; Name=2. {ECO:0000255}.
TRANSMEM 151 171 Helical; Name=3. {ECO:0000255}.
TRANSMEM 210 230 Helical; Name=4. {ECO:0000255}.
TRANSMEM 252 272 Helical; Name=5. {ECO:0000255}.
TRANSMEM 304 324 Helical; Name=6. {ECO:0000255}.
REPEAT 4 136 Solcar 1.
REPEAT 145 236 Solcar 2.
REPEAT 246 331 Solcar 3.
SEQUENCE 337 AA; 36096 MW; B8FBA4C4A91D11CF CRC64;
MGFKPFLEGG IAAIIAGALT HPLDLIKVRM QLQGEHSFSL DQNPNPNLSL DHNLPVKPYR
PVFALDSLIG SISLLPLHIH APSSSTRSVM TPFAVGAHIV KTEGPAALFS GVSATILRQM
LYSATRMGIY DFLKRRWTDQ LTGNFPLVTK ITAGLIAGAV GSVVGNPADV AMVRMQADGS
LPLNRRRNYK SVVDAIDRIA RQEGVSSLWR GSWLTVNRAM IVTASQLATY DHVKEILVAG
GRGTPGGIGT HVAASFAAGI VAAVASNPID VVKTRMMNAD KEIYGGPLDC AVKMVAEEGP
MALYKGLVPT ATRQGPFTMI LFLTLEQVRG LLKDVKF


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