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Mitogen-activated protein kinase (EC 2.7.11.24)

 G7P3B2_MACFA            Unreviewed;       360 AA.
G7P3B2;
25-JAN-2012, integrated into UniProtKB/TrEMBL.
25-JAN-2012, sequence version 1.
05-DEC-2018, entry version 33.
RecName: Full=Mitogen-activated protein kinase {ECO:0000256|SAAS:SAAS00574127};
EC=2.7.11.24 {ECO:0000256|SAAS:SAAS00574127};
Name=MAPK14 {ECO:0000313|Ensembl:ENSMFAP00000037420};
ORFNames=EGM_13534 {ECO:0000313|EMBL:EHH52983.1};
Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Cercopithecidae; Cercopithecinae; Macaca.
NCBI_TaxID=9541 {ECO:0000313|Proteomes:UP000009130};
[1] {ECO:0000313|EMBL:EHH52983.1, ECO:0000313|Proteomes:UP000009130}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=CE-4 {ECO:0000313|EMBL:EHH52983.1};
PubMed=22002653; DOI=10.1038/nbt.1992;
Yan G., Zhang G., Fang X., Zhang Y., Li C., Ling F., Cooper D.N.,
Li Q., Li Y., van Gool A.J., Du H., Chen J., Chen R., Zhang P.,
Huang Z., Thompson J.R., Meng Y., Bai Y., Wang J., Zhuo M., Wang T.,
Huang Y., Wei L., Li J., Wang Z., Hu H., Yang P., Le L., Stenson P.D.,
Li B., Liu X., Ball E.V., An N., Huang Q., Zhang Y., Fan W., Zhang X.,
Li Y., Wang W., Katze M.G., Su B., Nielsen R., Yang H., Wang J.,
Wang X., Wang J.;
"Genome sequencing and comparison of two nonhuman primate animal
models, the cynomolgus and Chinese rhesus macaques.";
Nat. Biotechnol. 29:1019-1023(2011).
[2] {ECO:0000313|Ensembl:ENSMFAP00000037420}
NUCLEOTIDE SEQUENCE.
Huang N.-L., Huang M.-D., Chen T.-L.L., Huang A.H.;
Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
[3] {ECO:0000313|Ensembl:ENSMFAP00000037420}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2018) to UniProtKB.
-!- CATALYTIC ACTIVITY:
Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
Evidence={ECO:0000256|SAAS:SAAS00574132};
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|SAAS:SAAS00610829};
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EMBL; AQIA01052032; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CM001279; EHH52983.1; -; Genomic_DNA.
RefSeq; XP_005553248.1; XM_005553191.2.
UniGene; Mfa.5003; -.
Ensembl; ENSMFAT00000011670; ENSMFAP00000037420; ENSMFAG00000037865.
GeneID; 101926770; -.
KEGG; mcf:101926770; -.
CTD; 1432; -.
GeneTree; ENSGT00940000155325; -.
KO; K04441; -.
Proteomes; UP000009130; Chromosome 4.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
GO; GO:0016607; C:nuclear speck; IEA:Ensembl.
GO; GO:0000922; C:spindle pole; IEA:Ensembl.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0004707; F:MAP kinase activity; IEA:UniProtKB-EC.
GO; GO:0048273; F:mitogen-activated protein kinase p38 binding; IEA:Ensembl.
GO; GO:0051525; F:NFAT protein binding; IEA:Ensembl.
GO; GO:0019903; F:protein phosphatase binding; IEA:Ensembl.
GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
GO; GO:0001502; P:cartilage condensation; IEA:Ensembl.
GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
GO; GO:0071479; P:cellular response to ionizing radiation; IEA:Ensembl.
GO; GO:0071223; P:cellular response to lipoteichoic acid; IEA:Ensembl.
GO; GO:0071356; P:cellular response to tumor necrosis factor; IEA:Ensembl.
GO; GO:0035924; P:cellular response to vascular endothelial growth factor stimulus; IEA:Ensembl.
GO; GO:0098586; P:cellular response to virus; IEA:Ensembl.
GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
GO; GO:0000077; P:DNA damage checkpoint; IEA:Ensembl.
GO; GO:0019395; P:fatty acid oxidation; IEA:Ensembl.
GO; GO:0006006; P:glucose metabolic process; IEA:Ensembl.
GO; GO:0031663; P:lipopolysaccharide-mediated signaling pathway; IEA:Ensembl.
GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; IEA:Ensembl.
GO; GO:0030316; P:osteoclast differentiation; IEA:Ensembl.
GO; GO:0038066; P:p38MAPK cascade; IEA:Ensembl.
GO; GO:0018105; P:peptidyl-serine phosphorylation; IEA:Ensembl.
GO; GO:0001890; P:placenta development; IEA:Ensembl.
GO; GO:0090336; P:positive regulation of brown fat cell differentiation; IEA:Ensembl.
GO; GO:0060045; P:positive regulation of cardiac muscle cell proliferation; IEA:Ensembl.
GO; GO:0031281; P:positive regulation of cyclase activity; IEA:Ensembl.
GO; GO:0002741; P:positive regulation of cytokine secretion involved in immune response; IEA:Ensembl.
GO; GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Ensembl.
GO; GO:0046326; P:positive regulation of glucose import; IEA:Ensembl.
GO; GO:2001184; P:positive regulation of interleukin-12 secretion; IEA:Ensembl.
GO; GO:0010759; P:positive regulation of macrophage chemotaxis; IEA:Ensembl.
GO; GO:1905050; P:positive regulation of metallopeptidase activity; IEA:Ensembl.
GO; GO:0045663; P:positive regulation of myoblast differentiation; IEA:Ensembl.
GO; GO:1901741; P:positive regulation of myoblast fusion; IEA:Ensembl.
GO; GO:0042307; P:positive regulation of protein import into nucleus; IEA:Ensembl.
GO; GO:2000379; P:positive regulation of reactive oxygen species metabolic process; IEA:Ensembl.
GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
GO; GO:1900015; P:regulation of cytokine production involved in inflammatory response; IEA:Ensembl.
GO; GO:0030278; P:regulation of ossification; IEA:Ensembl.
GO; GO:0099179; P:regulation of synaptic membrane adhesion; IEA:Ensembl.
GO; GO:0032495; P:response to muramyl dipeptide; IEA:Ensembl.
GO; GO:0035994; P:response to muscle stretch; IEA:Ensembl.
GO; GO:0042770; P:signal transduction in response to DNA damage; IEA:Ensembl.
GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
GO; GO:0090400; P:stress-induced premature senescence; IEA:Ensembl.
GO; GO:0051146; P:striated muscle cell differentiation; IEA:Ensembl.
GO; GO:0007178; P:transmembrane receptor protein serine/threonine kinase signaling pathway; IEA:Ensembl.
GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:Ensembl.
CDD; cd07877; STKc_p38alpha; 1.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR003527; MAP_kinase_CS.
InterPro; IPR008352; MAPK_p38-like.
InterPro; IPR038784; p38alpha.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
Pfam; PF00069; Pkinase; 1.
PRINTS; PR01773; P38MAPKINASE.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS01351; MAPK; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
4: Predicted;
ATP-binding {ECO:0000256|SAAS:SAAS00574094};
Complete proteome {ECO:0000313|Proteomes:UP000009130};
Kinase {ECO:0000256|SAAS:SAAS00574114};
Nucleotide-binding {ECO:0000256|SAAS:SAAS00574094};
Reference proteome {ECO:0000313|Proteomes:UP000009130};
Serine/threonine-protein kinase {ECO:0000256|SAAS:SAAS00574114};
Transferase {ECO:0000256|SAAS:SAAS00574114}.
DOMAIN 24 308 Protein kinase.
{ECO:0000259|PROSITE:PS50011}.
SEQUENCE 360 AA; 41279 MW; 286C81D048760010 CRC64;
MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ
SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ
KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT
GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG
TPGAELLKKI SSESARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA
QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVVSFVP PPLDQEEMES


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