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Mothers against decapentaplegic homolog 5 (MAD homolog 5) (Mothers against DPP homolog 5) (Protein somitabun) (SMAD family member 5) (SMAD 5) (Smad5)

 SMAD5_DANRE             Reviewed;         464 AA.
Q9W7E7;
27-MAY-2002, integrated into UniProtKB/Swiss-Prot.
01-NOV-1999, sequence version 1.
05-DEC-2018, entry version 143.
RecName: Full=Mothers against decapentaplegic homolog 5;
Short=MAD homolog 5;
Short=Mothers against DPP homolog 5;
AltName: Full=Protein somitabun;
AltName: Full=SMAD family member 5;
Short=SMAD 5;
Short=Smad5;
Name=smad5; Synonyms=madh5, sbn;
Danio rerio (Zebrafish) (Brachydanio rerio).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
Cyprinidae; Danio.
NCBI_TaxID=7955;
[1]
NUCLEOTIDE SEQUENCE [MRNA], VARIANT ILE-429, FUNCTION, AND
DEVELOPMENTAL STAGE.
TISSUE=Embryo;
PubMed=10207140;
Hild M., Dick A., Rauch G.J., Meier A., Bouwmeester T., Haffter P.,
Hammerschmidt M.;
"The smad5 mutation somitabun blocks Bmp2b signaling during early
dorsoventral patterning of the zebrafish embryo.";
Development 126:2149-2159(1999).
[2]
NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
TISSUE=Embryo;
PubMed=10525190; DOI=10.1016/S0925-4773(99)00173-2;
Mueller F., Blader P., Rastegar S., Fischer N., Knoechel W.,
Straehle U.;
"Characterization of zebrafish smad1, smad2 and smad5: the amino-
terminus of Smad1 and Smad5 is required for specific function in the
embryo.";
Mech. Dev. 88:73-88(1999).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Embryo;
NIH - Zebrafish Gene Collection (ZGC) project;
Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
[4]
FUNCTION.
PubMed=10590480;
DOI=10.1002/(SICI)1097-0177(199911)216:3<285::AID-DVDY7>3.0.CO;2-L;
Dick A., Meier A., Hammerschmidt M.;
"Smad1 and smad5 have distinct roles during dorsoventral patterning of
the zebrafish embryo.";
Dev. Dyn. 216:285-298(1999).
-!- FUNCTION: Involved in ventralization. May mediate Bmp2b signaling
during early phases of embryonic dorsal-ventral pattern formation.
Required for initiation of Smad1 expression during gastrulation.
{ECO:0000269|PubMed:10207140, ECO:0000269|PubMed:10590480}.
-!- SUBUNIT: May form trimers with the co-SMAD SMAD4. {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
{ECO:0000250}. Note=In the cytoplasm in the absence of ligand.
Migration to the nucleus when complexed with SMAD4 (By
similarity). {ECO:0000250}.
-!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
Uniform distribution at the cleavage, blastula, gastrula and early
somitogenesis stages. Levels decline during the early gastrula
stages. At 26 hours, still expressed in the head, forming gut and
dorsal neural tube. {ECO:0000269|PubMed:10207140,
ECO:0000269|PubMed:10525190}.
-!- SIMILARITY: Belongs to the dwarfin/SMAD family. {ECO:0000305}.
-----------------------------------------------------------------------
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EMBL; AF127920; AAD43904.1; -; mRNA.
EMBL; AF168775; AAF06738.1; -; mRNA.
EMBL; BC065644; AAH65644.1; -; mRNA.
RefSeq; NP_001333238.1; NM_001346309.1.
RefSeq; NP_571443.3; NM_131368.3.
RefSeq; XP_005173221.1; XM_005173164.3.
RefSeq; XP_009289292.1; XM_009291017.2.
UniGene; Dr.75335; -.
ProteinModelPortal; Q9W7E7; -.
SMR; Q9W7E7; -.
STRING; 7955.ENSDARP00000054174; -.
PaxDb; Q9W7E7; -.
Ensembl; ENSDART00000054175; ENSDARP00000054174; ENSDARG00000037238.
Ensembl; ENSDART00000183347; ENSDARP00000155132; ENSDARG00000037238.
Ensembl; ENSDART00000187280; ENSDARP00000153815; ENSDARG00000037238.
Ensembl; ENSDART00000191084; ENSDARP00000149901; ENSDARG00000037238.
Ensembl; ENSDART00000191143; ENSDARP00000154529; ENSDARG00000037238.
GeneID; 30641; -.
KEGG; dre:30641; -.
CTD; 4090; -.
ZFIN; ZDB-GENE-990603-9; smad5.
eggNOG; KOG3701; Eukaryota.
eggNOG; ENOG410XQKU; LUCA.
GeneTree; ENSGT00940000155437; -.
HOGENOM; HOG000286018; -.
HOVERGEN; HBG053353; -.
InParanoid; Q9W7E7; -.
KO; K16790; -.
OMA; DVQPVEY; -.
OrthoDB; EOG091G082C; -.
PhylomeDB; Q9W7E7; -.
TreeFam; TF314923; -.
PRO; PR:Q9W7E7; -.
Proteomes; UP000000437; Chromosome 14.
Bgee; ENSDARG00000037238; Expressed in 31 organ(s), highest expression level in mature ovarian follicle.
ExpressionAtlas; Q9W7E7; baseline and differential.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
GO; GO:0005667; C:transcription factor complex; IEA:InterPro.
GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0046982; F:protein heterodimerization activity; IDA:ZFIN.
GO; GO:0044212; F:transcription regulatory region DNA binding; IDA:ZFIN.
GO; GO:0048514; P:blood vessel morphogenesis; IGI:ZFIN.
GO; GO:0030509; P:BMP signaling pathway; IMP:UniProtKB.
GO; GO:0007368; P:determination of left/right symmetry; IMP:ZFIN.
GO; GO:0048264; P:determination of ventral identity; IDA:ZFIN.
GO; GO:0060030; P:dorsal convergence; IMP:ZFIN.
GO; GO:0009953; P:dorsal/ventral pattern formation; IMP:ZFIN.
GO; GO:0003143; P:embryonic heart tube morphogenesis; IMP:ZFIN.
GO; GO:0009880; P:embryonic pattern specification; IMP:UniProtKB.
GO; GO:0060022; P:hard palate development; IMP:ZFIN.
GO; GO:0001947; P:heart looping; IMP:ZFIN.
GO; GO:0001945; P:lymph vessel development; IMP:ZFIN.
GO; GO:0043049; P:otic placode formation; IEP:ZFIN.
GO; GO:0060037; P:pharyngeal system development; IMP:ZFIN.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:ZFIN.
GO; GO:0036342; P:post-anal tail morphogenesis; IMP:ZFIN.
GO; GO:0048922; P:posterior lateral line neuromast deposition; IMP:ZFIN.
GO; GO:0048919; P:posterior lateral line neuromast development; IMP:ZFIN.
GO; GO:2000223; P:regulation of BMP signaling pathway involved in heart jogging; IMP:ZFIN.
GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
GO; GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:InterPro.
Gene3D; 2.60.200.10; -; 1.
Gene3D; 3.90.520.10; -; 1.
InterPro; IPR013790; Dwarfin.
InterPro; IPR003619; MAD_homology1_Dwarfin-type.
InterPro; IPR013019; MAD_homology_MH1.
InterPro; IPR017855; SMAD-like_dom_sf.
InterPro; IPR001132; SMAD_dom_Dwarfin-type.
InterPro; IPR008984; SMAD_FHA_dom_sf.
InterPro; IPR036578; SMAD_MH1_sf.
PANTHER; PTHR13703; PTHR13703; 1.
Pfam; PF03165; MH1; 1.
Pfam; PF03166; MH2; 1.
SMART; SM00523; DWA; 1.
SMART; SM00524; DWB; 1.
SUPFAM; SSF49879; SSF49879; 1.
SUPFAM; SSF56366; SSF56366; 1.
PROSITE; PS51075; MH1; 1.
PROSITE; PS51076; MH2; 1.
2: Evidence at transcript level;
Complete proteome; Cytoplasm; Developmental protein; DNA-binding;
Metal-binding; Nucleus; Polymorphism; Reference proteome;
Transcription; Transcription regulation; Zinc.
CHAIN 1 464 Mothers against decapentaplegic homolog
5.
/FTId=PRO_0000090868.
DOMAIN 13 137 MH1. {ECO:0000255|PROSITE-
ProRule:PRU00438}.
DOMAIN 270 464 MH2. {ECO:0000255|PROSITE-
ProRule:PRU00439}.
COMPBIAS 40 46 Poly-Lys.
COMPBIAS 187 231 Pro-rich.
METAL 65 65 Zinc. {ECO:0000250}.
METAL 110 110 Zinc. {ECO:0000250}.
METAL 122 122 Zinc. {ECO:0000250}.
METAL 127 127 Zinc. {ECO:0000250}.
VARIANT 429 429 T -> I (in allele DTC24; dorsalized
embryos). {ECO:0000269|PubMed:10207140}.
SEQUENCE 464 AA; 51861 MW; 5018387FBA4072DC CRC64;
MTSMSSLFSF TSPAVKRLLG WKQGDEEEKW AEKAVDALVK KLKKKKGAME DLEKALSSPG
QPSKCVTIPR SLDGRLQVSH RKGLPHVIYC RVWRWPDLQS HHELKPLEVC EYPFGSKQKE
VCINPYHYKR VESPVLPPVL VPRHSEFNPQ HSLLVQFRNL SHNEPHMPLN ATFPESFQQH
SGGSSFPISP NSPYPPSPAS SGTYPNSPAS SGPSSPFQLP ADTPPPAYMP PDEQMGQDGS
QSMETGSSLA PQNMPRGDVQ PVEYQEPSHW CSIVYYELNN RVGEAYHASS TSVLVDGFTD
PSNNKNRFCL GLLSNVNRNS TIENTRRHIG KGVHLYYVGG EVYAECLSDT SIFVQSRNCN
YHHGFHPTTV CKIPSGCSLK IFNNQEFAQL LAQSVNHGFE AVYELTKMCT IRMSFVKGWG
AEYHRQDVTS TPCWIEVHLH GPLQWLDKVL TQMGSPLNPI SSVS


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