Did you know ? If you order before Friday 14h we deliver 90PCT of the the time next Tuesday, GENTAUR another in time delivery

Multidrug resistance protein MdtF

 MDTF_ECOLI              Reviewed;        1037 AA.
P37637; Q2M7H6;
01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
01-OCT-1994, sequence version 1.
28-MAR-2018, entry version 134.
RecName: Full=Multidrug resistance protein MdtF;
Name=mdtF; Synonyms=yhiV; OrderedLocusNames=b3514, JW3482;
Escherichia coli (strain K12).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=83333;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=8041620; DOI=10.1093/nar/22.13.2576;
Sofia H.J., Burland V., Daniels D.L., Plunkett G. III, Blattner F.R.;
"Analysis of the Escherichia coli genome. V. DNA sequence of the
region from 76.0 to 81.5 minutes.";
Nucleic Acids Res. 22:2576-2586(1994).
[2]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=9278503; DOI=10.1126/science.277.5331.1453;
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1462(1997).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=16738553; DOI=10.1038/msb4100049;
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains
MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[4]
FUNCTION IN MULTIDRUG RESISTANCE.
PubMed=11566977; DOI=10.1128/JB.183.20.5803-5812.2001;
Nishino K., Yamaguchi A.;
"Analysis of a complete library of putative drug transporter genes in
Escherichia coli.";
J. Bacteriol. 183:5803-5812(2001).
[5]
INDUCTION, AND SUBUNIT.
PubMed=11914367; DOI=10.1128/JB.184.8.2319-2323.2002;
Nishino K., Yamaguchi A.;
"EvgA of the two-component signal transduction system modulates
production of the yhiUV multidrug transporter in Escherichia coli.";
J. Bacteriol. 184:2319-2323(2002).
[6]
INDUCTION.
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=12399493; DOI=10.1128/JB.184.22.6225-6234.2002;
Masuda N., Church G.M.;
"Escherichia coli gene expression responsive to levels of the response
regulator EvgA.";
J. Bacteriol. 184:6225-6234(2002).
[7]
INDUCTION.
PubMed=14523115; DOI=10.1099/mic.0.26460-0;
Eguchi Y., Oshima T., Mori H., Aono R., Yamamoto K., Ishihama A.,
Utsumi R.;
"Transcriptional regulation of drug efflux genes by EvgAS, a two-
component system in Escherichia coli.";
Microbiology 149:2819-2828(2003).
[8]
INDUCTION.
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=12694615; DOI=10.1046/j.1365-2958.2003.03477.x;
Masuda N., Church G.M.;
"Regulatory network of acid resistance genes in Escherichia coli.";
Mol. Microbiol. 48:699-712(2003).
[9]
SUBUNIT, AND SUBCELLULAR LOCATION.
STRAIN=BL21-DE3;
PubMed=16079137; DOI=10.1074/jbc.M506479200;
Stenberg F., Chovanec P., Maslen S.L., Robinson C.V., Ilag L.,
von Heijne G., Daley D.O.;
"Protein complexes of the Escherichia coli cell envelope.";
J. Biol. Chem. 280:34409-34419(2005).
[10]
TOPOLOGY [LARGE SCALE ANALYSIS].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=15919996; DOI=10.1126/science.1109730;
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.;
"Global topology analysis of the Escherichia coli inner membrane
proteome.";
Science 308:1321-1323(2005).
-!- FUNCTION: Part of the tripartite efflux system MdtEF-TolC, which
confers resistance to compounds such as rhodamine 6G,
erythromycin, doxorubicin, ethidium bromide, TPP, SDS,
deoxycholate, crystal violet and benzalkonium.
{ECO:0000269|PubMed:11566977}.
-!- SUBUNIT: Homotrimer. Part of the tripartite efflux system MdtEF-
TolC, which is composed of an inner membrane transporter, MdtF, a
membrane fusion protein, MdtE, and an outer membrane component,
TolC. The complex forms a large protein conduit and can
translocate molecules across both the inner and outer membranes.
{ECO:0000269|PubMed:11914367, ECO:0000269|PubMed:16079137}.
-!- SUBCELLULAR LOCATION: Cell inner membrane
{ECO:0000269|PubMed:16079137}; Multi-pass membrane protein
{ECO:0000269|PubMed:16079137}.
-!- INDUCTION: Induced by EvgA, probably via YdeO.
{ECO:0000269|PubMed:11914367, ECO:0000269|PubMed:12399493,
ECO:0000269|PubMed:12694615, ECO:0000269|PubMed:14523115}.
-!- SIMILARITY: Belongs to the resistance-nodulation-cell division
(RND) (TC 2.A.6) family. {ECO:0000305}.
-----------------------------------------------------------------------
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
Distributed under the Creative Commons Attribution (CC BY 4.0) License
-----------------------------------------------------------------------
EMBL; U00039; AAB18490.1; -; Genomic_DNA.
EMBL; U00096; AAC76539.1; -; Genomic_DNA.
EMBL; AP009048; BAE77780.1; -; Genomic_DNA.
PIR; S47734; S47734.
RefSeq; NP_417971.1; NC_000913.3.
RefSeq; WP_000024872.1; NZ_LN832404.1.
ProteinModelPortal; P37637; -.
SMR; P37637; -.
BioGrid; 4262521; 292.
IntAct; P37637; 1.
STRING; 316385.ECDH10B_3690; -.
TCDB; 2.A.6.2.13; the resistance-nodulation-cell division (rnd) superfamily.
PaxDb; P37637; -.
PRIDE; P37637; -.
EnsemblBacteria; AAC76539; AAC76539; b3514.
EnsemblBacteria; BAE77780; BAE77780; BAE77780.
GeneID; 948030; -.
KEGG; ecj:JW3482; -.
KEGG; eco:b3514; -.
PATRIC; fig|1411691.4.peg.3204; -.
EchoBASE; EB2152; -.
EcoGene; EG12241; mdtF.
eggNOG; ENOG4105BZS; Bacteria.
eggNOG; COG0841; LUCA.
HOGENOM; HOG000158129; -.
InParanoid; P37637; -.
KO; K18899; -.
OMA; WDIPYDI; -.
PhylomeDB; P37637; -.
BioCyc; EcoCyc:YHIV-MONOMER; -.
PRO; PR:P37637; -.
Proteomes; UP000000318; Chromosome.
Proteomes; UP000000625; Chromosome.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0016020; C:membrane; HDA:UniProtKB.
GO; GO:0005886; C:plasma membrane; IDA:EcoCyc.
GO; GO:0015562; F:efflux transmembrane transporter activity; IEA:InterPro.
GO; GO:0005215; F:transporter activity; IMP:EcoliWiki.
GO; GO:0006855; P:drug transmembrane transport; IMP:EcoliWiki.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
Gene3D; 3.30.2090.10; -; 2.
InterPro; IPR027463; AcrB_DN_DC_subdom.
InterPro; IPR001036; Acrflvin-R.
InterPro; IPR004764; HAE1.
PANTHER; PTHR32063; PTHR32063; 1.
Pfam; PF00873; ACR_tran; 1.
PRINTS; PR00702; ACRIFLAVINRP.
SUPFAM; SSF82714; SSF82714; 2.
TIGRFAMs; TIGR00915; 2A0602; 1.
1: Evidence at protein level;
Antibiotic resistance; Cell inner membrane; Cell membrane;
Complete proteome; Membrane; Reference proteome; Transmembrane;
Transmembrane helix; Transport.
CHAIN 1 1037 Multidrug resistance protein MdtF.
/FTId=PRO_0000161841.
TOPO_DOM 1 9 Cytoplasmic. {ECO:0000250}.
TRANSMEM 10 28 Helical; Name=1. {ECO:0000250}.
TOPO_DOM 29 339 Periplasmic. {ECO:0000250}.
TRANSMEM 340 359 Helical; Name=2. {ECO:0000250}.
TOPO_DOM 360 365 Cytoplasmic. {ECO:0000250}.
TRANSMEM 366 385 Helical; Name=3. {ECO:0000250}.
TOPO_DOM 386 391 Periplasmic. {ECO:0000250}.
TRANSMEM 392 413 Helical; Name=4. {ECO:0000250}.
TOPO_DOM 414 441 Cytoplasmic. {ECO:0000250}.
TRANSMEM 442 460 Helical; Name=5. {ECO:0000250}.
TOPO_DOM 461 473 Periplasmic. {ECO:0000250}.
TRANSMEM 474 496 Helical; Name=6. {ECO:0000250}.
TOPO_DOM 497 536 Cytoplasmic. {ECO:0000250}.
TRANSMEM 537 555 Helical; Name=7. {ECO:0000250}.
TOPO_DOM 556 870 Periplasmic. {ECO:0000250}.
TRANSMEM 871 890 Helical; Name=8. {ECO:0000250}.
TOPO_DOM 891 896 Cytoplasmic. {ECO:0000250}.
TRANSMEM 897 916 Helical; Name=9. {ECO:0000250}.
TOPO_DOM 917 922 Periplasmic. {ECO:0000250}.
TRANSMEM 923 944 Helical; Name=10. {ECO:0000250}.
TOPO_DOM 945 972 Cytoplasmic. {ECO:0000250}.
TRANSMEM 973 991 Helical; Name=11. {ECO:0000250}.
TOPO_DOM 992 1004 Periplasmic. {ECO:0000250}.
TRANSMEM 1005 1027 Helical; Name=12. {ECO:0000250}.
TOPO_DOM 1028 1037 Cytoplasmic. {ECO:0000250}.
SEQUENCE 1037 AA; 111517 MW; 3B67502160F51724 CRC64;
MANYFIDRPV FAWVLAIIMM LAGGLAIMNL PVAQYPQIAP PTITVSATYP GADAQTVEDS
VTQVIEQNMN GLDGLMYMSS TSDAAGNASI TLTFETGTSP DIAQVQVQNK LQLAMPSLPE
AVQQQGISVD KSSSNILMVA AFISDNGSLN QYDIADYVAS NIKDPLSRTA GVGSVQLFGS
EYAMRIWLDP QKLNKYNLVP SDVISQIKVQ NNQISGGQLG GMPQAADQQL NASIIVQTRL
QTPEEFGKIL LKVQQDGSQV LLRDVARVEL GAEDYSTVAR YNGKPAAGIA IKLAAGANAL
DTSRAVKEEL NRLSAYFPAS LKTVYPYDTT PFIEISIQEV FKTLVEAIIL VFLVMYLFLQ
NFRATIIPTI AVPVVILGTF AILSAVGFTI NTLTMFGMVL AIGLLVDDAI VVVENVERVI
AEDKLPPKEA THKSMGQIQR ALVGIAVVLS AVFMPMAFMS GATGEIYRQF SITLISSMLL
SVFVAMSLTP ALCATILKAA PEGGHKPNAL FARFNTLFEK STQHYTDSTR SLLRCTGRYM
VVYLLICAGM AVLFLRTPTS FLPEEDQGVF MTTAQLPSGA TMVNTTKVLQ QVTDYYLTKE
KDNVQSVFTV GGFGFSGQGQ NNGLAFISLK PWSERVGEEN SVTAIIQRAM IALSSINKAV
VFPFNLPAVA ELGTASGFDM ELLDNGNLGH EKLTQARNEL LSLAAQSPNQ VTGVRPNGLE
DTPMFKVNVN AAKAEAMGVA LSDINQTIST AFGSSYVNDF LNQGRVKKVY VQAGTPFRML
PDNINQWYVR NASGTMAPLS AYSSTEWTYG SPRLERYNGI PSMEILGEAA AGKSTGDAMK
FMADLVAKLP AGVGYSWTGL SYQEALSSNQ APALYAISLV VVFLALAALY ESWSIPFSVM
LVVPLGVVGA LLATDLRGLS NDVYFQVGLL TTIGLSAKNA ILIVEFAVEM MQKEGKTPIE
AIIEAARMRL RPILMTSLAF ILGVLPLVIS HGAGSGAQNA VGTGVMGGMF AATVLAIYFV
PVFFVVVEHL FARFKKA


Related products :

Catalog number Product name Quantity
EIAAB25426 Abcc2,ATP-binding cassette sub-family C member 2,Canalicular multidrug resistance protein,Canalicular multispecific organic anion transporter 1,Cmoat,Cmrp,Mrp2,Multidrug resistance-associated protein
EIAAB25437 ABCC6,Anthracycline resistance-associated protein,ARA,ATP-binding cassette sub-family C member 6,Homo sapiens,Human,MOAT-E,MRP6,Multidrug resistance-associated protein 6,Multi-specific organic anion t
EIAAB25429 ABCC2,ATP-binding cassette sub-family C member 2,Canalicular multidrug resistance protein,Canalicular multispecific organic anion transporter 1,CMOAT,CMOAT1,CMRP,Homo sapiens,Human,MRP2,Multidrug resi
E12411395 Rat multidrug resistance-associated protein(MRP) ELISA Kit 1
EH3381 Multidrug Resistance-Associated Protein Elisa Kit 96T
ER431 Multidrug resistance-associated protein 1 Elisa Kit 96T
EM795 Multidrug resistance protein 1 Elisa Kit 96T
EH1203 Multidrug resistance-associated protein 1 Elisa Kit 96T
EH1170 Multidrug resistance protein 3 Elisa Kit 96T
ER678 Multidrug resistance protein 1 Elisa Kit 96T
EH2377 Multidrug resistance protein 1 Elisa Kit 96T
EH1169 Multidrug resistance-associated protein 9 Elisa Kit 96T
EH1167 Multidrug resistance-associated protein 4 Elisa Kit 96T
EH1168 Multidrug resistance-associated protein 6 Elisa Kit 96T
UB-E03722 Human multidrug resistance-associated protein(MRP)ELISA Kit 96T
CSB-EL001056DO Dog Multidrug resistance-associated protein 1(ABCC1) ELISA kit 96T
E1688Hu Human multidrug resistance-associated protein,MRP ELISA Kit 48T
E1688Hu Human multidrug resistance-associated protein,MRP ELISA Kit 96T
201-12-1689 Human multidrug resistance-associated protein,MRP ELISA Kit 96T
YHB2068Hu Human multidrug resistance-associated protein,MRP ELISA Kit 48T
E-EL-H1240 Human MRP (Multidrug Resistance-Associated Protein) ELISA Kit 96T
E-EL-P1151 Porcine MRP (Multidrug Resistance-Associated Protein) ELISA Kit 96T
CK-E97471 Human multidrug resistance-associated protein,MRP ELISAkit
201-12-1689 Human multidrug resistance-associated protein(MRP)ELISA Kit 96T
CK-E11665 Human multidrug resistance-associated protein,MRP ELISA Kit 96T


 

GENTAUR Belgium BVBA BE0473327336
Voortstraat 49, 1910 Kampenhout BELGIUM
Tel 0032 16 58 90 45

Fax 0032 16 50 90 45
info@gentaur.com | Gentaur





GENTAUR Ltd.
Howard Frank Turnberry House
1404-1410 High Road
Whetstone London N20 9BH
Tel 020 3393 8531 Fax 020 8445 9411
uk@gentaur.com | Gentaur

 

 




GENTAUR France SARL
9, rue Lagrange, 75005 Paris
Tel 01 43 25 01 50

Fax 01 43 25 01 60
RCS Paris B 484 237 888

SIRET 48423788800017

BNP PARIBAS PARIS PL MAUBERT BIC BNPAFRPPPRG

france@gentaur.com | Gentaur

GENTAUR GmbH
Marienbongard 20
52062 Aachen Deutschland
Support Karolina Elandt
Tel: 0035929830070
Fax: (+49) 241 56 00 47 88

Logistic :0241 40 08 90 86
Bankleitzahl 39050000
IBAN lautet DE8839050000107569353
Handelsregister Aachen HR B 16058
Umsatzsteuer-Identifikationsnummer *** DE 815175831
Steuernummer 201/5961/3925
de@gentaur.com | Gentaur

GENTAUR U.S.A
Genprice Inc, Logistics
547, Yurok Circle
San Jose, CA 95123
CA 95123
Tel (408) 780-0908,
Fax (408) 780-0908,
sales@genprice.com

Genprice Inc, Invoices and accounting
6017 Snell Ave, Ste 357
San Jose, CA 95123




GENTAUR Nederland BV
NL850396268B01 KVK nummer 52327027
Kuiper 1
5521 DG Eersel Nederland
Tel:  0208-080893  Fax: 0497-517897
nl@gentaur.com | Gentaur
IBAN: NL04 RABO 0156 9854 62   SWIFT RABONL2U






GENTAUR Spain
tel:0911876558
spain@gentaur.com | Gentaur






ГЕНТАУЪР БЪЛГАРИЯ
ID # 201 358 931 /BULSTAT
София 1000, ул. "Граф Игнатиев" 53 вх. В, ет. 2
Tel 0035924682280 Fax 0035924808322
e-mail: Sofia@gentaur.com | Gentaur
IBAN: BG11FINV91501014771636
BIC: FINVBGSF

GENTAUR Poland Sp. z o.o.


ul. Grunwaldzka 88/A m.2
81-771 Sopot, Poland
TEL Gdansk 058 710 33 44 FAX  058 710 33 48              

poland@gentaur.com | Gentaur

Other countries

Österreich +43720880899

Canada Montreal +15149077481

Ceská republika Praha +420246019719

Danmark +4569918806

Finland Helsset +358942419041

Magyarország Budapest +3619980547

Ireland Dublin+35316526556

Luxembourg+35220880274

Norge Oslo+4721031366

Sverige Stockholm+46852503438

Schweiz Züri+41435006251

US New York+17185132983

GENTAUR Italy
SRL IVA IT03841300167
Piazza Giacomo Matteotti, 6
24122 Bergamo Tel 02 36 00 65 93
Fax 02 36 00 65 94
italia@gentaur.com | Gentaur