GENTAUR Molecular Products.

 MNX1_MOUSE              Reviewed;         404 AA.
 Q9QZW9; E9QPC0;
 15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
 27-JUL-2011, sequence version 2.
 12-SEP-2018, entry version 132.
 RecName: Full=Motor neuron and pancreas homeobox protein 1;
 AltName: Full=Homeobox protein HB9;
 Name=Mnx1; Synonyms=Hlxb9;
 Mus musculus (Mouse).
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
 Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
 Muroidea; Muridae; Murinae; Mus; Mus.
 NCBI_TaxID=10090;
 [1]
 NUCLEOTIDE SEQUENCE [MRNA].
 STRAIN=Swiss Webster / NIH;
 PubMed=10471502; DOI=10.1038/12674;
 Harrison K.A., Thaler J., Pfaff S.L., Gu H., Kehrl J.H.;
 "Pancreas dorsal lobe agenesis and abnormal islets of Langerhans in
 Hlxb9-deficient mice.";
 Nat. Genet. 23:71-75(1999).
 [2]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
 STRAIN=C57BL/6J;
 PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
 Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S.,
 She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W.,
 Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T.,
 Zhou S., Teague B., Potamousis K., Churas C., Place M., Herschleb J.,
 Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z.,
 Lindblad-Toh K., Eichler E.E., Ponting C.P.;
 "Lineage-specific biology revealed by a finished genome assembly of
 the mouse.";
 PLoS Biol. 7:E1000112-E1000112(2009).
 -!- FUNCTION: Putative transcription factor involved in pancreas
     development and function.
 -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-
     ProRule:PRU00108}.
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 EMBL; AF153046; AAD49613.1; -; mRNA.
 EMBL; AC164700; -; NOT_ANNOTATED_CDS; Genomic_DNA.
 CCDS; CCDS19150.1; -.
 UniGene; Mm.103760; -.
 ProteinModelPortal; Q9QZW9; -.
 SMR; Q9QZW9; -.
 STRING; 10090.ENSMUSP00000129503; -.
 iPTMnet; Q9QZW9; -.
 PhosphoSitePlus; Q9QZW9; -.
 MaxQB; Q9QZW9; -.
 PaxDb; Q9QZW9; -.
 PRIDE; Q9QZW9; -.
 Ensembl; ENSMUST00000001608; ENSMUSP00000001608; ENSMUSG00000001566.
 MGI; MGI:109160; Mnx1.
 eggNOG; KOG0489; Eukaryota.
 eggNOG; ENOG410ZTBY; LUCA.
 GeneTree; ENSGT00910000144024; -.
 HOGENOM; HOG000234345; -.
 HOVERGEN; HBG051910; -.
 InParanoid; Q9QZW9; -.
 OrthoDB; EOG091G0PFO; -.
 PRO; PR:Q9QZW9; -.
 Proteomes; UP000000589; Chromosome 5.
 Bgee; ENSMUSG00000001566; Expressed in 39 organ(s), highest expression level in thymus.
 CleanEx; MM_MNX1; -.
 ExpressionAtlas; Q9QZW9; baseline and differential.
 Genevisible; Q9QZW9; MM.
 GO; GO:0005829; C:cytosol; ISO:MGI.
 GO; GO:0005730; C:nucleolus; ISO:MGI.
 GO; GO:0005634; C:nucleus; IDA:MGI.
 GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
 GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
 GO; GO:0048667; P:cell morphogenesis involved in neuron differentiation; IMP:MGI.
 GO; GO:0021953; P:central nervous system neuron differentiation; IMP:MGI.
 GO; GO:0060539; P:diaphragm development; IMP:MGI.
 GO; GO:0021904; P:dorsal/ventral neural tube patterning; IDA:MGI.
 GO; GO:0031018; P:endocrine pancreas development; IMP:MGI.
 GO; GO:0008045; P:motor neuron axon guidance; IMP:MGI.
 GO; GO:0021675; P:nerve development; IMP:MGI.
 GO; GO:0030182; P:neuron differentiation; IMP:MGI.
 GO; GO:0001764; P:neuron migration; IMP:MGI.
 GO; GO:0048812; P:neuron projection morphogenesis; IMP:MGI.
 GO; GO:0031016; P:pancreas development; IMP:MGI.
 GO; GO:0009791; P:post-embryonic development; IMP:MGI.
 GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
 GO; GO:0060541; P:respiratory system development; IMP:MGI.
 GO; GO:0021520; P:spinal cord motor neuron cell fate specification; IMP:MGI.
 GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
 CDD; cd00086; homeodomain; 1.
 InterPro; IPR009057; Homeobox-like_sf.
 InterPro; IPR017970; Homeobox_CS.
 InterPro; IPR001356; Homeobox_dom.
 InterPro; IPR020479; Homeobox_metazoa.
 Pfam; PF00046; Homeobox; 1.
 PRINTS; PR00024; HOMEOBOX.
 SMART; SM00389; HOX; 1.
 SUPFAM; SSF46689; SSF46689; 1.
 PROSITE; PS00027; HOMEOBOX_1; 1.
 PROSITE; PS50071; HOMEOBOX_2; 1.
 2: Evidence at transcript level;
 Acetylation; Complete proteome; DNA-binding; Homeobox; Nucleus;
 Phosphoprotein; Reference proteome; Transcription;
 Transcription regulation.
 CHAIN         1    404       Motor neuron and pancreas homeobox
                              protein 1.
                              /FTId=PRO_0000048906.
 DNA_BIND    241    300       Homeobox. {ECO:0000255|PROSITE-
                              ProRule:PRU00108}.
 COMPBIAS     40     50       Poly-Gly.
 COMPBIAS     99    105       Poly-Gly.
 COMPBIAS    121    134       Poly-Ala.
 COMPBIAS    168    176       Poly-Ala.
 COMPBIAS    315    324       Poly-Gly.
 MOD_RES       1      1       N-acetylmethionine.
                              {ECO:0000250|UniProtKB:P50219}.
 MOD_RES      78     78       Phosphoserine.
                              {ECO:0000250|UniProtKB:P50219}.
 MOD_RES      80     80       Phosphoserine.
                              {ECO:0000250|UniProtKB:P50219}.
 CONFLICT    232    232       E -> Q (in Ref. 1; AAD49613).
                              {ECO:0000305}.
 SEQUENCE   404 AA;  41331 MW;  1D2B56CD645DB50A CRC64;
 MEKSKNFRID ALLAVDPPRA ASTQSAPLAL VTSLATTVSG PGRGGSGGGG TSSGASRSCS
 PASSEATAAP GDRLRAESPS PPRLLAAHCA LLPKPGFLGA GGGGGAAGGP GTPHHHAHPG
 AAAAAAAAAA AAAAGGLALG LHPGGAQGGA GLPAQAALYG HPVYSYSAAA AAAALAGQHP
 ALSYSYPQVQ GAHPAHPADP IKLGASTFQL DQWLRASTAG MILPKMPDFS CEAQSNLLGK
 CRRPRTAFTS QQLLELEHQF KLNKYLSRPK RFEVATSLML TETQVKIWFQ NRRMKWKRSK
 KAKEQAAQEA EKQKGGGGGT GKGGSEEKTE EELMGPPVSG DKASGRRLRD LRDSDPDEDE
 DDEEEDNFPY SNGAGAHAAS SDCSSEDDSP PPRLGGPGHQ PLPQ

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