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Multidrug efflux pump accessory protein AcrZ (AcrAB-TolC multidrug efflux pump accessory protein AcrZ) (Acridine resistance protein Z)
ACRZ_ECOLI Reviewed; 49 AA.
P0AAW9; P75759;
11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
11-OCT-2005, sequence version 1.
13-FEB-2019, entry version 83.
RecName: Full=Multidrug efflux pump accessory protein AcrZ {ECO:0000255|HAMAP-Rule:MF_01484};
AltName: Full=AcrAB-TolC multidrug efflux pump accessory protein AcrZ {ECO:0000255|HAMAP-Rule:MF_01484};
AltName: Full=Acridine resistance protein Z {ECO:0000255|HAMAP-Rule:MF_01484};
Name=acrZ {ECO:0000255|HAMAP-Rule:MF_01484}; Synonyms=ybhT;
OrderedLocusNames=b0762, JW5102;
Escherichia coli (strain K12).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=83333;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=8905232; DOI=10.1093/dnares/3.3.137;
Oshima T., Aiba H., Baba T., Fujita K., Hayashi K., Honjo A.,
Ikemoto K., Inada T., Itoh T., Kajihara M., Kanai K., Kashimoto K.,
Kimura S., Kitagawa M., Makino K., Masuda S., Miki T., Mizobuchi K.,
Mori H., Motomura K., Nakamura Y., Nashimoto H., Nishio Y., Saito N.,
Sampei G., Seki Y., Tagami H., Takemoto K., Wada C., Yamamoto Y.,
Yano M., Horiuchi T.;
"A 718-kb DNA sequence of the Escherichia coli K-12 genome
corresponding to the 12.7-28.0 min region on the linkage map.";
DNA Res. 3:137-155(1996).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=9278503; DOI=10.1126/science.277.5331.1453;
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1462(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=16738553; DOI=10.1038/msb4100049;
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains
MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[4]
SUBCELLULAR LOCATION, AND INDUCTION.
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=19121005; DOI=10.1111/j.1365-2958.2008.06495.x;
Hemm M.R., Paul B.J., Schneider T.D., Storz G., Rudd K.E.;
"Small membrane proteins found by comparative genomics and ribosome
binding site models.";
Mol. Microbiol. 70:1487-1501(2008).
[5]
INDUCTION.
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=19734316; DOI=10.1128/JB.00872-09;
Hemm M.R., Paul B.J., Miranda-Rios J., Zhang A., Soltanzad N.,
Storz G.;
"Small stress response proteins in Escherichia coli: proteins missed
by classical proteomic studies.";
J. Bacteriol. 192:46-58(2010).
[6]
SUBCELLULAR LOCATION.
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=21778229; DOI=10.1074/jbc.M111.245696;
Fontaine F., Fuchs R.T., Storz G.;
"Membrane localization of small proteins in Escherichia coli.";
J. Biol. Chem. 286:32464-32474(2011).
[7]
FUNCTION, INTERACTION WITH ACRB, SUBUNIT, INDUCTION, DISRUPTION
PHENOTYPE, AND MUTAGENESIS OF GLY-30 AND 46-GLY--HIS-49.
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=23010927; DOI=10.1073/pnas.1210093109;
Hobbs E.C., Yin X., Paul B.J., Astarita J.L., Storz G.;
"Conserved small protein associates with the multidrug efflux pump
AcrB and differentially affects antibiotic resistance.";
Proc. Natl. Acad. Sci. U.S.A. 109:16696-16701(2012).
-!- FUNCTION: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex
with a broad substrate specificity. This protein binds to AcrB and
is required for efflux of some but not all substrates, suggesting
it may influence the specificity of drug export.
{ECO:0000255|HAMAP-Rule:MF_01484, ECO:0000269|PubMed:23010927}.
-!- SUBUNIT: Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts
directly with AcrB. {ECO:0000255|HAMAP-Rule:MF_01484,
ECO:0000269|PubMed:23010927}.
-!- INTERACTION:
P31224:acrB; NbExp=7; IntAct=EBI-6313593, EBI-551006;
-!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
Rule:MF_01484, ECO:0000269|PubMed:19121005,
ECO:0000269|PubMed:21778229}; Single-pass membrane protein
{ECO:0000255|HAMAP-Rule:MF_01484, ECO:0000269|PubMed:19121005,
ECO:0000269|PubMed:21778229}. Note=In sucrose cushions
fractionates with both the inner and outer membranes.
-!- INDUCTION: Constitutively expressed (PubMed:19121005), may be
repressed at 45 degrees Celsius (PubMed:19121005) (at protein
level). Positively regulated by MarA, Rob and SoxS transcriptional
regulators. {ECO:0000269|PubMed:19121005,
ECO:0000269|PubMed:19734316, ECO:0000269|PubMed:23010927}.
-!- DISRUPTION PHENOTYPE: Becomes sensitive to some antibiotics
(chloramphenicol, puromycin and tetracycline) but not to others
(erythromycin, rifampicin and fusidic acid).
{ECO:0000269|PubMed:23010927}.
-!- SIMILARITY: Belongs to the AcrZ family. {ECO:0000255|HAMAP-
Rule:MF_01484}.
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EMBL; U00096; AAC73849.1; -; Genomic_DNA.
EMBL; AP009048; BAA35426.2; -; Genomic_DNA.
PIR; B64812; B64812.
RefSeq; NP_415283.1; NC_000913.3.
RefSeq; WP_000891515.1; NZ_LN832404.1.
PDB; 4C48; X-ray; 3.30 A; C=1-49.
PDB; 5NC5; X-ray; 3.20 A; F/G/H=1-49.
PDB; 5NG5; EM; 6.50 A; M/N/O=1-49.
PDB; 5O66; EM; 5.90 A; M/N/O=1-49.
PDBsum; 4C48; -.
PDBsum; 5NC5; -.
PDBsum; 5NG5; -.
PDBsum; 5O66; -.
ProteinModelPortal; P0AAW9; -.
SMR; P0AAW9; -.
BioGrid; 4259947; 12.
DIP; DIP-11423N; -.
IntAct; P0AAW9; 2.
STRING; 316385.ECDH10B_0830; -.
TCDB; 2.A.6.2.2; the resistance-nodulation-cell division (rnd) superfamily.
TCDB; 8.A.50.1.1; the acrz rnd auxillary subunit (acrz) family.
PaxDb; P0AAW9; -.
PRIDE; P0AAW9; -.
EnsemblBacteria; AAC73849; AAC73849; b0762.
EnsemblBacteria; BAA35426; BAA35426; BAA35426.
GeneID; 945365; -.
KEGG; ecj:JW5102; -.
KEGG; eco:b0762; -.
PATRIC; fig|1411691.4.peg.1516; -.
EchoBASE; EB4074; -.
EcoGene; EG14328; acrZ.
HOGENOM; HOG000219534; -.
BioCyc; EcoCyc:G6396-MONOMER; -.
BioCyc; ECOL316407:JW5102-MONOMER; -.
PRO; PR:P0AAW9; -.
Proteomes; UP000000318; Chromosome.
Proteomes; UP000000625; Chromosome.
GO; GO:0009279; C:cell outer membrane; IDA:EcoCyc.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
GO; GO:0015238; F:drug transmembrane transporter activity; IMP:UniProtKB.
GO; GO:0036460; P:cellular response to cell envelope stress; IMP:EcoCyc.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
HAMAP; MF_01484; AcrZ; 1.
InterPro; IPR019702; AcrZ.
Pfam; PF10766; AcrZ; 1.
1: Evidence at protein level;
3D-structure; Antibiotic resistance; Cell inner membrane;
Cell membrane; Complete proteome; Membrane; Reference proteome;
Stress response; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 49 Multidrug efflux pump accessory protein
AcrZ.
/FTId=PRO_0000013811.
TOPO_DOM 1 7 Periplasmic. {ECO:0000305}.
TRANSMEM 8 28 Helical. {ECO:0000255|HAMAP-
Rule:MF_01484}.
TOPO_DOM 29 49 Cytoplasmic. {ECO:0000305}.
MUTAGEN 30 30 G->R: Loss of chloramphenicol resistance,
does not bind AcrB (dominant-negative to
wild-type). Partially suppressed by AcrB
H526Y. {ECO:0000269|PubMed:23010927}.
MUTAGEN 46 49 Missing: Loss of chloramphenicol
resistance, still binds AcrB (dominant-
negative to wild-type).
{ECO:0000269|PubMed:23010927}.
HELIX 2 35 {ECO:0000244|PDB:4C48}.
SEQUENCE 49 AA; 5300 MW; 1B1185D27F1F37F7 CRC64;
MLELLKSLVF AVIMVPVVMA IILGLIYGLG EVFNIFSGVG KKDQPGQNH
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Pathways :
WP2199: Seed Development
WP1049: G Protein Signaling Pathways
WP1165: G Protein Signaling Pathways
WP1371: G Protein Signaling Pathways
WP1438: Influenza A virus infection
WP1493: Carbon assimilation C4 pathway
WP1502: Mitochondrial biogenesis
WP1531: Vitamin D synthesis
WP1566: Citrate cycle (TCA cycle)
WP1613: 1,4-Dichlorobenzene degradation
WP1616: ABC transporters
WP1624: Bacterial secretion system
WP1625: Base excision repair
WP1644: DNA replication
WP1650: Fluorobenzoate degradation
WP1654: gamma-Hexachlorocyclohexane degradation
WP1657: Glycerolipid metabolism
WP1659: Glycine, serine and threonine metabolism
WP1661: Glyoxylate and dicarboxylate metabolism
WP1663: Homologous recombination
WP1665: Limonene and pinene degradation
WP1672: Mismatch repair
WP1673: Naphthalene and anthracene degradation
WP1675: Nitrogen metabolism
WP1676: Non-homologous end-joining
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