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Multidrug efflux pump subunit AcrA (AcrAB-TolC multidrug efflux pump subunit AcrA) (Acriflavine resistance protein A)

 ACRA_ECO57              Reviewed;         397 AA.
P0AE07; P31223;
06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
06-DEC-2005, sequence version 1.
23-MAY-2018, entry version 83.
RecName: Full=Multidrug efflux pump subunit AcrA;
AltName: Full=AcrAB-TolC multidrug efflux pump subunit AcrA;
AltName: Full=Acriflavine resistance protein A;
Flags: Precursor;
Name=acrA; OrderedLocusNames=Z0578, ECs0516;
Escherichia coli O157:H7.
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=83334;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=O157:H7 / EDL933 / ATCC 700927 / EHEC;
PubMed=11206551; DOI=10.1038/35054089;
Perna N.T., Plunkett G. III, Burland V., Mau B., Glasner J.D.,
Rose D.J., Mayhew G.F., Evans P.S., Gregor J., Kirkpatrick H.A.,
Posfai G., Hackett J., Klink S., Boutin A., Shao Y., Miller L.,
Grotbeck E.J., Davis N.W., Lim A., Dimalanta E.T., Potamousis K.,
Apodaca J., Anantharaman T.S., Lin J., Yen G., Schwartz D.C.,
Welch R.A., Blattner F.R.;
"Genome sequence of enterohaemorrhagic Escherichia coli O157:H7.";
Nature 409:529-533(2001).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=O157:H7 / Sakai / RIMD 0509952 / EHEC;
PubMed=11258796; DOI=10.1093/dnares/8.1.11;
Hayashi T., Makino K., Ohnishi M., Kurokawa K., Ishii K., Yokoyama K.,
Han C.-G., Ohtsubo E., Nakayama K., Murata T., Tanaka M., Tobe T.,
Iida T., Takami H., Honda T., Sasakawa C., Ogasawara N., Yasunaga T.,
Kuhara S., Shiba T., Hattori M., Shinagawa H.;
"Complete genome sequence of enterohemorrhagic Escherichia coli
O157:H7 and genomic comparison with a laboratory strain K-12.";
DNA Res. 8:11-22(2001).
-!- FUNCTION: AcrA-AcrB-AcrZ-TolC is a drug efflux protein complex
with broad substrate specificity that uses the proton motive force
to export substrates. This subunit may act as an adapter protein
that links AcrB and TolC stably together (By similarity).
{ECO:0000250}.
-!- SUBUNIT: Monomeric in solution. Homotrimeric; interacts
indpendently with AcrB and TolC as well as AcrZ. Part of the AcrA-
AcrB-TolC efflux pump (By similarity). {ECO:0000250}.
-!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Lipid-
anchor {ECO:0000255|PROSITE-ProRule:PRU00303}.
-!- SIMILARITY: Belongs to the membrane fusion protein (MFP) (TC
8.A.1) family. {ECO:0000305}.
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EMBL; AE005174; AAG54812.1; -; Genomic_DNA.
EMBL; BA000007; BAB33939.1; -; Genomic_DNA.
PIR; D90693; D90693.
PIR; H85543; H85543.
RefSeq; NP_308543.1; NC_002695.1.
RefSeq; WP_001295324.1; NZ_NOKN01000002.1.
ProteinModelPortal; P0AE07; -.
SMR; P0AE07; -.
STRING; 155864.Z0578; -.
EnsemblBacteria; AAG54812; AAG54812; Z0578.
EnsemblBacteria; BAB33939; BAB33939; BAB33939.
GeneID; 914620; -.
KEGG; ece:Z0578; -.
KEGG; ecs:ECs0516; -.
PATRIC; fig|386585.9.peg.621; -.
eggNOG; ENOG4105C1P; Bacteria.
eggNOG; ENOG410XNVN; LUCA.
HOGENOM; HOG000158247; -.
KO; K03585; -.
OMA; MQFKPAV; -.
Proteomes; UP000000558; Chromosome.
Proteomes; UP000002519; Chromosome.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005215; F:transporter activity; IEA:InterPro.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
InterPro; IPR032317; HlyD_D23.
InterPro; IPR006143; RND_pump_MFP.
Pfam; PF00529; HlyD; 1.
Pfam; PF16576; HlyD_D23; 1.
TIGRFAMs; TIGR01730; RND_mfp; 1.
PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
3: Inferred from homology;
Antibiotic resistance; Cell inner membrane; Cell membrane;
Coiled coil; Complete proteome; Lipoprotein; Membrane; Palmitate;
Reference proteome; Signal; Transport.
SIGNAL 1 24 {ECO:0000255|PROSITE-ProRule:PRU00303}.
CHAIN 25 397 Multidrug efflux pump subunit AcrA.
/FTId=PRO_0000043378.
COILED 98 172 {ECO:0000250}.
LIPID 25 25 N-palmitoyl cysteine.
{ECO:0000255|PROSITE-ProRule:PRU00303}.
LIPID 25 25 S-diacylglycerol cysteine.
{ECO:0000255|PROSITE-ProRule:PRU00303}.
SEQUENCE 397 AA; 42197 MW; 5B81DD5BC2B0A077 CRC64;
MNKNRGFTPL AVVLMLSGSL ALTGCDDKQA QQGGQQMPAV GVVTVKTEPL QITTELPGRT
SAYRIAEVRP QVSGIILKRN FKEGSDIEAG VSLYQIDPAT YQATYDSAKG DLAKAQAAAN
IAQLTVNRYQ KLLGTQYISK QEYDQALADA QQANAAVTAA KAAVETARIN LAYTKVTSPI
SGRIGKSNVT EGALVQNGQA TALATVQQLD PIYVDVTQSS NDFLRLKQEL ANGTLKQENG
KAKVSLITSD GIKFPQDGTL EFSDVTVDQT TGSITLRAIF PNPDHTLLPG MFVRARLEEG
LNPNAILVPQ QGVTRTPRGD ATVLVVGADD KVETRPIVAS QAIGDKWLVT EGLKAGDRVV
ISGLQKVRPG VQVKAQEVTA DNNQQAASGA QPEQSKS


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