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Multifunctional fusion protein [Includes: Ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III); GTPase Era]

 A0A0F3REP5_9RICK        Unreviewed;       567 AA.
A0A0F3REP5;
24-JUN-2015, integrated into UniProtKB/TrEMBL.
24-JUN-2015, sequence version 1.
12-SEP-2018, entry version 33.
RecName: Full=Multifunctional fusion protein {ECO:0000256|HAMAP-Rule:MF_00104, ECO:0000256|HAMAP-Rule:MF_00367};
Includes:
RecName: Full=Ribonuclease 3 {ECO:0000256|HAMAP-Rule:MF_00104};
EC=3.1.26.3 {ECO:0000256|HAMAP-Rule:MF_00104};
AltName: Full=Ribonuclease III {ECO:0000256|HAMAP-Rule:MF_00104};
Short=RNase III {ECO:0000256|HAMAP-Rule:MF_00104};
Includes:
RecName: Full=GTPase Era {ECO:0000256|HAMAP-Rule:MF_00367};
Name=rnc {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000313|EMBL:KJW03644.1};
Synonyms=era {ECO:0000256|HAMAP-Rule:MF_00367};
ORFNames=REIP_1679 {ECO:0000313|EMBL:KJW03644.1};
Rickettsia endosymbiont of Ixodes pacificus.
Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
Rickettsiaceae; Rickettsieae; Rickettsia.
NCBI_TaxID=1133329 {ECO:0000313|EMBL:KJW03644.1, ECO:0000313|Proteomes:UP000033390};
[1] {ECO:0000313|EMBL:KJW03644.1, ECO:0000313|Proteomes:UP000033390}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Humboldt {ECO:0000313|EMBL:KJW03644.1,
ECO:0000313|Proteomes:UP000033390};
Daugherty S.C., Su Q., Abolude K., Beier-Sexton M., Carlyon J.A.,
Carter R., Day N.P., Dumler S.J., Dyachenko V., Godinez A.,
Kurtti T.J., Lichay M., Mullins K.E., Ott S., Pappas-Brown V.,
Paris D.H., Patel P., Richards A.L., Sadzewicz L., Sears K.,
Seidman D., Sengamalay N., Stenos J., Tallon L.J., Vincent G.,
Fraser C.M., Munderloh U., Dunning-Hotopp J.C.;
"Genome Sequencing of Rickettsiales.";
Submitted (FEB-2015) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: An essential GTPase that binds both GDP and GTP, with
rapid nucleotide exchange. Plays a role in 16S rRNA processing and
30S ribosomal subunit biogenesis and possibly also in cell cycle
regulation and energy metabolism. {ECO:0000256|HAMAP-
Rule:MF_00367}.
-!- CATALYTIC ACTIVITY: Endonucleolytic cleavage to 5'-
phosphomonoester. {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00751514}.
-!- COFACTOR:
Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Evidence={ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00751453};
-!- SUBUNIT: Homodimer. {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00751513}.
-!- SUBUNIT: Monomer. {ECO:0000256|HAMAP-Rule:MF_00367,
ECO:0000256|SAAS:SAAS00337156}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00367}.
Cell membrane {ECO:0000256|HAMAP-Rule:MF_00367}; Peripheral
membrane protein {ECO:0000256|HAMAP-Rule:MF_00367}.
-!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-
like GTPase superfamily. Era GTPase family. {ECO:0000256|HAMAP-
Rule:MF_00367, ECO:0000256|RuleBase:RU003761,
ECO:0000256|SAAS:SAAS00858963}.
-!- SIMILARITY: Belongs to the ribonuclease III family.
{ECO:0000256|SAAS:SAAS00809456}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:KJW03644.1}.
-----------------------------------------------------------------------
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EMBL; LAOP01000001; KJW03644.1; -; Genomic_DNA.
EnsemblBacteria; KJW03644; KJW03644; REIP_1679.
PATRIC; fig|1133329.3.peg.1737; -.
Proteomes; UP000033390; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
GO; GO:0003924; F:GTPase activity; IEA:UniProtKB-UniRule.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0004525; F:ribonuclease III activity; IEA:UniProtKB-UniRule.
GO; GO:0070181; F:small ribosomal subunit rRNA binding; IEA:UniProtKB-UniRule.
GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-UniRule.
GO; GO:0042274; P:ribosomal small subunit biogenesis; IEA:UniProtKB-UniRule.
GO; GO:0016075; P:rRNA catabolic process; IEA:InterPro.
GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule.
GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
CDD; cd00048; DSRM; 1.
CDD; cd04163; Era; 1.
CDD; cd00593; RIBOc; 1.
Gene3D; 1.10.1520.10; -; 1.
Gene3D; 3.30.300.20; -; 1.
HAMAP; MF_00367; GTPase_Era; 1.
HAMAP; MF_00104; RNase_III; 1.
InterPro; IPR014720; dsRBD_dom.
InterPro; IPR030388; G_ERA_dom.
InterPro; IPR005662; GTP-bd_Era.
InterPro; IPR006073; GTP_binding_domain.
InterPro; IPR015946; KH_dom-like_a/b.
InterPro; IPR004044; KH_dom_type_2.
InterPro; IPR009019; KH_sf_prok-type.
InterPro; IPR027417; P-loop_NTPase.
InterPro; IPR005728; Rickett_RPE.
InterPro; IPR011907; RNase_III.
InterPro; IPR000999; RNase_III_dom.
InterPro; IPR036389; RNase_III_sf.
InterPro; IPR005225; Small_GTP-bd_dom.
Pfam; PF00035; dsrm; 1.
Pfam; PF07650; KH_2; 1.
Pfam; PF01926; MMR_HSR1; 1.
Pfam; PF14622; Ribonucleas_3_3; 1.
SMART; SM00358; DSRM; 1.
SMART; SM00535; RIBOc; 1.
SUPFAM; SSF52540; SSF52540; 1.
SUPFAM; SSF54814; SSF54814; 1.
SUPFAM; SSF69065; SSF69065; 1.
TIGRFAMs; TIGR00436; era; 1.
TIGRFAMs; TIGR02191; RNaseIII; 1.
TIGRFAMs; TIGR01045; RPE1; 1.
TIGRFAMs; TIGR00231; small_GTP; 1.
PROSITE; PS50137; DS_RBD; 1.
PROSITE; PS51713; G_ERA; 1.
PROSITE; PS50823; KH_TYPE_2; 1.
PROSITE; PS00517; RNASE_3_1; 1.
PROSITE; PS50142; RNASE_3_2; 1.
3: Inferred from homology;
Cell membrane {ECO:0000256|HAMAP-Rule:MF_00367,
ECO:0000256|SAAS:SAAS00085715};
Complete proteome {ECO:0000313|Proteomes:UP000033390};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00751501};
Endonuclease {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00751464};
GTP-binding {ECO:0000256|HAMAP-Rule:MF_00367,
ECO:0000256|RuleBase:RU003761, ECO:0000256|SAAS:SAAS00494972};
Hydrolase {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00751464};
Magnesium {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00751488};
Membrane {ECO:0000256|HAMAP-Rule:MF_00367,
ECO:0000256|SAAS:SAAS00085715};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00751459};
mRNA processing {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00751469};
Nuclease {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00751464};
Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00367,
ECO:0000256|RuleBase:RU003761, ECO:0000256|SAAS:SAAS00494972};
Ribosome biogenesis {ECO:0000256|HAMAP-Rule:MF_00367,
ECO:0000256|SAAS:SAAS00085766};
RNA-binding {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00085741};
rRNA processing {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00751509};
rRNA-binding {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00085741};
tRNA processing {ECO:0000256|HAMAP-Rule:MF_00104,
ECO:0000256|SAAS:SAAS00751473}.
DOMAIN 4 133 RNase III. {ECO:0000259|PROSITE:PS50142}.
DOMAIN 158 226 DRBM. {ECO:0000259|PROSITE:PS50137}.
DOMAIN 279 448 Era-type G.
{ECO:0000259|PROSITE:PS51713}.
DOMAIN 476 553 KH type-2. {ECO:0000259|PROSITE:PS50823}.
NP_BIND 287 294 GTP. {ECO:0000256|HAMAP-Rule:MF_00367}.
NP_BIND 334 338 GTP. {ECO:0000256|HAMAP-Rule:MF_00367}.
NP_BIND 396 399 GTP. {ECO:0000256|HAMAP-Rule:MF_00367}.
ACT_SITE 50 50 {ECO:0000256|HAMAP-Rule:MF_00104}.
ACT_SITE 122 122 {ECO:0000256|HAMAP-Rule:MF_00104}.
METAL 46 46 Magnesium. {ECO:0000256|HAMAP-
Rule:MF_00104}.
METAL 119 119 Magnesium. {ECO:0000256|HAMAP-
Rule:MF_00104}.
METAL 122 122 Magnesium. {ECO:0000256|HAMAP-
Rule:MF_00104}.
SEQUENCE 567 AA; 64610 MW; 594EDBA4880C2224 CRC64;
MESFEKLEKL LSYSFKNKEL LIEALSHPSL RQHHEYKDNK DYERLEFLGD AVLNLVITEI
LFKNFANYNE GNLAKIRSYL VCKETICMVG AKLALKDYII MTHGEKVVGG RDNPNNIENA
TEALIAAIYL DSNIETTHNI IGKLWEEFIK VQNLTDYDPK TALQEWAQAS DHHLPIYRLI
KREGAAHSST FTVLVKVKDY EQTGTGHSIK EAEKNAARSL LYRLKMTNRH LPKPTYREEF
KGDTECSTAA YTLVREDAST GSTSKLPLEA KFGKMSNQKT VSVCIIGRPN SGKSTLLNRI
IGEKLSIVTP KVQTTRSIIT GIITLKDTQV ILYDTPGIFE PKGTLEKAMV RCAWSSLHSA
DLVLLIIDSL KPFDDVTHNI LDKLCSLNIV PIFLLNKIDI ESKYLNDIKA FLTGNHPDSL
LFPISALSGK NIDGLLEYIT SKAKISPWLY AEDDITDLPM RFIAAEITRE QLFLNLQQEL
PYKLTVQTEK WEELKDKSVK INQVIVVSRE SYKTIILGKN GSKIKEIGAK SRMQMERFFG
SPVHLFLFVK VRELWENNQE FYQYMKI


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