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Myelin regulatory factor homolog 1 (EC 3.4.-.-) (Polyglutamine-repeat protein 47) [Cleaved into: Myelin regulatory factor homolog 1, N-terminal; Myelin regulatory factor homolog 1, C-terminal]

 MYRF1_CAEEL             Reviewed;         931 AA.
G5EFI7;
30-AUG-2017, integrated into UniProtKB/Swiss-Prot.
14-DEC-2011, sequence version 1.
25-OCT-2017, entry version 51.
RecName: Full=Myelin regulatory factor homolog 1 {ECO:0000303|PubMed:28441531};
EC=3.4.-.- {ECO:0000250|UniProtKB:Q9Y2G1};
AltName: Full=Polyglutamine-repeat protein 47 {ECO:0000303|PubMed:21989027};
Contains:
RecName: Full=Myelin regulatory factor homolog 1, N-terminal {ECO:0000305};
Contains:
RecName: Full=Myelin regulatory factor homolog 1, C-terminal {ECO:0000305};
Name=myrf-1 {ECO:0000303|PubMed:28441531,
ECO:0000312|WormBase:F59B10.1};
Synonyms=pqn-47 {ECO:0000303|PubMed:21989027,
ECO:0000312|WormBase:F59B10.1};
ORFNames=F59B10.1 {ECO:0000312|WormBase:F59B10.1};
Caenorhabditis elegans.
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis.
NCBI_TaxID=6239;
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=Bristol N2;
PubMed=9851916; DOI=10.1126/science.282.5396.2012;
The C. elegans sequencing consortium;
"Genome sequence of the nematode C. elegans: a platform for
investigating biology.";
Science 282:2012-2018(1998).
[2]
TISSUE SPECIFICITY.
PubMed=21989027; DOI=10.1016/j.ydbio.2011.09.025;
Russel S., Frand A.R., Ruvkun G.;
"Regulation of the C. elegans molt by pqn-47.";
Dev. Biol. 360:297-309(2011).
[3]
FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH MYRF-2, TISSUE
SPECIFICITY, DISRUPTION PHENOTYPE, PROTEOLYTIC PROCESSING, AND
MUTAGENESIS OF GLY-274 AND SER-483.
PubMed=28441531; DOI=10.1016/j.devcel.2017.03.022;
Meng J., Ma X., Tao H., Jin X., Witvliet D., Mitchell J., Zhu M.,
Dong M.Q., Zhen M., Jin Y., Qi Y.B.;
"Myrf ER-bound transcription factors drive C. elegans synaptic
plasticity via cleavage-dependent nuclear translocation.";
Dev. Cell 41:180-194(2017).
-!- FUNCTION: Myelin regulatory factor homolog 1: Constitutes a
precursor of the transcription factor (PubMed:28441531). Mediates
the autocatalytic cleavage that releases the Myelin regulatory
factor homolog 1, N-terminal component that specifically activates
transcription of genes involved in synaptic rewiring during
nervous system maturation (PubMed:28441531).
{ECO:0000269|PubMed:28441531}.
-!- FUNCTION: Myelin regulatory factor homolog 1, C-terminal:
Membrane-bound part that has no transcription factor activity and
remains attached to the endoplasmic reticulum membrane following
cleavage. {ECO:0000250|UniProtKB:Q9Y2G1}.
-!- FUNCTION: Myelin regulatory factor homolog 1, N-terminal:
Transcription factor that specifically activates expression of
genes involved in synaptic rewiring during nervous system
maturation (PubMed:28441531). Specifically required for dorsal D
(DD) GABAergic motor neurons synaptic rewiring (PubMed:28441531).
Acts in complex with myrf-2 paralog (PubMed:28441531).
{ECO:0000269|PubMed:28441531}.
-!- SUBUNIT: Homotrimer (By similarity). Interacts with myrf-2
(PubMed:28441531). {ECO:0000250|UniProtKB:Q9Y2G1,
ECO:0000269|PubMed:28441531}.
-!- SUBCELLULAR LOCATION: Myelin regulatory factor homolog 1:
Endoplasmic reticulum membrane {ECO:0000269|PubMed:28441531};
Single-pass membrane protein {ECO:0000255}.
-!- SUBCELLULAR LOCATION: Myelin regulatory factor homolog 1, N-
terminal: Nucleus {ECO:0000269|PubMed:28441531}. Cytoplasm
{ECO:0000269|PubMed:28441531}. Note=Translocates from the
cytoplasm to the nucleus upon autocatalytic cleavage.
{ECO:0000269|PubMed:28441531}.
-!- SUBCELLULAR LOCATION: Myelin regulatory factor homolog 1, C-
terminal: Endoplasmic reticulum membrane
{ECO:0000269|PubMed:28441531}; Single-pass membrane protein
{ECO:0000255}.
-!- TISSUE SPECIFICITY: Widely expressed in many tissues, including
neuronal, muscle and epidermal stem cells (PubMed:21989027). In
neurons, expressed in dorsal D (DD) GABAergic motor neurons
(PubMed:28441531). {ECO:0000269|PubMed:21989027,
ECO:0000269|PubMed:28441531}.
-!- DOMAIN: Myelin regulatory factor: The peptidase S74 domain, also
named Intramolecular Chaperone Auto-processed (ICA) domain or
Intramolecuar Chaperone Domain (ICD), has protease activity and
mediates autocatalytic processing of the protein to generate the
Myelin regulatory factor, N-terminal active transcription factor
and the Myelin regulatory factor, C-terminal components.
{ECO:0000250|UniProtKB:Q9Y2G1}.
-!- PTM: Myelin regulatory factor: Follows autocatalytic cleavage via
the peptidase S74 domain. Autoprocessing is apparently
constitutive and is essential for transcriptional activity.
{ECO:0000305|PubMed:28441531}.
-!- DISRUPTION PHENOTYPE: Worms show normal dorsal D (DD) GABAergic
motor neurons rewiring but show larval lethality. Worms lacking
both myrf-1 and myrf-2 display defective DD neurons rewiring.
{ECO:0000269|PubMed:28441531}.
-!- SIMILARITY: Belongs to the MRF family. {ECO:0000305}.
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EMBL; BX284602; CAA88602.3; -; Genomic_DNA.
PIR; H88293; H88293.
PIR; T22982; T22982.
RefSeq; NP_496262.2; NM_063861.4.
UniGene; Cel.4939; -.
ProteinModelPortal; G5EFI7; -.
SMR; G5EFI7; -.
IntAct; G5EFI7; 2.
STRING; 6239.F59B10.1; -.
EPD; G5EFI7; -.
PaxDb; G5EFI7; -.
PeptideAtlas; G5EFI7; -.
EnsemblMetazoa; F59B10.1; F59B10.1; WBGene00004134.
GeneID; 174614; -.
KEGG; cel:CELE_F59B10.1; -.
CTD; 174614; -.
WormBase; F59B10.1; CE36940; WBGene00004134; myrf-1.
eggNOG; KOG3661; Eukaryota.
eggNOG; ENOG410XPRK; LUCA.
GeneTree; ENSGT00530000063626; -.
InParanoid; G5EFI7; -.
OMA; GYSTESC; -.
OrthoDB; EOG091G0213; -.
PhylomeDB; G5EFI7; -.
Proteomes; UP000001940; Chromosome II.
Bgee; WBGene00004134; -.
GO; GO:0045178; C:basal part of cell; IDA:WormBase.
GO; GO:0005737; C:cytoplasm; IDA:WormBase.
GO; GO:0005783; C:endoplasmic reticulum; IDA:WormBase.
GO; GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
GO; GO:0005634; C:nucleus; IDA:UniProtKB.
GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-KW.
GO; GO:0003700; F:transcription factor activity, sequence-specific DNA binding; IEA:InterPro.
GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
GO; GO:0042395; P:ecdysis, collagen and cuticulin-based cuticle; IMP:WormBase.
GO; GO:0018996; P:molting cycle, collagen and cuticulin-based cuticle; IGI:WormBase.
GO; GO:0002119; P:nematode larval development; IMP:WormBase.
GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
GO; GO:1904799; P:regulation of neuron remodeling; IDA:UniProtKB.
GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW.
Gene3D; 1.10.10.10; -; 1.
Gene3D; 2.60.40.1390; -; 2.
InterPro; IPR026932; MRF_C1.
InterPro; IPR025719; MRF_C2.
InterPro; IPR024061; NDT80_DNA-bd_dom.
InterPro; IPR037141; NDT80_DNA-bd_dom_sf.
InterPro; IPR008967; p53-like_TF_DNA-bd.
InterPro; IPR030392; S74_ICA.
InterPro; IPR036388; WH-like_DNA-bd_sf.
Pfam; PF13887; MRF_C1; 1.
Pfam; PF13888; MRF_C2; 1.
Pfam; PF05224; NDT80_PhoG; 1.
Pfam; PF13884; Peptidase_S74; 1.
SUPFAM; SSF49417; SSF49417; 1.
PROSITE; PS51688; ICA; 1.
PROSITE; PS51517; NDT80; 1.
1: Evidence at protein level;
Activator; Autocatalytic cleavage; Complete proteome; Cytoplasm;
Differentiation; DNA-binding; Endoplasmic reticulum; Glycoprotein;
Hydrolase; Membrane; Nucleus; Protease; Reference proteome;
Transcription; Transcription regulation; Transmembrane;
Transmembrane helix.
CHAIN 1 931 Myelin regulatory factor homolog 1.
/FTId=PRO_0000441325.
CHAIN 1 482 Myelin regulatory factor homolog 1, N-
terminal. {ECO:0000305|PubMed:28441531}.
/FTId=PRO_0000441326.
CHAIN 483 931 Myelin regulatory factor homolog 1, C-
terminal. {ECO:0000305|PubMed:28441531}.
/FTId=PRO_0000441327.
TOPO_DOM 1 658 Cytoplasmic. {ECO:0000305}.
TRANSMEM 659 679 Helical. {ECO:0000255}.
TOPO_DOM 680 931 Lumenal. {ECO:0000305}.
DOMAIN 483 582 Peptidase S74. {ECO:0000255|PROSITE-
ProRule:PRU01025}.
DNA_BIND 169 436 NDT80. {ECO:0000255|PROSITE-
ProRule:PRU00850}.
COMPBIAS 48 167 Gln-rich. {ECO:0000255|PROSITE-
ProRule:PRU00006}.
SITE 482 483 Cleavage; by autocatalysis.
{ECO:0000269|PubMed:28441531}.
CARBOHYD 797 797 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
CARBOHYD 912 912 N-linked (GlcNAc...) asparagine.
{ECO:0000255|PROSITE-ProRule:PRU00498}.
MUTAGEN 274 274 G->R: In ju1121; defective dorsal D (DD)
GABAergic motor neurons rewiring. Impairs
the function of myrf-2 by obstructing its
function in the complex formed between
myrf-1 and myrf-2.
{ECO:0000269|PubMed:28441531}.
MUTAGEN 483 483 S->A: Prevents cleavage and generation of
Myelin regulatory factor homolog 1, N-
terminal part.
{ECO:0000269|PubMed:28441531}.
SEQUENCE 931 AA; 104463 MW; C1B7F38712BBF6CD CRC64;
MSSSDLLKGE FDGLNSEHFN MMQYLTQDTD EDDGSMVSPT SSADSMHQNL GVQQQQQQML
QAQQRQNQNG IFQPRRFPES PAMTDPCGNV SSSSSSSHHS DPMFSPNEFN GYAGANDNGN
QTMNNIQSQQ LSQQQHQQTR GGNLMMPQQS SIHAQMQNMN APQFWSQPGT AAVNQPTNTL
AQLNLFNIIR GGADSGMPSP VLEMPRKRSR LDTPCETPRI APSFAGIDGF PDENYSQQQA
IRFSKFQEEQ WSPLYDINAQ PLQQLQVHVV ADKGFNYNSN DNCFVNQKKN HFQISVNVEA
SDTMPPKYVN FNNRLVPIRD FKLSFCGVKA EMPSSEITIR QSRADRKPHT HTPVLFEIQE
RRMTKVCVPR LHFSETTLNN QRKQKNRPNP EQKFFLLVVR LFASIDESEH GVLIQSYASE
KVIVRATNPG SFEPQDTDIG WQRNGGALYT QGAVSVGTEH QVESAKLTVA GDIYMSGRII
NPSDIRLKEA ITERETAEAI ENLLKLRVVD YRYKPEVADI WGLDEQQRHR TGLIAQELQA
VLPDAVRDIG DYLTIDEGRV FYETVMATQQ LCRMTGDLDS KIDEKVAEIS RRLNEYAVRK
KLASSMASNL NGDNKSLSYS RCSLTSTATN ATSQPKRSRK HRAIKQAQSC GSRLSQGTVV
TLVSIMAACL LAMSALYVLD WHNRNYGYHQ HFETNTPSTK GELANLVISP ANFMPSFQPD
APILLEKCFN PSCKTYCCTD TPPVVEDSRA IATHGLDNGD EVYPESPSNR TNGIARAPNL
EHMAFETGVE IRIPALNVTL DQRYCVERSC NKRKGIFNVF VPVSRYMPDV ALEIEIKAPI
SKVVSNCGAF PSTEFNHKVC PLSRTQQSES PVPTSTRLFD NIFELSMGSF IQSAYRFRVG
YSTETCFSED SNGSYEEYNL IFYRMCTLSS S


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