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Muscarinic acetylcholine receptor M2

 ACM2_HUMAN              Reviewed;         466 AA.
P08172; Q4VBK6; Q9P1X9;
01-AUG-1988, integrated into UniProtKB/Swiss-Prot.
01-AUG-1988, sequence version 1.
12-SEP-2018, entry version 186.
RecName: Full=Muscarinic acetylcholine receptor M2;
Name=CHRM2;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3037705; DOI=10.1126/science.3037705;
Bonner T.I., Buckley N.J., Young A.C., Brann M.R.;
"Identification of a family of muscarinic acetylcholine receptor
genes.";
Science 237:527-532(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
PubMed=3443095;
Peralta E.G., Ashkenazi A., Winslow J.W., Smith D.H., Ramachandran J.,
Capon D.J.;
"Distinct primary structures, ligand-binding properties and tissue-
specific expression of four human muscarinic acetylcholine
receptors.";
EMBO J. 6:3923-3929(1987).
[3]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
"cDNA clones of human proteins involved in signal transduction
sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[5]
NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 27-466.
PubMed=15014171; DOI=10.1093/molbev/msh100;
Kitano T., Liu Y.-H., Ueda S., Saitou N.;
"Human-specific amino acid changes found in 103 protein-coding
genes.";
Mol. Biol. Evol. 21:936-944(2004).
[6]
INTERACTION WITH ARRB1 AND ARRB2.
PubMed=7822302; DOI=10.1074/jbc.270.2.720;
Gurevich V.V., Dion S.B., Onorato J.J., Ptasienski J., Kim C.M.,
Sterne-Marr R., Hosey M.M., Benovic J.L.;
"Arrestin interactions with G protein-coupled receptors. Direct
binding studies of wild type and mutant arrestins with rhodopsin, beta
2-adrenergic, and m2 muscarinic cholinergic receptors.";
J. Biol. Chem. 270:720-731(1995).
[7]
INDUCTION, AND IDENTIFICATION BY MASS SPECTROMETRY.
PubMed=16548883; DOI=10.1111/j.1462-5822.2005.00644.x;
Leong W.F., Chow V.T.;
"Transcriptomic and proteomic analyses of rhabdomyosarcoma cells
reveal differential cellular gene expression in response to
enterovirus 71 infection.";
Cell. Microbiol. 8:565-580(2006).
[8]
INVOLVEMENT IN SUSCEPTIBILITY TO ALCOHOLISM AND MAJOR DEPRESSIVE
DISORDER.
PubMed=15229186; DOI=10.1093/hmg/ddh194;
Wang J.C., Hinrichs A.L., Stock H., Budde J., Allen R., Bertelsen S.,
Kwon J.M., Wu W., Dick D.M., Rice J., Jones K., Nurnberger J.I. Jr.,
Tischfield J., Porjesz B., Edenberg H.J., Hesselbrock V., Crowe R.,
Schuckit M., Begleiter H., Reich T., Goate A.M., Bierut L.J.;
"Evidence of common and specific genetic effects: association of the
muscarinic acetylcholine receptor M2 (CHRM2) gene with alcohol
dependence and major depressive syndrome.";
Hum. Mol. Genet. 13:1903-1911(2004).
[9]
INTERACTION WITH RACK1.
PubMed=20976005; DOI=10.1371/journal.pone.0013517;
Reiner C.L., McCullar J.S., Kow R.L., Le J.H., Goodlett D.R.,
Nathanson N.M.;
"RACK1 associates with muscarinic receptors and regulates M(2)
receptor trafficking.";
PLoS ONE 5:E13517-E13517(2010).
[10]
X-RAY CRYSTALLOGRAPHY (3.00 ANGSTROMS) IN COMPLEX WITH THE ANTAGONIST
3-QUINUCLIDINYLBENZILATE, SUBCELLULAR LOCATION, TOPOLOGY, AND
DISULFIDE BOND.
PubMed=22278061; DOI=10.1038/nature10753;
Haga K., Kruse A.C., Asada H., Yurugi-Kobayashi T., Shiroishi M.,
Zhang C., Weis W.I., Okada T., Kobilka B.K., Haga T., Kobayashi T.;
"Structure of the human M2 muscarinic acetylcholine receptor bound to
an antagonist.";
Nature 482:547-551(2012).
[11]
X-RAY CRYSTALLOGRAPHY (3.50 ANGSTROMS) IN COMPLEXES WITH THE AGONIST
IPEROXO AND THE ALLOSTERIC EFFECTOR LY2119620, FUNCTION, SUBCELLULAR
LOCATION, TOPOLOGY, DISULFIDE BOND, MOTIF, AND MUTAGENESIS OF ASN-58;
ASP-103; TYR-206 AND ASN-404.
PubMed=24256733; DOI=10.1038/nature12735;
Kruse A.C., Ring A.M., Manglik A., Hu J., Hu K., Eitel K., Hubner H.,
Pardon E., Valant C., Sexton P.M., Christopoulos A., Felder C.C.,
Gmeiner P., Steyaert J., Weis W.I., Garcia K.C., Wess J.,
Kobilka B.K.;
"Activation and allosteric modulation of a muscarinic acetylcholine
receptor.";
Nature 504:101-106(2013).
-!- FUNCTION: The muscarinic acetylcholine receptor mediates various
cellular responses, including inhibition of adenylate cyclase,
breakdown of phosphoinositides and modulation of potassium
channels through the action of G proteins. Primary transducing
effect is adenylate cyclase inhibition. Signaling promotes
phospholipase C activity, leading to the release of inositol
trisphosphate (IP3); this then triggers calcium ion release into
the cytosol. {ECO:0000269|PubMed:24256733,
ECO:0000269|PubMed:3443095}.
-!- SUBUNIT: Interacts with ARRB1 and ARRB2. Interacts with RACK1; the
interaction regulates CHRM2 internalization.
{ECO:0000269|PubMed:20976005, ECO:0000269|PubMed:22278061,
ECO:0000269|PubMed:7822302}.
-!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22278061,
ECO:0000269|PubMed:24256733, ECO:0000269|PubMed:3443095}; Multi-
pass membrane protein {ECO:0000269|PubMed:22278061,
ECO:0000269|PubMed:24256733}. Cell junction, synapse, postsynaptic
cell membrane {ECO:0000305}; Multi-pass membrane protein
{ECO:0000305}. Note=Phosphorylation in response to agonist binding
promotes receptor internalization. {ECO:0000250|UniProtKB:P06199}.
-!- INDUCTION: Up-regulated in response to enterovirus 71 (EV71)
infection. {ECO:0000269|PubMed:16548883}.
-!- PTM: Phosphorylated in response to agonist treatment.
{ECO:0000250}.
-!- POLYMORPHISM: Genetic variations in CHRM2 can influence
susceptibility to alcoholism [MIM:103780].
{ECO:0000305|PubMed:15229186}.
-!- DISEASE: Major depressive disorder (MDD) [MIM:608516]: A common
psychiatric disorder. It is a complex trait characterized by one
or more major depressive episodes without a history of manic,
mixed, or hypomanic episodes. A major depressive episode is
characterized by at least 2 weeks during which there is a new
onset or clear worsening of either depressed mood or loss of
interest or pleasure in nearly all activities. Four additional
symptoms must also be present including changes in appetite,
weight, sleep, and psychomotor activity; decreased energy;
feelings of worthlessness or guilt; difficulty thinking,
concentrating, or making decisions; or recurrent thoughts of death
or suicidal ideation, plans, or attempts. The episode must be
accompanied by distress or impairment in social, occupational, or
other important areas of functioning.
{ECO:0000269|PubMed:15229186}. Note=Disease susceptibility is
associated with variations affecting the gene represented in this
entry.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; M16404; AAA51570.1; -; Genomic_DNA.
EMBL; X15264; CAA33335.1; -; Genomic_DNA.
EMBL; AF498916; AAM18939.1; -; mRNA.
EMBL; BC095547; AAH95547.1; -; mRNA.
EMBL; BC106741; AAI06742.1; -; mRNA.
EMBL; BC106742; AAI06743.1; -; mRNA.
EMBL; AB041391; BAA94476.1; -; Genomic_DNA.
CCDS; CCDS5843.1; -.
PIR; S10126; S10126.
RefSeq; NP_000730.1; NM_000739.2.
RefSeq; NP_001006627.1; NM_001006626.1.
RefSeq; NP_001006628.1; NM_001006627.1.
RefSeq; NP_001006629.1; NM_001006628.1.
RefSeq; NP_001006630.1; NM_001006629.1.
RefSeq; NP_001006631.1; NM_001006630.1.
RefSeq; NP_001006632.1; NM_001006631.1.
RefSeq; NP_001006633.1; NM_001006632.1.
RefSeq; XP_011514071.1; XM_011515769.2.
UniGene; Hs.535891; -.
PDB; 1LUB; Model; -; A=1-50.
PDB; 3UON; X-ray; 3.00 A; A=1-217, A=377-466.
PDB; 4MQS; X-ray; 3.50 A; A=1-466.
PDB; 4MQT; X-ray; 3.70 A; A=1-466.
PDBsum; 1LUB; -.
PDBsum; 3UON; -.
PDBsum; 4MQS; -.
PDBsum; 4MQT; -.
ProteinModelPortal; P08172; -.
SMR; P08172; -.
BioGrid; 107551; 4.
DIP; DIP-56282N; -.
IntAct; P08172; 14.
MINT; P08172; -.
STRING; 9606.ENSP00000319984; -.
BindingDB; P08172; -.
ChEMBL; CHEMBL211; -.
DrugBank; DB08897; Aclidinium.
DrugBank; DB05752; ALKS 27.
DrugBank; DB00321; Amitriptyline.
DrugBank; DB00543; Amoxapine.
DrugBank; DB00517; Anisotropine Methylbromide.
DrugBank; DB01238; Aripiprazole.
DrugBank; DB00572; Atropine.
DrugBank; DB00767; Benzquinamide.
DrugBank; DB01019; Bethanechol.
DrugBank; DB00835; Brompheniramine.
DrugBank; DB00411; Carbachol.
DrugBank; DB01239; Chlorprothixene.
DrugBank; DB00568; Cinnarizine.
DrugBank; DB00363; Clozapine.
DrugBank; DB00907; Cocaine.
DrugBank; DB00785; Cryptenamine.
DrugBank; DB00434; Cyproheptadine.
DrugBank; DB00496; Darifenacin.
DrugBank; DB01151; Desipramine.
DrugBank; DB00804; Dicyclomine.
DrugBank; DB08801; Dimetindene.
DrugBank; DB01075; Diphenhydramine.
DrugBank; DB01231; Diphenidol.
DrugBank; DB00280; Disopyramide.
DrugBank; DB01135; Doxacurium chloride.
DrugBank; DB01142; Doxepin.
DrugBank; DB00392; Ethopropazine.
DrugBank; DB06702; Fesoterodine.
DrugBank; DB01148; Flavoxate.
DrugBank; DB00483; Gallamine Triethiodide.
DrugBank; DB00986; Glycopyrronium.
DrugBank; DB00725; Homatropine Methylbromide.
DrugBank; DB00424; Hyoscyamine.
DrugBank; DB00458; Imipramine.
DrugBank; DB00332; Ipratropium bromide.
DrugBank; DB01221; Ketamine.
DrugBank; DB00408; Loxapine.
DrugBank; DB00934; Maprotiline.
DrugBank; DB01403; Methotrimeprazine.
DrugBank; DB00462; Methylscopolamine bromide.
DrugBank; DB00340; Metixene.
DrugBank; DB01336; Metocurine.
DrugBank; DB01226; Mivacurium.
DrugBank; DB00622; Nicardipine.
DrugBank; DB00540; Nortriptyline.
DrugBank; DB00334; Olanzapine.
DrugBank; DB01062; Oxybutynin.
DrugBank; DB00383; Oxyphencyclimine.
DrugBank; DB01337; Pancuronium.
DrugBank; DB00715; Paroxetine.
DrugBank; DB00454; Pethidine.
DrugBank; DB01085; Pilocarpine.
DrugBank; DB01338; Pipecuronium.
DrugBank; DB00387; Procyclidine.
DrugBank; DB00420; Promazine.
DrugBank; DB01069; Promethazine.
DrugBank; DB00777; Propiomazine.
DrugBank; DB01224; Quetiapine.
DrugBank; DB00728; Rocuronium.
DrugBank; DB00747; Scopolamine.
DrugBank; DB01591; Solifenacin.
DrugBank; DB00202; Succinylcholine.
DrugBank; DB00342; Terfenadine.
DrugBank; DB01409; Tiotropium.
DrugBank; DB01036; Tolterodine.
DrugBank; DB00505; Tridihexethyl.
DrugBank; DB00508; Triflupromazine.
DrugBank; DB00376; Trihexyphenidyl.
DrugBank; DB00726; Trimipramine.
DrugBank; DB00809; Tropicamide.
DrugBank; DB09076; Umeclidinium.
DrugBank; DB00246; Ziprasidone.
GuidetoPHARMACOLOGY; 14; -.
iPTMnet; P08172; -.
PhosphoSitePlus; P08172; -.
SwissPalm; P08172; -.
BioMuta; CHRM2; -.
DMDM; 113122; -.
PaxDb; P08172; -.
PeptideAtlas; P08172; -.
PRIDE; P08172; -.
ProteomicsDB; 52076; -.
DNASU; 1129; -.
Ensembl; ENST00000320658; ENSP00000319984; ENSG00000181072.
Ensembl; ENST00000401861; ENSP00000384401; ENSG00000181072.
Ensembl; ENST00000445907; ENSP00000399745; ENSG00000181072.
Ensembl; ENST00000453373; ENSP00000415386; ENSG00000181072.
GeneID; 1129; -.
KEGG; hsa:1129; -.
UCSC; uc003vtg.2; human.
CTD; 1129; -.
DisGeNET; 1129; -.
EuPathDB; HostDB:ENSG00000181072.11; -.
GeneCards; CHRM2; -.
HGNC; HGNC:1951; CHRM2.
HPA; CAB022338; -.
HPA; HPA029795; -.
MIM; 103780; phenotype.
MIM; 118493; gene.
MIM; 608516; phenotype.
neXtProt; NX_P08172; -.
OpenTargets; ENSG00000181072; -.
PharmGKB; PA111; -.
eggNOG; KOG4220; Eukaryota.
eggNOG; ENOG410YCQR; LUCA.
GeneTree; ENSGT00780000121874; -.
HOGENOM; HOG000231484; -.
HOVERGEN; HBG105720; -.
InParanoid; P08172; -.
KO; K04130; -.
OMA; CIKIVTK; -.
OrthoDB; EOG091G06VI; -.
PhylomeDB; P08172; -.
TreeFam; TF320495; -.
Reactome; R-HSA-390648; Muscarinic acetylcholine receptors.
Reactome; R-HSA-418594; G alpha (i) signalling events.
Reactome; R-HSA-8856825; Cargo recognition for clathrin-mediated endocytosis.
Reactome; R-HSA-8856828; Clathrin-mediated endocytosis.
SignaLink; P08172; -.
SIGNOR; P08172; -.
ChiTaRS; CHRM2; human.
GeneWiki; Muscarinic_acetylcholine_receptor_M2; -.
GenomeRNAi; 1129; -.
PRO; PR:P08172; -.
Proteomes; UP000005640; Chromosome 7.
Bgee; ENSG00000181072; Expressed in 60 organ(s), highest expression level in heart.
CleanEx; HS_CHRM2; -.
ExpressionAtlas; P08172; baseline and differential.
Genevisible; P08172; HS.
GO; GO:0032279; C:asymmetric synapse; IEA:Ensembl.
GO; GO:0043679; C:axon terminus; IEA:Ensembl.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0030665; C:clathrin-coated vesicle membrane; TAS:Reactome.
GO; GO:0030425; C:dendrite; IEA:Ensembl.
GO; GO:0016021; C:integral component of membrane; IDA:CAFA.
GO; GO:0005887; C:integral component of plasma membrane; IDA:UniProtKB.
GO; GO:0043025; C:neuronal cell body; IEA:Ensembl.
GO; GO:0005886; C:plasma membrane; IDA:LIFEdb.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:0032280; C:symmetric synapse; IEA:Ensembl.
GO; GO:0045202; C:synapse; IBA:GO_Central.
GO; GO:1990763; F:arrestin family protein binding; IPI:CAFA.
GO; GO:0008144; F:drug binding; IEA:Ensembl.
GO; GO:0016907; F:G-protein coupled acetylcholine receptor activity; IDA:UniProtKB.
GO; GO:0007197; P:adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway; IBA:GO_Central.
GO; GO:0007188; P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway; TAS:ProtInc.
GO; GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; IDA:UniProtKB.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:Reactome.
GO; GO:0007187; P:G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; TAS:ProtInc.
GO; GO:0061024; P:membrane organization; TAS:Reactome.
GO; GO:0007399; P:nervous system development; TAS:ProtInc.
GO; GO:0007207; P:phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway; TAS:ProtInc.
GO; GO:0008016; P:regulation of heart contraction; IBA:GO_Central.
GO; GO:0006940; P:regulation of smooth muscle contraction; IBA:GO_Central.
GO; GO:0009615; P:response to virus; IEP:UniProtKB.
GO; GO:0007271; P:synaptic transmission, cholinergic; IBA:GO_Central.
CDD; cd15297; 7tmA_mAChR_M2; 1.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR001065; Musac_Ach_M2_rcpt.
InterPro; IPR000995; Musac_Ach_rcpt.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00243; MUSCARINICR.
PRINTS; PR00539; MUSCRINICM2R.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
3D-structure; Cell junction; Cell membrane; Complete proteome;
Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane;
Phosphoprotein; Postsynaptic cell membrane; Receptor;
Reference proteome; Synapse; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 466 Muscarinic acetylcholine receptor M2.
/FTId=PRO_0000069021.
TOPO_DOM 1 22 Extracellular.
TRANSMEM 23 45 Helical; Name=1.
TOPO_DOM 46 59 Cytoplasmic.
TRANSMEM 60 80 Helical; Name=2.
TOPO_DOM 81 97 Extracellular.
TRANSMEM 98 119 Helical; Name=3.
TOPO_DOM 120 139 Cytoplasmic.
TRANSMEM 140 162 Helical; Name=4.
TOPO_DOM 163 184 Extracellular.
TRANSMEM 185 209 Helical; Name=5.
TOPO_DOM 210 387 Cytoplasmic.
TRANSMEM 388 410 Helical; Name=6.
TOPO_DOM 411 418 Extracellular.
TRANSMEM 419 442 Helical; Name=7.
TOPO_DOM 443 466 Cytoplasmic.
REGION 103 107 Agonist binding. {ECO:0000305}.
REGION 403 404 Agonist binding. {ECO:0000305}.
REGION 426 430 Agonist binding. {ECO:0000305}.
MOTIF 120 122 Important for signaling.
MOTIF 436 440 Important for signaling.
MOD_RES 232 232 Phosphoserine.
{ECO:0000250|UniProtKB:Q9ERZ4}.
MOD_RES 446 446 Phosphothreonine. {ECO:0000255}.
MOD_RES 450 450 Phosphothreonine. {ECO:0000255}.
MOD_RES 465 465 Phosphothreonine. {ECO:0000255}.
CARBOHYD 2 2 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 3 3 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 6 6 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 9 9 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 96 176
DISULFID 413 416
MUTAGEN 58 58 N->A: Nearly abolishes signaling via
downstream effectors.
{ECO:0000269|PubMed:24256733}.
MUTAGEN 103 103 D->E: Reduced affinity for acetylcholine.
Abolishes signaling via downstream
effectors. {ECO:0000269|PubMed:24256733}.
MUTAGEN 206 206 Y->F: Abolishes signaling via downstream
effectors. {ECO:0000269|PubMed:24256733}.
MUTAGEN 404 404 N->Q: Reduced affinity for acetylcholine.
Reduces signaling via downstream
effectors. {ECO:0000269|PubMed:24256733}.
HELIX 23 50 {ECO:0000244|PDB:3UON}.
HELIX 52 54 {ECO:0000244|PDB:3UON}.
HELIX 57 74 {ECO:0000244|PDB:3UON}.
HELIX 76 85 {ECO:0000244|PDB:3UON}.
STRAND 86 88 {ECO:0000244|PDB:3UON}.
HELIX 93 126 {ECO:0000244|PDB:3UON}.
TURN 128 130 {ECO:0000244|PDB:3UON}.
HELIX 132 134 {ECO:0000244|PDB:3UON}.
HELIX 137 166 {ECO:0000244|PDB:3UON}.
HELIX 179 182 {ECO:0000244|PDB:3UON}.
HELIX 184 194 {ECO:0000244|PDB:3UON}.
HELIX 196 213 {ECO:0000244|PDB:3UON}.
HELIX 384 412 {ECO:0000244|PDB:3UON}.
HELIX 414 416 {ECO:0000244|PDB:4MQS}.
HELIX 419 431 {ECO:0000244|PDB:3UON}.
TURN 432 434 {ECO:0000244|PDB:3UON}.
HELIX 435 443 {ECO:0000244|PDB:3UON}.
HELIX 445 454 {ECO:0000244|PDB:3UON}.
SEQUENCE 466 AA; 51715 MW; 2FC2FD7748C22BEC CRC64;
MNNSTNSSNN SLALTSPYKT FEVVFIVLVA GSLSLVTIIG NILVMVSIKV NRHLQTVNNY
FLFSLACADL IIGVFSMNLY TLYTVIGYWP LGPVVCDLWL ALDYVVSNAS VMNLLIISFD
RYFCVTKPLT YPVKRTTKMA GMMIAAAWVL SFILWAPAIL FWQFIVGVRT VEDGECYIQF
FSNAAVTFGT AIAAFYLPVI IMTVLYWHIS RASKSRIKKD KKEPVANQDP VSPSLVQGRI
VKPNNNNMPS SDDGLEHNKI QNGKAPRDPV TENCVQGEEK ESSNDSTSVS AVASNMRDDE
ITQDENTVST SLGHSKDENS KQTCIRIGTK TPKSDSCTPT NTTVEVVGSS GQNGDEKQNI
VARKIVKMTK QPAKKKPPPS REKKVTRTIL AILLAFIITW APYNVMVLIN TFCAPCIPNT
VWTIGYWLCY INSTINPACY ALCNATFKKT FKHLLMCHYK NIGATR


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AP06976PU-N Muscarinic acetylcholine receptor M3 50 µg
NLS220 Muscarinic acetylcholine receptor M4 0.05 ml
NLS219 Muscarinic acetylcholine receptor M4 0.05 ml
NLS1831 Muscarinic acetylcholine receptor M2 0.05 ml
NLS1338 Muscarinic acetylcholine receptor M5 0.05 ml
SP5119P Muscarinic acetylcholine receptor M1 0.2 mg
AP01304PU-N Muscarinic acetylcholine receptor M2 100 µg


 

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