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Multidrug resistance-associated protein 5 (ATP-binding cassette sub-family C member 5) (Multi-specific organic anion transporter C) (MOAT-C) (SMRP) (pABC11)

 MRP5_HUMAN              Reviewed;        1437 AA.
O15440; B9EIQ2; O14517; Q29ZA9; Q29ZB1; Q86UX3; Q86W30; Q9UN85;
Q9UNP5; Q9UQC3;
15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
01-DEC-2000, sequence version 2.
25-OCT-2017, entry version 168.
RecName: Full=Multidrug resistance-associated protein 5;
AltName: Full=ATP-binding cassette sub-family C member 5;
AltName: Full=Multi-specific organic anion transporter C;
Short=MOAT-C;
AltName: Full=SMRP;
AltName: Full=pABC11;
Name=ABCC5; Synonyms=MRP5;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=9827529; DOI=10.1093/jnci/90.22.1735;
Belinsky M.G., Bain L.J., Balsara B.B., Testa J.R., Kruh G.D.;
"Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT
subfamily of transporter proteins.";
J. Natl. Cancer Inst. 90:1735-1741(1998).
[2]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
TISSUE=Brain;
PubMed=10438534; DOI=10.1074/jbc.274.33.23541;
McAleer M.A., Breen M.A., White N.L., Matthews N.;
"pABC11 (also known as MOAT-C and MRP5), a member of the ABC family of
proteins, has anion transporter activity but does not confer multidrug
resistance when overexpressed in human embryonic kidney 293 cells.";
J. Biol. Chem. 274:23541-23548(1999).
[3]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
PubMed=10721709; DOI=10.1016/S0378-1119(99)00529-6;
Suzuki T., Sasaki H., Kuh H.J., Agui M., Tatsumi Y., Tanabe S.,
Terada M., Saijo N., Nishio K.;
"Detailed structural analysis on both human MRP5 and mouse mrp5
transcripts.";
Gene 242:167-173(2000).
[4]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND FUNCTION.
TISSUE=Brain, and Ovarian carcinoma;
PubMed=10840050; DOI=10.1073/pnas.120159197;
Wijnholds J., Mol C.A.A.M., van Deemter L., de Haas M., Scheffer G.L.,
Baas F., Beijnen J.H., Scheper R.J., Hatse S., De Clercq E.,
Balzarini J., Borst P.;
"Multidrug-resistance protein 5 is a multispecific organic anion
transporter able to transport nucleotide analogs.";
Proc. Natl. Acad. Sci. U.S.A. 97:7476-7481(2000).
[5]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4), TISSUE SPECIFICITY,
AND ALTERNATIVE SPLICING.
TISSUE=Retina;
PubMed=17521428; DOI=10.1186/1471-2199-8-42;
Stojic J., Stohr H., Weber B.H.;
"Three novel ABCC5 splice variants in human retina and their role as
regulators of ABCC5 gene expression.";
BMC Mol. Biol. 8:42-42(2007).
[6]
NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5).
TISSUE=Skeletal muscle;
Ito T., Kato R., Ishikawa T.;
Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
[7]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16641997; DOI=10.1038/nature04728;
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R.,
Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R.,
Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V.,
Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.,
Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B.,
Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S.,
Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q.,
Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z.,
Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C.,
Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G.,
Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B.,
Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R.,
Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J.,
Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A.,
Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B.,
Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H.,
Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J.,
Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J.,
Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H.,
Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G.,
Gibbs R.A.;
"The DNA sequence, annotation and analysis of human chromosome 3.";
Nature 440:1194-1198(2006).
[8]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
Venter J.C.;
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
[9]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
TISSUE=Brain, and Pancreas;
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[10]
NUCLEOTIDE SEQUENCE [MRNA] OF 492-1437 (ISOFORM 1).
TISSUE=Bone marrow;
PubMed=9325169; DOI=10.1006/bbrc.1997.7346;
Suzuki T., Nishio K., Sasaki H., Kurokawa H., Saito-Ohara F.,
Ikeuch T., Tanabe S., Terada M., Saijo N.;
"cDNA cloning of a short type of multidrug resistance protein
homologue, SMRP, from a human lung cancer cell line.";
Biochem. Biophys. Res. Commun. 238:790-794(1997).
[11]
NUCLEOTIDE SEQUENCE [MRNA] OF 1216-1437 (ISOFORM 1).
TISSUE=Brain;
PubMed=9270026;
Kool M., de Haas M., Scheffer G.L., Scheper R.J., van Eijk M.J.,
Juijn J.A., Baas F., Borst P.;
"Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5,
homologues of the multidrug resistance-associated protein gene (MRP1),
in human cancer cell lines.";
Cancer Res. 57:3537-3547(1997).
[12]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509 AND THR-513, AND
IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=18669648; DOI=10.1073/pnas.0805139105;
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
Elledge S.J., Gygi S.P.;
"A quantitative atlas of mitotic phosphorylation.";
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
[13]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-509, AND IDENTIFICATION
BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
TISSUE=Cervix carcinoma;
PubMed=20068231; DOI=10.1126/scisignal.2000475;
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S.,
Mann M.;
"Quantitative phosphoproteomics reveals widespread full
phosphorylation site occupancy during mitosis.";
Sci. Signal. 3:RA3-RA3(2010).
[14]
PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-14; SER-19; SER-60;
SER-505 AND SER-509, AND IDENTIFICATION BY MASS SPECTROMETRY [LARGE
SCALE ANALYSIS].
TISSUE=Cervix carcinoma, and Erythroleukemia;
PubMed=23186163; DOI=10.1021/pr300630k;
Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
Mohammed S.;
"Toward a comprehensive characterization of a human cancer cell
phosphoproteome.";
J. Proteome Res. 12:260-271(2013).
-!- FUNCTION: Acts as a multispecific organic anion pump which can
transport nucleotide analogs. {ECO:0000269|PubMed:10840050}.
-!- SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
-!- ALTERNATIVE PRODUCTS:
Event=Alternative splicing; Named isoforms=5;
Name=1;
IsoId=O15440-1; Sequence=Displayed;
Name=2; Synonyms=SV1;
IsoId=O15440-2; Sequence=VSP_043397, VSP_043402;
Note=May be produced at very low levels due to a premature stop
codon in the mRNA, leading to nonsense-mediated mRNA decay.;
Name=3; Synonyms=SV2;
IsoId=O15440-3; Sequence=VSP_043398, VSP_043401, VSP_043402;
Note=Predominant isoform in retinal pigment epithelium, bladder,
and stomach.;
Name=4; Synonyms=SV3;
IsoId=O15440-4; Sequence=VSP_043399, VSP_043400, VSP_043402;
Name=5;
IsoId=O15440-5; Sequence=VSP_055354;
-!- TISSUE SPECIFICITY: All isoforms are equally expressed in retina.
{ECO:0000269|PubMed:17521428}.
-!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC
family. Conjugate transporter (TC 3.A.1.208) subfamily.
{ECO:0000305}.
-!- WEB RESOURCE: Name=ABCMdb; Note=Database for mutations in ABC
proteins;
URL="http://abcmutations.hegelab.org/proteinDetails?uniprot_id=O15440";
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EMBL; AF104942; AAD04169.1; -; mRNA.
EMBL; AF146074; AAD37716.1; -; mRNA.
EMBL; AB019002; BAA76608.1; -; mRNA.
EMBL; U83661; AAB71758.2; -; mRNA.
EMBL; AY754874; AAW82948.1; -; mRNA.
EMBL; AY754875; AAW82949.1; -; mRNA.
EMBL; AY754876; AAW82950.1; -; mRNA.
EMBL; AY196484; AAO49801.1; -; mRNA.
EMBL; AC068644; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; CH471052; EAW78307.1; -; Genomic_DNA.
EMBL; CH471052; EAW78308.1; -; Genomic_DNA.
EMBL; BC050744; AAH50744.1; -; mRNA.
EMBL; BC140771; AAI40772.1; -; mRNA.
EMBL; BC142719; AAI42720.1; -; mRNA.
EMBL; AB005659; BAA22887.1; -; mRNA.
CCDS; CCDS33898.1; -. [O15440-4]
CCDS; CCDS43176.1; -. [O15440-1]
PIR; JC5667; JC5667.
RefSeq; NP_001018881.1; NM_001023587.2. [O15440-4]
RefSeq; NP_001306961.1; NM_001320032.1.
RefSeq; NP_005679.2; NM_005688.3. [O15440-1]
RefSeq; XP_005247115.1; XM_005247058.4. [O15440-1]
RefSeq; XP_005247116.1; XM_005247059.4. [O15440-1]
RefSeq; XP_011510616.1; XM_011512314.1. [O15440-1]
RefSeq; XP_016860982.1; XM_017005493.1. [O15440-4]
RefSeq; XP_016860983.1; XM_017005494.1. [O15440-4]
UniGene; Hs.368563; -.
UniGene; Hs.732645; -.
UniGene; Hs.743953; -.
ProteinModelPortal; O15440; -.
SMR; O15440; -.
BioGrid; 115368; 13.
IntAct; O15440; 8.
STRING; 9606.ENSP00000333926; -.
BindingDB; O15440; -.
ChEMBL; CHEMBL2046258; -.
DrugBank; DB00718; Adefovir Dipivoxil.
DrugBank; DB00770; Alprostadil.
DrugBank; DB01076; Atorvastatin.
DrugBank; DB00515; Cisplatin.
DrugBank; DB02527; Cyclic Adenosine Monophosphate.
DrugBank; DB00917; Dinoprostone.
DrugBank; DB00975; Dipyridamole.
DrugBank; DB00544; Fluorouracil.
DrugBank; DB00143; Glutathione.
DrugBank; DB01033; Mercaptopurine.
DrugBank; DB01032; Probenecid.
DrugBank; DB01045; Rifampicin.
DrugBank; DB00203; Sildenafil.
DrugBank; DB01138; Sulfinpyrazone.
DrugBank; DB00495; Zidovudine.
GuidetoPHARMACOLOGY; 783; -.
TCDB; 3.A.1.208.15; the atp-binding cassette (abc) superfamily.
iPTMnet; O15440; -.
PhosphoSitePlus; O15440; -.
BioMuta; ABCC5; -.
EPD; O15440; -.
MaxQB; O15440; -.
PaxDb; O15440; -.
PeptideAtlas; O15440; -.
PRIDE; O15440; -.
Ensembl; ENST00000265586; ENSP00000265586; ENSG00000114770. [O15440-5]
Ensembl; ENST00000334444; ENSP00000333926; ENSG00000114770. [O15440-1]
Ensembl; ENST00000382494; ENSP00000371934; ENSG00000114770. [O15440-4]
Ensembl; ENST00000392579; ENSP00000376358; ENSG00000114770. [O15440-2]
Ensembl; ENST00000443376; ENSP00000416840; ENSG00000114770. [O15440-3]
GeneID; 10057; -.
KEGG; hsa:10057; -.
UCSC; uc003fmg.4; human. [O15440-1]
CTD; 10057; -.
DisGeNET; 10057; -.
EuPathDB; HostDB:ENSG00000114770.16; -.
GeneCards; ABCC5; -.
HGNC; HGNC:56; ABCC5.
HPA; HPA044067; -.
HPA; HPA052295; -.
MIM; 605251; gene.
neXtProt; NX_O15440; -.
OpenTargets; ENSG00000114770; -.
PharmGKB; PA395; -.
eggNOG; KOG0054; Eukaryota.
eggNOG; COG1132; LUCA.
GeneTree; ENSGT00880000137856; -.
HOGENOM; HOG000116132; -.
HOVERGEN; HBG108314; -.
InParanoid; O15440; -.
KO; K05668; -.
OMA; YPAMMFV; -.
OrthoDB; EOG091G01TC; -.
PhylomeDB; O15440; -.
TreeFam; TF105202; -.
Reactome; R-HSA-2142850; Hyaluronan biosynthesis and export.
Reactome; R-HSA-382556; ABC-family proteins mediated transport.
ChiTaRS; ABCC5; human.
GeneWiki; ABCC5; -.
GenomeRNAi; 10057; -.
PRO; PR:O15440; -.
Proteomes; UP000005640; Chromosome 3.
Bgee; ENSG00000114770; -.
CleanEx; HS_ABCC5; -.
ExpressionAtlas; O15440; baseline and differential.
Genevisible; O15440; HS.
GO; GO:0005887; C:integral component of plasma membrane; TAS:ProtInc.
GO; GO:0016020; C:membrane; IDA:MGI.
GO; GO:0005886; C:plasma membrane; TAS:Reactome.
GO; GO:0005524; F:ATP binding; TAS:ProtInc.
GO; GO:0042626; F:ATPase activity, coupled to transmembrane movement of substances; IBA:GO_Central.
GO; GO:0043225; F:ATPase-coupled anion transmembrane transporter activity; TAS:Reactome.
GO; GO:0008514; F:organic anion transmembrane transporter activity; TAS:Reactome.
GO; GO:0030213; P:hyaluronan biosynthetic process; TAS:Reactome.
GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
GO; GO:0006810; P:transport; TAS:ProtInc.
Gene3D; 1.20.1560.10; -; 2.
InterPro; IPR003593; AAA+_ATPase.
InterPro; IPR011527; ABC1_TM_dom.
InterPro; IPR036640; ABC1_TM_sf.
InterPro; IPR003439; ABC_transporter-like.
InterPro; IPR017871; ABC_transporter_CS.
InterPro; IPR030238; ABCC5.
InterPro; IPR027417; P-loop_NTPase.
PANTHER; PTHR24223:SF196; PTHR24223:SF196; 1.
Pfam; PF00664; ABC_membrane; 2.
Pfam; PF00005; ABC_tran; 2.
SMART; SM00382; AAA; 2.
SUPFAM; SSF52540; SSF52540; 2.
SUPFAM; SSF90123; SSF90123; 2.
PROSITE; PS50929; ABC_TM1F; 2.
PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
1: Evidence at protein level;
Alternative splicing; ATP-binding; Complete proteome; Glycoprotein;
Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome;
Repeat; Transmembrane; Transmembrane helix; Transport.
CHAIN 1 1437 Multidrug resistance-associated protein
5.
/FTId=PRO_0000093363.
TRANSMEM 179 199 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 219 239 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 296 316 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 317 337 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 400 420 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 434 454 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 608 628 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 848 868 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 917 937 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 997 1017 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 1018 1038 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 1104 1124 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
TRANSMEM 1127 1147 Helical. {ECO:0000255|PROSITE-
ProRule:PRU00441}.
DOMAIN 179 459 ABC transmembrane type-1 1.
{ECO:0000255|PROSITE-ProRule:PRU00441}.
DOMAIN 562 783 ABC transporter 1. {ECO:0000255|PROSITE-
ProRule:PRU00434}.
DOMAIN 859 1155 ABC transmembrane type-1 2.
{ECO:0000255|PROSITE-ProRule:PRU00441}.
DOMAIN 1193 1427 ABC transporter 2. {ECO:0000255|PROSITE-
ProRule:PRU00434}.
NP_BIND 595 602 ATP 1. {ECO:0000255|PROSITE-
ProRule:PRU00434}.
NP_BIND 1227 1234 ATP 2. {ECO:0000255|PROSITE-
ProRule:PRU00434}.
MOD_RES 14 14 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 19 19 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 60 60 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 505 505 Phosphoserine.
{ECO:0000244|PubMed:23186163}.
MOD_RES 509 509 Phosphoserine.
{ECO:0000244|PubMed:18669648,
ECO:0000244|PubMed:20068231,
ECO:0000244|PubMed:23186163}.
MOD_RES 513 513 Phosphothreonine.
{ECO:0000244|PubMed:18669648}.
CARBOHYD 494 494 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 636 636 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 684 684 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 890 890 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 897 897 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1044 1044 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1329 1329 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 1417 1417 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
VAR_SEQ 198 225 AFMVKHLLEYTQATESNLQYSLLLVLGL -> PSFGDCSIS
AEVCGNRLHCTAILLSCFT (in isoform 2).
{ECO:0000303|PubMed:15489334,
ECO:0000303|PubMed:17521428}.
/FTId=VSP_043397.
VAR_SEQ 198 212 AFMVKHLLEYTQATE -> LAWCCQDLDLGGVSL (in
isoform 3).
{ECO:0000303|PubMed:17521428}.
/FTId=VSP_043398.
VAR_SEQ 198 208 AFMVKHLLEYT -> NFQDGCILRSE (in isoform
4). {ECO:0000303|PubMed:17521428}.
/FTId=VSP_043399.
VAR_SEQ 209 225 Missing (in isoform 4).
{ECO:0000303|PubMed:17521428}.
/FTId=VSP_043400.
VAR_SEQ 213 225 Missing (in isoform 3).
{ECO:0000303|PubMed:17521428}.
/FTId=VSP_043401.
VAR_SEQ 226 1437 Missing (in isoform 2, isoform 3 and
isoform 4). {ECO:0000303|PubMed:15489334,
ECO:0000303|PubMed:17521428}.
/FTId=VSP_043402.
VAR_SEQ 1033 1075 Missing (in isoform 5).
{ECO:0000303|Ref.6}.
/FTId=VSP_055354.
CONFLICT 176 176 R -> P (in Ref. 3; BAA76608).
{ECO:0000305}.
CONFLICT 400 400 S -> G (in Ref. 1; AAD04169).
{ECO:0000305}.
CONFLICT 581 581 I -> V (in Ref. 2; AAD37716).
{ECO:0000305}.
CONFLICT 1383 1383 T -> N (in Ref. 3; BAA76608 and 8;
BAA22887). {ECO:0000305}.
SEQUENCE 1437 AA; 160660 MW; 00558076B3BB4C00 CRC64;
MKDIDIGKEY IIPSPGYRSV RERTSTSGTH RDREDSKFRR TRPLECQDAL ETAARAEGLS
LDASMHSQLR ILDEEHPKGK YHHGLSALKP IRTTSKHQHP VDNAGLFSCM TFSWLSSLAR
VAHKKGELSM EDVWSLSKHE SSDVNCRRLE RLWQEELNEV GPDAASLRRV VWIFCRTRLI
LSIVCLMITQ LAGFSGPAFM VKHLLEYTQA TESNLQYSLL LVLGLLLTEI VRSWSLALTW
ALNYRTGVRL RGAILTMAFK KILKLKNIKE KSLGELINIC SNDGQRMFEA AAVGSLLAGG
PVVAILGMIY NVIILGPTGF LGSAVFILFY PAMMFASRLT AYFRRKCVAA TDERVQKMNE
VLTYIKFIKM YAWVKAFSQS VQKIREEERR ILEKAGYFQS ITVGVAPIVV VIASVVTFSV
HMTLGFDLTA AQAFTVVTVF NSMTFALKVT PFSVKSLSEA SVAVDRFKSL FLMEEVHMIK
NKPASPHIKI EMKNATLAWD SSHSSIQNSP KLTPKMKKDK RASRGKKEKV RQLQRTEHQA
VLAEQKGHLL LDSDERPSPE EEEGKHIHLG HLRLQRTLHS IDLEIQEGKL VGICGSVGSG
KTSLISAILG QMTLLEGSIA ISGTFAYVAQ QAWILNATLR DNILFGKEYD EERYNSVLNS
CCLRPDLAIL PSSDLTEIGE RGANLSGGQR QRISLARALY SDRSIYILDD PLSALDAHVG
NHIFNSAIRK HLKSKTVLFV THQLQYLVDC DEVIFMKEGC ITERGTHEEL MNLNGDYATI
FNNLLLGETP PVEINSKKET SGSQKKSQDK GPKTGSVKKE KAVKPEEGQL VQLEEKGQGS
VPWSVYGVYI QAAGGPLAFL VIMALFMLNV GSTAFSTWWL SYWIKQGSGN TTVTRGNETS
VSDSMKDNPH MQYYASIYAL SMAVMLILKA IRGVVFVKGT LRASSRLHDE LFRRILRSPM
KFFDTTPTGR ILNRFSKDMD EVDVRLPFQA EMFIQNVILV FFCVGMIAGV FPWFLVAVGP
LVILFSVLHI VSRVLIRELK RLDNITQSPF LSHITSSIQG LATIHAYNKG QEFLHRYQEL
LDDNQAPFFL FTCAMRWLAV RLDLISIALI TTTGLMIVLM HGQIPPAYAG LAISYAVQLT
GLFQFTVRLA SETEARFTSV ERINHYIKTL SLEAPARIKN KAPSPDWPQE GEVTFENAEM
RYRENLPLVL KKVSFTIKPK EKIGIVGRTG SGKSSLGMAL FRLVELSGGC IKIDGVRISD
IGLADLRSKL SIIPQEPVLF SGTVRSNLDP FNQYTEDQIW DALERTHMKE CIAQLPLKLE
SEVMENGDNF SVGERQLLCI ARALLRHCKI LILDEATAAM DTETDLLIQE TIREAFADCT
MLTIAHRLHT VLGSDRIMVL AQGQVVEFDT PSVLLSNDSS RFYAMFAAAE NKVAVKG


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