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Muscarinic acetylcholine receptor M3

 ACM3_HUMAN              Reviewed;         590 AA.
P20309; Q0VAJ8; Q4QRI3; Q5VXY2; Q9HB60;
01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
01-FEB-1991, sequence version 1.
25-OCT-2017, entry version 178.
RecName: Full=Muscarinic acetylcholine receptor M3;
Name=CHRM3;
Homo sapiens (Human).
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
Catarrhini; Hominidae; Homo.
NCBI_TaxID=9606;
[1]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3443095;
Peralta E.G., Ashkenazi A., Winslow J.W., Smith D.H., Ramachandran J.,
Capon D.J.;
"Distinct primary structures, ligand-binding properties and tissue-
specific expression of four human muscarinic acetylcholine
receptors.";
EMBO J. 6:3923-3929(1987).
[2]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=3272174; DOI=10.1016/0896-6273(88)90190-0;
Bonner T.I., Young A.C., Brann M.R., Buckley N.J.;
"Cloning and expression of the human and rat m5 muscarinic
acetylcholine receptor genes.";
Neuron 1:403-410(1988).
[3]
NUCLEOTIDE SEQUENCE [GENOMIC DNA].
PubMed=15014171; DOI=10.1093/molbev/msh100;
Kitano T., Liu Y.-H., Ueda S., Saitou N.;
"Human-specific amino acid changes found in 103 protein-coding
genes.";
Mol. Biol. Evol. 21:936-944(2004).
[4]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
TISSUE=Brain;
Puhl H.L. III, Ikeda S.R., Aronstam R.S.;
"cDNA clones of human proteins involved in signal transduction
sequenced by the Guthrie cDNA resource center (www.cdna.org).";
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases.
[5]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
PubMed=16710414; DOI=10.1038/nature04727;
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D.,
Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A.,
Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F.,
McDonald L., Evans R., Phillips K., Atkinson A., Cooper R., Jones C.,
Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P.,
Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K.,
Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G.,
Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D.,
Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G.,
Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J.,
Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R.,
Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D.,
Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G.,
Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M.,
Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J.,
Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M.,
Loveland J., Lovell J., Lush M.J., Lyne R., Martin S.,
Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S.,
Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C.,
Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z.,
Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E.,
Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A.,
Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R.,
Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V.,
Beck S., Rogers J., Bentley D.R.;
"The DNA sequence and biological annotation of human chromosome 1.";
Nature 441:315-321(2006).
[6]
NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
PubMed=15489334; DOI=10.1101/gr.2596504;
The MGC Project Team;
"The status, quality, and expansion of the NIH full-length cDNA
project: the Mammalian Gene Collection (MGC).";
Genome Res. 14:2121-2127(2004).
[7]
NUCLEOTIDE SEQUENCE [MRNA] OF 1-384.
TISSUE=Teratocarcinoma;
PubMed=11238933; DOI=10.1128/MCB.21.6.1973-1985.2001;
Speek M.;
"Antisense promoter of human L1 retrotransposon drives transcription
of adjacent cellular genes.";
Mol. Cell. Biol. 21:1973-1985(2001).
[8]
FUNCTION.
PubMed=7565628;
Yang J., Williams J.A., Yule D.I., Logsdon C.D.;
"Mutation of carboxyl-terminal threonine residues in human M3
muscarinic acetylcholine receptor modulates the extent of
sequestration and desensitization.";
Mol. Pharmacol. 48:477-485(1995).
[9]
INVOLVEMENT IN PBS.
PubMed=22077972; DOI=10.1016/j.ajhg.2011.10.007;
Weber S., Thiele H., Mir S., Toliat M.R., Sozeri B., Reutter H.,
Draaken M., Ludwig M., Altmuller J., Frommolt P., Stuart H.M.,
Ranjzad P., Hanley N.A., Jennings R., Newman W.G., Wilcox D.T.,
Thiel U., Schlingmann K.P., Beetz R., Hoyer P.F., Konrad M.,
Schaefer F., Nurnberg P., Woolf A.S.;
"Muscarinic acetylcholine receptor M3 mutation causes urinary bladder
disease and a prune-belly-like syndrome.";
Am. J. Hum. Genet. 89:668-674(2011).
[10]
SUBUNIT, AND SUBCELLULAR LOCATION.
PubMed=23521066; DOI=10.1042/BJ20121902;
Patowary S., Alvarez-Curto E., Xu T.R., Holz J.D., Oliver J.A.,
Milligan G., Raicu V.;
"The muscarinic M3 acetylcholine receptor exists as two differently
sized complexes at the plasma membrane.";
Biochem. J. 452:303-312(2013).
[11]
STRUCTURE BY NMR OF 271-289, MUTAGENESIS OF GLU-276; PHE-280 AND
VAL-281, AND SUBCELLULAR LOCATION.
PubMed=15870063; DOI=10.1074/jbc.M501264200;
Iverson H.A., Fox D. III, Nadler L.S., Klevit R.E., Nathanson N.M.;
"Identification and structural determination of the M(3) muscarinic
acetylcholine receptor basolateral sorting signal.";
J. Biol. Chem. 280:24568-24575(2005).
-!- FUNCTION: The muscarinic acetylcholine receptor mediates various
cellular responses, including inhibition of adenylate cyclase,
breakdown of phosphoinositides and modulation of potassium
channels through the action of G proteins. Primary transducing
effect is Pi turnover. {ECO:0000269|PubMed:7565628}.
-!- SUBUNIT: Homodimer; the dimers can form tetramers
(PubMed:23521066). Interacts with NALCN (By similarity).
{ECO:0000250|UniProtKB:Q9ERZ3, ECO:0000269|PubMed:23521066}.
-!- INTERACTION:
Q8IZF0:NALCN; NbExp=3; IntAct=EBI-2687785, EBI-7085333;
-!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
Cell junction, synapse, postsynaptic cell membrane; Multi-pass
membrane protein. Basolateral cell membrane; Multi-pass membrane
protein.
-!- DISEASE: Prune belly syndrome (PBS) [MIM:100100]: A syndrome
characterized by thin abdominal musculature with overlying lax
skin, cryptorchism, megacystis with disorganized detrusor muscle,
and urinary tract abnormalities. {ECO:0000269|PubMed:22077972}.
Note=The disease is caused by mutations affecting the gene
represented in this entry.
-!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
Muscarinic acetylcholine receptor subfamily. CHRM3 sub-subfamily.
{ECO:0000255|PROSITE-ProRule:PRU00521}.
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EMBL; X15266; CAA33337.1; -; Genomic_DNA.
EMBL; U29589; AAA70337.1; -; Genomic_DNA.
EMBL; AB041395; BAA94480.1; -; Genomic_DNA.
EMBL; AF498917; AAM18940.1; -; mRNA.
EMBL; AL356361; -; NOT_ANNOTATED_CDS; Genomic_DNA.
EMBL; BC096844; AAH96844.1; -; mRNA.
EMBL; BC121026; AAI21027.1; -; mRNA.
EMBL; AF279779; AAG30036.1; -; mRNA.
CCDS; CCDS1616.1; -.
PIR; S10128; S10128.
RefSeq; NP_000731.1; NM_000740.3.
RefSeq; NP_001334645.1; NM_001347716.1.
RefSeq; XP_005273089.1; XM_005273032.3.
RefSeq; XP_011542343.1; XM_011544041.2.
RefSeq; XP_011542345.1; XM_011544043.2.
RefSeq; XP_011542346.1; XM_011544044.2.
RefSeq; XP_011542348.1; XM_011544046.2.
RefSeq; XP_011542349.1; XM_011544047.2.
RefSeq; XP_016855641.1; XM_017000152.1.
RefSeq; XP_016855642.1; XM_017000153.1.
RefSeq; XP_016855643.1; XM_017000154.1.
RefSeq; XP_016855644.1; XM_017000155.1.
RefSeq; XP_016855645.1; XM_017000156.1.
RefSeq; XP_016855646.1; XM_017000157.1.
RefSeq; XP_016855647.1; XM_017000158.1.
RefSeq; XP_016855648.1; XM_017000159.1.
RefSeq; XP_016855649.1; XM_017000160.1.
RefSeq; XP_016855650.1; XM_017000161.1.
RefSeq; XP_016855651.1; XM_017000162.1.
RefSeq; XP_016855652.1; XM_017000163.1.
UniGene; Hs.155736; -.
UniGene; Hs.7138; -.
PDB; 2CSA; NMR; -; A=271-289.
PDBsum; 2CSA; -.
ProteinModelPortal; P20309; -.
SMR; P20309; -.
BioGrid; 107553; 58.
DIP; DIP-44291N; -.
IntAct; P20309; 4.
MINT; MINT-4953628; -.
STRING; 9606.ENSP00000255380; -.
BindingDB; P20309; -.
ChEMBL; CHEMBL245; -.
DrugBank; DB08897; Aclidinium.
DrugBank; DB05752; ALKS 27.
DrugBank; DB00321; Amitriptyline.
DrugBank; DB00543; Amoxapine.
DrugBank; DB00517; Anisotropine Methylbromide.
DrugBank; DB01238; Aripiprazole.
DrugBank; DB00572; Atropine.
DrugBank; DB00767; Benzquinamide.
DrugBank; DB00835; Brompheniramine.
DrugBank; DB00185; Cevimeline.
DrugBank; DB00477; Chlorpromazine.
DrugBank; DB01239; Chlorprothixene.
DrugBank; DB00568; Cinnarizine.
DrugBank; DB00363; Clozapine.
DrugBank; DB00785; Cryptenamine.
DrugBank; DB00434; Cyproheptadine.
DrugBank; DB00496; Darifenacin.
DrugBank; DB01151; Desipramine.
DrugBank; DB09357; Dexpanthenol.
DrugBank; DB00729; Diphemanil Methylsulfate.
DrugBank; DB01231; Diphenidol.
DrugBank; DB00280; Disopyramide.
DrugBank; DB01142; Doxepin.
DrugBank; DB06702; Fesoterodine.
DrugBank; DB00986; Glycopyrronium.
DrugBank; DB00725; Homatropine Methylbromide.
DrugBank; DB00424; Hyoscyamine.
DrugBank; DB00458; Imipramine.
DrugBank; DB00332; Ipratropium bromide.
DrugBank; DB01625; Isopropamide.
DrugBank; DB04924; Itopride.
DrugBank; DB01221; Ketamine.
DrugBank; DB00408; Loxapine.
DrugBank; DB00934; Maprotiline.
DrugBank; DB04843; Mepenzolate.
DrugBank; DB06709; Methacholine.
DrugBank; DB01403; Methotrimeprazine.
DrugBank; DB00462; Methylscopolamine bromide.
DrugBank; DB00340; Metixene.
DrugBank; DB01226; Mivacurium.
DrugBank; DB00622; Nicardipine.
DrugBank; DB00540; Nortriptyline.
DrugBank; DB00334; Olanzapine.
DrugBank; DB01062; Oxybutynin.
DrugBank; DB00383; Oxyphencyclimine.
DrugBank; DB01337; Pancuronium.
DrugBank; DB00715; Paroxetine.
DrugBank; DB00454; Pethidine.
DrugBank; DB01085; Pilocarpine.
DrugBank; DB01338; Pipecuronium.
DrugBank; DB00387; Procyclidine.
DrugBank; DB00420; Promazine.
DrugBank; DB01069; Promethazine.
DrugBank; DB00777; Propiomazine.
DrugBank; DB01224; Quetiapine.
DrugBank; DB00747; Scopolamine.
DrugBank; DB01591; Solifenacin.
DrugBank; DB00202; Succinylcholine.
DrugBank; DB00342; Terfenadine.
DrugBank; DB01409; Tiotropium.
DrugBank; DB01036; Tolterodine.
DrugBank; DB00193; Tramadol.
DrugBank; DB00505; Tridihexethyl.
DrugBank; DB00376; Trihexyphenidyl.
DrugBank; DB00726; Trimipramine.
DrugBank; DB00809; Tropicamide.
DrugBank; DB09076; Umeclidinium.
DrugBank; DB00246; Ziprasidone.
GuidetoPHARMACOLOGY; 15; -.
iPTMnet; P20309; -.
PhosphoSitePlus; P20309; -.
BioMuta; CHRM3; -.
DMDM; 113125; -.
MaxQB; P20309; -.
PaxDb; P20309; -.
PeptideAtlas; P20309; -.
PRIDE; P20309; -.
DNASU; 1131; -.
Ensembl; ENST00000255380; ENSP00000255380; ENSG00000133019.
Ensembl; ENST00000615928; ENSP00000482377; ENSG00000133019.
GeneID; 1131; -.
KEGG; hsa:1131; -.
UCSC; uc001hyp.4; human.
CTD; 1131; -.
DisGeNET; 1131; -.
EuPathDB; HostDB:ENSG00000133019.11; -.
GeneCards; CHRM3; -.
HGNC; HGNC:1952; CHRM3.
HPA; HPA024106; -.
HPA; HPA048036; -.
MalaCards; CHRM3; -.
MIM; 100100; phenotype.
MIM; 118494; gene.
neXtProt; NX_P20309; -.
OpenTargets; ENSG00000133019; -.
Orphanet; 2970; Prune belly syndrome.
PharmGKB; PA112; -.
eggNOG; KOG4220; Eukaryota.
eggNOG; ENOG410YCQR; LUCA.
GeneTree; ENSGT00780000121874; -.
HOGENOM; HOG000231484; -.
HOVERGEN; HBG105720; -.
InParanoid; P20309; -.
KO; K04131; -.
OMA; CQCDKRK; -.
OrthoDB; EOG091G06VI; -.
PhylomeDB; P20309; -.
TreeFam; TF320495; -.
Reactome; R-HSA-390648; Muscarinic acetylcholine receptors.
Reactome; R-HSA-399997; Acetylcholine regulates insulin secretion.
Reactome; R-HSA-416476; G alpha (q) signalling events.
SignaLink; P20309; -.
ChiTaRS; CHRM3; human.
EvolutionaryTrace; P20309; -.
GeneWiki; Muscarinic_acetylcholine_receptor_M3; -.
GenomeRNAi; 1131; -.
PRO; PR:P20309; -.
Proteomes; UP000005640; Chromosome 1.
Bgee; ENSG00000133019; -.
CleanEx; HS_CHRM3; -.
ExpressionAtlas; P20309; baseline and differential.
Genevisible; P20309; HS.
GO; GO:0032279; C:asymmetric synapse; IEA:Ensembl.
GO; GO:0043679; C:axon terminus; IEA:Ensembl.
GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
GO; GO:0030054; C:cell junction; IEA:UniProtKB-KW.
GO; GO:0030425; C:dendrite; IEA:Ensembl.
GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
GO; GO:0005886; C:plasma membrane; IDA:HPA.
GO; GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
GO; GO:0045202; C:synapse; IBA:GO_Central.
GO; GO:0042166; F:acetylcholine binding; ISS:UniProtKB.
GO; GO:0008144; F:drug binding; IEA:Ensembl.
GO; GO:0016907; F:G-protein coupled acetylcholine receptor activity; ISS:UniProtKB.
GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; TAS:ProtInc.
GO; GO:0004872; F:receptor activity; TAS:ProtInc.
GO; GO:0007197; P:adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway; IBA:GO_Central.
GO; GO:0008283; P:cell proliferation; TAS:ProtInc.
GO; GO:0006464; P:cellular protein modification process; TAS:ProtInc.
GO; GO:0007213; P:G-protein coupled acetylcholine receptor signaling pathway; ISS:UniProtKB.
GO; GO:0007186; P:G-protein coupled receptor signaling pathway; TAS:ProtInc.
GO; GO:0007399; P:nervous system development; TAS:ProtInc.
GO; GO:0007207; P:phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway; IBA:GO_Central.
GO; GO:0045987; P:positive regulation of smooth muscle contraction; IEA:Ensembl.
GO; GO:0003056; P:regulation of vascular smooth muscle contraction; IBA:GO_Central.
GO; GO:0046541; P:saliva secretion; IEA:InterPro.
GO; GO:0007165; P:signal transduction; TAS:ProtInc.
GO; GO:0006939; P:smooth muscle contraction; IEA:Ensembl.
GO; GO:0007271; P:synaptic transmission, cholinergic; IBA:GO_Central.
CDD; cd15299; 7tmA_mAChR_M3; 1.
InterPro; IPR000276; GPCR_Rhodpsn.
InterPro; IPR017452; GPCR_Rhodpsn_7TM.
InterPro; IPR001183; Musac_Ach_M3_rcpt.
InterPro; IPR000995; Musac_Ach_rcpt.
Pfam; PF00001; 7tm_1; 1.
PRINTS; PR00237; GPCRRHODOPSN.
PRINTS; PR00243; MUSCARINICR.
PRINTS; PR00540; MUSCRINICM3R.
SMART; SM01381; 7TM_GPCR_Srsx; 1.
PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
1: Evidence at protein level;
3D-structure; Cell junction; Cell membrane; Complete proteome;
Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane;
Phosphoprotein; Polymorphism; Postsynaptic cell membrane; Receptor;
Reference proteome; Synapse; Transducer; Transmembrane;
Transmembrane helix.
CHAIN 1 590 Muscarinic acetylcholine receptor M3.
/FTId=PRO_0000069029.
TOPO_DOM 1 67 Extracellular. {ECO:0000250}.
TRANSMEM 68 91 Helical; Name=1. {ECO:0000250}.
TOPO_DOM 92 104 Cytoplasmic. {ECO:0000250}.
TRANSMEM 105 130 Helical; Name=2. {ECO:0000250}.
TOPO_DOM 131 142 Extracellular. {ECO:0000250}.
TRANSMEM 143 164 Helical; Name=3. {ECO:0000250}.
TOPO_DOM 165 184 Cytoplasmic. {ECO:0000250}.
TRANSMEM 185 206 Helical; Name=4. {ECO:0000250}.
TOPO_DOM 207 229 Extracellular. {ECO:0000250}.
TRANSMEM 230 252 Helical; Name=5. {ECO:0000250}.
TOPO_DOM 253 491 Cytoplasmic. {ECO:0000250}.
TRANSMEM 492 514 Helical; Name=6. {ECO:0000250}.
TOPO_DOM 515 526 Extracellular. {ECO:0000250}.
TRANSMEM 527 546 Helical; Name=7. {ECO:0000250}.
TOPO_DOM 547 590 Cytoplasmic. {ECO:0000250}.
REGION 148 152 Agonist binding. {ECO:0000250}.
REGION 507 530 Agonist binding. {ECO:0000250}.
MOTIF 275 281 Basolateral sorting signal.
MOD_RES 385 385 Phosphoserine.
{ECO:0000250|UniProtKB:Q9ERZ3}.
CARBOHYD 5 5 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 6 6 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 15 15 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 41 41 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
CARBOHYD 48 48 N-linked (GlcNAc...) asparagine.
{ECO:0000255}.
DISULFID 141 221 {ECO:0000255|PROSITE-ProRule:PRU00521}.
DISULFID 517 520 {ECO:0000255|PROSITE-ProRule:PRU00521}.
VARIANT 65 65 V -> I (in dbSNP:rs2067481).
/FTId=VAR_033461.
VARIANT 431 431 L -> P (in dbSNP:rs16839102).
/FTId=VAR_049368.
MUTAGEN 276 276 E->A: Loss of basolateral sorting.
{ECO:0000269|PubMed:15870063}.
MUTAGEN 276 276 E->D: Loss of basolateral sorting. No
effect on basolateral sorting; when
associated with L-280 and L-281.
{ECO:0000269|PubMed:15870063}.
MUTAGEN 280 280 F->A: Loss of basolateral sorting.
{ECO:0000269|PubMed:15870063}.
MUTAGEN 280 280 F->L: No effect on basolateral sorting.
{ECO:0000269|PubMed:15870063}.
MUTAGEN 281 281 V->A: Loss of basolateral sorting.
{ECO:0000269|PubMed:15870063}.
MUTAGEN 281 281 V->L: No effect on basolateral sorting.
{ECO:0000269|PubMed:15870063}.
CONFLICT 382 384 KLP -> RLS (in Ref. 7; AAG30036).
{ECO:0000305}.
STRAND 280 283 {ECO:0000244|PDB:2CSA}.
SEQUENCE 590 AA; 66128 MW; 5CB473C57B9526E9 CRC64;
MTLHNNSTTS PLFPNISSSW IHSPSDAGLP PGTVTHFGSY NVSRAAGNFS SPDGTTDDPL
GGHTVWQVVF IAFLTGILAL VTIIGNILVI VSFKVNKQLK TVNNYFLLSL ACADLIIGVI
SMNLFTTYII MNRWALGNLA CDLWLAIDYV ASNASVMNLL VISFDRYFSI TRPLTYRAKR
TTKRAGVMIG LAWVISFVLW APAILFWQYF VGKRTVPPGE CFIQFLSEPT ITFGTAIAAF
YMPVTIMTIL YWRIYKETEK RTKELAGLQA SGTEAETENF VHPTGSSRSC SSYELQQQSM
KRSNRRKYGR CHFWFTTKSW KPSSEQMDQD HSSSDSWNNN DAAASLENSA SSDEEDIGSE
TRAIYSIVLK LPGHSTILNS TKLPSSDNLQ VPEEELGMVD LERKADKLQA QKSVDDGGSF
PKSFSKLPIQ LESAVDTAKT SDVNSSVGKS TATLPLSFKE ATLAKRFALK TRSQITKRKR
MSLVKEKKAA QTLSAILLAF IITWTPYNIM VLVNTFCDSC IPKTFWNLGY WLCYINSTVN
PVCYALCNKT FRTTFKMLLL CQCDKKKRRK QQYQQRQSVI FHKRAPEQAL


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AP06823PU-N Muscarinic acetylcholine receptor M3 50 µg
NLS1333 Muscarinic acetylcholine receptor M2 0.05 ml
NLS1334 Muscarinic acetylcholine receptor M5 0.05 ml
AP06824PU-N Muscarinic acetylcholine receptor M3 50 µg
NLS5259 Muscarinic acetylcholine receptor M3 0.05 ml
AP06825PU-N Muscarinic acetylcholine receptor M3 50 µg
AP06826PU-N Muscarinic acetylcholine receptor M3 50 µg
AP06976PU-N Muscarinic acetylcholine receptor M3 50 µg
NLS220 Muscarinic acetylcholine receptor M4 0.05 ml
NLS219 Muscarinic acetylcholine receptor M4 0.05 ml
NLS1831 Muscarinic acetylcholine receptor M2 0.05 ml
NLS1338 Muscarinic acetylcholine receptor M5 0.05 ml
SP5119P Muscarinic acetylcholine receptor M1 0.2 mg
AP01304PU-N Muscarinic acetylcholine receptor M2 100 µg


 

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