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Multifunctional fusion protein [Includes: N5-carboxyaminoimidazole ribonucleotide synthase (N5-CAIR synthase) (EC 6.3.4.18) (5-(carboxyamino)imidazole ribonucleotide synthetase); N5-carboxyaminoimidazole ribonucleotide mutase (N5-CAIR mutase) (EC 5.4.99.18) (5-(carboxyamino)imidazole ribonucleotide mutase)]

 A0A1X6XPG1_9MICO        Unreviewed;       623 AA.
A0A1X6XPG1;
05-JUL-2017, integrated into UniProtKB/TrEMBL.
05-JUL-2017, sequence version 1.
22-NOV-2017, entry version 5.
RecName: Full=Multifunctional fusion protein {ECO:0000256|HAMAP-Rule:MF_01928, ECO:0000256|HAMAP-Rule:MF_01929};
Includes:
RecName: Full=N5-carboxyaminoimidazole ribonucleotide synthase {ECO:0000256|HAMAP-Rule:MF_01928};
Short=N5-CAIR synthase {ECO:0000256|HAMAP-Rule:MF_01928};
EC=6.3.4.18 {ECO:0000256|HAMAP-Rule:MF_01928};
AltName: Full=5-(carboxyamino)imidazole ribonucleotide synthetase {ECO:0000256|HAMAP-Rule:MF_01928};
Includes:
RecName: Full=N5-carboxyaminoimidazole ribonucleotide mutase {ECO:0000256|HAMAP-Rule:MF_01929};
Short=N5-CAIR mutase {ECO:0000256|HAMAP-Rule:MF_01929};
EC=5.4.99.18 {ECO:0000256|HAMAP-Rule:MF_01929};
AltName: Full=5-(carboxyamino)imidazole ribonucleotide mutase {ECO:0000256|HAMAP-Rule:MF_01929};
Name=purE {ECO:0000256|HAMAP-Rule:MF_01929};
Synonyms=purK {ECO:0000256|HAMAP-Rule:MF_01928};
ORFNames=FM105_14105 {ECO:0000313|EMBL:SLN01112.1};
Brevibacterium yomogidense.
Bacteria; Actinobacteria; Micrococcales; Brevibacteriaceae;
Brevibacterium.
NCBI_TaxID=946573 {ECO:0000313|EMBL:SLN01112.1, ECO:0000313|Proteomes:UP000196581};
[1] {ECO:0000313|EMBL:SLN01112.1, ECO:0000313|Proteomes:UP000196581}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=B Co 03.10 {ECO:0000313|EMBL:SLN01112.1,
ECO:0000313|Proteomes:UP000196581};
Peterson S.W.;
Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the ATP-dependent conversion of 5-
aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-
carboxyaminoimidazole ribonucleotide (N5-CAIR).
{ECO:0000256|HAMAP-Rule:MF_01928}.
-!- FUNCTION: Catalyzes the conversion of N5-carboxyaminoimidazole
ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole
ribonucleotide (CAIR). {ECO:0000256|HAMAP-Rule:MF_01929}.
-!- CATALYTIC ACTIVITY: 5-carboxyamino-1-(5-phospho-D-
ribosyl)imidazole = 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-
carboxylate. {ECO:0000256|HAMAP-Rule:MF_01929}.
-!- CATALYTIC ACTIVITY: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole
+ HCO(3)(-) = ADP + phosphate + 5-carboxyamino-1-(5-phospho-D-
ribosyl)imidazole. {ECO:0000256|HAMAP-Rule:MF_01928}.
-!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-
amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 1/2.
{ECO:0000256|HAMAP-Rule:MF_01928}.
-!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway;
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate from 5-
amino-1-(5-phospho-D-ribosyl)imidazole (N5-CAIR route): step 2/2.
{ECO:0000256|HAMAP-Rule:MF_01929}.
-!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_01928}.
-!- SIMILARITY: Belongs to the AIR carboxylase family. Class I
subfamily. {ECO:0000256|HAMAP-Rule:MF_01929}.
-!- SIMILARITY: Belongs to the PurK/PurT family. {ECO:0000256|HAMAP-
Rule:MF_01928}.
-!- CAUTION: Lacks conserved residue(s) required for the propagation
of feature annotation. {ECO:0000256|HAMAP-Rule:MF_01928}.
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EMBL; FWFF01000021; SLN01112.1; -; Genomic_DNA.
UniPathway; UPA00074; UER00942.
UniPathway; UPA00074; UER00943.
Proteomes; UP000196581; Unassembled WGS sequence.
GO; GO:0034023; F:5-(carboxyamino)imidazole ribonucleotide mutase activity; IEA:UniProtKB-UniRule.
GO; GO:0034028; F:5-(carboxyamino)imidazole ribonucleotide synthase activity; IEA:UniProtKB-UniRule.
GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:InterPro.
GO; GO:0004638; F:phosphoribosylaminoimidazole carboxylase activity; IEA:InterPro.
GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniRule.
Gene3D; 3.30.1490.20; -; 1.
Gene3D; 3.40.50.7700; -; 1.
HAMAP; MF_01929; PurE_classI; 1.
HAMAP; MF_01928; PurK; 1.
InterPro; IPR011761; ATP-grasp.
InterPro; IPR003135; ATP-grasp_carboxylate-amine.
InterPro; IPR013815; ATP_grasp_subdomain_1.
InterPro; IPR016185; PreATP-grasp_dom_sf.
InterPro; IPR033747; PurE_ClassI.
InterPro; IPR000031; PurE_dom.
InterPro; IPR035893; PurE_sf.
InterPro; IPR005875; PurK.
InterPro; IPR011054; Rudment_hybrid_motif.
Pfam; PF00731; AIRC; 1.
Pfam; PF02222; ATP-grasp; 1.
SMART; SM01001; AIRC; 1.
SUPFAM; SSF51246; SSF51246; 1.
SUPFAM; SSF52255; SSF52255; 1.
SUPFAM; SSF52440; SSF52440; 1.
TIGRFAMs; TIGR01162; purE; 1.
TIGRFAMs; TIGR01161; purK; 1.
PROSITE; PS50975; ATP_GRASP; 1.
3: Inferred from homology;
ATP-binding {ECO:0000256|HAMAP-Rule:MF_01928, ECO:0000256|PROSITE-
ProRule:PRU00409, ECO:0000256|SAAS:SAAS00653136};
Complete proteome {ECO:0000313|Proteomes:UP000196581};
Isomerase {ECO:0000256|HAMAP-Rule:MF_01929};
Ligase {ECO:0000256|HAMAP-Rule:MF_01928};
Lyase {ECO:0000313|EMBL:SLN01112.1};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_01928,
ECO:0000256|PROSITE-ProRule:PRU00409, ECO:0000256|SAAS:SAAS00653136};
Purine biosynthesis {ECO:0000256|HAMAP-Rule:MF_01929,
ECO:0000256|SAAS:SAAS00653155};
Reference proteome {ECO:0000313|Proteomes:UP000196581}.
DOMAIN 107 292 ATP-grasp. {ECO:0000259|PROSITE:PS50975}.
NP_BIND 177 180 ATP. {ECO:0000256|HAMAP-Rule:MF_01928}.
NP_BIND 262 263 ATP. {ECO:0000256|HAMAP-Rule:MF_01928}.
BINDING 103 103 ATP. {ECO:0000256|HAMAP-Rule:MF_01928}.
BINDING 143 143 ATP. {ECO:0000256|HAMAP-Rule:MF_01928}.
BINDING 185 185 ATP. {ECO:0000256|HAMAP-Rule:MF_01928}.
BINDING 455 455 Substrate. {ECO:0000256|HAMAP-
Rule:MF_01929}.
BINDING 458 458 Substrate. {ECO:0000256|HAMAP-
Rule:MF_01929}.
BINDING 485 485 Substrate. {ECO:0000256|HAMAP-
Rule:MF_01929}.
SEQUENCE 623 AA; 64308 MW; 6D2E971260005665 CRC64;
MTFPKIGVVG GGQLARMMAP AAEALGVSFH VLSEADGASA AQVSAYVTVG DYRDWDTLKA
FADTVDVLTF DHEHVPPEHL RALEAAGHSV HPGPDALIHA QDKLVMRAKI DELGLPNPRW
AEVGSVDELE AASRDLGLPL ILKTPRGGYD GHGVRVIHDP AEAADWFAEA PGTLLAEEKV
AFTRELAVMV GRSPSGQTAV WPVVATHQQD GVCKEALAPA PDLSRELSAR IQGDVIALAT
RLGVTGVMAM EMFEVDGGYL VNELAMRPHN TGHWTQDGSI TSQFEQHLRA VLDLPLGDPS
AIAPLTAMVN VLGSDRDDLY HSYLHVLAHD PAVKVHMYGK GVRPGRKLGH VNLSGADAPE
HLLARARHAA DFIAGVDTNP HPDFGDAANA AGAGIATSAA RGTETDAPAA ASSPAAAASP
AAGATSEASA ATASAAGAAS AGPDDRSRVG IVMGSDSDWP TMSAAADALR EFGIPFTAEV
VSAHRMPEDM VEWGRTAADR GLEVIIAGAG GAAHLPGMLA SLTSLPVIGV PVPLTYLDGM
DSLLSIVQMP AGVPVATVSV GGAANAGLLA VRILASGAAG DEAQGSTDLR SALDDHRLAL
REKAMAKGRA LSKRVAAEGD AHH


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