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Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)

 Q7KPL1_DROME            Unreviewed;       745 AA.
Q7KPL1;
05-JUL-2004, integrated into UniProtKB/TrEMBL.
05-JUL-2004, sequence version 1.
12-SEP-2018, entry version 106.
RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
Name=Med {ECO:0000313|FlyBase:FBgn0011655};
Synonyms=Medea {ECO:0000313|EMBL:AAC62005.1};
ORFNames=CG1775 {ECO:0000313|FlyBase:FBgn0011655};
Drosophila melanogaster (Fruit fly).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
Ephydroidea; Drosophilidae; Drosophila; Sophophora.
NCBI_TaxID=7227 {ECO:0000313|EMBL:AAC62005.1};
[1] {ECO:0000313|EMBL:AAC62005.1}
NUCLEOTIDE SEQUENCE.
PubMed=9693372;
Inoue H., Imamura T., Ishidou Y., Takase M., Udagawa Y., Oka Y.,
Tsuneizumi K., Tabata T., Miyazono K., Kawabata M.;
"Interplay of signal mediators of decapentaplegic (Dpp): molecular
characterization of mothers against dpp, Medea, and daughters against
dpp.";
Mol. Biol. Cell 9:2145-2156(1998).
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
Nucleus {ECO:0000256|RuleBase:RU361195,
ECO:0000256|SAAS:SAAS00573677}.
-!- SIMILARITY: Belongs to the dwarfin/SMAD family.
{ECO:0000256|RuleBase:RU361195}.
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EMBL; AF057162; AAC62005.1; -; mRNA.
ProteinModelPortal; Q7KPL1; -.
PRIDE; Q7KPL1; -.
EnsemblMetazoa; FBtr0337030; FBpp0307959; FBgn0011655.
FlyBase; FBgn0011655; Med.
eggNOG; KOG3701; Eukaryota.
eggNOG; ENOG410XQKU; LUCA.
GeneTree; ENSGT00760000119091; -.
OrthoDB; EOG091G05Z9; -.
Reactome; R-DME-1181150; Signaling by NODAL.
Reactome; R-DME-1502540; Signaling by Activin.
Reactome; R-DME-201451; Signaling by BMP.
Reactome; R-DME-2173789; TGF-beta receptor signaling activates SMADs.
Reactome; R-DME-2173795; Downregulation of SMAD2/3:SMAD4 transcriptional activity.
Reactome; R-DME-2173796; SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.
Reactome; R-DME-5689880; Ub-specific processing proteases.
Reactome; R-DME-8941855; RUNX3 regulates CDKN1A transcription.
Bgee; FBgn0011655; Expressed in 35 organ(s), highest expression level in embryo.
ExpressionAtlas; Q7KPL1; baseline and differential.
GO; GO:0005737; C:cytoplasm; IDA:FlyBase.
GO; GO:0005634; C:nucleus; IPI:FlyBase.
GO; GO:0005667; C:transcription factor complex; IEA:InterPro.
GO; GO:0003677; F:DNA binding; TAS:FlyBase.
GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
GO; GO:0030616; F:transforming growth factor beta receptor, common-partner cytoplasmic mediator activity; NAS:FlyBase.
GO; GO:0030509; P:BMP signaling pathway; TAS:FlyBase.
GO; GO:0008283; P:cell proliferation; IMP:FlyBase.
GO; GO:0009950; P:dorsal/ventral axis specification; IMP:FlyBase.
GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:FlyBase.
GO; GO:0042078; P:germ-line stem cell division; IMP:FlyBase.
GO; GO:0030718; P:germ-line stem cell population maintenance; IMP:FlyBase.
GO; GO:0007507; P:heart development; TAS:FlyBase.
GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IMP:FlyBase.
GO; GO:0007476; P:imaginal disc-derived wing morphogenesis; IMP:FlyBase.
GO; GO:0045705; P:negative regulation of salivary gland boundary specification; TAS:FlyBase.
GO; GO:0048666; P:neuron development; IMP:FlyBase.
GO; GO:0030707; P:ovarian follicle cell development; IMP:FlyBase.
GO; GO:0045887; P:positive regulation of synaptic growth at neuromuscular junction; IMP:FlyBase.
GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:FlyBase.
GO; GO:0031290; P:retinal ganglion cell axon guidance; IMP:FlyBase.
GO; GO:0035019; P:somatic stem cell population maintenance; IMP:FlyBase.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IMP:FlyBase.
Gene3D; 2.60.200.10; -; 1.
Gene3D; 3.90.520.10; -; 1.
InterPro; IPR013790; Dwarfin.
InterPro; IPR003619; MAD_homology1_Dwarfin-type.
InterPro; IPR013019; MAD_homology_MH1.
InterPro; IPR017855; SMAD-like_dom_sf.
InterPro; IPR001132; SMAD_dom_Dwarfin-type.
InterPro; IPR008984; SMAD_FHA_dom_sf.
InterPro; IPR036578; SMAD_MH1_sf.
PANTHER; PTHR13703; PTHR13703; 1.
Pfam; PF03165; MH1; 1.
Pfam; PF03166; MH2; 1.
SMART; SM00523; DWA; 1.
SMART; SM00524; DWB; 1.
SUPFAM; SSF49879; SSF49879; 1.
SUPFAM; SSF56366; SSF56366; 1.
PROSITE; PS51075; MH1; 1.
PROSITE; PS51076; MH2; 1.
2: Evidence at transcript level;
Coiled coil {ECO:0000256|SAM:Coils};
Cytoplasm {ECO:0000256|RuleBase:RU361195};
DNA-binding {ECO:0000256|RuleBase:RU361195};
Nucleus {ECO:0000256|RuleBase:RU361195,
ECO:0000256|SAAS:SAAS00094706};
Transcription {ECO:0000256|RuleBase:RU361195,
ECO:0000256|SAAS:SAAS00464859};
Transcription regulation {ECO:0000256|RuleBase:RU361195,
ECO:0000256|SAAS:SAAS00464859}.
DOMAIN 20 144 MH1. {ECO:0000259|PROSITE:PS51075}.
DOMAIN 520 745 MH2. {ECO:0000259|PROSITE:PS51076}.
COILED 39 66 {ECO:0000256|SAM:Coils}.
COILED 327 350 {ECO:0000256|SAM:Coils}.
SEQUENCE 745 AA; 79086 MW; AA02AA6D8E0AB1A1 CRC64;
MVQMPPPPSN APTSADACLS IVHSLMCHRQ GGESEGFAKR AIESLVKKLK EKRDELDSLI
TAITTNGAHP SKCVTIQRTL DGRLQVAGRK GFPHVIYARI WRWPDLHKNE LKHVKYCAFA
FDLKCDSVCV NPYHYERVVS PGIDLSGLSL QSGPSRLVKD EYSAGPLVGS MDIDGNDIGT
IQHHPTQMVG PGGYGYPQGP SEYVGDANPM SAMFPTGRTI PKIEPQDGVA GSRGSWMVPP
PPRLGQPPQQ QQQQPQQQTP QPTQQQQAQS QAAAHSLPVP HGMPGMPGPM NPGPVMAPPP
PPQQAQNPQG NGVHHTQANS PTDPASALAM QQQQQQQQQQ QQQQQQQQQQ SGGVPNGSVN
AGGGAAAGGQ YYGQPPPVSQ MQGAGGGGTS VAPSVHAQQN GYVSQPGSAG SAPVGGGGVF
GTAQPTPQQP QQPPTGVQAN TGSAGAQAGA GGGAAGTWTG PNTLTYTQSM QPPDPRSLPG
GFWNSSLSGD LGSPQQTPPQ QQQQQQQPRL LSRQPPPEYW CSIAYFELDT QVGETFKVPS
AKPNVIIDGY VDPSGGNRFC LGALSNVHRT EQSERARLHI GKGVQLDLRG EGDVWLRCLS
DNSVFVQSYY LDREAGRTPG DAVHKIYPAA CIKVFDLRQC HQQMHSLATN AQAAAAAQAA
AVAGVANQQM GGGGRSMTAA AGIGVDDLRR LCILRLSFVK GWGPDYPRQS IKETPCWIEV
HLHRALQLLD EVLHAMPIDG PRAAA


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