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Multifunctional fusion protein [Includes: UDP-3-O-acyl-N-acetylglucosamine deacetylase (UDP-3-O-acyl-GlcNAc deacetylase) (EC 3.5.1.108) (UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase); 3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ (EC 4.2.1.59) ((3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase) (Beta-hydroxyacyl-ACP dehydratase) ((3R)-hydroxymyristoyl-ACP dehydrase)]

 A0A095SSZ9_9FLAO        Unreviewed;       462 AA.
A0A095SSZ9;
26-NOV-2014, integrated into UniProtKB/TrEMBL.
26-NOV-2014, sequence version 1.
22-NOV-2017, entry version 27.
RecName: Full=Multifunctional fusion protein {ECO:0000256|HAMAP-Rule:MF_00388, ECO:0000256|HAMAP-Rule:MF_00406};
Includes:
RecName: Full=UDP-3-O-acyl-N-acetylglucosamine deacetylase {ECO:0000256|HAMAP-Rule:MF_00388};
Short=UDP-3-O-acyl-GlcNAc deacetylase {ECO:0000256|HAMAP-Rule:MF_00388};
EC=3.5.1.108 {ECO:0000256|HAMAP-Rule:MF_00388};
AltName: Full=UDP-3-O-[R-3-hydroxymyristoyl]-N-acetylglucosamine deacetylase {ECO:0000256|HAMAP-Rule:MF_00388};
Includes:
RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ {ECO:0000256|HAMAP-Rule:MF_00406};
EC=4.2.1.59 {ECO:0000256|HAMAP-Rule:MF_00406};
AltName: Full=(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase {ECO:0000256|HAMAP-Rule:MF_00406};
AltName: Full=Beta-hydroxyacyl-ACP dehydratase {ECO:0000256|HAMAP-Rule:MF_00406};
Short=(3R)-hydroxymyristoyl-ACP dehydrase {ECO:0000256|HAMAP-Rule:MF_00406};
Name=lpxC {ECO:0000256|HAMAP-Rule:MF_00388};
Synonyms=fabZ {ECO:0000256|HAMAP-Rule:MF_00406};
ORFNames=LG45_11665 {ECO:0000313|EMBL:KGD67771.1};
Flavobacterium aquatile LMG 4008.
Bacteria; Bacteroidetes; Flavobacteriia; Flavobacteriales;
Flavobacteriaceae; Flavobacterium.
NCBI_TaxID=1453498 {ECO:0000313|EMBL:KGD67771.1, ECO:0000313|Proteomes:UP000029554};
[1] {ECO:0000313|EMBL:KGD67771.1, ECO:0000313|Proteomes:UP000029554}
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=LMG 4008 {ECO:0000313|EMBL:KGD67771.1,
ECO:0000313|Proteomes:UP000029554};
Gale A.N., Pipes S.E., Newman J.D.;
"Whole Genome Shotgun of Flavobacterium aquatile LMG 4008.";
Submitted (SEP-2014) to the EMBL/GenBank/DDBJ databases.
-!- FUNCTION: Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-
acetylglucosamine to form UDP-3-O-myristoylglucosamine and
acetate, the committed step in lipid A biosynthesis.
{ECO:0000256|HAMAP-Rule:MF_00388, ECO:0000256|SAAS:SAAS00531485}.
-!- FUNCTION: Involved in unsaturated fatty acids biosynthesis.
Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and
long chain saturated and unsaturated beta-hydroxyacyl-ACPs.
{ECO:0000256|HAMAP-Rule:MF_00406, ECO:0000256|SAAS:SAAS00064865}.
-!- CATALYTIC ACTIVITY: A (3R)-3-hydroxyacyl-[acyl-carrier protein] =
a trans-2-enoyl-[acyl-carrier protein] + H(2)O.
{ECO:0000256|HAMAP-Rule:MF_00406, ECO:0000256|SAAS:SAAS00371036}.
-!- CATALYTIC ACTIVITY: UDP-3-O-((3R)-3-hydroxytetradecanoyl)-N-
acetyl-alpha-D-glucosamine + H(2)O = UDP-3-O-((3R)-3-
hydroxytetradecanoyl)-alpha-D-glucosamine + acetate.
{ECO:0000256|HAMAP-Rule:MF_00388, ECO:0000256|SAAS:SAAS00531490}.
-!- COFACTOR:
Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
Evidence={ECO:0000256|HAMAP-Rule:MF_00388,
ECO:0000256|SAAS:SAAS00531487};
-!- PATHWAY: Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid
IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and
UDP-N-acetyl-alpha-D-glucosamine: step 2/6. {ECO:0000256|HAMAP-
Rule:MF_00388, ECO:0000256|SAAS:SAAS00089518}.
-!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00406,
ECO:0000256|SAAS:SAAS00371052}.
-!- SIMILARITY: Belongs to the LpxC family. {ECO:0000256|HAMAP-
Rule:MF_00388, ECO:0000256|SAAS:SAAS00904468}.
-!- SIMILARITY: Belongs to the thioester dehydratase family. FabZ
subfamily. {ECO:0000256|HAMAP-Rule:MF_00406,
ECO:0000256|SAAS:SAAS00829032}.
-!- CAUTION: The sequence shown here is derived from an
EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
preliminary data. {ECO:0000313|EMBL:KGD67771.1}.
-----------------------------------------------------------------------
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EMBL; JRHH01000004; KGD67771.1; -; Genomic_DNA.
RefSeq; WP_035127265.1; NZ_JRHH01000004.1.
EnsemblBacteria; KGD67771; KGD67771; LG45_11665.
UniPathway; UPA00359; UER00478.
Proteomes; UP000029554; Unassembled WGS sequence.
GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
GO; GO:0047451; F:3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
GO; GO:0008759; F:UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity; IEA:UniProtKB-UniRule.
GO; GO:0103117; F:UDP-3-O-acyl-N-acetylglucosamine deacetylase activity; IEA:UniProtKB-EC.
GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniRule.
GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-UniRule.
Gene3D; 3.30.1700.10; -; 1.
Gene3D; 3.30.230.20; -; 1.
HAMAP; MF_00406; FabZ; 1.
HAMAP; MF_00388; LpxC; 1.
InterPro; IPR013114; FabA_FabZ.
InterPro; IPR010084; FabZ.
InterPro; IPR029069; HotDog_dom_sf.
InterPro; IPR020568; Ribosomal_S5_D2-typ_fold.
InterPro; IPR004463; UDP-acyl_GlcNac_deAcase.
InterPro; IPR011334; UDP-acyl_GlcNac_deAcase_C.
InterPro; IPR015870; UDP-acyl_N-AcGlcN_deAcase_N.
PANTHER; PTHR33694; PTHR33694; 2.
Pfam; PF07977; FabA; 1.
Pfam; PF03331; LpxC; 1.
SUPFAM; SSF54211; SSF54211; 2.
SUPFAM; SSF54637; SSF54637; 1.
TIGRFAMs; TIGR01750; fabZ; 1.
TIGRFAMs; TIGR00325; lpxC; 1.
3: Inferred from homology;
Complete proteome {ECO:0000313|Proteomes:UP000029554};
Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00406,
ECO:0000256|SAAS:SAAS00448527};
Hydrolase {ECO:0000256|HAMAP-Rule:MF_00388,
ECO:0000256|SAAS:SAAS00041385};
Lipid A biosynthesis {ECO:0000256|HAMAP-Rule:MF_00388,
ECO:0000256|SAAS:SAAS00448519};
Lipid biosynthesis {ECO:0000256|HAMAP-Rule:MF_00388,
ECO:0000256|SAAS:SAAS00448519};
Lipid metabolism {ECO:0000256|HAMAP-Rule:MF_00388,
ECO:0000256|SAAS:SAAS00448519};
Lyase {ECO:0000256|HAMAP-Rule:MF_00406,
ECO:0000256|SAAS:SAAS00064841};
Metal-binding {ECO:0000256|HAMAP-Rule:MF_00388,
ECO:0000256|SAAS:SAAS00531484};
Reference proteome {ECO:0000313|Proteomes:UP000029554};
Zinc {ECO:0000256|HAMAP-Rule:MF_00388, ECO:0000256|SAAS:SAAS00531488}.
DOMAIN 329 453 FabA. {ECO:0000259|Pfam:PF07977}.
ACT_SITE 287 287 Proton donor. {ECO:0000256|HAMAP-
Rule:MF_00388}.
ACT_SITE 365 365 {ECO:0000256|HAMAP-Rule:MF_00406}.
METAL 78 78 Zinc; via tele nitrogen.
{ECO:0000256|HAMAP-Rule:MF_00388}.
METAL 260 260 Zinc; via tele nitrogen.
{ECO:0000256|HAMAP-Rule:MF_00388}.
METAL 264 264 Zinc. {ECO:0000256|HAMAP-Rule:MF_00388}.
SEQUENCE 462 AA; 51186 MW; BF0F7D6F1324935E CRC64;
MVKQKTIKNE ISLTGVGLHT GKEVKMTFKP APINNGFTFV RVDLEGAPII EADANYVVNT
QRGTNLEKLG VKIQTSEHVL AAFVGCDIDN AIIELDASEP PIMDGSSKYF VEAIEKAGIE
EQDAERKFYV VKEVISFTDE ATGSEILVMP SDDYQVTAMV DFGTKVLGTQ NATLKNISDF
KTEIANSRTF SFLHELETLL DNGLIKGGDL NNAIVYVDKE ISPSTMENLK KAFGKDSIAV
KENGILDNLT LHYPNEAARH KLLDVIGDLA LIGIRIKGKV IANKPGHFVN TQFAKKMSKI
IKIEQKNHIP SYDLNLPPLM DIHQIMNILP HRPPFLLIDR IIEMSDTHVV GMKNVTMNEN
FFVGHFPDAP VMPGVLIVEA MAQSGGILVL STVPDPENYL TYFMKIDNVK FKYKVLPGDT
LIFKCDLITP IRRGICHMQA NAYANGRLVA EAELMAQIAK KQ


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