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Moira

 Q7KPY3_DROME            Unreviewed;      1189 AA.
Q7KPY3;
05-JUL-2004, integrated into UniProtKB/TrEMBL.
05-JUL-2004, sequence version 1.
18-JUL-2018, entry version 113.
SubName: Full=Moira {ECO:0000313|EMBL:AAD12718.1};
Name=mor {ECO:0000313|EMBL:AAD12718.1,
ECO:0000313|FlyBase:FBgn0002783};
ORFNames=CG18740 {ECO:0000313|FlyBase:FBgn0002783};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000313|EMBL:AAD12718.1};
[1] {ECO:0000313|EMBL:AAD12718.1}
NUCLEOTIDE SEQUENCE.
Crosby M., Miller C., Zak N.B.;
Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:AAD12718.1}
NUCLEOTIDE SEQUENCE.
PubMed=9891050;
Crosby M.A., Miller C., Alon T., Watson K.L., Verrijzer C.P.,
Goldman-Levi R., Zak N.B.;
"The trithorax group gene moira encodes a brahma-associated putative
chromatin-remodeling factor in Drosophila melanogaster.";
Mol. Cell. Biol. 19:1159-1170(1999).
-!- INTERACTION:
Self; NbExp=2; IntAct=EBI-1182199, EBI-1182199;
P25439:brm; NbExp=3; IntAct=EBI-1182199, EBI-868480;
P09956:z; NbExp=2; IntAct=EBI-1182199, EBI-167915;
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00548613}.
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EMBL; AF033823; AAD12718.1; -; mRNA.
ProteinModelPortal; Q7KPY3; -.
IntAct; Q7KPY3; 5.
PeptideAtlas; Q7KPY3; -.
PRIDE; Q7KPY3; -.
FlyBase; FBgn0002783; mor.
eggNOG; KOG1279; Eukaryota.
eggNOG; COG5259; LUCA.
OrthoDB; EOG091G06AJ; -.
Reactome; R-DME-3214858; RMTs methylate histone arginines.
Reactome; R-DME-8939243; RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known.
Bgee; FBgn0002783; -.
ExpressionAtlas; Q7KPY3; baseline and differential.
GO; GO:0035060; C:brahma complex; IDA:FlyBase.
GO; GO:0071565; C:nBAF complex; IEA:InterPro.
GO; GO:0071564; C:npBAF complex; IEA:InterPro.
GO; GO:0005634; C:nucleus; IDA:FlyBase.
GO; GO:0016586; C:RSC-type complex; IDA:FlyBase.
GO; GO:0016514; C:SWI/SNF complex; IEA:InterPro.
GO; GO:0003677; F:DNA binding; IEA:InterPro.
GO; GO:0042802; F:identical protein binding; IPI:IntAct.
GO; GO:0043044; P:ATP-dependent chromatin remodeling; ISS:FlyBase.
GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IGI:FlyBase.
GO; GO:0008587; P:imaginal disc-derived wing margin morphogenesis; IMP:FlyBase.
GO; GO:0008586; P:imaginal disc-derived wing vein morphogenesis; IMP:FlyBase.
GO; GO:0007474; P:imaginal disc-derived wing vein specification; IMP:FlyBase.
GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IGI:FlyBase.
GO; GO:0007406; P:negative regulation of neuroblast proliferation; IGI:FlyBase.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:FlyBase.
GO; GO:0045088; P:regulation of innate immune response; IGI:FlyBase.
GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:FlyBase.
Gene3D; 1.10.10.10; -; 1.
InterPro; IPR036420; BRCT_dom_sf.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR001005; SANT/Myb.
InterPro; IPR017884; SANT_dom.
InterPro; IPR038044; SMARCC2.
InterPro; IPR032451; SMARCC_C.
InterPro; IPR032450; SMARCC_N.
InterPro; IPR007526; SWIRM.
InterPro; IPR032448; SWIRM-assoc.
InterPro; IPR036388; WH-like_DNA-bd_sf.
PANTHER; PTHR12802:SF38; PTHR12802:SF38; 1.
Pfam; PF00249; Myb_DNA-binding; 1.
Pfam; PF04433; SWIRM; 1.
Pfam; PF16495; SWIRM-assoc_1; 1.
Pfam; PF16496; SWIRM-assoc_2; 1.
Pfam; PF16498; SWIRM-assoc_3; 1.
SMART; SM00717; SANT; 1.
SUPFAM; SSF46689; SSF46689; 2.
SUPFAM; SSF52113; SSF52113; 2.
PROSITE; PS51293; SANT; 1.
PROSITE; PS50934; SWIRM; 1.
1: Evidence at protein level;
Coiled coil {ECO:0000256|SAM:Coils};
Nucleus {ECO:0000256|SAAS:SAAS00501360}.
DOMAIN 430 527 SWIRM. {ECO:0000259|PROSITE:PS50934}.
DOMAIN 630 681 SANT. {ECO:0000259|PROSITE:PS51293}.
COILED 964 994 {ECO:0000256|SAM:Coils}.
SEQUENCE 1189 AA; 129025 MW; 6E59C06E00B7C50A CRC64;
MALSGGEKKT IYSQPYLLQY LAHSSEPITK ESLAQLFIHF LQYVEAKLGK NSADPPATRI
PMRCFLDFKS GGGLCIIFST MFRFRAEQRG KKFDFSIGKN PTRKDPNIQL LIEIEQALVE
ADLYRIPYIY IRPEIEKGFE GKLREILDNR RVEIVSDEED ATHIVYPVVD PHPDEYARPI
FKRGGHVMLH WYYFPESYDS WAVNNFDLPD HIPENPESPA ERWRVSASWI VDLEQYNEWM
AEEDYEVDEQ GKKKTHKQRM SIDDIMSFGD EKKKPAASSG GGKQKRRRSP SPASSASTSK
PGKRKRSPAV VHKKSRNDDD DEDLTRDLDD PPAEPNVQEV HKANAALQST ASPAPGGKSR
GDNDMMPIKG GTMTDLDDEM TGGSAAQAMS TGDGENSQTG KTSDNSNTQE FSSSAKEDME
DNVTEQTHHI IVPSYSAWFD YNSIHVIEKR AMPEFFNSKN KSKTPEIYMA YRNFMIDTYR
LNPTEYLTTT ACRRNLAGDV CAIMRVHAFL EQWGLINYQI DADVRPTPMG PPPTSHFHIL
SDTPSGLQSI NPQKTQQPSA AKTLLDLDKK PLGKDGGLEL GDKSGLTGIK TEALENGAAG
GLSSGVSQFG LKLDQYAKKP AAMRNRTAAS MAREWTDQET LLLLEGLEMH KDDWNKVCEH
VGSRTQDECI LHFLRLPIED PYLEDDGGFL GPLACQPIPF SKSGNPIMST VAFLASVVDP
RVAAAAAKAA MEEFAAIKDE VPATIMDNHL KNVEKASAGG KFNPNFGLAN SGIAGTGNDK
DDEEGKEGGA SASAGGSDEE MKDLSKKDDD AKSKDNTKSD KTNTNTDSSS TSSSATGNTN
NTDKKPKESS GSSPSGDKSA IKSDKSNKSS PTETAAAASG GEVDIKTEDS SGDGETKDGT
EAKEGTGTGT GPLAVPKEGT FSENNMQTAA AAALASAAVK AKHLAALEER KIKSLVALLV
ETQMKKLEIK LRHFEELEAT MEREREGLEY QRQQLITERQ QFHLEQLKAA EFRARQQAHH
RLQQELQGQA AAGSMILPQQ QQLPQAQQPQ QQQQTLPPHP HLAQQQQLPP HPHQLPPQSQ
PLAGPTAQHQ PLPPHVVSSP NGAPFAAPPI SLTGGLPPGA PTAIVTNPSD QTGPVAAGAA
QSQAPTPMDT TPPSSGPVSD ANAPPGSAMP PGGIPPANTA PIAGVAPSS


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