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Multifunctional fusion protein [Includes: Cysteine--tRNA ligase (EC 6.1.1.16) (Cysteinyl-tRNA synthetase) (CysRS); Mini-ribonuclease 3 (Mini-3) (Mini-RNase 3) (EC 3.1.26.-) (Mini-RNase III) (Mini-III)]

 U7UCM2_9FIRM            Unreviewed;       644 AA.
U7UCM2;
22-JAN-2014, integrated into UniProtKB/TrEMBL.
22-JAN-2014, sequence version 1.
12-SEP-2018, entry version 38.
RecName: Full=Multifunctional fusion protein {ECO:0000256|HAMAP-Rule:MF_00041, ECO:0000256|HAMAP-Rule:MF_01468};
Includes:
RecName: Full=Mini-ribonuclease 3 {ECO:0000256|HAMAP-Rule:MF_01468};
Short=Mini-3 {ECO:0000256|HAMAP-Rule:MF_01468};
Short=Mini-RNase 3 {ECO:0000256|HAMAP-Rule:MF_01468};
EC=3.1.26.- {ECO:0000256|HAMAP-Rule:MF_01468};
AltName: Full=Mini-RNase III {ECO:0000256|HAMAP-Rule:MF_01468};
Short=Mini-III {ECO:0000256|HAMAP-Rule:MF_01468};
Includes:
RecName: Full=Cysteine--tRNA ligase {ECO:0000256|HAMAP-Rule:MF_00041};
EC=6.1.1.16 {ECO:0000256|HAMAP-Rule:MF_00041};
AltName: Full=Cysteinyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00041};
Short=CysRS {ECO:0000256|HAMAP-Rule:MF_00041};
Name=cysS {ECO:0000256|HAMAP-Rule:MF_00041,
ECO:0000313|EMBL:ERT57120.1};
Synonyms=mrnC {ECO:0000256|HAMAP-Rule:MF_01468};
ORFNames=HMPREF1250_1653 {ECO:0000313|EMBL:ERT57120.1};
Megasphaera sp. BV3C16-1.
Bacteria; Firmicutes; Negativicutes; Veillonellales; Veillonellaceae;
Megasphaera.
NCBI_TaxID=1111454 {ECO:0000313|EMBL:ERT57120.1, ECO:0000313|Proteomes:UP000017090};
[1] {ECO:0000313|EMBL:ERT57120.1, ECO:0000313|Proteomes:UP000017090}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=BV3C16-1 {ECO:0000313|EMBL:ERT57120.1,
ECO:0000313|Proteomes:UP000017090};
Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M.,
Haft D.H., Methe B., Sutton G., Nelson K.E.;
Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Involved in correct processing of both the 5' and 3'
ends of 23S rRNA precursor. Processes 30S rRNA precursor
transcript even in absence of ribonuclease 3 (Rnc); Rnc processes
30S rRNA into smaller rRNA precursors. {ECO:0000256|HAMAP-
Rule:MF_01468}.
-!- CATALYTIC ACTIVITY: ATP + L-cysteine + tRNA(Cys) = AMP +
diphosphate + L-cysteinyl-tRNA(Cys). {ECO:0000256|HAMAP-
Rule:MF_00041, ECO:0000256|SAAS:SAAS00676348}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|HAMAP-Rule:MF_01468};
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000256|HAMAP-Rule:MF_00041};
Note=Binds 1 zinc ion per subunit. {ECO:0000256|HAMAP-
Rule:MF_00041};
-!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01468}.
-!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00041}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01468,
ECO:0000256|SAAS:SAAS00676353}.
-!- SIMILARITY: Belongs to the MrnC RNase family. {ECO:0000256|HAMAP-
Rule:MF_01468}.
-!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase
family. {ECO:0000256|HAMAP-Rule:MF_00041,
ECO:0000256|SAAS:SAAS00676344}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_00041}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:ERT57120.1}.
-----------------------------------------------------------------------
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EMBL; AWXA01000053; ERT57120.1; -; Genomic_DNA.
EnsemblBacteria; ERT57120; ERT57120; HMPREF1250_1653.
PATRIC; fig|1111454.3.peg.1944; -.
OrthoDB; POG091H004K; -.
Proteomes; UP000017090; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0004817; F:cysteine-tRNA ligase activity; IEA:UniProtKB-UniRule.
GO; GO:0004525; F:ribonuclease III activity; IEA:InterPro.
GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-UniRule.
GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
GO; GO:0006423; P:cysteinyl-tRNA aminoacylation; IEA:UniProtKB-UniRule.
GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
CDD; cd00672; CysRS_core; 1.
Gene3D; 1.10.1520.10; -; 1.
Gene3D; 3.40.50.620; -; 1.
HAMAP; MF_00041; Cys_tRNA_synth; 1.
HAMAP; MF_01468; RNase_Mini_III; 1.
InterPro; IPR015803; Cys-tRNA-ligase.
InterPro; IPR015273; Cys-tRNA-synt_Ia_DALR.
InterPro; IPR024909; Cys-tRNA/MSH_ligase.
InterPro; IPR008226; Mini3_fam.
InterPro; IPR000999; RNase_III_dom.
InterPro; IPR036389; RNase_III_sf.
InterPro; IPR014729; Rossmann-like_a/b/a_fold.
InterPro; IPR032678; tRNA-synt_1_cat_dom.
InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
PANTHER; PTHR10890; PTHR10890; 1.
Pfam; PF09190; DALR_2; 1.
Pfam; PF00636; Ribonuclease_3; 1.
Pfam; PF01406; tRNA-synt_1e; 1.
PRINTS; PR00983; TRNASYNTHCYS.
SMART; SM00840; DALR_2; 1.
SUPFAM; SSF47323; SSF47323; 1.
SUPFAM; SSF69065; SSF69065; 1.
TIGRFAMs; TIGR00435; cysS; 1.
3: Inferred from homology;
Aminoacyl-tRNA synthetase {ECO:0000256|HAMAP-Rule:MF_00041,
ECO:0000256|SAAS:SAAS00676352};
ATP-binding {ECO:0000256|HAMAP-Rule:MF_00041,
ECO:0000256|SAAS:SAAS00676343};
Complete proteome {ECO:0000313|Proteomes:UP000017090};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_01468,
ECO:0000256|SAAS:SAAS00676342};
Endonuclease {ECO:0000256|HAMAP-Rule:MF_01468};
Hydrolase {ECO:0000256|HAMAP-Rule:MF_01468};
Ligase {ECO:0000256|HAMAP-Rule:MF_00041,
ECO:0000256|SAAS:SAAS00676352};
Magnesium {ECO:0000256|HAMAP-Rule:MF_01468};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_00041,
ECO:0000256|SAAS:SAAS00676351};
Nuclease {ECO:0000256|HAMAP-Rule:MF_01468};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00041,
ECO:0000256|SAAS:SAAS00676343};
Protein biosynthesis {ECO:0000256|HAMAP-Rule:MF_00041,
ECO:0000256|SAAS:SAAS00676350};
Reference proteome {ECO:0000313|Proteomes:UP000017090};
Ribosome biogenesis {ECO:0000256|HAMAP-Rule:MF_01468};
RNA-binding {ECO:0000256|HAMAP-Rule:MF_01468};
rRNA processing {ECO:0000256|HAMAP-Rule:MF_01468};
rRNA-binding {ECO:0000256|HAMAP-Rule:MF_01468};
Zinc {ECO:0000256|HAMAP-Rule:MF_00041, ECO:0000256|SAAS:SAAS00676347}.
DOMAIN 356 425 DALR_2. {ECO:0000259|SMART:SM00840}.
MOTIF 268 272 "KMSKS" region. {ECO:0000256|HAMAP-
Rule:MF_00041}.
ACT_SITE 524 524 {ECO:0000256|HAMAP-Rule:MF_01468}.
METAL 30 30 Zinc. {ECO:0000256|HAMAP-Rule:MF_00041}.
METAL 210 210 Zinc. {ECO:0000256|HAMAP-Rule:MF_00041}.
METAL 235 235 Zinc. {ECO:0000256|HAMAP-Rule:MF_00041}.
METAL 239 239 Zinc. {ECO:0000256|HAMAP-Rule:MF_00041}.
BINDING 271 271 ATP. {ECO:0000256|HAMAP-Rule:MF_00041}.
SEQUENCE 644 AA; 73038 MW; 45FBA30531F99D73 CRC64;
MRELMVYNTL TRKKEKFVPV TPGQVKMYVC GITPYNHSHM GNARPFVTWD VIKRYLEHLG
YEVLHIQNFT DVDDKIINAA NGEDVSWDTI SNRYIASYFE VMDALHVRRA DKYPRVSDHM
RDIIRMVETL IEKGHAYVLD HDVYYKVDSF ANYGQLSGRT LDDMMAGARI EIDDRKENPM
DFALWKGAKP GEPAWDSPWG KGRPGWHIEC SAMSNRYLGD TFDFHGGGSD LIFPHHENEI
AQSEAFCGHG PMVRYWLHNG FITINSEKMS KSLNNFFLVK DVLAHYSADA LRYFLISNHY
RSPLDFSDER LEEMTRSLER LGTAIDNTLF LLEQPSGAQS AAGKQLLADA QKAEEDYEAA
MCDDFNTALA SASMFELAKK INIYKNDVVA NGVPVDASVL AEVKRIFKTM TDILGILEAR
WTGSASSAND EDYAKLMAAI LEIRQECRVQ KQYALADAIR DKLAALGITI EDSPQGAHWK
KVKFKQFTSL KKKAYDAFAA GSRLDVPQQQ AIGLDSISLA FVGDAYYALY LRRRLVATGI
PNVQVLHTLA AEFVSARVQA YVYRQLQRTL TEEEAACCRR ARNAYSQVPR SASVAEYHDS
TALEALIGYL VMAEDAERLT EMMEMVYTCT RDYCRTVHVV KERE


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