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Multiple antibiotic resistance protein MarA

 MARA_ECOLI              Reviewed;         127 AA.
P0ACH5; P27246;
22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
13-NOV-2007, sequence version 2.
25-APR-2018, entry version 104.
RecName: Full=Multiple antibiotic resistance protein MarA;
Name=marA; OrderedLocusNames=b1531, JW5249;
Escherichia coli (strain K12).
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
Enterobacteriaceae; Escherichia.
NCBI_TaxID=83333;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=8383113; DOI=10.1128/jb.175.5.1484-1492.1993;
Cohen S.P., Haechler H., Levy S.B.;
"Genetic and functional analysis of the multiple antibiotic resistance
(mar) locus in Escherichia coli.";
J. Bacteriol. 175:1484-1492(1993).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
STRAIN=K12;
PubMed=8491710; DOI=10.1128/jb.175.10.2888-2894.1993;
Gambino L., Gracheck S., Miller P.F.;
"Overexpression of the MarA positive regulator is sufficient to confer
multiple antibiotic resistance in Escherichia coli.";
J. Bacteriol. 175:2888-2894(1993).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=9097039; DOI=10.1093/dnares/3.6.363;
Aiba H., Baba T., Fujita K., Hayashi K., Inada T., Isono K., Itoh T.,
Kasai H., Kashimoto K., Kimura S., Kitakawa M., Kitagawa M.,
Makino K., Miki T., Mizobuchi K., Mori H., Mori T., Motomura K.,
Nakade S., Nakamura Y., Nashimoto H., Nishio Y., Oshima T., Saito N.,
Sampei G., Seki Y., Sivasundaram S., Tagami H., Takeda J.,
Takemoto K., Takeuchi Y., Wada C., Yamamoto Y., Horiuchi T.;
"A 570-kb DNA sequence of the Escherichia coli K-12 genome
corresponding to the 28.0-40.1 min region on the linkage map.";
DNA Res. 3:363-377(1996).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / MG1655 / ATCC 47076;
PubMed=9278503; DOI=10.1126/science.277.5331.1453;
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V.,
Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F.,
Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J.,
Mau B., Shao Y.;
"The complete genome sequence of Escherichia coli K-12.";
Science 277:1453-1462(1997).
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=K12 / W3110 / ATCC 27325 / DSM 5911;
PubMed=16738553; DOI=10.1038/msb4100049;
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S.,
Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.;
"Highly accurate genome sequences of Escherichia coli K-12 strains
MG1655 and W3110.";
Mol. Syst. Biol. 2:E1-E5(2006).
[6]
X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).
PubMed=9724717; DOI=10.1073/pnas.95.18.10413;
Rhee S., Martin R.G., Rosner J.L., Davies D.R.;
"A novel DNA-binding motif in MarA: the first structure for an AraC
family transcriptional activator.";
Proc. Natl. Acad. Sci. U.S.A. 95:10413-10418(1998).
-!- FUNCTION: May be a transcriptional activator of genes involved in
the multiple antibiotic resistance (Mar) phenotype. It can also
activate genes such as sodA, zwf and micF.
-!- SUBUNIT: Monomer.
-!- INDUCTION: By various antibiotics or by sodium salicylate.
-!- SEQUENCE CAUTION:
Sequence=AAC16395.1; Type=Erroneous initiation; Evidence={ECO:0000305};
-----------------------------------------------------------------------
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EMBL; M96235; AAC16395.1; ALT_INIT; Genomic_DNA.
EMBL; L06966; AAA24113.1; -; Genomic_DNA.
EMBL; U00096; AAC74604.2; -; Genomic_DNA.
EMBL; AP009048; BAA15221.2; -; Genomic_DNA.
PIR; B47072; B47072.
RefSeq; NP_416048.2; NC_000913.3.
RefSeq; WP_000091199.1; NZ_LN832404.1.
PDB; 1BL0; X-ray; 2.30 A; A=1-127.
PDB; 1XS9; NMR; -; A=1-127.
PDBsum; 1BL0; -.
PDBsum; 1XS9; -.
ProteinModelPortal; P0ACH5; -.
SMR; P0ACH5; -.
BioGrid; 4259110; 129.
DIP; DIP-48136N; -.
IntAct; P0ACH5; 1.
STRING; 316385.ECDH10B_1662; -.
PaxDb; P0ACH5; -.
PRIDE; P0ACH5; -.
EnsemblBacteria; AAC74604; AAC74604; b1531.
EnsemblBacteria; BAA15221; BAA15221; BAA15221.
GeneID; 947613; -.
KEGG; ecj:JW5249; -.
KEGG; eco:b1531; -.
PATRIC; fig|1411691.4.peg.735; -.
EchoBASE; EB1404; -.
EcoGene; EG11434; marA.
eggNOG; ENOG4108XW0; Bacteria.
eggNOG; ENOG4111IUP; LUCA.
HOGENOM; HOG000120762; -.
InParanoid; P0ACH5; -.
KO; K13632; -.
OMA; ATFTRIF; -.
PhylomeDB; P0ACH5; -.
BioCyc; EcoCyc:PD00365; -.
EvolutionaryTrace; P0ACH5; -.
PRO; PR:P0ACH5; -.
Proteomes; UP000000318; Chromosome.
Proteomes; UP000000625; Chromosome.
GO; GO:0032991; C:protein-containing complex; IMP:CAFA.
GO; GO:0032993; C:protein-DNA complex; IMP:CAFA.
GO; GO:0000985; F:bacterial-type RNA polymerase core promoter sequence-specific DNA binding; IMP:CAFA.
GO; GO:0001217; F:bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding; IMP:CAFA.
GO; GO:0003677; F:DNA binding; IDA:EcoCyc.
GO; GO:0019172; F:glyoxalase III activity; IBA:GO_Central.
GO; GO:0042803; F:protein homodimerization activity; IMP:CAFA.
GO; GO:0036245; P:cellular response to menadione; IDA:CAFA.
GO; GO:0072756; P:cellular response to paraquat; IDA:CAFA.
GO; GO:0019243; P:methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione; IBA:GO_Central.
GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:CAFA.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:EcoCyc.
GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
InterPro; IPR009057; Homeobox-like_sf.
InterPro; IPR018060; HTH_AraC.
InterPro; IPR018062; HTH_AraC-typ_CS.
Pfam; PF12833; HTH_18; 1.
SMART; SM00342; HTH_ARAC; 1.
SUPFAM; SSF46689; SSF46689; 2.
PROSITE; PS00041; HTH_ARAC_FAMILY_1; 1.
PROSITE; PS01124; HTH_ARAC_FAMILY_2; 1.
1: Evidence at protein level;
3D-structure; Activator; Antibiotic resistance; Complete proteome;
DNA-binding; Reference proteome; Repeat; Transcription;
Transcription regulation.
CHAIN 1 127 Multiple antibiotic resistance protein
MarA.
/FTId=PRO_0000194531.
DOMAIN 12 110 HTH araC/xylS-type. {ECO:0000255|PROSITE-
ProRule:PRU00593}.
DNA_BIND 29 50 H-T-H motif. {ECO:0000255|PROSITE-
ProRule:PRU00593}.
DNA_BIND 77 100 H-T-H motif. {ECO:0000255|PROSITE-
ProRule:PRU00593}.
HELIX 8 19 {ECO:0000244|PDB:1BL0}.
TURN 20 23 {ECO:0000244|PDB:1BL0}.
HELIX 29 34 {ECO:0000244|PDB:1BL0}.
STRAND 35 37 {ECO:0000244|PDB:1BL0}.
HELIX 39 50 {ECO:0000244|PDB:1BL0}.
HELIX 54 72 {ECO:0000244|PDB:1BL0}.
HELIX 77 83 {ECO:0000244|PDB:1BL0}.
HELIX 89 100 {ECO:0000244|PDB:1BL0}.
HELIX 104 108 {ECO:0000244|PDB:1BL0}.
STRAND 115 117 {ECO:0000244|PDB:1XS9}.
SEQUENCE 127 AA; 15184 MW; A547C8F1553A9196 CRC64;
MSRRNTDAIT IHSILDWIED NLESPLSLEK VSERSGYSKW HLQRMFKKET GHSLGQYIRS
RKMTEIAQKL KESNEPILYL AERYGFESQQ TLTRTFKNYF DVPPHKYRMT NMQGESRFLH
PLNHYNS


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