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Mitogen-activated protein kinase kinase kinase 1 (EC 2.7.11.25) (MAPK/ERK kinase kinase 1) (MEK kinase 1) (MEKK 1)

 M3K1_MOUSE              Reviewed;        1493 AA.
P53349; Q60831; Q9R0U3; Q9R256;
01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
26-SEP-2001, sequence version 3.
18-JUL-2018, entry version 172.
RecName: Full=Mitogen-activated protein kinase kinase kinase 1;
EC=2.7.11.25;
AltName: Full=MAPK/ERK kinase kinase 1;
Short=MEK kinase 1;
Short=MEKK 1;
Name=Map3k1; Synonyms=Mekk, Mekk1;
Mus musculus (Mouse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
NCBI_TaxID=10090;
[1]
NUCLEOTIDE SEQUENCE [MRNA].
Lange C.A., Blumer K.J., Sather S.L., Johnson G.L.;
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-659.
TISSUE=Spleen;
PubMed=10523642; DOI=10.1128/MCB.19.11.7539;
Ito M., Yoshioka K., Akechi M., Yamashita S., Takamatsu N.,
Sugiyama K., Hibi M., Nakabeppu Y., Shiba T., Yamamoto K.;
"JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein
that functions as a scaffold factor in the JNK signaling pathway.";
Mol. Cell. Biol. 19:7539-7548(1999).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 660-1493.
STRAIN=BALB/cJ; TISSUE=Brain;
PubMed=8385802; DOI=10.1126/science.8385802;
Lange-Carter C.A., Pleiman C.M., Gardner A.M., Blumer K.J.,
Johnson G.L.;
"A divergence in the MAP kinase regulatory network defined by MEK
kinase and Raf.";
Science 260:315-319(1993).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 796-1493.
STRAIN=BALB/cJ; TISSUE=Heart;
Whitmarsh A.J., Shore P., Sharrocks A.D., Davis R.J.;
Submitted (JAN-1996) to the EMBL/GenBank/DDBJ databases.
[5]
ENZYME REGULATION, MUTAGENESIS OF THR-1381 AND THR-1393, AND
PHOSPHORYLATION AT THR-1381 AND THR-1393.
PubMed=9078260; DOI=10.1042/bj3220185;
Deak J.C., Templeton D.J.;
"Regulation of the activity of MEK kinase 1 (MEKK1) by
autophosphorylation within the kinase activation domain.";
Biochem. J. 322:185-192(1997).
[6]
FUNCTION, INTERACTION WITH IKBKB AND MAP2K4, ENZYME REGULATION, AND
MUTAGENESIS OF THR-1381; THR-1393; ILE-1394; PHE-1396; MET-1397;
VAL-1401; LEU-1402; ARG-1403 AND GLY-1404.
PubMed=14500727; DOI=10.1074/jbc.M304234200;
Tu Z., Lee F.S.;
"Subdomain VIII is a specificity-determining region in MEKK1.";
J. Biol. Chem. 278:48498-48505(2003).
[7]
INTERACTION WITH AXIN1.
PubMed=15262978; DOI=10.1074/jbc.M404598200;
Wong C.K., Luo W., Deng Y., Zou H., Ye Z., Lin S.-C.;
"The DIX domain protein coiled-coil-DIX1 inhibits c-Jun N-terminal
kinase activation by Axin and dishevelled through distinct
mechanisms.";
J. Biol. Chem. 279:39366-39373(2004).
[8]
FUNCTION.
PubMed=17761173; DOI=10.1016/j.febslet.2007.08.008;
Ye B., Yu W.P., Thomas G.M., Huganir R.L.;
"GRASP-1 is a neuronal scaffold protein for the JNK signaling
pathway.";
FEBS Lett. 581:4403-4410(2007).
[9]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
PubMed=19144319; DOI=10.1016/j.immuni.2008.11.006;
Trost M., English L., Lemieux S., Courcelles M., Desjardins M.,
Thibault P.;
"The phagosomal proteome in interferon-gamma-activated macrophages.";
Immunity 30:143-154(2009).
[10]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-142 AND SER-287, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Brown adipose tissue, Lung, and Spleen;
PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
"A tissue-specific atlas of mouse protein phosphorylation and
expression.";
Cell 143:1174-1189(2010).
-!- FUNCTION: Component of a protein kinase signal transduction
cascade (PubMed:14500727). Activates the ERK and JNK kinase
pathways by phosphorylation of MAP2K1 and MAP2K4
(PubMed:14500727). May phosphorylate the MAPK8/JNK1 kinase
(PubMed:17761173). Activates CHUK and IKBKB, the central protein
kinases of the NF-kappa-B pathway (PubMed:14500727).
{ECO:0000269|PubMed:14500727, ECO:0000269|PubMed:17761173}.
-!- CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
-!- ENZYME REGULATION: Activated by autophosphorylation on Thr-1381
and Thr-1393 following oligomerization.
{ECO:0000269|PubMed:14500727, ECO:0000269|PubMed:9078260}.
-!- SUBUNIT: Binds both upstream activators and downstream substrates
in multimolecular complexes through its N-terminus. Oligomerizes
after binding MAP4K2 or TRAF2. Interacts with AXIN1. Interacts
(via the kinase catalytic domain) with STK38 (By similarity).
Interacts with GRIPAP1 (By similarity).
{ECO:0000250|UniProtKB:Q13233, ECO:0000250|UniProtKB:Q62925}.
-!- INTERACTION:
P47809:Map2k4; NbExp=2; IntAct=EBI-447913, EBI-447934;
Q9ESN9-2:Mapk8ip3; NbExp=3; IntAct=EBI-447913, EBI-9549291;
Q8CF89:Tab1; NbExp=4; IntAct=EBI-447913, EBI-1778503;
P62991:Ubc; NbExp=2; IntAct=EBI-447913, EBI-413074;
-!- TISSUE SPECIFICITY: Highly expressed in the heart and spleen while
a lower level expression is seen in the liver.
-!- PTM: Autophosphorylated. {ECO:0000269|PubMed:9078260}.
-!- SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr
protein kinase family. MAP kinase kinase kinase subfamily.
{ECO:0000305}.
-!- SEQUENCE CAUTION:
Sequence=AAA97500.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; AF117340; AAD25049.1; -; mRNA.
EMBL; AB014614; BAA85878.1; -; mRNA.
EMBL; L13103; AAA97500.1; ALT_INIT; mRNA.
EMBL; U23470; AAA85038.1; -; mRNA.
CCDS; CCDS26771.1; -.
PIR; A46212; A46212.
UniGene; Mm.15918; -.
ProteinModelPortal; P53349; -.
SMR; P53349; -.
CORUM; P53349; -.
DIP; DIP-32487N; -.
IntAct; P53349; 8.
MINT; P53349; -.
STRING; 10090.ENSMUSP00000104890; -.
iPTMnet; P53349; -.
PhosphoSitePlus; P53349; -.
EPD; P53349; -.
MaxQB; P53349; -.
PaxDb; P53349; -.
PeptideAtlas; P53349; -.
PRIDE; P53349; -.
MGI; MGI:1346872; Map3k1.
eggNOG; KOG4279; Eukaryota.
eggNOG; ENOG410XQGS; LUCA.
HOGENOM; HOG000113437; -.
HOVERGEN; HBG006302; -.
InParanoid; P53349; -.
PhylomeDB; P53349; -.
BRENDA; 2.7.11.25; 3474.
ChiTaRS; Map3k1; mouse.
PRO; PR:P53349; -.
Proteomes; UP000000589; Unplaced.
CleanEx; MM_MAP3K1; -.
GO; GO:0030054; C:cell junction; IDA:MGI.
GO; GO:0005737; C:cytoplasm; ISO:MGI.
GO; GO:0005829; C:cytosol; TAS:Reactome.
GO; GO:0031941; C:filamentous actin; IDA:MGI.
GO; GO:0016020; C:membrane; ISO:MGI.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
GO; GO:0008092; F:cytoskeletal protein binding; IDA:MGI.
GO; GO:0008432; F:JUN kinase binding; ISO:MGI.
GO; GO:0004706; F:JUN kinase kinase kinase activity; IDA:MGI.
GO; GO:0004709; F:MAP kinase kinase kinase activity; ISO:MGI.
GO; GO:0051019; F:mitogen-activated protein kinase binding; ISO:MGI.
GO; GO:0031434; F:mitogen-activated protein kinase kinase binding; ISO:MGI.
GO; GO:0004672; F:protein kinase activity; EXP:Reactome.
GO; GO:0019901; F:protein kinase binding; ISO:MGI.
GO; GO:0004674; F:protein serine/threonine kinase activity; ISO:MGI.
GO; GO:0046625; F:sphingolipid binding; ISO:MGI.
GO; GO:0004842; F:ubiquitin-protein transferase activity; ISO:MGI.
GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
GO; GO:0007257; P:activation of JUN kinase activity; IDA:BHF-UCL.
GO; GO:0008637; P:apoptotic mitochondrial changes; IMP:MGI.
GO; GO:0043010; P:camera-type eye development; IMP:MGI.
GO; GO:0003382; P:epithelial cell morphogenesis; IMP:MGI.
GO; GO:0061029; P:eyelid development in camera-type eye; IMP:MGI.
GO; GO:0007254; P:JNK cascade; IDA:MGI.
GO; GO:0002011; P:morphogenesis of an epithelial sheet; IMP:MGI.
GO; GO:0030838; P:positive regulation of actin filament polymerization; IMP:MGI.
GO; GO:0042981; P:regulation of apoptotic process; IBA:GO_Central.
GO; GO:0030334; P:regulation of cell migration; IMP:MGI.
GO; GO:0007346; P:regulation of mitotic cell cycle; IBA:GO_Central.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:MGI.
GO; GO:0042060; P:wound healing; IMP:MGI.
Gene3D; 1.25.10.10; -; 1.
Gene3D; 3.30.40.10; -; 1.
InterPro; IPR011989; ARM-like.
InterPro; IPR016024; ARM-type_fold.
InterPro; IPR011009; Kinase-like_dom_sf.
InterPro; IPR000719; Prot_kinase_dom.
InterPro; IPR017441; Protein_kinase_ATP_BS.
InterPro; IPR008271; Ser/Thr_kinase_AS.
InterPro; IPR001841; Znf_RING.
InterPro; IPR013083; Znf_RING/FYVE/PHD.
InterPro; IPR007527; Znf_SWIM.
Pfam; PF00069; Pkinase; 1.
Pfam; PF04434; SWIM; 1.
SMART; SM00220; S_TKc; 1.
SUPFAM; SSF48371; SSF48371; 1.
SUPFAM; SSF56112; SSF56112; 1.
PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
PROSITE; PS50089; ZF_RING_2; 1.
PROSITE; PS50966; ZF_SWIM; 1.
1: Evidence at protein level;
Acetylation; ATP-binding; Complete proteome; Kinase; Magnesium;
Metal-binding; Nucleotide-binding; Phosphoprotein; Reference proteome;
Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
INIT_MET 1 1 Removed. {ECO:0000250|UniProtKB:Q13233}.
CHAIN 2 1493 Mitogen-activated protein kinase kinase
kinase 1.
/FTId=PRO_0000086241.
DOMAIN 1224 1489 Protein kinase. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
ZN_FING 333 361 SWIM-type. {ECO:0000255|PROSITE-
ProRule:PRU00325}.
ZN_FING 438 487 RING-type. {ECO:0000255|PROSITE-
ProRule:PRU00175}.
NP_BIND 1230 1238 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
COMPBIAS 25 32 Poly-Gly.
COMPBIAS 74 149 Pro-rich.
COMPBIAS 233 291 Pro-rich.
COMPBIAS 417 426 Poly-Ser.
ACT_SITE 1350 1350 Proton acceptor. {ECO:0000255|PROSITE-
ProRule:PRU00159, ECO:0000255|PROSITE-
ProRule:PRU10027}.
BINDING 1253 1253 ATP. {ECO:0000255|PROSITE-
ProRule:PRU00159}.
MOD_RES 2 2 N-acetylalanine.
{ECO:0000250|UniProtKB:Q13233}.
MOD_RES 21 21 Phosphoserine.
{ECO:0000250|UniProtKB:Q13233}.
MOD_RES 142 142 Phosphoserine.
{ECO:0000244|PubMed:19144319,
ECO:0000244|PubMed:21183079}.
MOD_RES 270 270 Phosphoserine.
{ECO:0000250|UniProtKB:Q13233}.
MOD_RES 280 280 Phosphothreonine.
{ECO:0000250|UniProtKB:Q13233}.
MOD_RES 287 287 Phosphoserine.
{ECO:0000244|PubMed:21183079}.
MOD_RES 292 292 Phosphoserine.
{ECO:0000250|UniProtKB:Q13233}.
MOD_RES 295 295 Phosphoserine.
{ECO:0000250|UniProtKB:Q13233}.
MOD_RES 502 502 Phosphoserine.
{ECO:0000250|UniProtKB:Q13233}.
MOD_RES 526 526 Phosphoserine.
{ECO:0000250|UniProtKB:Q13233}.
MOD_RES 915 915 Phosphoserine.
{ECO:0000250|UniProtKB:Q13233}.
MOD_RES 999 999 Phosphoserine.
{ECO:0000250|UniProtKB:Q13233}.
MOD_RES 1024 1024 Phosphoserine.
{ECO:0000250|UniProtKB:Q13233}.
MOD_RES 1381 1381 Phosphothreonine; by autocatalysis.
{ECO:0000269|PubMed:9078260}.
MOD_RES 1393 1393 Phosphothreonine; by autocatalysis.
{ECO:0000269|PubMed:9078260}.
MUTAGEN 1381 1381 T->A: Fails to activate MAP2K1, MAP2K4,
MAP2K7, CHUK and IKBKB.
{ECO:0000269|PubMed:14500727,
ECO:0000269|PubMed:9078260}.
MUTAGEN 1381 1381 T->E: Loss of kinase activity and
autophosphorylation.
{ECO:0000269|PubMed:14500727,
ECO:0000269|PubMed:9078260}.
MUTAGEN 1381 1381 T->S: Reduced kinase activity and
autophosphorylation.
{ECO:0000269|PubMed:14500727,
ECO:0000269|PubMed:9078260}.
MUTAGEN 1393 1393 T->A: Loss of kinase activity and
autophosphorylation. Fails to activate
MAP2K1, MAP2K4, MAP2K7, CHUK and IKBKB.
{ECO:0000269|PubMed:14500727,
ECO:0000269|PubMed:9078260}.
MUTAGEN 1393 1393 T->E: Loss of kinase activity and
autophosphorylation.
{ECO:0000269|PubMed:14500727,
ECO:0000269|PubMed:9078260}.
MUTAGEN 1393 1393 T->S: Reduced kinase activity and
autophosphorylation.
{ECO:0000269|PubMed:14500727,
ECO:0000269|PubMed:9078260}.
MUTAGEN 1394 1394 I->A: Loss of NF-kappa-B transcription
factor activity and reduced ability to
activate MAP2K1, MAP2K4, MAP2K7. No
effect on AP-1 activity or activation of
CHUK and IKBKB. Loss of binding to IKBKB.
{ECO:0000269|PubMed:14500727}.
MUTAGEN 1396 1396 F->A: Loss of AP-1 and NF-kappa-B
transcription factor activity. Reduced
ability to activate MAP2K1, MAP2K4,
MAP2K7, CHUK and IKBKB.
{ECO:0000269|PubMed:14500727}.
MUTAGEN 1397 1397 M->A: Loss of AP-1 and NF-kappa-B
transcription factor activity. Reduced
ability to activate MAP2K1, MAP2K4,
MAP2K7, CHUK and IKBKB.
{ECO:0000269|PubMed:14500727}.
MUTAGEN 1401 1401 V->A: Loss of AP-1 and NF-kappa-B
transcription factor activity. Reduced
ability to activate MAP2K1, MAP2K4,
MAP2K7, CHUK and IKBKB.
{ECO:0000269|PubMed:14500727}.
MUTAGEN 1402 1402 L->A: Loss of AP-1 transcription factor
activity and reduced ability to activate
CHUK and IKBKB. No effect on NF-kappa-B
activity or activation of MAP2K1, MAP2K4,
MAP2K7. Loss of binding to MAP2K4.
{ECO:0000269|PubMed:14500727}.
MUTAGEN 1403 1403 R->A: Loss of AP-1 transcription factor
activity, no effect on NF-kappa-B
activity. {ECO:0000269|PubMed:14500727}.
MUTAGEN 1404 1404 G->A: Loss of AP-1 and NF-kappa-B
transcription factor activity.
{ECO:0000269|PubMed:14500727}.
CONFLICT 30 39 GGGALQGSGA -> ALQGSG (in Ref. 2).
{ECO:0000305}.
CONFLICT 103 103 Missing (in Ref. 2; BAA85878).
{ECO:0000305}.
CONFLICT 257 257 V -> E (in Ref. 2; BAA85878).
{ECO:0000305}.
CONFLICT 307 307 M -> V (in Ref. 2; BAA85878).
{ECO:0000305}.
CONFLICT 413 413 S -> C (in Ref. 2; BAA85878).
{ECO:0000305}.
CONFLICT 559 559 V -> A (in Ref. 2; BAA85878).
{ECO:0000305}.
CONFLICT 883 883 V -> L (in Ref. 3; AAA85038).
{ECO:0000305}.
CONFLICT 1467 1467 V -> L (in Ref. 3; AAA85038).
{ECO:0000305}.
SEQUENCE 1493 AA; 161289 MW; CA65C9B7703C6BF9 CRC64;
MAAAAGDRAS SSGFPGAAAA SPEAGGGGGG GGALQGSGAP AAGAAGLLRE PGSAGRERAD
WRRRQLRKVR SVELDQLPEQ PLFLAAASPP CPSTSPSPEP ADAAAGASRF QPAAGPPPPG
AASRCGSHSA ELAAARDSGA RSPAGAEPPS AAAPSGREME NKETLKGLHK MEDRPEERMI
REKLKATCMP AWKHEWLERR NRRGPVVVKP IPIKGDGSEV NNLAAEPQGE GQAGSAAPAP
KGRRSPSPGS SPSGRSVKPE SPGVRRKRVS PVPFQSGRIT PPRRAPSPDG FSPYSPEETS
RRVNKVMRAR LYLLQQIGPN SFLIGGDSPD NKYRVFIGPQ NCSCGRGAFC IHLLFVMLRV
FQLEPSDPML WRKTLKNFEV ESLFQKYHSR RSSRIKAPSR NTIQKFVSRM SNSHTLSSSS
TSTSSSENSI KDEEEQMCPI CLLGMLDEES LTVCEDGCRN KLHHHCMSIW AEECRRNREP
LICPLCRSKW RSHDFYSHEL SSPVESPASL RAVQQPSSPQ QPVAGSQRRN QESSFNLTHF
GTQQIPSAYK DLAEPWIQVF GMELVGCLFS RNWNVREMAL RRLSHDVSGA LLLANGESTG
NSGGGSGGSL SAGAASGSSQ PSISGDVVEA CCSVLSIVCA DPVYKVYVAA LKTLRAMLVY
TPCHSLAERI KLQRLLRPVV DTILVKCADA NSRTSQLSIS TVLELCKGQA GELAVGREIL
KAGSIGVGGV DYVLSCILGN QAESNNWQEL LGRLCLIDRL LLEFPAEFYP HIVSTDVSQA
EPVEIRYKKL LSLLTFALQS IDNSHSMVGK LSRRIYLSSA RMVTAVPAVF SKLVTMLNAS
GSTHFTRMRR RLMAIADEVE IAEVIQLGVE DTVDGHQDSL QAVAPTSCLE NSSLEHTVHR
EKTGKGLSAT RLSASSEDIS DRLAGVSVGL PSSTTTEQPK PAVQTKGRPH SQCLNSSPLS
HAQLMFPAPS APCSSAPSVP DISKHRPQAF VPCKIPSASP QTQRKFSLQF QRNCSEHRDS
DQLSPVFTQS RPPPSSNIHR PKPSRPVPGS TSKLGDATKS SMTLDLGSAS RCDDSFGGGG
NSGNAVIPSD ETVFTPVEDK CRLDVNTELN SSIEDLLEAS MPSSDTTVTF KSEVAVLSPE
KAENDDTYKD DVNHNQKCKE KMEAEEEEAL AIAMAMSASQ DALPIVPQLQ VENGEDIIII
QQDTPETLPG HTKAKQPYRE DAEWLKGQQI GLGAFSSCYQ AQDVGTGTLM AVKQVTYVRN
TSSEQEEVVE ALREEIRMMG HLNHPNIIRM LGATCEKSNY NLFIEWMAGG SVAHLLSKYG
AFKESVVINY TEQLLRGLSY LHENQIIHRD VKGANLLIDS TGQRLRIADF GAAARLASKG
TGAGEFQGQL LGTIAFMAPE VLRGQQYGRS CDVWSVGCAI IEMACAKPPW NAEKHSNHLA
LIFKIASATT APSIPSHLSP GLRDVAVRCL ELQPQDRPPS RELLKHPVFR TTW


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U1206h CLIA ERK2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,Homo sapiens,Human,MAP kinase 1,MAP kinase 2,MAP kinase isoform p42,MAPK 1,MAPK 2,MAPK1,Mitogen-activated protein kinase 1,Mitogen-activate 96T
U1206m CLIA Erk2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,MAP kinase 1,MAP kinase 2,MAP kinase isoform p42,Mapk,MAPK 1,MAPK 2,Mapk1,Mitogen-activated protein kinase 1,Mitogen-activated protein kina 96T
U1206r CLIA Erk2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,MAP kinase 1,MAP kinase 2,MAP kinase isoform p42,Mapk,MAPK 1,MAPK 2,Mapk1,Mitogen-activated protein kinase 1,Mitogen-activated protein kina 96T
EIAAB25246 c-Jun N-terminal kinase kinase 2,Dual specificity mitogen-activated protein kinase kinase 7,Homo sapiens,Human,JNK kinase 2,JNK-activating kinase 2,JNKK 2,JNKK2,MAP kinase kinase 7,MAP2K7,MAPK_ERK kin
U1206b CLIA Bos taurus,Bovine,ERK2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,MAP kinase 1,MAP kinase 2,MAPK 1,MAPK 2,MAPK1,Mitogen-activated protein kinase 1,Mitogen-activated protein kinase 2,PRKM1 96T
E1206b ELISA Bos taurus,Bovine,ERK2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,MAP kinase 1,MAP kinase 2,MAPK 1,MAPK 2,MAPK1,Mitogen-activated protein kinase 1,Mitogen-activated protein kinase 2,PRKM 96T
EIAAB25240 c-Jun N-terminal kinase kinase 1,Dual specificity mitogen-activated protein kinase kinase 4,Homo sapiens,Human,JNK-activating kinase 1,JNKK,JNKK1,MAP kinase kinase 4,MAP2K4,MAPK_ERK kinase 4,MAPKK 4,M
E1206m ELISA Erk2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,MAP kinase 1,MAP kinase 2,MAP kinase isoform p42,Mapk,MAPK 1,MAPK 2,Mapk1,Mitogen-activated protein kinase 1,Mitogen-activated protein kin 96T
E1206r ELISA Erk2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,MAP kinase 1,MAP kinase 2,MAP kinase isoform p42,Mapk,MAPK 1,MAPK 2,Mapk1,Mitogen-activated protein kinase 1,Mitogen-activated protein kin 96T
E1206b ELISA kit Bos taurus,Bovine,ERK2,ERK-2,ERT1,Extracellular signal-regulated kinase 2,MAP kinase 1,MAP kinase 2,MAPK 1,MAPK 2,MAPK1,Mitogen-activated protein kinase 1,Mitogen-activated protein kinase 2 96T


 

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