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Monocarboxylate transporter MCT4

 A5JST7_HORSE            Unreviewed;       462 AA.
A5JST7;
26-JUN-2007, integrated into UniProtKB/TrEMBL.
05-MAY-2009, sequence version 2.
30-AUG-2017, entry version 64.
SubName: Full=Monocarboxylate transporter MCT4 {ECO:0000313|EMBL:ABQ53582.2};
Name=SLC16A3 {ECO:0000313|Ensembl:ENSECAP00000007519};
Equus caballus (Horse).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus.
NCBI_TaxID=9796 {ECO:0000313|EMBL:ABQ53582.2};
[1] {ECO:0000313|Ensembl:ENSECAP00000007519, ECO:0000313|Proteomes:UP000002281}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007519,
ECO:0000313|Proteomes:UP000002281};
PubMed=19892987; DOI=10.1126/science.1178158;
Broad Institute Genome Sequencing Platform;
Broad Institute Whole Genome Assembly Team;
Wade C.M., Giulotto E., Sigurdsson S., Zoli M., Gnerre S., Imsland F.,
Lear T.L., Adelson D.L., Bailey E., Bellone R.R., Bloecker H.,
Distl O., Edgar R.C., Garber M., Leeb T., Mauceli E., MacLeod J.N.,
Penedo M.C.T., Raison J.M., Sharpe T., Vogel J., Andersson L.,
Antczak D.F., Biagi T., Binns M.M., Chowdhary B.P., Coleman S.J.,
Della Valle G., Fryc S., Guerin G., Hasegawa T., Hill E.W., Jurka J.,
Kiialainen A., Lindgren G., Liu J., Magnani E., Mickelson J.R.,
Murray J., Nergadze S.G., Onofrio R., Pedroni S., Piras M.F.,
Raudsepp T., Rocchi M., Roeed K.H., Ryder O.A., Searle S., Skow L.,
Swinburne J.E., Syvaenen A.C., Tozaki T., Valberg S.J., Vaudin M.,
White J.R., Zody M.C., Lander E.S., Lindblad-Toh K.;
"Genome sequence, comparative analysis, and population genetics of the
domestic horse.";
Science 326:865-867(2009).
[2] {ECO:0000313|EMBL:ABQ53582.2}
NUCLEOTIDE SEQUENCE.
PubMed=21036377; DOI=10.1016/j.rvsc.2010.09.025;
Mykkanen A.K., Koho N.M., Reeben M., McGowan C.M., Poso A.R.;
"MCT1, MCT4 and CD147 gene polymorphisms in healthy horses and horses
with myopathy.";
Res. Vet. Sci. 91:473-477(2011).
[3] {ECO:0000313|Ensembl:ENSECAP00000007519}
IDENTIFICATION.
STRAIN=Thoroughbred {ECO:0000313|Ensembl:ENSECAP00000007519};
Ensembl;
Submitted (JUL-2011) to UniProtKB.
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EMBL; EF564279; ABQ53582.2; -; mRNA.
RefSeq; NP_001139004.1; NM_001145532.1.
RefSeq; XP_005597048.1; XM_005596991.2.
RefSeq; XP_005597049.1; XM_005596992.2.
RefSeq; XP_005597050.1; XM_005596993.2.
RefSeq; XP_005597051.1; XM_005596994.1.
UniGene; Eca.15176; -.
STRING; 9796.ENSECAP00000007519; -.
Ensembl; ENSECAT00000009822; ENSECAP00000007519; ENSECAG00000009524.
GeneID; 100056191; -.
KEGG; ecb:100056191; -.
CTD; 9123; -.
eggNOG; KOG2504; Eukaryota.
eggNOG; COG0477; LUCA.
GeneTree; ENSGT00760000118926; -.
HOGENOM; HOG000280688; -.
HOVERGEN; HBG006384; -.
KO; K08180; -.
OMA; RIMNGIS; -.
OrthoDB; EOG091G05SW; -.
TreeFam; TF313792; -.
Proteomes; UP000002281; Chromosome 11.
Bgee; ENSECAG00000009524; -.
GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
GO; GO:0005887; C:integral component of plasma membrane; IEA:InterPro.
GO; GO:0031965; C:nuclear membrane; IEA:Ensembl.
GO; GO:0015129; F:lactate transmembrane transporter activity; IEA:InterPro.
GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IBA:GO_Central.
GO; GO:0003723; F:RNA binding; IEA:Ensembl.
CDD; cd06174; MFS; 1.
InterPro; IPR004743; MCT.
InterPro; IPR030756; MCT4.
InterPro; IPR011701; MFS.
InterPro; IPR020846; MFS_dom.
PANTHER; PTHR11360:SF183; PTHR11360:SF183; 1.
Pfam; PF07690; MFS_1; 1.
SUPFAM; SSF103473; SSF103473; 1.
TIGRFAMs; TIGR00892; 2A0113; 1.
PROSITE; PS50850; MFS; 1.
2: Evidence at transcript level;
Complete proteome {ECO:0000313|Proteomes:UP000002281};
Membrane {ECO:0000256|SAM:Phobius};
Reference proteome {ECO:0000313|Proteomes:UP000002281};
Transmembrane {ECO:0000256|SAM:Phobius};
Transmembrane helix {ECO:0000256|SAM:Phobius}.
TRANSMEM 20 39 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 60 85 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 97 130 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 151 170 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 176 197 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 229 252 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 264 282 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 294 313 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 319 341 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 353 372 Helical. {ECO:0000256|SAM:Phobius}.
TRANSMEM 384 406 Helical. {ECO:0000256|SAM:Phobius}.
DOMAIN 21 410 MFS. {ECO:0000259|PROSITE:PS50850}.
SEQUENCE 462 AA; 49417 MW; 33E8F6C3BC7E2D05 CRC64;
MGGAVVDEGP TGIKAPDGGW GWAVLLGCFV ITGFSYAFPK AVSVFFKELI REFGIGYSDT
AWISSILLAM LYGTGPLCSV CVNRFGCRPV MLAGGLLASL GMVSASFCGS IIQLYLTTGV
ITGLGLALNF QPSLIMLNRY FNKRRPMANG LAAAGSPVFL CALSPLGQLL QDHYGWRGGF
LILGGLLLNC CVCAALMRPL EAPKPGSRPG PQRPSRRLLD LSVFRDRGFV IYAVAASIMV
LGLFVPPVFV VSYAKDLGVP DTQAAFLLTI LGFIDIFARP TAGFITGLKK VRPYSVYLFS
FAMFFNGFTD LTGSTASDYG GLVVFCIFFG ISYGMVGALQ FEVLMAIVGT HKFSSAIGLV
LLLEAVAVLI GPPSGGKLLD ATHVYQYVFL LAGAEVVTSS FVLVLGNFFC IGRRPKAAAE
EEEHHKPPPD ADVRVDSREV EHFLKAEPEK NGEVVHTPET SV


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