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Monomeric sarcosine oxidase (MSOX) (EC 1.5.3.1)

 MSOX_ARTST              Reviewed;         389 AA.
P40873; O66180;
01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
23-JAN-2007, sequence version 2.
28-FEB-2018, entry version 97.
RecName: Full=Monomeric sarcosine oxidase;
Short=MSOX;
EC=1.5.3.1;
Name=soxA;
Arthrobacter sp. (strain TE1826).
Bacteria; Actinobacteria; Micrococcales; Micrococcaceae; Arthrobacter.
NCBI_TaxID=68999;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 2-6.
Nishiya Y., Imanaka T.;
"Cloning and sequencing of the sarcosine oxidase gene from
Arthrobacter sp. TE1826.";
J. Ferment. Bioeng. 75:239-244(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=9563845; DOI=10.1007/s004380050685;
Nishiya Y., Toda A., Imanaka T.;
"Gene cluster for creatinine degradation in Arthrobacter sp. TE1826.";
Mol. Gen. Genet. 257:581-586(1998).
[3]
MUTAGENESIS OF CYS-265 AND CYS-318.
PubMed=7887617;
Nishiya Y., Zuihara S., Imanaka T.;
"Active site analysis and stabilization of sarcosine oxidase by the
substitution of cysteine residues.";
Appl. Environ. Microbiol. 61:367-370(1995).
[4]
MUTAGENESIS OF GLY-13; ALA-14; GLY-15; SER-16; MET-17; GLY-18 AND
ASP-36.
PubMed=8779579;
Nishiya Y., Imanaka T.;
"Analysis of interaction between the Arthrobacter sarcosine oxidase
and the coenzyme flavin adenine dinucleotide by site-directed
mutagenesis.";
Appl. Environ. Microbiol. 62:2405-2410(1996).
[5]
MUTAGENESIS OF CYS-318.
PubMed=11035956; DOI=10.1006/prep.2000.1299;
Nishiya Y.;
"A mutant sarcosine oxidase in which activity depends on flavin
adenine dinucleotide.";
Protein Expr. Purif. 20:95-97(2000).
-!- FUNCTION: Catalyzes the oxidative demethylation of sarcosine.
-!- CATALYTIC ACTIVITY: Sarcosine + H(2)O + O(2) = glycine +
formaldehyde + H(2)O(2).
-!- COFACTOR:
Name=FAD; Xref=ChEBI:CHEBI:57692;
Note=Binds 1 FAD per subunit.;
-!- SUBUNIT: Monomer.
-!- SUBCELLULAR LOCATION: Cytoplasm.
-!- MISCELLANEOUS: Decreases in function by replacement in the G-X-G-
X-X-G motif are suppressed by chloride or bromide ion.
-!- SIMILARITY: Belongs to the MSOX/MTOX family. MSOX subfamily.
{ECO:0000305}.
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EMBL; D63413; BAA09716.1; -; Genomic_DNA.
EMBL; AB007122; BAA25926.1; -; Genomic_DNA.
PIR; T44248; T44248.
ProteinModelPortal; P40873; -.
SMR; P40873; -.
BioCyc; MetaCyc:MONOMER-11002; -.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0008115; F:sarcosine oxidase activity; IEA:UniProtKB-EC.
GO; GO:0046653; P:tetrahydrofolate metabolic process; IEA:InterPro.
Gene3D; 3.50.50.60; -; 3.
HAMAP; MF_00516; MSOX; 1.
InterPro; IPR006076; FAD-dep_OxRdtase.
InterPro; IPR036188; FAD/NAD-bd_sf.
InterPro; IPR006281; SoxA_mon.
Pfam; PF01266; DAO; 1.
SUPFAM; SSF51905; SSF51905; 2.
TIGRFAMs; TIGR01377; soxA_mon; 1.
1: Evidence at protein level;
Cytoplasm; Direct protein sequencing; FAD; Flavoprotein;
Oxidoreductase.
INIT_MET 1 1 Removed. {ECO:0000269|Ref.1}.
CHAIN 2 389 Monomeric sarcosine oxidase.
/FTId=PRO_0000213760.
NP_BIND 8 38 FAD. {ECO:0000255}.
MOD_RES 318 318 S-8alpha-FAD cysteine. {ECO:0000305}.
MUTAGEN 13 13 G->A: Loss of activity.
{ECO:0000269|PubMed:8779579}.
MUTAGEN 14 14 A->D,K: Loss of activity.
{ECO:0000269|PubMed:8779579}.
MUTAGEN 14 14 A->I,V: Decrease in activity.
{ECO:0000269|PubMed:8779579}.
MUTAGEN 14 14 A->L,W,Y: Weak activity.
{ECO:0000269|PubMed:8779579}.
MUTAGEN 15 15 G->A: Loss of activity.
{ECO:0000269|PubMed:8779579}.
MUTAGEN 16 16 S->P: Weak activity. Loss of activity;
when associated with G-17.
{ECO:0000269|PubMed:8779579}.
MUTAGEN 17 17 M->G: Weak activity. Loss of activity;
when associated with P-16.
{ECO:0000269|PubMed:8779579}.
MUTAGEN 18 18 G->A: Weak activity.
{ECO:0000269|PubMed:8779579}.
MUTAGEN 36 36 D->A: Loss of activity.
{ECO:0000269|PubMed:8779579}.
MUTAGEN 36 36 D->E: Almost no change in activity.
{ECO:0000269|PubMed:8779579}.
MUTAGEN 36 36 D->N: 100-fold decrease in activity.
{ECO:0000269|PubMed:8779579}.
MUTAGEN 265 265 C->A,D: Decrease in activity. Stabilizes
SoxA against chemicals and metal ions.
{ECO:0000269|PubMed:7887617}.
MUTAGEN 265 265 C->R,S: Almost no change in activity.
Stabilizes SoxA against chemicals and
metal ions. {ECO:0000269|PubMed:7887617}.
MUTAGEN 318 318 C->S: Weak activity.
{ECO:0000269|PubMed:11035956,
ECO:0000269|PubMed:7887617}.
CONFLICT 39 39 H -> D (in Ref. 2; BAA09716/BAA25926).
{ECO:0000305}.
CONFLICT 316 316 D -> A (in Ref. 2; BAA09716/BAA25926).
{ECO:0000305}.
SEQUENCE 389 AA; 43294 MW; 77437C4F12B4AC7F CRC64;
MSIKKDYDVI VVGAGSMGMA AGYYLSKQGV KTLLVDSFHP PHTNGSHHGD TRIIRHAYGE
GREYVPFALR AQELWYELEK ETHHKIFTKT GVLVFGPKGE APFVAETMEA AKEHSLDVDL
LEGSEINKRW PGVTVPENYN AIFEKNSGVL FSENCIRAYR ELAEANGAKV LTYTPVEDFE
IAEDFVKIQT AYGSFTASKL IVSMGAWNSK LLSKLNIEIP LQPYRQVVGF FECDEKKYSN
THGYPAFMVE VPTGIYYGFP SFGGCGLKIG YHTYGQKIDP DTINREFGIY PEDEGNIRKF
LETYMPGATG ELKSGDVCMY TKTPDEHFVI DLHPQFSNVA IAAGFSGHGF KFSSVVGETL
SQLAVTGKTE HDISIFSINR PALKQKETI


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