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Mitotic checkpoint protein bub-3 (Budding uninhibited by benzimidazole 3)

 BUB3_CAEEL              Reviewed;         343 AA.
Q9XWH0;
06-JUL-2016, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
05-JUL-2017, entry version 136.
RecName: Full=Mitotic checkpoint protein bub-3 {ECO:0000250|UniProtKB:O43684};
AltName: Full=Budding uninhibited by benzimidazole 3 {ECO:0000250|UniProtKB:Q21776};
Name=bub-3 {ECO:0000312|WormBase:Y54G9A.6};
ORFNames=Y54G9A.6 {ECO:0000312|WormBase:Y54G9A.6};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
[1] {ECO:0000312|Proteomes:UP000001940}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[2] {ECO:0000305}
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=18248670; DOI=10.1186/1747-1028-3-6;
Hajeri V.A., Stewart A.M., Moore L.L., Padilla P.A.;
"Genetic analysis of the spindle checkpoint genes san-1, mdf-2, bub-3
and the CENP-F homologues hcp-1 and hcp-2 in Caenorhabditis elegans.";
Cell Div. 3:6-6(2008).
[3] {ECO:0000305}
FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=19109417; DOI=10.1091/mbc.E08-10-1047;
Essex A., Dammermann A., Lewellyn L., Oegema K., Desai A.;
"Systematic analysis in Caenorhabditis elegans reveals that the
spindle checkpoint is composed of two largely independent branches.";
Mol. Biol. Cell 20:1252-1267(2009).
[4] {ECO:0000305}
INTERACTION WITH BUB-1.
PubMed=24567362; DOI=10.1083/jcb.201311015;
Moyle M.W., Kim T., Hattersley N., Espeut J., Cheerambathur D.K.,
Oegema K., Desai A.;
"A Bub1-Mad1 interaction targets the Mad1-Mad2 complex to unattached
kinetochores to initiate the spindle checkpoint.";
J. Cell Biol. 204:647-657(2014).
[5] {ECO:0000305}
FUNCTION, INTERACTION WITH BUB-1, SUBCELLULAR LOCATION, AND DISRUPTION
PHENOTYPE.
PubMed=25987605; DOI=10.1083/jcb.201412035;
Kim T., Moyle M.W., Lara-Gonzalez P., De Groot C., Oegema K.,
Desai A.;
"Kinetochore-localized BUB-1/BUB-3 complex promotes anaphase onset in
C. elegans.";
J. Cell Biol. 209:507-517(2015).
[6] {ECO:0000305}
FUNCTION, AND DISRUPTION PHENOTYPE.
PubMed=26483555; DOI=10.1083/jcb.201409035;
Bohr T., Nelson C.R., Klee E., Bhalla N.;
"Spindle assembly checkpoint proteins regulate and monitor meiotic
synapsis in C. elegans.";
J. Cell Biol. 211:233-242(2015).
-!- FUNCTION: Has a dual function in spindle-assembly checkpoint
signaling and in promoting the establishment of correct
kinetochore-microtubule (K-MT) attachments (PubMed:18248670,
PubMed:19109417, PubMed:25987605). Promotes the formation of
stable end-on bipolar attachments of chromosomes
(PubMed:25987605). Necessary for expression and kinetochore
localization of bub-1 (PubMed:19109417, PubMed:25987605). Plays a
role in synapsis checkpoint signaling inducing apoptosis in
response to unsynapsed chromosomes and thus controlling
chromosomal segregation during oocyte meiosis (PubMed:26483555).
{ECO:0000269|PubMed:18248670, ECO:0000269|PubMed:19109417,
ECO:0000269|PubMed:25987605, ECO:0000269|PubMed:26483555}.
-!- SUBUNIT: May interact with bub-1; for localization at the
kinetochore and the onset of anaphase.
{ECO:0000269|PubMed:24567362, ECO:0000269|PubMed:25987605}.
-!- INTERACTION:
O02053:san-1; NbExp=5; IntAct=EBI-331258, EBI-316339;
-!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
{ECO:0000269|PubMed:19109417, ECO:0000269|PubMed:25987605}.
Nucleus {ECO:0000305}. Note=Localizes at kinetochores on
condensing chromosomes in late prophase and during metaphase
(PubMed:19109417). Localization to the kinetochore is dependent on
bub-1 (PubMed:25987605). {ECO:0000269|PubMed:19109417,
ECO:0000269|PubMed:25987605}.
-!- DISRUPTION PHENOTYPE: Viable, but with a reduced brood size
(PubMed:25987605). Reduced bub-1 expression and localization at
the kinetochore which may lead to the delay in the onset of
anaphase during embryogenesis (PubMed:25987605). Defective
synapsis with increased numbers of nuclei that contain
asymmetrically aligned (clustered) chromosomes (PubMed:26483555).
RNAi-mediated knockdown results in reduced survival as compared to
wild-type animals in anoxic conditions (PubMed:18248670).
{ECO:0000269|PubMed:18248670, ECO:0000269|PubMed:25987605,
ECO:0000269|PubMed:26483555}.
-!- SIMILARITY: Belongs to the WD repeat BUB3 family. {ECO:0000305}.
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EMBL; BX284602; CAA21698.1; -; Genomic_DNA.
PIR; T27185; T27185.
RefSeq; NP_496879.1; NM_064478.4.
UniGene; Cel.7533; -.
ProteinModelPortal; Q9XWH0; -.
DIP; DIP-26143N; -.
IntAct; Q9XWH0; 7.
MINT; MINT-1052446; -.
STRING; 6239.Y54G9A.6; -.
EPD; Q9XWH0; -.
PaxDb; Q9XWH0; -.
PeptideAtlas; Q9XWH0; -.
EnsemblMetazoa; Y54G9A.6; Y54G9A.6; WBGene00013209.
GeneID; 175018; -.
KEGG; cel:CELE_Y54G9A.6; -.
UCSC; Y54G9A.6; c. elegans.
CTD; 175018; -.
WormBase; Y54G9A.6; CE19233; WBGene00013209; bub-3.
eggNOG; KOG1036; Eukaryota.
eggNOG; ENOG410XRBG; LUCA.
GeneTree; ENSGT00530000063440; -.
HOGENOM; HOG000208822; -.
InParanoid; Q9XWH0; -.
KO; K02180; -.
OMA; CMPNDAG; -.
OrthoDB; EOG091G0AB8; -.
PhylomeDB; Q9XWH0; -.
Reactome; R-CEL-141430; Inactivation of APC/C via direct inhibition of the APC/C complex.
SignaLink; Q9XWH0; -.
PRO; PR:Q9XWH0; -.
Proteomes; UP000001940; Chromosome II.
Bgee; WBGene00013209; -.
GO; GO:1990298; C:bub1-bub3 complex; IBA:GO_Central.
GO; GO:0000777; C:condensed chromosome kinetochore; IEA:UniProtKB-SubCell.
GO; GO:0000776; C:kinetochore; IBA:GO_Central.
GO; GO:0033597; C:mitotic checkpoint complex; IBA:GO_Central.
GO; GO:0005654; C:nucleoplasm; IDA:UniProtKB.
GO; GO:0043130; F:ubiquitin binding; IBA:GO_Central.
GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
GO; GO:0009792; P:embryo development ending in birth or egg hatching; IGI:WormBase.
GO; GO:0033316; P:meiotic spindle assembly checkpoint; IGI:WormBase.
GO; GO:0007094; P:mitotic spindle assembly checkpoint; IMP:WormBase.
GO; GO:0051726; P:regulation of cell cycle; IMP:UniProtKB.
Gene3D; 2.130.10.10; -; 1.
InterPro; IPR020472; G-protein_beta_WD-40_rep.
InterPro; IPR015943; WD40/YVTN_repeat-like_dom.
InterPro; IPR001680; WD40_repeat.
InterPro; IPR019775; WD40_repeat_CS.
InterPro; IPR017986; WD40_repeat_dom.
Pfam; PF00400; WD40; 2.
PRINTS; PR00320; GPROTEINBRPT.
SMART; SM00320; WD40; 5.
SUPFAM; SSF50978; SSF50978; 1.
PROSITE; PS00678; WD_REPEATS_1; 1.
PROSITE; PS50082; WD_REPEATS_2; 2.
PROSITE; PS50294; WD_REPEATS_REGION; 1.
1: Evidence at protein level;
Cell cycle; Cell division; Centromere; Chromosome; Complete proteome;
Kinetochore; Meiosis; Mitosis; Nucleus; Reference proteome; Repeat;
WD repeat.
CHAIN 1 343 Mitotic checkpoint protein bub-3.
{ECO:0000305}.
/FTId=PRO_0000436607.
REPEAT 21 62 WD 1. {ECO:0000255}.
REPEAT 67 105 WD 2. {ECO:0000255}.
REPEAT 107 146 WD 3. {ECO:0000255}.
REPEAT 150 187 WD 4. {ECO:0000255}.
REPEAT 192 232 WD 5. {ECO:0000255}.
REPEAT 249 288 WD 6. {ECO:0000255}.
REPEAT 291 331 WD 7. {ECO:0000255}.
SEQUENCE 343 AA; 38127 MW; 021AD0398C6BD5ED CRC64;
MSTYQAATIV AAPNEFRVPF PPFVQISKVQ FQREAGSRLL AASGWDGTCR VYEVGKLGDI
SEKLVFTHGK PLLTCTFAGY NKVAFGGVDH NVKLADIETG NGTQLGSHAL AVRCMEFNPM
SSLIVSGGWD SSVKLWDARS YGNGAIESVN VSSSVYAMDV LKHTILVGTK DRKIFMYDSR
KLREPLQVRD SPLKYQTRAV QFFPTGEAFV VSSIEGRVAV EYVDQSGEEM MKRKYAFKCH
REKDTDGTEL IHPVHTVAFH PKYGTFATGG ADGIVNIWDP FNRKRIIQLH KFETSISSLS
FNEDGSQLAI ATSYQYEKEI DPSPLPNNSI TIRHITDPES RPK


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