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Multidrug efflux pump accessory protein AcrZ (AcrAB-TolC multidrug efflux pump accessory protein AcrZ) (Acridine resistance protein Z)

 ACRZ_ECO57              Reviewed;          49 AA.
P0AAX1; P75759;
11-OCT-2005, integrated into UniProtKB/Swiss-Prot.
11-OCT-2005, sequence version 1.
22-NOV-2017, entry version 59.
RecName: Full=Multidrug efflux pump accessory protein AcrZ {ECO:0000255|HAMAP-Rule:MF_01484};
AltName: Full=AcrAB-TolC multidrug efflux pump accessory protein AcrZ {ECO:0000255|HAMAP-Rule:MF_01484};
AltName: Full=Acridine resistance protein Z {ECO:0000255|HAMAP-Rule:MF_01484};
Name=acrZ {ECO:0000255|HAMAP-Rule:MF_01484};
OrderedLocusNames=Z0932, ECs0790;
Escherichia coli O157:H7.
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=83334;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
PubMed=11206551; DOI=10.1038/35054089;
Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
Welch R.A., Blattner F.R.;
"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
Nature 409:529-533(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
PubMed=11258796; DOI=10.1093/dnares/8.1.11;
Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
Kuhara S., Shiba T., Hattori M., Shinagawa H.;
"Complete genome sequence of enterohemorrhagic Escherichia coli
O157:H7 and genomic comparison with a laboratory strain K-12.";
DNA Res. 8:11-22(2001).
-!- FUNCTION: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex
with a broad substrate specificity. This protein binds to AcrB and
is required for efflux of some but not all substrates, suggesting
it may influence the specificity of drug export.
{ECO:0000255|HAMAP-Rule:MF_01484}.
-!- SUBUNIT: Part of the AcrA-AcrB-AcrZ-TolC efflux pump, interacts
directly with AcrB. {ECO:0000255|HAMAP-Rule:MF_01484}.
-!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
Rule:MF_01484}; Single-pass membrane protein {ECO:0000255|HAMAP-
Rule:MF_01484}.
-!- SIMILARITY: Belongs to the AcrZ family. {ECO:0000255|HAMAP-
Rule:MF_01484}.
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EMBL; AE005174; AAG55091.1; -; Genomic_DNA.
EMBL; BA000007; BAB34213.1; -; Genomic_DNA.
PIR; F90727; F90727.
PIR; G85578; G85578.
RefSeq; NP_308817.1; NC_002695.1.
RefSeq; WP_000891515.1; NZ_NOKN01000002.1.
ProteinModelPortal; P0AAX1; -.
SMR; P0AAX1; -.
STRING; 155864.Z0932; -.
EnsemblBacteria; AAG55091; AAG55091; Z0932.
EnsemblBacteria; BAB34213; BAB34213; BAB34213.
GeneID; 917527; -.
KEGG; ece:Z0932; -.
KEGG; ecs:ECs0790; -.
PATRIC; fig|386585.9.peg.910; -.
eggNOG; ENOG410680R; Bacteria.
eggNOG; ENOG410XV2A; LUCA.
HOGENOM; HOG000219534; -.
Proteomes; UP000000558; Chromosome.
Proteomes; UP000002519; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0015238; F:drug transmembrane transporter activity; IEA:InterPro.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
HAMAP; MF_01484; AcrZ; 1.
InterPro; IPR019702; AcrZ.
Pfam; PF10766; AcrZ; 1.
3: Inferred from homology;
Antibiotic resistance; Cell inner membrane; Cell membrane;
Complete proteome; Membrane; Transmembrane; Transmembrane helix;
Transport.
CHAIN 1 49 Multidrug efflux pump accessory protein
AcrZ.
/FTId=PRO_0000042561.
TOPO_DOM 1 7 Periplasmic. {ECO:0000250}.
TRANSMEM 8 28 Helical. {ECO:0000255|HAMAP-
Rule:MF_01484}.
TOPO_DOM 29 49 Cytoplasmic. {ECO:0000250}.
SEQUENCE 49 AA; 5300 MW; 1B1185D27F1F37F7 CRC64;
MLELLKSLVF AVIMVPVVMA IILGLIYGLG EVFNIFSGVG KKDQPGQNH


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