Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Monothiol glutaredoxin-4

 GLRX4_SCHPO             Reviewed;         244 AA.
O74790;
19-JUL-2004, integrated into UniProtKB/Swiss-Prot.
01-NOV-1998, sequence version 1.
28-FEB-2018, entry version 121.
RecName: Full=Monothiol glutaredoxin-4;
Name=grx4; ORFNames=SPBC26H8.06;
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
Schizosaccharomycetes; Schizosaccharomycetales;
Schizosaccharomycetaceae; Schizosaccharomyces.
NCBI_TaxID=284812;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Kim H.-G., Lim C.-J.;
"Stress response of monothiol glutaredoxin genes from
Schizosaccharomyces pombe.";
Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=972 / ATCC 24843;
PubMed=11859360; DOI=10.1038/nature724;
Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M.,
Collins M., Connor R., Cronin A., Davis P., Feltwell T., Fraser A.,
Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G.,
Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K.,
James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J.,
Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C.,
Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E.,
Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S.,
Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K.,
Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S.,
Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B.,
Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S.,
Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D.,
Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R.,
Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B.,
Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S.,
Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M.,
Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G.,
Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J.,
Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L.,
Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J.,
Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.;
"The genome sequence of Schizosaccharomyces pombe.";
Nature 415:871-880(2002).
[3]
SUBCELLULAR LOCATION.
PubMed=15796926; DOI=10.1016/j.bbrc.2005.02.183;
Chung W.H., Kim K.D., Roe J.H.;
"Localization and function of three monothiol glutaredoxins in
Schizosaccharomyces pombe.";
Biochem. Biophys. Res. Commun. 330:604-610(2005).
[4]
INDUCTION.
PubMed=16175211; DOI=10.1139/w05-034;
Kim H.G., Kim B.C., Park E.H., Lim C.J.;
"Stress-dependent regulation of a monothiol glutaredoxin gene from
Schizosaccharomyces pombe.";
Can. J. Microbiol. 51:613-620(2005).
[5]
SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
PubMed=16823372; DOI=10.1038/nbt1222;
Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
Yoshida M.;
"ORFeome cloning and global analysis of protein localization in the
fission yeast Schizosaccharomyces pombe.";
Nat. Biotechnol. 24:841-847(2006).
[6]
INTERACTION WITH PHP4.
PubMed=19502236; DOI=10.1074/jbc.M109.009563;
Mercier A., Labbe S.;
"Both Php4 function and subcellular localization are regulated by iron
via a multistep mechanism involving the glutaredoxin Grx4 and the
exportin Crm1.";
J. Biol. Chem. 284:20249-20262(2009).
-!- FUNCTION: Monothiol glutaredoxin involved in the biogenesis of
iron-sulfur clusters (By similarity). Binds one iron-sulfur
cluster per dimer. The iron-sulfur cluster is bound between
subunits, and is complexed by a bound glutathione and a cysteine
residue from each subunit (By similarity). {ECO:0000250}.
-!- SUBUNIT: Homodimer (By similarity). Interacts with php4.
{ECO:0000250, ECO:0000269|PubMed:19502236}.
-!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
-!- SIMILARITY: Belongs to the glutaredoxin family. Monothiol
subfamily. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
EMBL; AY435094; AAR08197.1; -; Genomic_DNA.
EMBL; CU329671; CAA21098.1; -; Genomic_DNA.
PIR; T40018; T40018.
RefSeq; NP_596647.1; NM_001022569.2.
ProteinModelPortal; O74790; -.
SMR; O74790; -.
BioGrid; 277104; 9.
STRING; 4896.SPBC26H8.06.1; -.
MaxQB; O74790; -.
PaxDb; O74790; -.
PRIDE; O74790; -.
EnsemblFungi; SPBC26H8.06.1; SPBC26H8.06.1:pep; SPBC26H8.06.
GeneID; 2540578; -.
KEGG; spo:SPBC26H8.06; -.
EuPathDB; FungiDB:SPBC26H8.06; -.
PomBase; SPBC26H8.06; grx4.
HOGENOM; HOG000165751; -.
InParanoid; O74790; -.
OMA; CFAHANG; -.
OrthoDB; EOG092C3TIP; -.
PhylomeDB; O74790; -.
PRO; PR:O74790; -.
Proteomes; UP000002485; Chromosome II.
GO; GO:0005737; C:cytoplasm; IDA:PomBase.
GO; GO:0005829; C:cytosol; IDA:PomBase.
GO; GO:0005634; C:nucleus; IDA:PomBase.
GO; GO:0051537; F:2 iron, 2 sulfur cluster binding; IDA:PomBase.
GO; GO:0009055; F:electron transfer activity; IEA:InterPro.
GO; GO:0015038; F:glutathione disulfide oxidoreductase activity; IMP:PomBase.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0015035; F:protein disulfide oxidoreductase activity; IEA:InterPro.
GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
GO; GO:0006879; P:cellular iron ion homeostasis; IMP:PomBase.
GO; GO:0098869; P:cellular oxidant detoxification; IC:PomBase.
GO; GO:0051220; P:cytoplasmic sequestering of protein; IMP:PomBase.
GO; GO:1903026; P:negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; IMP:PomBase.
CDD; cd03028; GRX_PICOT_like; 1.
InterPro; IPR002109; Glutaredoxin.
InterPro; IPR033658; GRX_PICOT-like.
InterPro; IPR004480; Monothiol_GRX-rel.
InterPro; IPR036249; Thioredoxin-like_sf.
InterPro; IPR013766; Thioredoxin_domain.
PANTHER; PTHR10293; PTHR10293; 1.
Pfam; PF00462; Glutaredoxin; 1.
Pfam; PF00085; Thioredoxin; 1.
SUPFAM; SSF52833; SSF52833; 2.
TIGRFAMs; TIGR00365; TIGR00365; 1.
PROSITE; PS51354; GLUTAREDOXIN_2; 1.
PROSITE; PS51352; THIOREDOXIN_2; 1.
1: Evidence at protein level;
2Fe-2S; Complete proteome; Cytoplasm; Iron; Iron-sulfur;
Metal-binding; Nucleus; Redox-active center; Reference proteome.
CHAIN 1 244 Monothiol glutaredoxin-4.
/FTId=PRO_0000102253.
DOMAIN 2 106 Thioredoxin. {ECO:0000255|PROSITE-
ProRule:PRU00691}.
DOMAIN 147 244 Glutaredoxin. {ECO:0000255|PROSITE-
ProRule:PRU00686}.
REGION 201 205 Glutathione binding. {ECO:0000250}.
REGION 226 227 Glutathione binding. {ECO:0000250}.
METAL 172 172 Iron-sulfur (2Fe-2S); shared with dimeric
partner. {ECO:0000250}.
BINDING 164 164 Glutathione. {ECO:0000250}.
SEQUENCE 244 AA; 27099 MW; 63D9022435EB6385 CRC64;
MSVEITFVEQ FQEILQNGKE QIILLNFYAP WAAPCKQMNQ VFDQFAKDTK NAVFLKIEAE
KFSDIAESFD VNAVPLFVLI HGAKVLARIS GANPQKLKAA IDEYIQPLIS QISSTNASVE
TQVNSVQTTN TTSNTSKAPN GLDSELNERL STLTNAHNVM LFLKGTPSEP ACGFSRKLVG
LLREQNVQYG FFNILADDSV RQGLKVFSDW PTFPQLYIKG EFVGGLDIVS EMIENGELQE
MLPN


Related products :

Catalog number Product name Quantity
orb90120 Yeast Glutaredoxin 2 protein Glutaredoxin-2 Saccharamyces cerevisiae Recombinant conaining 6x His tag at C-terminus produced in E.coli is a single, non-glycosylated, Polypeptide chain having a molecul 10
orb90118 Yeast Glutaredoxin 1 protein Glutaredoxin Saccharamyces cerevisiae Recombinant conaining 6x His tag at C-Terminus produced in E.coli is a single, non-glycosylated, Polypeptide chain having a molecular 10
LF-MA0082 anti-Glutaredoxin 1 (30A1), Mouse monoclonal to Glutaredoxin 1, Isotype IgG1, Host Mouse 100 ul
orb90119 Human Glutaredoxin 2 protein Glutaredoxin-2 Human Recombinant produced in E.coli is a single, non-glycosylated, Polypeptide chain containing 154 amino acids (20-164 a.a.) and having a molecular mass o 5
orb90117 Human Glutaredoxin 1 protein Glutaredoxin Human Recombinant produced in E.coli is a single, non-glycosylated, Polypeptide chain containing 106 amino acids having a molecular mass of 11.7 kDa. For rese 10
PC-566 Glutaredoxin 1 100 uL
BC-340 Glutaredoxin 1 (Human) 0.1 mg
PC-566 Glutaredoxin 1 Poly 100 uL
BC-340 Glutaredoxin 1 (Human) 0.1 mg
MC-1028 Glutaredoxin 1 100 uL
RP17936130010 Glutaredoxin 1 10 µg
MC-1028 Glutaredoxin 1 100 uL
RP17936130050 Glutaredoxin 1 50 µg
RP17936160001 Glutaredoxin 1 1 mg
RP17939130010 Glutaredoxin 1 10 µg
RP17939130050 Glutaredoxin 1 50 µg
RP17939160001 Glutaredoxin 1 1 mg
RP17936030050 Glutaredoxin 2 50 µg
RP17936030010 Glutaredoxin 2 10 µg
RP17936060001 Glutaredoxin 2 1 mg
enz-391 Recombinant Human Glutaredoxin 1 1mg
enz-360 Recombinant Yeast Glutaredoxin 2 1mg
orb100395 Glutaredoxin 1 antibody 200 ug
enz-361 Recombinant Yeast Glutaredoxin 1 1mg
enz-130 Recombinant E.Coli Glutaredoxin-2 20


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur