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Mothers against decapentaplegic homolog (MAD homolog) (Mothers against DPP homolog) (SMAD family member)

 W5P3J1_SHEEP            Unreviewed;       553 AA.
W5P3J1;
16-APR-2014, integrated into UniProtKB/TrEMBL.
16-APR-2014, sequence version 1.
25-OCT-2017, entry version 25.
RecName: Full=Mothers against decapentaplegic homolog {ECO:0000256|RuleBase:RU361195};
Short=MAD homolog {ECO:0000256|RuleBase:RU361195};
Short=Mothers against DPP homolog {ECO:0000256|RuleBase:RU361195};
AltName: Full=SMAD family member {ECO:0000256|RuleBase:RU361195};
Name=SMAD4 {ECO:0000313|Ensembl:ENSOARP00000004992};
Ovis aries (Sheep).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
Pecora; Bovidae; Caprinae; Ovis.
NCBI_TaxID=9940 {ECO:0000313|Ensembl:ENSOARP00000004992, ECO:0000313|Proteomes:UP000002356};
[1] {ECO:0000313|Ensembl:ENSOARP00000004992, ECO:0000313|Proteomes:UP000002356}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Texel {ECO:0000313|Ensembl:ENSOARP00000004992};
PubMed=20809919; DOI=10.1111/j.1365-2052.2010.02100.x;
Archibald A.L., Cockett N.E., Dalrymple B.P., Faraut T., Kijas J.W.,
Maddox J.F., McEwan J.C., Hutton Oddy V., Raadsma H.W., Wade C.,
Wang J., Wang W., Xun X.;
"The sheep genome reference sequence: a work in progress.";
Anim. Genet. 41:449-453(2010).
[2] {ECO:0000313|Ensembl:ENSOARP00000004992}
IDENTIFICATION.
Ensembl;
Submitted (FEB-2014) to UniProtKB.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU361195}.
Nucleus {ECO:0000256|RuleBase:RU361195}.
-!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|SAAS:SAAS00573677}.
-!- SIMILARITY: Belongs to the dwarfin/SMAD family.
{ECO:0000256|RuleBase:RU361195}.
-!- CAUTION: The sequence shown here is derived from an Ensembl
automatic analysis pipeline and should be considered as
preliminary data. {ECO:0000313|Ensembl:ENSOARP00000004992}.
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EMBL; AMGL01067217; -; NOT_ANNOTATED_CDS; Genomic_DNA.
Ensembl; ENSOART00000005077; ENSOARP00000004992; ENSOARG00000004662.
GeneTree; ENSGT00760000119091; -.
OMA; DIGTIQH; -.
OrthoDB; EOG091G05Z9; -.
Proteomes; UP000002356; Chromosome 23.
GO; GO:0032444; C:activin responsive factor complex; IEA:Ensembl.
GO; GO:0005813; C:centrosome; IEA:Ensembl.
GO; GO:0005829; C:cytosol; IEA:Ensembl.
GO; GO:0000790; C:nuclear chromatin; IEA:Ensembl.
GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
GO; GO:0071141; C:SMAD protein complex; IEA:Ensembl.
GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
GO; GO:0005518; F:collagen binding; IEA:Ensembl.
GO; GO:0070411; F:I-SMAD binding; IEA:Ensembl.
GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
GO; GO:0070412; F:R-SMAD binding; IEA:Ensembl.
GO; GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IEA:Ensembl.
GO; GO:0001085; F:RNA polymerase II transcription factor binding; IEA:Ensembl.
GO; GO:0043199; F:sulfate binding; IEA:Ensembl.
GO; GO:0001076; F:transcription factor activity, RNA polymerase II transcription factor binding; IEA:Ensembl.
GO; GO:0001077; F:transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding; IEA:Ensembl.
GO; GO:0030616; F:transforming growth factor beta receptor, common-partner cytoplasmic mediator activity; IEA:Ensembl.
GO; GO:0036302; P:atrioventricular canal development; IEA:Ensembl.
GO; GO:0003190; P:atrioventricular valve formation; IEA:Ensembl.
GO; GO:0007411; P:axon guidance; IEA:Ensembl.
GO; GO:0030509; P:BMP signaling pathway; IEA:Ensembl.
GO; GO:0003360; P:brainstem development; IEA:Ensembl.
GO; GO:0001658; P:branching involved in ureteric bud morphogenesis; IEA:Ensembl.
GO; GO:0008283; P:cell proliferation; IEA:Ensembl.
GO; GO:0006879; P:cellular iron ion homeostasis; IEA:Ensembl.
GO; GO:0048589; P:developmental growth; IEA:Ensembl.
GO; GO:0042733; P:embryonic digit morphogenesis; IEA:Ensembl.
GO; GO:0060956; P:endocardial cell differentiation; IEA:Ensembl.
GO; GO:0007492; P:endoderm development; IEA:Ensembl.
GO; GO:0042118; P:endothelial cell activation; IEA:Ensembl.
GO; GO:0003198; P:epithelial to mesenchymal transition involved in endocardial cushion formation; IEA:Ensembl.
GO; GO:0061040; P:female gonad morphogenesis; IEA:Ensembl.
GO; GO:0048859; P:formation of anatomical boundary; IEA:Ensembl.
GO; GO:0001702; P:gastrulation with mouth forming second; IEA:Ensembl.
GO; GO:0001701; P:in utero embryonic development; IEA:Ensembl.
GO; GO:0070102; P:interleukin-6-mediated signaling pathway; IEA:Ensembl.
GO; GO:0035556; P:intracellular signal transduction; IEA:Ensembl.
GO; GO:0003220; P:left ventricular cardiac muscle tissue morphogenesis; IEA:Ensembl.
GO; GO:0007498; P:mesoderm development; IEA:Ensembl.
GO; GO:0072133; P:metanephric mesenchyme morphogenesis; IEA:Ensembl.
GO; GO:0010614; P:negative regulation of cardiac muscle hypertrophy; IEA:Ensembl.
GO; GO:1905305; P:negative regulation of cardiac myofibril assembly; IEA:Ensembl.
GO; GO:0060548; P:negative regulation of cell death; IEA:Ensembl.
GO; GO:0030308; P:negative regulation of cell growth; IEA:Ensembl.
GO; GO:0008285; P:negative regulation of cell proliferation; IEA:Ensembl.
GO; GO:0070373; P:negative regulation of ERK1 and ERK2 cascade; IEA:Ensembl.
GO; GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Ensembl.
GO; GO:0072134; P:nephrogenic mesenchyme morphogenesis; IEA:Ensembl.
GO; GO:0014033; P:neural crest cell differentiation; IEA:Ensembl.
GO; GO:0048663; P:neuron fate commitment; IEA:Ensembl.
GO; GO:0003148; P:outflow tract septum morphogenesis; IEA:Ensembl.
GO; GO:0001541; P:ovarian follicle development; IEA:Ensembl.
GO; GO:0060021; P:palate development; IEA:Ensembl.
GO; GO:0030513; P:positive regulation of BMP signaling pathway; IEA:Ensembl.
GO; GO:0003251; P:positive regulation of cell proliferation involved in heart valve morphogenesis; IEA:Ensembl.
GO; GO:0010718; P:positive regulation of epithelial to mesenchymal transition; IEA:Ensembl.
GO; GO:0046881; P:positive regulation of follicle-stimulating hormone secretion; IEA:Ensembl.
GO; GO:0051571; P:positive regulation of histone H3-K4 methylation; IEA:Ensembl.
GO; GO:2000617; P:positive regulation of histone H3-K9 acetylation; IEA:Ensembl.
GO; GO:0033686; P:positive regulation of luteinizing hormone secretion; IEA:Ensembl.
GO; GO:0010862; P:positive regulation of pathway-restricted SMAD protein phosphorylation; IEA:Ensembl.
GO; GO:0060391; P:positive regulation of SMAD protein import into nucleus; IEA:Ensembl.
GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
GO; GO:0070207; P:protein homotrimerization; IEA:Ensembl.
GO; GO:0051098; P:regulation of binding; IEA:Ensembl.
GO; GO:0051797; P:regulation of hair follicle development; IEA:Ensembl.
GO; GO:0032909; P:regulation of transforming growth factor beta2 production; IEA:Ensembl.
GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
GO; GO:0048733; P:sebaceous gland development; IEA:Ensembl.
GO; GO:0072520; P:seminiferous tubule development; IEA:Ensembl.
GO; GO:0007338; P:single fertilization; IEA:Ensembl.
GO; GO:0007183; P:SMAD protein complex assembly; IEA:Ensembl.
GO; GO:0060395; P:SMAD protein signal transduction; IEA:Ensembl.
GO; GO:0032525; P:somite rostral/caudal axis specification; IEA:Ensembl.
GO; GO:0007283; P:spermatogenesis; IEA:Ensembl.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
GO; GO:0060065; P:uterus development; IEA:Ensembl.
GO; GO:0060412; P:ventricular septum morphogenesis; IEA:Ensembl.
Gene3D; 2.60.200.10; -; 1.
Gene3D; 3.90.520.10; -; 1.
InterPro; IPR013790; Dwarfin.
InterPro; IPR003619; MAD_homology1_Dwarfin-type.
InterPro; IPR013019; MAD_homology_MH1.
InterPro; IPR017855; SMAD_dom-like.
InterPro; IPR001132; SMAD_dom_Dwarfin-type.
InterPro; IPR008984; SMAD_FHA_domain.
InterPro; IPR036578; SMAD_MH1_sf.
PANTHER; PTHR13703; PTHR13703; 1.
Pfam; PF03165; MH1; 1.
Pfam; PF03166; MH2; 1.
SMART; SM00523; DWA; 1.
SMART; SM00524; DWB; 1.
SUPFAM; SSF49879; SSF49879; 1.
SUPFAM; SSF56366; SSF56366; 1.
PROSITE; PS51075; MH1; 1.
PROSITE; PS51076; MH2; 1.
3: Inferred from homology;
Coiled coil {ECO:0000256|SAM:Coils};
Complete proteome {ECO:0000313|Proteomes:UP000002356};
Cytoplasm {ECO:0000256|RuleBase:RU361195};
DNA-binding {ECO:0000256|RuleBase:RU361195};
Nucleus {ECO:0000256|RuleBase:RU361195,
ECO:0000256|SAAS:SAAS00094706};
Reference proteome {ECO:0000313|Proteomes:UP000002356};
Transcription {ECO:0000256|RuleBase:RU361195,
ECO:0000256|SAAS:SAAS00464859};
Transcription regulation {ECO:0000256|RuleBase:RU361195,
ECO:0000256|SAAS:SAAS00464859}.
DOMAIN 18 142 MH1. {ECO:0000259|PROSITE:PS51075}.
DOMAIN 324 553 MH2. {ECO:0000259|PROSITE:PS51076}.
COILED 37 64 {ECO:0000256|SAM:Coils}.
SEQUENCE 553 AA; 60585 MW; 67A9A71033C433B7 CRC64;
MDNMSITNTP TSNDACLSIV HSLMCHRQGG ESETFAKRAI ESLVKKLKEK KDELDSLITA
ITTNGAHPSK CVTIQRTLDG RLQVAGRKGF PHVIYARLWR WPDLHKNELK HVKYCQYAFD
LKCDSVCVNP YHYERVVSPG IDLSGLTLQS NAPPSMLVKD EYVHDFEGQP SLSTEGHSIQ
TIQHPPSNRA STETYSTPAL LAPSESNATS TTNFPNIPVA STSQPASILA ASHSKGLLQI
ASGPQPGQQQ NGFTGQPATY HHNSTTTWTG SRTAPYTPNL PHHQNGHLQH HPPMPPHPGH
YWPPVHNELA FQPPISNHPA PEYWCSIAYF EMDVQVGETF KVPSSCPIVT VDGYVDPSGG
DRFCLGQLSN VHRTEAIERA RLHIGKGVQL ECKGEGDVWV RCLSDHAVFV QSYYLDREAG
RAPGDAVHKI YPSAYIKVFD LRQCHRQMQQ QAATAQAAAA AQAAAVAGNI PGPGSVGGIA
PAISLSAAAG IGVDDLRRLC ILRMSFVKGW GPDYPRQSIK ETPCWIEIHL HRALQLLDEV
LHTMPIADPQ PLD


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