Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Mu-cyrtautoxin-As1a (Mu-CUTX-As1a) (Aptotoxin III) (Aps III) (Aptotoxin-3) (Aps-3) (Paralytic peptide III) (PP III)

 TXP3_APOSC              Reviewed;          37 AA.
P49268;
01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
01-FEB-1996, sequence version 1.
05-JUL-2017, entry version 66.
RecName: Full=Mu-cyrtautoxin-As1a;
Short=Mu-CUTX-As1a;
AltName: Full=Aptotoxin III {ECO:0000303|PubMed:23473802};
Short=Aps III {ECO:0000303|PubMed:23473802};
AltName: Full=Aptotoxin-3;
Short=Aps-3;
AltName: Full=Paralytic peptide III;
Short=PP III;
Apomastus schlingeri (Trap-door spider) (Aptostichus schlingeri).
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
Araneae; Mygalomorphae; Euctenizidae; Apomastus.
NCBI_TaxID=12944;
[1]
PROTEIN SEQUENCE, BIOASSAY, AND LETHAL DOSE.
TISSUE=Venom;
PubMed=1440641; DOI=10.1016/0041-0101(92)90049-B;
Skinner W.S., Dennis P.A., Li J.P., Quistad G.B.;
"Identification of insecticidal peptides from venom of the trap-door
spider, Aptostichus schlingeri (Ctenizidae).";
Toxicon 30:1043-1050(1992).
[2]
FUNCTION, STRUCTURE BY NMR, AND DISULFIDE BONDS.
PubMed=23473802; DOI=10.1016/j.bcp.2013.02.030;
Bende N.S., Kang E., Herzig V., Bosmans F., Nicholson G.M., Mobli M.,
King G.F.;
"The insecticidal neurotoxin Aps III is an atypical knottin peptide
that potently blocks insect voltage-gated sodium channels.";
Biochem. Pharmacol. 85:1542-1554(2013).
-!- FUNCTION: The recombinant mu-cyrtautoxin-As1a potently and
voltage-independently blocks voltage-gated sodium channels (Nav)
of insects. It acts by pluging the outer vestibule of the channel.
It acts in combination with a weak (30%) voltage-independent block
of insect voltage-gated calcium (Cav) channels (low-voltage and
high-voltage channels). Tested on DUM neurons, it inhibits sodium
currents with an IC(50) of 540 nM (and a Hill coefficient >1,
reflecting an incomplete block at higher concentrations). It
induces flaccid paralysis in adult Australian sheep blowfly
Lucilia cuprina (PubMed:23473802). Is both paralytic and lethal,
when injected into lepidopteran larvae. Is a slower acting toxin,
being lethal at 24 hours, but not paralytic at 1 hour post-
injection (PubMed:1440641). {ECO:0000269|PubMed:1440641,
ECO:0000269|PubMed:23473802}.
-!- SUBCELLULAR LOCATION: Secreted.
-!- TISSUE SPECIFICITY: Expressed by the venom gland.
-!- DOMAIN: The presence of a 'disulfide through disulfide knot'
structurally defines this protein as a knottin.
-!- TOXIC DOSE: LD(50) is 133 pmol/g against the tobacco hornworm
Manduca sexta (PubMed:1440641) and more than 2.66 pmol/g against
the beet armyworm Spodoptera exigua (PubMed:1440641).
{ECO:0000269|PubMed:1440641}.
-!- TOXIC DOSE: PD(50) measured 24h after injection in adult
Australian sheep blowfly Lucilia cuprina is 700 +- 35 pmol/g.
{ECO:0000269|PubMed:1440641, ECO:0000269|PubMed:23473802}.
-!- MISCELLANEOUS: Does not modulate the activity of delayed-
rectifier, "A-type" or BKCa potassium channels.
{ECO:0000305|PubMed:23473802}.
-!- SIMILARITY: Belongs to the insecticidal toxin ABC family. Aps III
subfamily. {ECO:0000305}.
-!- CAUTION: No comparison between the natural toxin and the
recombinant one has been done to attest that the results can be
also attributed to the natural toxin (mode of action and disulfide
bonds). {ECO:0000305|PubMed:23473802}.
-!- WEB RESOURCE: Name=Biological Magnetic Resonance Data Bank;
URL="http://www.bmrb.wisc.edu/data_library/summary/index.php?bmrbId=18946";
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
Distributed under the Creative Commons Attribution-NoDerivs License
-----------------------------------------------------------------------
PIR; E44007; E44007.
PDB; 2M36; NMR; -; A=1-37.
PDBsum; 2M36; -.
SMR; P49268; -.
TCDB; 8.B.21.1.1; the spider insecticidal neurotoxin cyrtautoxin (cyrautoxin) family.
ArachnoServer; AS000403; mu-cyrtautoxin-As1a.
GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
GO; GO:0044487; P:envenomation resulting in modulation of transmission of nerve impulse in other organism; IDA:UniProtKB.
GO; GO:0044475; P:envenomation resulting in negative regulation of high voltage-gated calcium channel activity in other organism; IDA:UniProtKB.
GO; GO:0044476; P:envenomation resulting in negative regulation of low voltage-gated calcium channel activity in other organism; IDA:UniProtKB.
GO; GO:0044493; P:envenomation resulting in negative regulation of voltage-gated sodium channel activity in other organism; IDA:UniProtKB.
GO; GO:0009405; P:pathogenesis; IEA:InterPro.
InterPro; IPR012626; Spider_insecticidal_peptide.
Pfam; PF08091; Toxin_21; 1.
1: Evidence at protein level;
3D-structure; Calcium channel impairing toxin;
Direct protein sequencing; Disulfide bond;
Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Toxin;
Voltage-gated calcium channel impairing toxin;
Voltage-gated sodium channel impairing toxin.
PEPTIDE 1 37 Mu-cyrtautoxin-As1a.
/FTId=PRO_0000044986.
DISULFID 1 15 {ECO:0000269|PubMed:23473802}.
DISULFID 8 19 {ECO:0000269|PubMed:23473802}.
DISULFID 14 35 {ECO:0000269|PubMed:23473802}.
DISULFID 26 31 {ECO:0000269|PubMed:23473802}.
STRAND 7 10 {ECO:0000244|PDB:2M36}.
HELIX 11 13 {ECO:0000244|PDB:2M36}.
STRAND 24 26 {ECO:0000244|PDB:2M36}.
STRAND 28 30 {ECO:0000244|PDB:2M36}.
STRAND 33 35 {ECO:0000244|PDB:2M36}.
SEQUENCE 37 AA; 3769 MW; CBD01091694E1908 CRC64;
CNSKGTPCTN ADECCGGKCA YNVWNCIGGG CSKTCGY


Related products :

Catalog number Product name Quantity
RBIOR1902 Saxitoxin, Paralytic Shellfish Poisoning (PSP), fast EIA KIT (detection 50 ppg) kit
32-119 BNP (brain natriuretic peptide) belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. ANP 0.1 mL
32-121 BNP (brain natriuretic peptide) belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. ANP 0.1 mL
32-120 BNP (brain natriuretic peptide) belongs to a family of structurally similar peptide hormones, which includes atrial natriuretic peptide (ANP), BNP, C-type natriuretic peptide (CNP) and urodilatin. ANP 0.1 mL
NANP51-P (NANP)5 peptide (repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control blocking peptide 1 mg
PPPP321-P (PPPPNAND)3 peptide (repeat-sequence peptide of the P. berghei circumsporozoite protein, CSP) control blocking peptide 100 ug
ABPEP-30U Custom Anti-Peptide antibodies (peptide synth. up to 30-aa, conjug., 2 rabbits, ELISA; with peptide amounts upgrade) 1
ABPEP-20SU Custom Anti-Peptide antibodies (peptide up to 20-aa, peptide amounts upgrade; conjugation, 1 sheep, ELISA) 1
ABPEP-20GU Custom Anti-Peptide antibodies (peptide up to 20-aa, peptide amounts upgrade; conjugation, 1 goat, ELISA) 1
NVDP41-P (NVDP)4 peptide (minor repeat-sequence peptide of the P. falciparum circumsporozoite protein, CSP) control blocking peptide 100 ug
ABPEP-25U Custom Anti-Peptide antibodies (peptide synth. up to 25-aa, conjug., 2 rabbits, ELISA; with peptide amounts upgrade) 1
ABPEP-20U Custom Anti-Peptide antibodies (peptide synth. up to 20-aa, conjug., 2 rabbits, ELISA; with peptide amounts upgrade) 1
ABPEP-20UA Custom Anti-Peptide antibodies (peptide synth. ~20-aa, conjug., 2 rabbits, ELISA; with peptide upgrade and Aff. Purif.) 1
ABPEP-25UA Custom Anti-Peptide antibodies (peptide synth. ~25-aa, conjug., 2 rabbits, ELISA; with peptide upgrade and Aff. Purif.) 1
ABPEP-30UA Custom Anti-Peptide antibodies (peptide synth. ~30-aa, conjug., 2 rabbits, ELISA; with peptide upgrade and Aff. Purif.) 1
ABPEP-30U Custom Anti-Peptide antibodies (peptide synth. up to 30-aa, conjug., 2 rabbits, ELISA; with peptide amounts upgrade) Species Reactivity: 1 Product tipe: Service
ABPEP-25U Custom Anti-Peptide antibodies (peptide synth. up to 25-aa, conjug., 2 rabbits, ELISA; with peptide amounts upgrade) Species Reactivity: 1 Product tipe: Service
ABPEP-20U Custom Anti-Peptide antibodies (peptide synth. up to 20-aa, conjug., 2 rabbits, ELISA; with peptide amounts upgrade) Species Reactivity: 1 Product tipe: Service
ABPEP-20SU Custom Anti-Peptide antibodies (peptide up to 20-aa, peptide amounts upgrade; conjugation, 1 sheep, ELISA) Species Reactivity: 1 Product tipe: Service
ABPEP-20GU Custom Anti-Peptide antibodies (peptide up to 20-aa, peptide amounts upgrade; conjugation, 1 goat, ELISA) Species Reactivity: 1 Product tipe: Service
EIAAB41375 ABCB2,Antigen peptide transporter 1,APT1,ATP-binding cassette sub-family B member 2,Homo sapiens,Human,Peptide supply factor 1,Peptide transporter involved in antigen processing 1,Peptide transporter
EIAAB41377 ABCB3,Antigen peptide transporter 2,APT2,ATP-binding cassette sub-family B member 3,Homo sapiens,Human,Peptide supply factor 2,Peptide transporter involved in antigen processing 2,Peptide transporter
ABPEP-20UA Custom Anti-Peptide antibodies (peptide synth. ~20-aa, conjug., 2 rabbits, ELISA; with peptide upgrade and Aff. Purif.) Species Reactivity: 1 Product tipe: Service
ABPEP-25UA Custom Anti-Peptide antibodies (peptide synth. ~25-aa, conjug., 2 rabbits, ELISA; with peptide upgrade and Aff. Purif.) Species Reactivity: 1 Product tipe: Service
ABPEP-30UA Custom Anti-Peptide antibodies (peptide synth. ~30-aa, conjug., 2 rabbits, ELISA; with peptide upgrade and Aff. Purif.) Species Reactivity: 1 Product tipe: Service


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur