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Multifunctional fusion protein [Includes: N5-carboxyaminoimidazole ribonucleotide synthase (N5-CAIR synthase) (EC 6.3.4.18) (5-(carboxyamino)imidazole ribonucleotide synthetase); N5-carboxyaminoimidazole ribonucleotide mutase (N5-CAIR mutase) (EC 5.4.99.18) (5-(carboxyamino)imidazole ribonucleotide mutase)]

 A0A085LG34_9MICO        Unreviewed;       594 AA.
A0A085LG34;
29-OCT-2014, integrated into UniProtKB/TrEMBL.
29-OCT-2014, sequence version 1.
22-NOV-2017, entry version 24.
RecName: Full=Multifunctional fusion protein {ECO:0000256|HAMAP-Rule:MF_01928, ECO:0000256|HAMAP-Rule:MF_01929};
Includes:
RecName: Full=N5-carboxyaminoimidazole ribonucleotide synthase {ECO:0000256|HAMAP-Rule:MF_01928};
Short=N5-CAIR synthase {ECO:0000256|HAMAP-Rule:MF_01928};
EC=6.3.4.18 {ECO:0000256|HAMAP-Rule:MF_01928};
AltName: Full=5-(carboxyamino)imidazole ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_01928};
Includes:
RecName: Full=N5-carboxyaminoimidazole ribonucleotide mutase {ECO:0000256|HAMAP-Rule:MF_01929};
Short=N5-CAIR mutase {ECO:0000256|HAMAP-Rule:MF_01929};
EC=5.4.99.18 {ECO:0000256|HAMAP-Rule:MF_01929};
AltName: Full=5-(carboxyamino)imidazole ribonucleotide mutase {ECO:0000256|HAMAP-Rule:MF_01929};
Name=purK {ECO:0000256|HAMAP-Rule:MF_01928};
Synonyms=purE {ECO:0000256|HAMAP-Rule:MF_01929};
ORFNames=IU11_06985 {ECO:0000313|EMBL:KFD43930.1};
Cellulosimicrobium sp. MM.
Bacteria; Actinobacteria; Micrococcales; Promicromonosporaceae;
Cellulosimicrobium.
NCBI_TaxID=1523621 {ECO:0000313|EMBL:KFD43930.1, ECO:0000313|Proteomes:UP000028634};
[1] {ECO:0000313|EMBL:KFD43930.1, ECO:0000313|Proteomes:UP000028634}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MM {ECO:0000313|EMBL:KFD43930.1,
ECO:0000313|Proteomes:UP000028634};
Lal R., Sharma A., Sangwan N., Hira P.;
Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
[2] {ECO:0000313|EMBL:KFD43930.1, ECO:0000313|Proteomes:UP000028634}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=MM {ECO:0000313|EMBL:KFD43930.1,
ECO:0000313|Proteomes:UP000028634};
Khurana J.P.;
"Draft genome sequence of Cellulosimicrobium sp. MM isolated from
arsenic rich microbial mats of a himalayan hotspring.";
Submitted (AUG-2014) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the ATP-dependent conversion of 5-
aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-
carboxyaminoimidazole ribonucleotide (N5-CAIR).
{ECO:0000256|HAMAP-Rule:MF_01928}.
-!- FUNCTION: Catalyzes the conversion of N5-carboxyaminoimidazole
ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole
ribonucleotide (CAIR). {ECO:0000256|HAMAP-Rule:MF_01929}.
-!- CATALYTIC ACTIVITY: 5-carboxyamino-1-(5-phospho-D-
ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
carboxylate. {ECO:0000256|HAMAP-Rule:MF_01929}.
-!- CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole
+ HCO(3)(-) = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-
ribosyl)imidazole. {ECO:0000256|HAMAP-Rule:MF_01928}.
-!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-
amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.
{ECO:0000256|HAMAP-Rule:MF_01928}.
-!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-
amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.
{ECO:0000256|HAMAP-Rule:MF_01929}.
-!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01928}.
-!- SIMILARITY: Belongs to the AIR carboxylase family. Class I
subfamily. {ECO:0000256|HAMAP-Rule:MF_01929}.
-!- SIMILARITY: Belongs to the PurK/PurT family. {ECO:0000256|HAMAP-
Rule:MF_01928}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_01928}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:KFD43930.1}.
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EMBL; JPQW01000114; KFD43930.1; -; Genomic_DNA.
EnsemblBacteria; KFD43930; KFD43930; IU11_06985.
UniPathway; UPA00074; UER00942.
UniPathway; UPA00074; UER00943.
Proteomes; UP000028634; Unassembled WGS sequence.
GO; GO:0034023; F:5-(carboxyamino)imidazole ribonucleotide mutase activity; IEA:UniProtKB-UniRule.
GO; GO:0034028; F:5-(carboxyamino)imidazole ribonucleotide synthase activity; IEA:UniProtKB-UniRule.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:InterPro.
GO; GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity; IEA:InterPro.
GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
Gene3D; 3.30.1490.20; -; 1.
Gene3D; 3.40.50.7700; -; 1.
HAMAP; MF_01929; PurE_classI; 1.
HAMAP; MF_01928; PurK; 1.
InterPro; IPR011761; ATP-grasp.
InterPro; IPR003135; ATP-grasp_carboxylate-amine.
InterPro; IPR013815; ATP_grasp_subdomain_1.
InterPro; IPR016185; PreATP-grasp_dom_sf.
InterPro; IPR033747; PurE_ClassI.
InterPro; IPR000031; PurE_dom.
InterPro; IPR035893; PurE_sf.
InterPro; IPR005875; PurK.
InterPro; IPR011054; Rudment_hybrid_motif.
Pfam; PF00731; AIRC; 1.
Pfam; PF02222; ATP-grasp; 1.
SMART; SM01001; AIRC; 1.
SUPFAM; SSF51246; SSF51246; 1.
SUPFAM; SSF52255; SSF52255; 1.
SUPFAM; SSF52440; SSF52440; 1.
TIGRFAMs; TIGR01162; purE; 1.
TIGRFAMs; TIGR01161; purK; 1.
PROSITE; PS50975; ATP_GRASP; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|HAMAP-Rule:MF_01928, ECO:0000256|PROSITE-
ProRule:PRU00409, ECO:0000256|SAAS:SAAS00653136};
Complete proteome {ECO:0000313|Proteomes:UP000028634};
Isomerase {ECO:0000256|HAMAP-Rule:MF_01929};
Ligase {ECO:0000256|HAMAP-Rule:MF_01928};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01928,
ECO:0000256|PROSITE-ProRule:PRU00409, ECO:0000256|SAAS:SAAS00653136};
Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01929,
ECO:0000256|SAAS:SAAS00653155};
Reference proteome {ECO:0000313|Proteomes:UP000028634}.
DOMAIN 114 321 ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
NP_BIND 196 199 ATP. {ECO:0000256|HAMAP-Rule:MF_01928}.
NP_BIND 291 292 ATP. {ECO:0000256|HAMAP-Rule:MF_01928}.
BINDING 110 110 ATP. {ECO:0000256|HAMAP-Rule:MF_01928}.
BINDING 155 155 ATP. {ECO:0000256|HAMAP-Rule:MF_01928}.
BINDING 204 204 ATP. {ECO:0000256|HAMAP-Rule:MF_01928}.
BINDING 428 428 Substrate. {ECO:0000256|HAMAP-
Rule:MF_01929}.
BINDING 431 431 Substrate. {ECO:0000256|HAMAP-
Rule:MF_01929}.
BINDING 458 458 Substrate. {ECO:0000256|HAMAP-
Rule:MF_01929}.
SEQUENCE 594 AA; 61493 MW; 4263113E77C34C9D CRC64;
MHVAAPVIAV VGGGQLARMM APAAGELGVH LRVLVEAADS SAAQVVVDAP VGVASDEAAV
RSLIAPAGAA PANVLTFEHE HVPNALLTDL LEHGTPVRPG PDALVHAQDK IVMRRRLTEL
GVPCPRWAAL PTDPTAARAA LTDFLAEVGG EAVVKTARGG YDGKGVRVVS AAAGGPAQVA
EWIEAAATDG PELLVEEKVP FTRELAVLVA RRPSGGADGR GEVRTWPVVE SIQRDGVCAE
VIAPAPGLTD AEAERARAAA VRIAEGLGVT GVLAVEMFEV AGEEGPRVLV NELAMRPHNS
GHWTIDGAVT SQFEQHLRAV LDLPLGDTAA TARWTVMANV LGSTLDELTD ALPDVLAAFP
DARVNLYGKG VRPGRKLGHV NVSGDDMDEV RRRALAAARD PAGRASRDRP ERGARMSQNP
VVGIVMGSDS DWPVMEAAAD ALAEFDVPVE VDVVSAHRMP VEMIDYGRTA AERGLRVIVA
GAGGAAHLPG MLAAVTPLPV IGVPVPLRHL DGMDSLLSIV QMPAGVPVAT VSVGGARNAG
LLAARILAAG TDDDAARLRE RMVAFQADLG EQARAKGARL RASRAGGQRT GFGA


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