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Mucin-16 (MUC-16) (Ovarian cancer-related tumor marker CA125) (CA-125) (Ovarian carcinoma antigen CA125)

 MUC16_HUMAN             Reviewed;       14507 AA.
Q8WXI7; B5ME49; Q6ZQW5; Q96RK2;
31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
11-MAY-2016, sequence version 3.
25-OCT-2017, entry version 118.
RecName: Full=Mucin-16 {ECO:0000305};
Short=MUC-16;
AltName: Full=Ovarian cancer-related tumor marker CA125 {ECO:0000303|PubMed:12218296};
Short=CA-125 {ECO:0000303|PubMed:12218296};
AltName: Full=Ovarian carcinoma antigen CA125 {ECO:0000303|PubMed:11369781};
Name=MUC16 {ECO:0000312|HGNC:HGNC:15582};
Synonyms=CA125 {ECO:0000303|PubMed:11786729};
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=15057824; DOI=10.1038/nature02399;
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
Rubin E.M., Lucas S.M.;
"The DNA sequence and biology of human chromosome 19.";
Nature 428:529-535(2004).
[2]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-10429, SEQUENCE REVISION TO
N-TERMINUS, TISSUE SPECIFICITY, AND INDUCTION.
PubMed=12218296; DOI=10.1159/000064032;
O'Brien T.J., Beard J.B., Underwood L.J., Shigemasa K.;
"The CA 125 gene: a newly discovered extension of the glycosylated N-
terminal domain doubles the size of this extracellular
superstructure.";
Tumor Biol. 23:154-169(2002).
[3]
NUCLEOTIDE SEQUENCE [MRNA] OF 10430-14507, REGION, AND POLYMORPHISM.
PubMed=11786729; DOI=10.1159/000050638;
O'Brien T.J., Beard J.B., Underwood L.J., Dennis R.A., Santin A.D.,
York L.;
"The CA 125 gene: an extracellular superstructure dominated by repeat
sequences.";
Tumor Biol. 22:348-366(2001).
[4]
NUCLEOTIDE SEQUENCE [MRNA] OF 8295-14507, PROTEIN SEQUENCE OF
13715-13720 AND 14338-14350, AND TISSUE SPECIFICITY.
PubMed=11369781; DOI=10.1074/jbc.M103554200;
Yin B.W.T., Lloyd K.O.;
"Molecular cloning of the CA125 ovarian cancer antigen: identification
as a new mucin, MUC16.";
J. Biol. Chem. 276:27371-27375(2001).
[5]
SEQUENCE REVISION.
Lloyd K.O., Yin B.W.T.;
Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12828-14050.
TISSUE=Uterus;
PubMed=14702039; DOI=10.1038/ng1285;
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
"Complete sequencing and characterization of 21,243 full-length human
cDNAs.";
Nat. Genet. 36:40-45(2004).
[7]
PHOSPHORYLATION.
PubMed=9276028;
Fendrick J.L., Konishi I., Geary S.M., Parmley T.H., Quirk J.G. Jr.,
O'Brien T.J.;
"CA125 phosphorylation is associated with its secretion from the WISH
human amnion cell line.";
Tumor Biol. 18:278-289(1997).
[8]
GLYCOSYLATION.
PubMed=12734200; DOI=10.1074/jbc.M302741200;
Kui Wong N., Easton R.L., Panico M., Sutton-Smith M., Morrison J.C.,
Lattanzio F.A., Morris H.R., Clark G.F., Dell A., Patankar M.S.;
"Characterization of the oligosaccharides associated with the human
ovarian tumor marker CA125.";
J. Biol. Chem. 278:28619-28634(2003).
[9]
INTERACTION WITH MSLN.
PubMed=14676194; DOI=10.1074/jbc.M312372200;
Rump A., Morikawa Y., Tanaka M., Minami S., Umesaki N., Takeuchi M.,
Miyajima A.;
"Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates
cell adhesion.";
J. Biol. Chem. 279:9190-9198(2004).
[10]
REVIEW, AND POLYMORPHISM.
PubMed=15788735; DOI=10.1177/1099800404274445;
McLemore M.R., Aouizerat B.;
"Introducing the MUC16 gene: implications for prevention and early
detection in epithelial ovarian cancer.";
Biol. Res. Nurs. 6:262-267(2005).
[11]
TISSUE SPECIFICITY.
PubMed=16384952; DOI=10.1167/iovs.05-0735;
Argueso P., Tisdale A., Spurr-Michaud S., Sumiyoshi M., Gipson I.K.;
"Mucin characteristics of human corneal-limbal epithelial cells that
exclude the rose bengal anionic dye.";
Invest. Ophthalmol. Vis. Sci. 47:113-119(2006).
-!- FUNCTION: Thought to provide a protective, lubricating barrier
against particles and infectious agents at mucosal surfaces.
{ECO:0000250}.
-!- SUBUNIT: Binds to MSLN. Binding to MSLN mediates heterotypic cell
adhesion. This may contribute to the metastasis of ovarian cancer
to the peritoneum by initiating cell attachment to the mesothelial
epithelium via binding to MSLN.
-!- SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane
protein. Secreted, extracellular space. Note=May be liberated into
the extracellular space following the phosphorylation of the
intracellular C-terminus which induces the proteolytic cleavage
and liberation of the extracellular domain.
-!- TISSUE SPECIFICITY: Expressed in corneal and conjunctival
epithelia (at protein level). Overexpressed in ovarian carcinomas
and ovarian low malignant potential (LMP) tumors as compared to
the expression in normal ovarian tissue and ovarian adenomas.
{ECO:0000269|PubMed:11369781, ECO:0000269|PubMed:12218296,
ECO:0000269|PubMed:16384952}.
-!- INDUCTION: Up-regulated in ovarian cancer cells.
{ECO:0000269|PubMed:12218296}.
-!- DOMAIN: Composed of three domains, a Ser-, Thr-rich N-terminal
domain, a repeated domain containing between 12 and 60 partially
conserved tandem repeats of 156 amino acids and a C-terminal
transmembrane contain domain with a short cytoplasmic tail.
{ECO:0000269|PubMed:11786729}.
-!- PTM: Heavily O-glycosylated; expresses both type 1 and type 2 core
glycans. {ECO:0000269|PubMed:12734200}.
-!- PTM: Heavily N-glycosylated; expresses primarily high mannose and
complex bisecting type N-linked glycans.
{ECO:0000269|PubMed:12734200}.
-!- PTM: May be phosphorylated. Phosphorylation of the intracellular
C-terminal domain may induce proteolytic cleavage and the
liberation of the extracellular domain into the extracellular
space. {ECO:0000269|PubMed:9276028}.
-!- PTM: May contain numerous disulfide bridges. Association of
several molecules of the secreted form may occur through
interchain disulfide bridges providing an extraordinarily large
gel-like matrix in the extracellular space or in the lumen of
secretory ducts.
-!- POLYMORPHISM: The number of repeats is highly polymorphic and can
be composed between 12 and 60 extracellular mucin repeats.
{ECO:0000305|PubMed:11786729}.
-!- MISCELLANEOUS: Antigen that is the basis for a widely used serum
assay for the monitoring of patients with ovarian epithelial
cancer. Due to lack of sensitivity for stage I disease and lack of
specificity, it is of little value in the detection of early
ovarian cancer. Due to its similarly elevated levels in some
nonmalignant conditions, it is not specific enough to be used for
population screening.
-!- SEQUENCE CAUTION:
Sequence=AAL65133.2; Type=Frameshift; Positions=3905, 3924, 3940; Evidence={ECO:0000305};
Sequence=BAC87568.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
-!- WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology
and Haematology;
URL="http://atlasgeneticsoncology.org/Genes/MUC16ID41455ch19q13.html";
-!- WEB RESOURCE: Name=Mucin database;
URL="http://www.medkem.gu.se/mucinbiology/databases/";
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EMBL; AC008734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; KF456494; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AC016584; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; AF414442; AAL65133.2; ALT_FRAME; mRNA.
EMBL; AF361486; AAK74120.3; -; mRNA.
EMBL; AK128681; BAC87568.1; ALT_INIT; mRNA.
CCDS; CCDS54212.1; -.
RefSeq; NP_078966.2; NM_024690.2.
UniGene; Hs.432676; -.
ProteinModelPortal; Q8WXI7; -.
SMR; Q8WXI7; -.
BioGrid; 125094; 9.
IntAct; Q8WXI7; 2.
STRING; 9606.ENSP00000381008; -.
ChEMBL; CHEMBL3580482; -.
DrugBank; DB04964; Oregovomab.
iPTMnet; Q8WXI7; -.
PhosphoSitePlus; Q8WXI7; -.
SwissPalm; Q8WXI7; -.
BioMuta; MUC16; -.
EPD; Q8WXI7; -.
MaxQB; Q8WXI7; -.
PaxDb; Q8WXI7; -.
PeptideAtlas; Q8WXI7; -.
PRIDE; Q8WXI7; -.
Ensembl; ENST00000397910; ENSP00000381008; ENSG00000181143.
GeneID; 94025; -.
KEGG; hsa:94025; -.
UCSC; uc002mkp.3; human.
CTD; 94025; -.
DisGeNET; 94025; -.
EuPathDB; HostDB:ENSG00000181143.15; -.
GeneCards; MUC16; -.
H-InvDB; HIX0021715; -.
HGNC; HGNC:15582; MUC16.
MIM; 606154; gene.
neXtProt; NX_Q8WXI7; -.
OpenTargets; ENSG00000181143; -.
PharmGKB; PA31314; -.
eggNOG; ENOG410IEHG; Eukaryota.
eggNOG; ENOG4111B0P; LUCA.
GeneTree; ENSGT00440000039287; -.
KO; K16145; -.
OMA; ETTYMEA; -.
OrthoDB; EOG091G00SO; -.
PhylomeDB; Q8WXI7; -.
TreeFam; TF335600; -.
Reactome; R-HSA-5083625; Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC).
Reactome; R-HSA-5083632; Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS).
Reactome; R-HSA-5083636; Defective GALNT12 causes colorectal cancer 1 (CRCS1).
Reactome; R-HSA-5621480; Dectin-2 family.
Reactome; R-HSA-913709; O-linked glycosylation of mucins.
Reactome; R-HSA-977068; Termination of O-glycan biosynthesis.
ChiTaRS; MUC16; human.
GeneWiki; CA-125; -.
GenomeRNAi; 94025; -.
PRO; PR:Q8WXI7; -.
Proteomes; UP000005640; Chromosome 19.
Bgee; ENSG00000181143; -.
CleanEx; HS_MUC16; -.
ExpressionAtlas; Q8WXI7; baseline and differential.
Genevisible; B5ME49; HS.
GO; GO:0070062; C:extracellular exosome; IDA:UniProtKB.
GO; GO:0019898; C:extrinsic component of membrane; IDA:UniProtKB.
GO; GO:0005796; C:Golgi lumen; TAS:Reactome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0031982; C:vesicle; IDA:UniProtKB.
GO; GO:0007155; P:cell adhesion; NAS:UniProtKB.
GO; GO:0016266; P:O-glycan processing; TAS:Reactome.
GO; GO:0002223; P:stimulatory C-type lectin receptor signaling pathway; TAS:Reactome.
Gene3D; 3.30.70.960; -; 16.
InterPro; IPR028850; MUC16.
InterPro; IPR000082; SEA_dom.
InterPro; IPR036364; SEA_dom_sf.
PANTHER; PTHR14672; PTHR14672; 25.
Pfam; PF01390; SEA; 16.
SMART; SM00200; SEA; 7.
SUPFAM; SSF82671; SSF82671; 16.
PROSITE; PS50024; SEA; 65.
1: Evidence at protein level;
Cell membrane; Complete proteome; Direct protein sequencing;
Disulfide bond; Glycoprotein; Membrane; Phosphoprotein; Polymorphism;
Reference proteome; Repeat; Secreted; Transmembrane;
Transmembrane helix.
CHAIN 1 14507 Mucin-16.
/FTId=PRO_0000436078.
TOPO_DOM 1 14451 Extracellular. {ECO:0000305}.
TRANSMEM 14452 14472 Helical. {ECO:0000255}.
TOPO_DOM 14473 14507 Cytoplasmic. {ECO:0000305}.
REPEAT 12067 12223 1. {ECO:0000269|PubMed:11786729}.
DOMAIN 12072 12193 SEA 1. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
REPEAT 12224 12381 2. {ECO:0000269|PubMed:11786729}.
DOMAIN 12228 12349 SEA 2. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
REPEAT 12382 12537 3. {ECO:0000269|PubMed:11786729}.
DOMAIN 12386 12507 SEA 3. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
REPEAT 12538 12692 4. {ECO:0000269|PubMed:11786729}.
DOMAIN 12542 12663 SEA 4. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
REPEAT 12693 12848 5. {ECO:0000269|PubMed:11786729}.
DOMAIN 12697 12818 SEA 5. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
REPEAT 12849 13004 6. {ECO:0000269|PubMed:11786729}.
DOMAIN 12853 12974 SEA 6. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
REPEAT 13005 13160 7. {ECO:0000269|PubMed:11786729}.
DOMAIN 13009 13130 SEA 7. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
REPEAT 13161 13316 8. {ECO:0000269|PubMed:11786729}.
DOMAIN 13165 13286 SEA 8. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
REPEAT 13317 13472 9. {ECO:0000269|PubMed:11786729}.
DOMAIN 13321 13442 SEA 9. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
REPEAT 13473 13628 10. {ECO:0000269|PubMed:11786729}.
DOMAIN 13477 13598 SEA 10. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
REPEAT 13629 13784 11. {ECO:0000269|PubMed:11786729}.
DOMAIN 13633 13754 SEA 11. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
REPEAT 13785 13939 12. {ECO:0000269|PubMed:11786729}.
DOMAIN 13789 13909 SEA 12. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
DOMAIN 13922 14043 SEA 13. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
DOMAIN 14073 14193 SEA 14. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
DOMAIN 14198 14309 SEA 15. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
DOMAIN 14319 14438 SEA 16. {ECO:0000255|PROSITE-
ProRule:PRU00188}.
REGION 12067 13939 12 X approximate tandem repeats.
{ECO:0000269|PubMed:11786729}.
COMPBIAS 14 12083 Thr-rich. {ECO:0000255|PROSITE-
ProRule:PRU00017}.
COMPBIAS 1638 3054 Ser-rich. {ECO:0000255|PROSITE-
ProRule:PRU00016}.
COMPBIAS 2365 2371 Poly-Ser. {ECO:0000255}.
COMPBIAS 3899 4383 Ser-rich. {ECO:0000255|PROSITE-
ProRule:PRU00016}.
COMPBIAS 4743 4953 Ser-rich. {ECO:0000255|PROSITE-
ProRule:PRU00016}.
COMPBIAS 7083 10394 Ser-rich. {ECO:0000255|PROSITE-
ProRule:PRU00016}.
CARBOHYD 139 139 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 434 434 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 787 787 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 930 930 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 957 957 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1375 1375 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1633 1633 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1840 1840 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1877 1877 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1890 1890 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 2345 2345 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 2375 2375 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 2737 2737 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 3085 3085 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 3178 3178 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 3501 3501 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 4220 4220 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 4498 4498 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 4606 4606 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 4613 4613 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 4624 4624 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 4861 4861 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 5096 5096 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 5131 5131 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 5228 5228 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 5320 5320 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 5394 5394 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 5470 5470 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 5689 5689 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 5863 5863 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 6088 6088 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 6732 6732 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 6859 6859 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 6961 6961 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 8029 8029 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 8055 8055 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 8324 8324 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 8618 8618 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 8684 8684 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 8913 8913 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 9202 9202 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 9493 9493 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 9785 9785 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 10075 10075 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 10173 10173 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 10510 10510 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 10700 10700 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 10749 10749 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 11053 11053 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 11224 11224 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 11263 11263 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 11367 11367 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 11594 11594 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12079 12079 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12100 12100 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12116 12116 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12168 12168 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12235 12235 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12272 12272 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12393 12393 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12414 12414 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12430 12430 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12549 12549 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12570 12570 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12586 12586 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12704 12704 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12725 12725 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12741 12741 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12824 12824 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12860 12860 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12881 12881 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 12897 12897 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13016 13016 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13037 13037 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13053 13053 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13172 13172 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13193 13193 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13328 13328 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13349 13349 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13365 13365 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13484 13484 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13505 13505 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13521 13521 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13640 13640 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13661 13661 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13733 13733 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13744 13744 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13796 13796 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13816 13816 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13832 13832 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13929 13929 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 13950 13950 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 14080 14080 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 14100 14100 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 14195 14195 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 14212 14212 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 14254 14254 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 14287 14287 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 14326 14326 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 14363 14363 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 14417 14417 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 14423 14423 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 12126 12146 {ECO:0000255}.
DISULFID 12282 12302 {ECO:0000255}.
DISULFID 12440 12460 {ECO:0000255}.
DISULFID 12596 12616 {ECO:0000255}.
DISULFID 12751 12771 {ECO:0000255}.
DISULFID 12907 12927 {ECO:0000255}.
DISULFID 13063 13083 {ECO:0000255}.
DISULFID 13219 13239 {ECO:0000255}.
DISULFID 13375 13395 {ECO:0000255}.
DISULFID 13531 13551 {ECO:0000255}.
DISULFID 13687 13707 {ECO:0000255}.
DISULFID 13976 13996 {ECO:0000255}.
DISULFID 14126 14146 {ECO:0000255}.
DISULFID 14373 14393 {ECO:0000255}.
VARIANT 545 545 T -> A (in dbSNP:rs17000957).
/FTId=VAR_056592.
VARIANT 1015 1015 R -> G (in dbSNP:rs17000950).
/FTId=VAR_056593.
VARIANT 1032 1032 S -> T (in dbSNP:rs10411228).
/FTId=VAR_056594.
VARIANT 1041 1041 P -> S (in dbSNP:rs10406202).
/FTId=VAR_056595.
VARIANT 1162 1162 T -> I (in dbSNP:rs17000947).
/FTId=VAR_056596.
VARIANT 1266 1266 K -> N (in dbSNP:rs1596797).
/FTId=VAR_056597.
VARIANT 1353 1353 H -> Y (in dbSNP:rs12611293).
/FTId=VAR_056598.
VARIANT 1400 1400 K -> N (in dbSNP:rs1596798).
/FTId=VAR_056599.
VARIANT 1833 1833 L -> F (in dbSNP:rs4520945).
/FTId=VAR_056600.
VARIANT 1953 1953 S -> P (in dbSNP:rs1108380).
/FTId=VAR_056601.
VARIANT 2058 2058 S -> P (in dbSNP:rs1574479).
/FTId=VAR_056602.
VARIANT 2150 2150 I -> V (in dbSNP:rs10407633).
/FTId=VAR_056603.
VARIANT 2271 2271 T -> A (in dbSNP:rs11085805).
/FTId=VAR_056604.
VARIANT 2288 2288 V -> L (in dbSNP:rs10410933).
/FTId=VAR_056605.
VARIANT 2356 2356 D -> E (in dbSNP:rs10416013).
/FTId=VAR_056606.
VARIANT 2747 2747 A -> T (in dbSNP:rs10402538).
/FTId=VAR_056607.
VARIANT 2786 2786 M -> I (in dbSNP:rs17000886).
/FTId=VAR_056608.
VARIANT 2834 2834 T -> M (in dbSNP:rs10407623).
/FTId=VAR_056609.
VARIANT 3573 3573 R -> H (in dbSNP:rs2591594).
/FTId=VAR_056610.
VARIANT 5741 5741 H -> D (in dbSNP:rs1559172).
/FTId=VAR_056611.
VARIANT 5754 5754 A -> T (in dbSNP:rs1559171).
/FTId=VAR_056612.
VARIANT 5852 5852 F -> V (in dbSNP:rs1862460).
/FTId=VAR_056613.
VARIANT 7063 7063 T -> A (in dbSNP:rs17000770).
/FTId=VAR_056614.
VARIANT 7272 7272 I -> V (in dbSNP:rs1867691).
/FTId=VAR_056615.
VARIANT 10507 10507 T -> N (in dbSNP:rs11670461).
/FTId=VAR_056616.
CONFLICT 1898 1898 Y -> D (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 2506 2506 T -> A (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 3190 3190 S -> T (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 3202 3202 M -> V (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 3932 3932 I -> V (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 4440 4440 S -> T (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 5682 5682 P -> T (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 6303 6303 V -> M (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 6655 6655 L -> V (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 6866 6866 E -> V (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 6895 6895 S -> C (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 6906 6906 A -> T (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 7191 7191 S -> F (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 7425 7425 L -> P (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 7475 7475 S -> P (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 7923 7923 D -> A (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 8301 8301 N -> T (in Ref. 2; AAL65133 and 4;
AAK74120). {ECO:0000305}.
CONFLICT 8344 8344 D -> A (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 8578 8578 T -> A (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 9059 9059 T -> S (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 9072 9072 T -> A (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 9129 9129 D -> E (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 9213 9213 I -> T (in Ref. 2; AAL65133 and 4;
AAK74120). {ECO:0000305}.
CONFLICT 9405 9405 Q -> R (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 9502 9502 A -> T (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 9608 9608 P -> S (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 9850 9850 D -> E (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 9899 9899 Y -> F (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 9920 9920 I -> T (in Ref. 2; AAL65133 and 4;
AAK74120). {ECO:0000305}.
CONFLICT 10013 10013 L -> P (in Ref. 2; AAL65133 and 4;
AAK74120). {ECO:0000305}.
CONFLICT 10169 10169 F -> L (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 10394 10394 S -> T (in Ref. 2; AAL65133).
{ECO:0000305}.
CONFLICT 10828 10828 P -> S (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 11154 11154 S -> F (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 11199 11199 A -> G (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 11455 11455 G -> D (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 12514 12514 S -> T (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 12580 12580 L -> V (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 12692 12692 T -> TSA (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 12832 12832 T -> A (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12834 12834 D -> H (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12836 12836 G -> E (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12842 12842 S -> A (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12846 12847 SP -> GH (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12849 12850 SA -> AP (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12873 12873 H -> R (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12892 12894 GPM -> KPL (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12897 12897 N -> S (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12902 12902 L -> P (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12917 12917 N -> R (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12923 12925 MDA -> VDT (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12928 12928 S -> T (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12934 12935 KS -> LN (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12939 12939 N -> D (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12949 12949 Q -> K (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12952 12952 H -> R (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12955 12955 K -> I (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12961 12961 T -> L (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12965 12965 N -> G (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12976 12977 SS -> NF (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12979 12980 AP -> PI (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12990 12990 D -> H (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 12995 12995 G -> E (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 13002 13007 SPTTAV -> RPIVPG (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 13025 13027 GED -> EEA (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 13048 13048 G -> R (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 13054 13056 SSV -> TSI (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 13062 13062 G -> S (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 13332 13332 T -> I (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 13341 13341 R -> H (in Ref. 4; AAK74120).
{ECO:0000305}.
CONFLICT 13386 13386 G -> K (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 13394 13394 V -> I (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 13398 13398 R -> H (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 13402 13402 K -> Q (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 13407 13407 D -> N (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 13410 13410 R -> Q (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 13414 13414 K -> E (in Ref. 6; BAC87568).
{ECO:0000305}.
CONFLICT 13472 13472 M -> T (in Ref. 6; BAC87568 and 4;
AAK74120). {ECO:0000305}.
CONFLICT 14041 14050 YNEPGPDEPP -> HHTLQRQSTT (in Ref. 6;
BAC87568). {ECO:0000305}.
CONFLICT 14466 14466 V -> L (in Ref. 4; AAK74120).
{ECO:0000305}.
SEQUENCE 14507 AA; 1519175 MW; 7D5E9A14F70EB90A CRC64;
MLKPSGLPGS SSPTRSLMTG SRSTKATPEM DSGLTGATLS PKTSTGAIVV TEHTLPFTSP
DKTLASPTSS VVGRTTQSLG VMSSALPEST SRGMTHSEQR TSPSLSPQVN GTPSRNYPAT
SMVSGLSSPR TRTSSTEGNF TKEASTYTLT VETTSGPVTE KYTVPTETST TEGDSTETPW
DTRYIPVKIT SPMKTFADST ASKENAPVSM TPAETTVTDS HTPGRTNPSF GTLYSSFLDL
SPKGTPNSRG ETSLELILST TGYPFSSPEP GSAGHSRIST SAPLSSSASV LDNKISETSI
FSGQSLTSPL SPGVPEARAS TMPNSAIPFS MTLSNAETSA ERVRSTISSL GTPSISTKQT
AETILTFHAF AETMDIPSTH IAKTLASEWL GSPGTLGGTS TSALTTTSPS TTLVSEETNT
HHSTSGKETE GTLNTSMTPL ETSAPGEESE MTATLVPTLG FTTLDSKIRS PSQVSSSHPT
RELRTTGSTS GRQSSSTAAH GSSDILRATT SSTSKASSWT SESTAQQFSE PQHTQWVETS
PSMKTERPPA STSVAAPITT SVPSVVSGFT TLKTSSTKGI WLEETSADTL IGESTAGPTT
HQFAVPTGIS MTGGSSTRGS QGTTHLLTRA TASSETSADL TLATNGVPVS VSPAVSKTAA
GSSPPGGTKP SYTMVSSVIP ETSSLQSSAF REGTSLGLTP LNTRHPFSSP EPDSAGHTKI
STSIPLLSSA SVLEDKVSAT STFSHHKATS SITTGTPEIS TKTKPSSAVL SSMTLSNAAT
SPERVRNATS PLTHPSPSGE ETAGSVLTLS TSAETTDSPN IHPTGTLTSE SSESPSTLSL
PSVSGVKTTF SSSTPSTHLF TSGEETEETS NPSVSQPETS VSRVRTTLAS TSVPTPVFPT
MDTWPTRSAQ FSSSHLVSEL RATSSTSVTN STGSALPKIS HLTGTATMSQ TNRDTFNDSA
APQSTTWPET SPRFKTGLPS ATTTVSTSAT SLSATVMVSK FTSPATSSME ATSIREPSTT
ILTTETTNGP GSMAVASTNI PIGKGYITEG RLDTSHLPIG TTASSETSMD FTMAKESVSM
SVSPSQSMDA AGSSTPGRTS QFVDTFSDDV YHLTSREITI PRDGTSSALT PQMTATHPPS
PDPGSARSTW LGILSSSPSS PTPKVTMSST FSTQRVTTSM IMDTVETSRW NMPNLPSTTS
LTPSNIPTSG AIGKSTLVPL DTPSPATSLE ASEGGLPTLS TYPESTNTPS IHLGAHASSE
SPSTIKLTMA SVVKPGSYTP LTFPSIETHI HVSTARMAYS SGSSPEMTAP GETNTGSTWD
PTTYITTTDP KDTSSAQVST PHSVRTLRTT ENHPKTESAT PAAYSGSPKI SSSPNLTSPA
TKAWTITDTT EHSTQLHYTK LAEKSSGFET QSAPGPVSVV IPTSPTIGSS TLELTSDVPG
EPLVLAPSEQ TTITLPMATW LSTSLTEEMA STDLDISSPS SPMSTFAIFP PMSTPSHELS
KSEADTSAIR NTDSTTLDQH LGIRSLGRTG DLTTVPITPL TTTWTSVIEH STQAQDTLSA
TMSPTHVTQS LKDQTSIPAS ASPSHLTEVY PELGTQGRSS SEATTFWKPS TDTLSREIET
GPTNIQSTPP MDNTTTGSSS SGVTLGIAHL PIGTSSPAET STNMALERRS STATVSMAGT
MGLLVTSAPG RSISQSLGRV SSVLSESTTE GVTDSSKGSS PRLNTQGNTA LSSSLEPSYA
EGSQMSTSIP LTSSPTTPDV EFIGGSTFWT KEVTTVMTSD ISKSSARTES SSATLMSTAL
GSTENTGKEK LRTASMDLPS PTPSMEVTPW ISLTLSNAPN TTDSLDLSHG VHTSSAGTLA
TDRSLNTGVT RASRLENGSD TSSKSLSMGN STHTSMTYTE KSEVSSSIHP RPETSAPGAE
TTLTSTPGNR AISLTLPFSS IPVEEVISTG ITSGPDINSA PMTHSPITPP TIVWTSTGTI
EQSTQPLHAV SSEKVSVQTQ STPYVNSVAV SASPTHENSV SSGSSTSSPY SSASLESLDS
TISRRNAITS WLWDLTTSLP TTTWPSTSLS EALSSGHSGV SNPSSTTTEF PLFSAASTSA
AKQRNPETET HGPQNTAAST LNTDASSVTG LSETPVGASI SSEVPLPMAI TSRSDVSGLT
SESTANPSLG TASSAGTKLT RTISLPTSES LVSFRMNKDP WTVSIPLGSH PTTNTETSIP
VNSAGPPGLS TVASDVIDTP SDGAESIPTV SFSPSPDTEV TTISHFPEKT THSFRTISSL
THELTSRVTP IPGDWMSSAM STKPTGASPS ITLGERRTIT SAAPTTSPIV LTASFTETST
VSLDNETTVK TSDILDARKT NELPSDSSSS SDLINTSIAS STMDVTKTAS ISPTSISGMT
ASSSPSLFSS DRPQVPTSTT ETNTATSPSV SSNTYSLDGG SNVGGTPSTL PPFTITHPVE
TSSALLAWSR PVRTFSTMVS TDTASGENPT SSNSVVTSVP APGTWTSVGS TTDLPAMGFL
KTSPAGEAHS LLASTIEPAT AFTPHLSAAV VTGSSATSEA SLLTTSESKA IHSSPQTPTT
PTSGANWETS ATPESLLVVT ETSDTTLTSK ILVTDTILFS TVSTPPSKFP STGTLSGASF
PTLLPDTPAI PLTATEPTSS LATSFDSTPL VTIASDSLGT VPETTLTMSE TSNGDALVLK
TVSNPDRSIP GITIQGVTES PLHPSSTSPS KIVAPRNTTY EGSITVALST LPAGTTGSLV
FSQSSENSET TALVDSSAGL ERASVMPLTT GSQGMASSGG IRSGSTHSTG TKTFSSLPLT
MNPGEVTAMS EITTNRLTAT QSTAPKGIPV KPTSAESGLL TPVSASSSPS KAFASLTTAP
PTWGIPQSTL TFEFSEVPSL DTKSASLPTP GQSLNTIPDS DASTASSSLS KSPEKNPRAR
MMTSTKAISA SSFQSTGFTE TPEGSASPSM AGHEPRVPTS GTGDPRYASE SMSYPDPSKA
SSAMTSTSLA SKLTTLFSTG QAARSGSSSS PISLSTEKET SFLSPTASTS RKTSLFLGPS
MARQPNILVH LQTSALTLSP TSTLNMSQEE PPELTSSQTI AEEEGTTAET QTLTFTPSET
PTSLLPVSSP TEPTARRKSS PETWASSISV PAKTSLVETT DGTLVTTIKM SSQAAQGNST
WPAPAEETGS SPAGTSPGSP EMSTTLKIMS SKEPSISPEI RSTVRNSPWK TPETTVPMET
TVEPVTLQST ALGSGSTSIS HLPTGTTSPT KSPTENMLAT ERVSLSPSPP EAWTNLYSGT
PGGTRQSLAT MSSVSLESPT ARSITGTGQQ SSPELVSKTT GMEFSMWHGS TGGTTGDTHV
SLSTSSNILE DPVTSPNSVS SLTDKSKHKT ETWVSTTAIP STVLNNKIMA AEQQTSRSVD
EAYSSTSSWS DQTSGSDITL GASPDVTNTL YITSTAQTTS LVSLPSGDQG ITSLTNPSGG
KTSSASSVTS PSIGLETLRA NVSAVKSDIA PTAGHLSQTS SPAEVSILDV TTAPTPGIST
TITTMGTNSI STTTPNPEVG MSTMDSTPAT ERRTTSTEHP STWSSTAASD SWTVTDMTSN
LKVARSPGTI STMHTTSFLA SSTELDSMST PHGRITVIGT SLVTPSSDAS AVKTETSTSE
RTLSPSDTTA STPISTFSRV QRMSISVPDI LSTSWTPSST EAEDVPVSMV STDHASTKTD
PNTPLSTFLF DSLSTLDWDT GRSLSSATAT TSAPQGATTP QELTLETMIS PATSQLPFSI
GHITSAVTPA AMARSSGVTF SRPDPTSKKA EQTSTQLPTT TSAHPGQVPR SAATTLDVIP
HTAKTPDATF QRQGQTALTT EARATSDSWN EKEKSTPSAP WITEMMNSVS EDTIKEVTSS
SSVLRTLNTL DINLESGTTS SPSWKSSPYE RIAPSESTTD KEAIHPSTNT VETTGWVTSS
EHASHSTIPA HSASSKLTSP VVTTSTREQA IVSMSTTTWP ESTRARTEPN SFLTIELRDV
SPYMDTSSTT QTSIISSPGS TAITKGPRTE ITSSKRISSS FLAQSMRSSD SPSEAITRLS
NFPAMTESGG MILAMQTSPP GATSLSAPTL DTSATASWTG TPLATTQRFT YSEKTTLFSK
GPEDTSQPSP PSVEETSSSS SLVPIHATTS PSNILLTSQG HSPSSTPPVT SVFLSETSGL
GKTTDMSRIS LEPGTSLPPN LSSTAGEALS TYEASRDTKA IHHSADTAVT NMEATSSEYS
PIPGHTKPSK ATSPLVTSHI MGDITSSTSV FGSSETTEIE TVSSVNQGLQ ERSTSQVASS
ATETSTVITH VSSGDATTHV TKTQATFSSG TSISSPHQFI TSTNTFTDVS TNPSTSLIMT
ESSGVTITTQ TGPTGAATQG PYLLDTSTMP YLTETPLAVT PDFMQSEKTT LISKGPKDVS
WTSPPSVAET SYPSSLTPFL VTTIPPATST LQGQHTSSPV SATSVLTSGL VKTTDMLNTS
MEPVTNSPQN LNNPSNEILA TLAATTDIET IHPSINKAVT NMGTASSAHV LHSTLPVSSE
PSTATSPMVP ASSMGDALAS ISIPGSETTD IEGEPTSSLT AGRKENSTLQ EMNSTTESNI
ILSNVSVGAI TEATKMEVPS FDATFIPTPA QSTKFPDIFS VASSRLSNSP PMTISTHMTT
TQTGSSGATS KIPLALDTST LETSAGTPSV VTEGFAHSKI TTAMNNDVKD VSQTNPPFQD
EASSPSSQAP VLVTTLPSSV AFTPQWHSTS SPVSMSSVLT SSLVKTAGKV DTSLETVTSS
PQSMSNTLDD ISVTSAATTD IETTHPSINT VVTNVGTTGS AFESHSTVSA YPEPSKVTSP
NVTTSTMEDT TISRSIPKSS KTTRTETETT SSLTPKLRET SISQEITSST ETSTVPYKEL
TGATTEVSRT DVTSSSSTSF PGPDQSTVSL DISTETNTRL STSPIMTESA EITITTQTGP
HGATSQDTFT MDPSNTTPQA GIHSAMTHGF SQLDVTTLMS RIPQDVSWTS PPSVDKTSSP
SSFLSSPAMT TPSLISSTLP EDKLSSPMTS LLTSGLVKIT DILRTRLEPV TSSLPNFSST
SDKILATSKD SKDTKEIFPS INTEETNVKA NNSGHESHSP ALADSETPKA TTQMVITTTV
GDPAPSTSMP VHGSSETTNI KREPTYFLTP RLRETSTSQE SSFPTDTSFL LSKVPTGTIT
EVSSTGVNSS SKISTPDHDK STVPPDTFTG EIPRVFTSSI KTKSAEMTIT TQASPPESAS
HSTLPLDTST TLSQGGTHST VTQGFPYSEV TTLMGMGPGN VSWMTTPPVE ETSSVSSLMS
SPAMTSPSPV SSTSPQSIPS SPLPVTALPT SVLVTTTDVL GTTSPESVTS SPPNLSSITH
ERPATYKDTA HTEAAMHHST NTAVTNVGTS GSGHKSQSSV LADSETSKAT PLMSTTSTLG
DTSVSTSTPN ISQTNQIQTE PTASLSPRLR ESSTSEKTSS TTETNTAFSY VPTGAITQAS
RTEISSSRTS ISDLDRPTIA PDISTGMITR LFTSPIMTKS AEMTVTTQTT TPGATSQGIL
PWDTSTTLFQ GGTHSTVSQG FPHSEITTLR SRTPGDVSWM TTPPVEETSS GFSLMSPSMT
SPSPVSSTSP ESIPSSPLPV TALLTSVLVT TTNVLGTTSP EPVTSSPPNL SSPTQERLTT
YKDTAHTEAM HASMHTNTAV ANVGTSISGH ESQSSVPADS HTSKATSPMG ITFAMGDTSV
STSTPAFFET RIQTESTSSL IPGLRDTRTS EEINTVTETS TVLSEVPTTT TTEVSRTEVI
TSSRTTISGP DHSKMSPYIS TETITRLSTF PFVTGSTEMA ITNQTGPIGT ISQATLTLDT
SSTASWEGTH SPVTQRFPHS EETTTMSRST KGVSWQSPPS VEETSSPSSP VPLPAITSHS
SLYSAVSGSS PTSALPVTSL LTSGRRKTID MLDTHSELVT SSLPSASSFS GEILTSEAST
NTETIHFSEN TAETNMGTTN SMHKLHSSVS IHSQPSGHTP PKVTGSMMED AIVSTSTPGS
PETKNVDRDS TSPLTPELKE DSTALVMNST TESNTVFSSV SLDAATEVSR AEVTYYDPTF
MPASAQSTKS PDISPEASSS HSNSPPLTIS THKTIATQTG PSGVTSLGQL TLDTSTIATS
AGTPSARTQD FVDSETTSVM NNDLNDVLKT SPFSAEEANS LSSQAPLLVT TSPSPVTSTL
QEHSTSSLVS VTSVPTPTLA KITDMDTNLE PVTRSPQNLR NTLATSEATT DTHTMHPSIN
TAVANVGTTS SPNEFYFTVS PDSDPYKATS AVVITSTSGD SIVSTSMPRS SAMKKIESET
TFSLIFRLRE TSTSQKIGSS SDTSTVFDKA FTAATTEVSR TELTSSSRTS IQGTEKPTMS
PDTSTRSVTM LSTFAGLTKS EERTIATQTG PHRATSQGTL TWDTSITTSQ AGTHSAMTHG
FSQLDLSTLT SRVPEYISGT SPPSVEKTSS SSSLLSLPAI TSPSPVPTTL PESRPSSPVH
LTSLPTSGLV KTTDMLASVA SLPPNLGSTS HKIPTTSEDI KDTEKMYPST NIAVTNVGTT
TSEKESYSSV PAYSEPPKVT SPMVTSFNIR DTIVSTSMPG SSEITRIEME STFSLAHGLK
GTSTSQDPIV STEKSAVLHK LTTGATETSR TEVASSRRTS IPGPDHSTES PDISTEVIPS
LPISLGITES SNMTIITRTG PPLGSTSQGT FTLDTPTTSS RAGTHSMATQ EFPHSEMTTV
MNKDPEILSW TIPPSIEKTS FSSSLMPSPA MTSPPVSSTL PKTIHTTPSP MTSLLTPSLV
MTTDTLGTSP EPTTSSPPNL SSTSHEILTT DEDTTAIEAM HPSTSTAATN VETTSSGHGS
QSSVLADSEK TKATAPMDTT STMGHTTVST SMSVSSETTK IKRESTYSLT PGLRETSISQ
NASFSTDTSI VLSEVPTGTT AEVSRTEVTS SGRTSIPGPS QSTVLPEIST RTMTRLFASP
TMTESAEMTI PTQTGPSGST SQDTLTLDTS TTKSQAKTHS TLTQRFPHSE MTTLMSRGPG
DMSWQSSPSL ENPSSLPSLL SLPATTSPPP ISSTLPVTIS SSPLPVTSLL TSSPVTTTDM
LHTSPELVTS SPPKLSHTSD ERLTTGKDTT NTEAVHPSTN TAASNVEIPS SGHESPSSAL
ADSETSKATS PMFITSTQED TTVAISTPHF LETSRIQKES ISSLSPKLRE TGSSVETSSA
IETSAVLSEV SIGATTEISR TEVTSSSRTS ISGSAESTML PEISTTRKII KFPTSPILAE
SSEMTIKTQT SPPGSTSEST FTLDTSTTPS LVITHSTMTQ RLPHSEITTL VSRGAGDVPR
PSSLPVEETS PPSSQLSLSA MISPSPVSST LPASSHSSSA SVTSLLTPGQ VKTTEVLDAS
AEPETSSPPS LSSTSVEILA TSEVTTDTEK IHPFSNTAVT KVGTSSSGHE SPSSVLPDSE
TTKATSAMGT ISIMGDTSVS TLTPALSNTR KIQSEPASSL TTRLRETSTS EETSLATEAN
TVLSKVSTGA TTEVSRTEAI SFSRTSMSGP EQSTMSQDIS IGTIPRISAS SVLTESAKMT
ITTQTGPSES TLESTLNLNT ATTPSWVETH SIVIQGFPHP EMTTSMGRGP GGVSWPSPPF
VKETSPPSSP LSLPAVTSPH PVSTTFLAHI PPSPLPVTSL LTSGPATTTD ILGTSTEPGT
SSSSSLSTTS HERLTTYKDT AHTEAVHPST NTGGTNVATT SSGYKSQSSV LADSSPMCTT
STMGDTSVLT STPAFLETRR IQTELASSLT PGLRESSGSE GTSSGTKMST VLSKVPTGAT
TEISKEDVTS IPGPAQSTIS PDISTRTVSW FSTSPVMTES AEITMNTHTS PLGATTQGTS
TLDTSSTTSL TMTHSTISQG FSHSQMSTLM RRGPEDVSWM SPPLLEKTRP SFSLMSSPAT
TSPSPVSSTL PESISSSPLP VTSLLTSGLA KTTDMLHKSS EPVTNSPANL SSTSVEILAT
SEVTTDTEKT HPSSNRTVTD VGTSSSGHES TSFVLADSQT SKVTSPMVIT STMEDTSVST
STPGFFETSR IQTEPTSSLT LGLRKTSSSE GTSLATEMST VLSGVPTGAT AEVSRTEVTS
SSRTSISGFA QLTVSPETST ETITRLPTSS IMTESAEMMI KTQTDPPGST PESTHTVDIS
TTPNWVETHS TVTQRFSHSE MTTLVSRSPG DMLWPSQSSV EETSSASSLL SLPATTSPSP
VSSTLVEDFP SASLPVTSLL NPGLVITTDR MGISREPGTS STSNLSSTSH ERLTTLEDTV
DTEDMQPSTH TAVTNVRTSI SGHESQSSVL SDSETPKATS PMGTTYTMGE TSVSISTSDF
FETSRIQIEP TSSLTSGLRE TSSSERISSA TEGSTVLSEV PSGATTEVSR TEVISSRGTS
MSGPDQFTIS PDISTEAITR LSTSPIMTES AESAITIETG SPGATSEGTL TLDTSTTTFW
SGTHSTASPG FSHSEMTTLM SRTPGDVPWP SLPSVEEASS VSSSLSSPAM TSTSFFSTLP
ESISSSPHPV TALLTLGPVK TTDMLRTSSE PETSSPPNLS STSAEILATS EVTKDREKIH
PSSNTPVVNV GTVIYKHLSP SSVLADLVTT KPTSPMATTS TLGNTSVSTS TPAFPETMMT
QPTSSLTSGL REISTSQETS SATERSASLS GMPTGATTKV SRTEALSLGR TSTPGPAQST
ISPEISTETI TRISTPLTTT GSAEMTITPK TGHSGASSQG TFTLDTSSRA SWPGTHSAAT
HRSPHSGMTT PMSRGPEDVS WPSRPSVEKT SPPSSLVSLS AVTSPSPLYS TPSESSHSSP
LRVTSLFTPV MMKTTDMLDT SLEPVTTSPP SMNITSDESL ATSKATMETE AIQLSENTAV
TQMGTISARQ EFYSSYPGLP EPSKVTSPVV TSSTIKDIVS TTIPASSEIT RIEMESTSTL
TPTPRETSTS QEIHSATKPS TVPYKALTSA TIEDSMTQVM SSSRGPSPDQ STMSQDISTE
VITRLSTSPI KTESTEMTIT TQTGSPGATS RGTLTLDTST TFMSGTHSTA SQGFSHSQMT
ALMSRTPGDV PWLSHPSVEE ASSASFSLSS PVMTSSSPVS STLPDSIHSS SLPVTSLLTS
GLVKTTELLG TSSEPETSSP PNLSSTSAEI LAITEVTTDT EKLEMTNVVT SGYTHESPSS
VLADSVTTKA TSSMGITYPT GDTNVLTSTP AFSDTSRIQT KSKLSLTPGL METSISEETS
SATEKSTVLS SVPTGATTEV SRTEAISSSR TSIPGPAQST MSSDTSMETI TRISTPLTRK
ESTDMAITPK TGPSGATSQG TFTLDSSSTA SWPGTHSATT QRFPQSVVTT PMSRGPEDVS
WPSPLSVEKN SPPSSLVSSS SVTSPSPLYS TPSGSSHSSP VPVTSLFTSI MMKATDMLDA
SLEPETTSAP NMNITSDESL AASKATTETE AIHVFENTAA SHVETTSATE ELYSSSPGFS
EPTKVISPVV TSSSIRDNMV STTMPGSSGI TRIEIESMSS LTPGLRETRT SQDITSSTET
STVLYKMPSG ATPEVSRTEV MPSSRTSIPG PAQSTMSLDI SDEVVTRLST SPIMTESAEI
TITTQTGYSL ATSQVTLPLG TSMTFLSGTH STMSQGLSHS EMTNLMSRGP ESLSWTSPRF
VETTRSSSSL TSLPLTTSLS PVSSTLLDSS PSSPLPVTSL ILPGLVKTTE VLDTSSEPKT
SSSPNLSSTS VEIPATSEIM TDTEKIHPSS NTAVAKVRTS SSVHESHSSV LADSETTITI
PSMGITSAVD DTTVFTSNPA FSETRRIPTE PTFSLTPGFR ETSTSEETTS ITETSAVLYG
VPTSATTEVS MTEIMSSNRI HIPDSDQSTM SPDIITEVIT RLSSSSMMSE STQMTITTQK
SSPGATAQST LTLATTTAPL ARTHSTVPPR FLHSEMTTLM SRSPENPSWK SSLFVEKTSS
SSSLLSLPVT TSPSVSSTLP QSIPSSSFSV TSLLTPGMVK TTDTSTEPGT SLSPNLSGTS
VEILAASEVT TDTEKIHPSS SMAVTNVGTT SSGHELYSSV SIHSEPSKAT YPVGTPSSMA
ETSISTSMPA NFETTGFEAE PFSHLTSGFR KTNMSLDTSS VTPTNTPSSP GSTHLLQSSK
TDFTSSAKTS SPDWPPASQY TEIPVDIITP FNASPSITES TGITSFPESR FTMSVTESTH
HLSTDLLPSA ETISTGTVMP SLSEAMTSFA TTGVPRAISG SGSPFSRTES GPGDATLSTI
AESLPSSTPV PFSSSTFTTT DSSTIPALHE ITSSSATPYR VDTSLGTESS TTEGRLVMVS
TLDTSSQPGR TSSSPILDTR MTESVELGTV TSAYQVPSLS TRLTRTDGIM EHITKIPNEA
AHRGTIRPVK GPQTSTSPAS PKGLHTGGTK RMETTTTALK TTTTALKTTS RATLTTSVYT
PTLGTLTPLN ASMQMASTIP TEMMITTPYV FPDVPETTSS LATSLGAETS TALPRTTPSV
FNRESETTAS LVSRSGAERS PVIQTLDVSS SEPDTTASWV IHPAETIPTV SKTTPNFFHS
ELDTVSSTAT SHGADVSSAI PTNISPSELD ALTPLVTISG TDTSTTFPTL TKSPHETETR
TTWLTHPAET SSTIPRTIPN FSHHESDATP SIATSPGAET SSAIPIMTVS PGAEDLVTSQ
VTSSGTDRNM TIPTLTLSPG EPKTIASLVT HPEAQTSSAI PTSTISPAVS RLVTSMVTSL
AAKTSTTNRA LTNSPGEPAT TVSLVTHPAQ TSPTVPWTTS IFFHSKSDTT PSMTTSHGAE
SSSAVPTPTV STEVPGVVTP LVTSSRAVIS TTIPILTLSP GEPETTPSMA TSHGEEASSA
IPTPTVSPGV PGVVTSLVTS SRAVTSTTIP ILTFSLGEPE TTPSMATSHG TEAGSAVPTV
LPEVPGMVTS LVASSRAVTS TTLPTLTLSP GEPETTPSMA TSHGAEASST VPTVSPEVPG
VVTSLVTSSS GVNSTSIPTL ILSPGELETT PSMATSHGAE ASSAVPTPTV SPGVSGVVTP
LVTSSRAVTS TTIPILTLSS SEPETTPSMA TSHGVEASSA VLTVSPEVPG MVTSLVTSSR
AVTSTTIPTL TISSDEPETT TSLVTHSEAK MISAIPTLAV SPTVQGLVTS LVTSSGSETS
AFSNLTVASS QPETIDSWVA HPGTEASSVV PTLTVSTGEP FTNISLVTHP AESSSTLPRT
TSRFSHSELD TMPSTVTSPE AESSSAISTT ISPGIPGVLT SLVTSSGRDI SATFPTVPES
PHESEATASW VTHPAVTSTT VPRTTPNYSH SEPDTTPSIA TSPGAEATSD FPTITVSPDV
PDMVTSQVTS SGTDTSITIP TLTLSSGEPE TTTSFITYSE THTSSAIPTL PVSPGASKML
TSLVISSGTD STTTFPTLTE TPYEPETTAI QLIHPAETNT MVPRTTPKFS HSKSDTTLPV
AITSPGPEAS SAVSTTTISP DMSDLVTSLV PSSGTDTSTT FPTLSETPYE PETTATWLTH
PAETSTTVSG TIPNFSHRGS DTAPSMVTSP GVDTRSGVPT TTIPPSIPGV VTSQVTSSAT
DTSTAIPTLT PSPGEPETTA SSATHPGTQT GFTVPIRTVP SSEPDTMASW VTHPPQTSTP
VSRTTSSFSH SSPDATPVMA TSPRTEASSA VLTTISPGAP EMVTSQITSS GAATSTTVPT
LTHSPGMPET TALLSTHPRT ETSKTFPAST VFPQVSETTA SLTIRPGAET STALPTQTTS
SLFTLLVTGT SRVDLSPTAS PGVSAKTAPL STHPGTETST MIPTSTLSLG LLETTGLLAT
SSSAETSTST LTLTVSPAVS GLSSASITTD KPQTVTSWNT ETSPSVTSVG PPEFSRTVTG
TTMTLIPSEM PTPPKTSHGE GVSPTTILRT TMVEATNLAT TGSSPTVAKT TTTFNTLAGS
LFTPLTTPGM STLASESVTS RTSYNHRSWI STTSSYNRRY WTPATSTPVT STFSPGISTS
SIPSSTAATV PFMVPFTLNF TITNLQYEED MRHPGSRKFN ATERELQGLL KPLFRNSSLE
YLYSGCRLAS LRPEKDSSAT AVDAICTHRP DPEDLGLDRE RLYWELSNLT NGIQELGPYT
LDRNSLYVNG FTHRSSMPTT STPGTSTVDV GTSGTPSSSP SPTTAGPLLM PFTLNFTITN
LQYEEDMRRT GSRKFNTMES VLQGLLKPLF KNTSVGPLYS GCRLTLLRPE KDGAATGVDA
ICTHRLDPKS PGLNREQLYW ELSKLTNDIE ELGPYTLDRN SLYVNGFTHQ SSVSTTSTPG
TSTVDLRTSG TPSSLSSPTI MAAGPLLVPF TLNFTITNLQ YGEDMGHPGS RKFNTTERVL
QGLLGPIFKN TSVGPLYSGC RLTSLRSEKD GAATGVDAIC IHHLDPKSPG LNRERLYWEL
SQLTNGIKEL GPYTLDRNSL YVNGFTHRTS VPTSSTPGTS TVDLGTSGTP FSLPSPATAG
PLLVLFTLNF TITNLKYEED MHRPGSRKFN TTERVLQTLL GPMFKNTSVG LLYSGCRLTL
LRSEKDGAAT GVDAICTHRL DPKSPGVDRE QLYWELSQLT NGIKELGPYT LDRNSLYVNG
FTHWIPVPTS STPGTSTVDL GSGTPSSLPS PTTAGPLLVP FTLNFTITNL KYEEDMHCPG
SRKFNTTERV LQSLLGPMFK NTSVGPLYSG CRLTLLRSEK DGAATGVDAI CTHRLDPKSP
GVDREQLYWE LSQLTNGIKE LGPYTLDRNS LYVNGFTHQT SAPNTSTPGT STVDLGTSGT
PSSLPSPTSA GPLLVPFTLN FTITNLQYEE DMHHPGSRKF NTTERVLQGL LGPMFKNTSV
GLLYSGCRLT LLRPEKNGAA TGMDAICSHR LDPKSPGLNR EQLYWELSQL THGIKELGPY
TLDRNSLYVN GFTHRSSVAP TSTPGTSTVD LGTSGTPSSL PSPTTAVPLL VPFTLNFTIT
NLQYGEDMRH PGSRKFNTTE RVLQGLLGPL FKNSSVGPLY SGCRLISLRS EKDGAATGVD
AICTHHLNPQ SPGLDREQLY WQLSQMTNGI KELGPYTLDR NSLYVNGFTH RSSGLTTSTP
WTSTVDLGTS GTPSPVPSPT TTGPLLVPFT LNFTITNLQY EENMGHPGSR KFNITESVLQ
GLLKPLFKST SVGPLYSGCR LTLLRPEKDG VATRVDAICT HRPDPKIPGL DRQQLYWELS
QLTHSITELG PYTLDRDSLY VNGFTQRSSV PTTSTPGTFT VQPETSETPS SLPGPTATGP
VLLPFTLNFT ITNLQYEEDM RRPGSRKFNT TERVLQGLLM PLFKNTSVSS LYSGCRLTLL
RPEKDGAATR VDAVCTHRPD PKSPGLDRER LYWKLSQLTH GITELGPYTL DRHSLYVNGF
THQSSMTTTR TPDTSTMHLA TSRTPASLSG PMTASPLLVL FTINFTITNL RYEENMHHPG
SRKFNTTERV LQGLLRPVFK NTSVGPLYSG CRLTLLRPKK DGAATKVDAI CTYRPDPKSP
GLDREQLYWE LSQLTHSITE LGPYTLDRDS LYVNGFTQRS SVPTTSIPGT PTVDLGTSGT
PVSKPGPSAA SPLLVLFTLN FTITNLRYEE NMQHPGSRKF NTTERVLQGL LRSLFKSTSV
GPLYSGCRLT LLRPEKDGTA TGVDAICTHH PDPKSPRLDR EQLYWELSQL THNITELGPY
ALDNDSLFVN GFTHRSSVST TSTPGTPTVY LGASKTPASI FGPSAASHLL ILFTLNFTIT
NLRYEENMWP GSRKFNTTER VLQGLLRPLF KNTSVGPLYS GCRLTLLRPE KDGEATGVDA
ICTHRPDPTG PGLDREQLYL ELSQLTHSIT ELGPYTLDRD SLYVNGFTHR SSVPTTSTGV
VSEEPFTLNF TINNLRYMAD MGQPGSLKFN ITDNVMQHLL SPLFQRSSLG ARYTGCRVIA
LRSVKNGAET RVDLLCTYLQ PLSGPGLPIK QVFHELSQQT HGITRLGPYS LDKDSLYLNG
YNEPGPDEPP TTPKPATTFL PPLSEATTAM GYHLKTLTLN FTISNLQYSP DMGKGSATFN
STEGVLQHLL RPLFQKSSMG PFYLGCQLIS LRPEKDGAAT GVDTTCTYHP DPVGPGLDIQ
QLYWELSQLT HGVTQLGFYV LDRDSLFING YAPQNLSIRG EYQINFHIVN WNLSNPDPTS
SEYITLLRDI QDKVTTLYKG SQLHDTFRFC LVTNLTMDSV LVTVKALFSS NLDPSLVEQV
FLDKTLNASF HWLGSTYQLV DIHVTEMESS VYQPTSSSST QHFYLNFTIT NLPYSQDKAQ
PGTTNYQRNK RNIEDALNQL FRNSSIKSYF SDCQVSTFRS VPNRHHTGVD SLCNFSPLAR
RVDRVAIYEE FLRMTRNGTQ LQNFTLDRSS VLVDGYSPNR NEPLTGNSDL PFWAVILIGL
AGLLGVITCL ICGVLVTTRR RKKEGEYNVQ QQCPGYYQSH LDLEDLQ


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